Lesson Guide

DIPOLOG MEDICAL CENTER
COLLEGE FOUNDATION
ALLIED MEDICAL SCIENCES
MEDICAL TECHNOLOGY DEPARTMENT
FIRST SEMESTER SY 2018-2019
PERIOD August 13 – 20, 2018

TOPIC : Liver Function Test
A. Gross and Micrsocopic anatomy of Liver

B. Functions of liver
I. Synthetic Function and its corresponding Laboratory test
a) Total protein
b) Albumin
c) A/G ratio
II. Conjugation and Excretion Function and its corresponding Laboratory test
a) Bilirubin metabolism and disorders
b) Bilirubin assay
c) Bromsulfonthalein (BSP) Dye excretion Test
III. Detoxification Function
a) Enzyme tests
b) Ammonia
Powerpoint Presentation
Quiz
Difference between Nephrotic and Nephritic Syndrome
Chapter Exam
Advance reading for Enzymes

COLLEGE FOUNDATION
PERIOD
TOPIC : ENZYMES
A. Introduction to Enzymes
I. Nomenclature of enzymes
II. Classification of enzymes
III. Identification of terms related to enzymes
IV. Mode of Enzyme Activity
V. Models for enzyme activity
a) Lock and Key model (Emil Fisher)
b) Induce fit model (Daniel Koshland)
VI. Factors Affecting Rate of Enzyme Reaction
a) Temperature
b) pH
c) Subtrate concentration
d) Enzyme Concentration
VII. Clinical significance of enzymes
Quiz
Assignment :
Advance reading for Enzymes Alkaline phosphatase, Alanine aminotransferase, Aspartate

aminotransferase
COLLEGE FOUNDATION
PERIOD
TOPIC : ENZYMES
A. Enzymatic Reaction
i. First-order kinetics
ii. Zero-order kinetics
B. Alkaline phosphatase (ALP)
i. Function and Importance of ALP in the body
ii. Normal and Abnormal Isoenzymes of ALP
iii. Methods that measure ALP
iv. Specimen consideration for ALP samples
v. Conditions related to High or Low levels of ALP
C. Acid phosphatase (ACP)
i. Function and Importance of ACP in the body
ii. Methods that measure ACP
iii. Specimen consideration for ACP samples
iv. Conditions related to High or Low levels of ACP
D. Alanine aminotransferase (ALT)
i. Function and Importance of in the body
ii. Normal and Abnormal Isoenzymes of ALT
iii. Methods that measure ALT
iv. Specimen consideration for ALT samples
v. Conditions related to High or Low levels of ALT
E. Aspartate aminotransferase (AST)
i. Function and Importance of AST in the body
ii. Normal and Abnormal Isoenzymes of AST
iii. Methods that measure AST
iv. Specimen consideration for AST samples
v. Conditions related to High or Low levels of AST
F. Lactate dehydrogenase (LD)
i. Function and Importance of LD in the body
ii. Normal and Abnormal Isoenzymes of LD
iii. Methods that measure LD
iv. Specimen consideration for LD samples
v. Conditions related to High or Low levels of LD
Quiz
Advance reading for Cardiac and Pancreatic Enzymes and Pseudocholinesterase

COLLEGE FOUNDATION
PERIOD
TOPIC : ENZYMES
A. Pseudocholinesterase
B. Cardiac Enzymes
i. LD
ii. Creatine kinase
a) Diagnostic significance
b) Creatine kinase isoenzymes
c) Specimen consideration
d) Method to measure Creatine kinase
iii. Myoglobin
iv. Troponin
C. Acute pancreatitis Enzymes
i. Amylase
b) Amylase isoenzymes
d) Method to measure Amylase
ii. Lipase
b) Lipase isoenzymes
d) Method to measure Lipase
D. Prostatic Cancer Enzymes
i. ACP
ii. PSA
Quiz
Advance reading for Other enzymes

COLLEGE FOUNDATION
PERIOD
TOPIC : ENZYMES
A. Aldolase
i. Diagnostic significance
ii. Specimen consideration
iii. Method to measure Aldolase
B. Leucine Aminopeptidase (LAP)
ii. Specimen consideration
iii. Method to measure LAP
C. Trypsin
ii. Method to measure trypsin
D. 5’ Nucleotidase
ii. Method to measure 5’ Nucleotidase
E. Isocitric Dehydrognase
ii. Method to measure Isocitric Dehydrognase
F. Sorbitol Dehydrogenase
ii. Method to measure Sorbitol Dehydrogenase
G. G 6 PD
ii. Method to measure G 6 PD
H. Ornithine Carbamoyl Transferase
ii. Method to measure Ornithine Carbamoyl Transferase
Chapter exam for the whole topic of enzymes
Advance reading for Electrolytes

COLLEGE FOUNDATION
PERIOD
TOPIC : ELECTROLYTES
A. Introduction to Electrolytes
a. Discussion about Anions and Cations
b. Water content of the body
i. Extracellular Fluid (ECF)
ii. Intracellular Fluid (ICF)
iii. Interstitial Fluid
c. Normal Plasma Composition
B. Definition of terms
a. Osmosis
b. Osmotic pressure
c. Osmolality
C. Importance of Electrolytes in the Body’s processes
D. Maintenance of Ion in the plasma or regulation of body fluid compartments
E. Importance of Osmolality
F. Regulation of Blood Volume
Word Presentation
Quiz
Advance reading for the electrolyte Sodium

COLLEGE FOUNDATION
PERIOD
A. Sodium (Na)
i. Clinical significance of Sodium (Na)
ii. Processes that determine the plasma Na concentration
iii. Clinical Application of Na
a) Normal Value Range
b) Hyponatremia
a. Increased Na loss in the urine
b. Increased water retention or water imbalance
i. Renal failure
ii. Nephrotic syndrome
iii. Hepatic cirrhosis
iv. Congestive heart failure
v. Excess water intake
vi. Pseudohyponatremia
vii. Syndrome of Inappropriate ADH secretion
c) Hypernatremia
i. K
iv. Determination of Na
a) Specimen Consideration
b) Laboratory Methods
Word Presentation
Quiz
Advance reading for the electrolyte Potassium, Chloride, Calcium

COLLEGE FOUNDATION
PERIOD
A. Potassium (K)
a. Clinical Significance of K
b. Reference Values
i. Serum
ii. Plasma
iii. Sweat
iv. Urine
c. Absorption/Excretion of K in the kidneys
d. Function of K
e. Hyperkalemia
i. Conditions related to Hyperkalemia
f.

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DIPOLOG MEDICAL CENTER

PERIOD August 13 – 20, 2018

A. Gross and Micrsocopic anatomy of Liver

Difference between Nephrotic and Nephritic Syndrome

Advance reading for Enzymes

Advance reading for Enzymes Alkaline phosphatase, Alanine aminotransferase, Aspartate

Advance reading for Cardiac and Pancreatic Enzymes and Pseudocholinesterase

Advance reading for Other enzymes

Chapter exam for the whole topic of enzymes

Advance reading for Electrolytes

Advance reading for the electrolyte Sodium

Advance reading for the electrolyte Potassium, Chloride, Calcium

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