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Dosis Antibiotik

Research · November 2015

DOI: 10.13140/RG.2.1.1077.7041

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 DOSIS ANTIMIKROBA catatan seorang residen mikrobiologi klinik

NAMA OBAT DOSIS DEWASA DOSIS ANAK KET

ACYCLOVIR Herpes labialis Neonates: Cimetidin,

400mg 5x/hr 5hr p.o  200mg/kg q8h 14-21 hr i.v theofilin dan
 Kronik:75mg/kg q12h p.o probenecid
Genital herpes menaikkan
Awal 200mg 5x/hr 10hr p.o Anak levelnya dan efek
Ulang (<6x/th):200 mg 5x/hr HSV: 10-20mg/kg q6h 5-10hr ginjal
5hr p.o or
Kronik (>6x/th):400 mg q12h 5mg/kg/dosis q8h 5hr
1th p.o
CrCl 10-25:sesuai dosis Varicella: 20mg/kg q6h 5hr
normal
CrCl<10ml/mnt:200mg q12h
Post HD: 200mg

Mukosa/genital
5mg/kg q8h 7hr i.v or
400 mg 5x/hr 7hr p.o
Messag er

Varicella
800 mg q6h 5hr p.o or
10 mg/kg q8h 5hr i.v
no God but All oh, and Muhammad is H is

CrCl 10-25:800 mg q8h

CrCl<10ml/mnt:800mg q12h
Post HD: 800mg
AMIKACIN 15mg/kg q24h i.v or Neonates: Jgn dg
1 g q24h i.v  ≤27mggu: 18mg/kg q48h amphoterecin,
 28-30 mggu: 18mg/kg q36h polymyxin,
CrCl 50-80: 7,5 mg/kg q24h  31-33 mggu: 16mg/kg q36h vancomycin,
i.v or  ≥34 mggu: 15mg/kg q24h
500mg q24h i.v
CrCl 10-50: 7,5 mg/kg q48h Anak
i.v or 5-7,5 mg/kg q8h i.v
500mg q48h i.v
CrCl <10: 3,75 mg/kg q48h
i.v or
Ther e i s

250mg q48h i.v

Post HD: 7,5 mg/kg i.v or
500mg i.v
 NAMA OBAT DOSIS DEWASA DOSIS ANAK KET

AMOXICILLIN 1g q8h p.o Neonates:

CrCl 50-80: 500 mg q8h p.o Tak boleh
CrCl 10-50: 500 mg q12h p.o
CrCl <10: 500 mg q24h p.o Anak
Post HD: 500 mg 22,5-45 mg/kg q12h p.o
AMOXICLAV 500/125mg q8h p.o Neonates:
Severe/ISPA 875/125mg q12h Tak boleh
p.o
CrCl 50-80: 500/125mg q12h Anak
p.o 22,5-45 mg/kg q12h p.o
CrCl 10-50: 500/125mg q24h
p.o
CrCl <10: 250/125mg q23h
p.o
Post HD: 250/125mg p.o
AMPICILLIN 2g q4h i.v Neonates: Menaikkan
500mg q6h p.o 25-50 mg/kg/dosis i.v/i.m OT/PT, diare, C.
CrCl 50-80: 1g q4h i.v difficile
500 mg q6h p.o Severe group B streptococcal
Messag er

CrCl 10-50: 1g q8h i.v sepsis

250 mg q8h p.o 100 mg/kg/dosis
CrCl <10: 1g q12h i.v GA+CA CA Interval
no God but All oh, and Muhammad is H is

250 mg q12h p.o Mggu Hari Jam

Post HD: 1g i.v ≤29 0-28 12
500mg p.o >28 8
30-36 0-14 12
>14 8
≥37 0-7 12
>7 8

Anak
25-50 mg/kg q6h p.o
AMPICILLIN 1,5-3 g q6h i.v Neonates: Dpt utk MDR
SULBACTAM CrCl 50-80: 1,5g q6h i.v Tak boleh Acinetobacter
CrCl 10-50: 1,5g q12h i.v
CrCl <10: 1,5g q24h i.v Anak
Ther e i s

Post HD: 1,5g i.v 25-50 mg/kg q6h p.o

 NAMA OBAT DOSIS DEWASA DOSIS ANAK KET
AZITHROMYCIN 500mg single dose i.v/p.o lalu Neonates: Menaikkn QT
250 mg q24h i.v/p.o Tak boleh interval
Anak
30mg/kg dosis tunggal p.o
10mg/kg q24h 3hr p.o
AZTREONAM 2g q8h i.v Neonates:
CrCl 50-80: 2g q8h i.v 30 mg/kg/dosis i.v/i.m
CrCl 10-50: 1g q8h i.v
CrCl <10: 500mg q8h i.v GA+CA CA Interval
Post HD: 250mg i.v Mggu Hari Jam
≤29 0-28 12
>28 8
30-36 0-14 12
>14 8
≥37 0-7 12
>7 8

Anak
30 mg/kg/dosis i.v/i.m q6-8h
Messag er

CEFADROXIL 1000mg q12h p.o Neonates: Penetrasi ke secret

CrCl 50-80: 500mg q12h p.o Tak boleh sal. nafas bagus.
CrCl 10-50: 500mg q24h p.o Anak
no God but All oh, and Muhammad is H is

CrCl <10: 500mg q36h p.o 15mg/kg q12h p.o

Post HD: 500mg p.o
CEFEPIME 2g q12h i.v Neonates: Bagus utk
CrCl 50-80: 2g q24h i.v 50mg/kg q8-12h i.v Pseudomonas
CrCl 10-50: 2g q48h i.v Anak
CrCl <10: 500mg q24h i.v 33,3-50mg/kg q8h i.v/i.m
Post HD: 2g i.v
CEFIXIME 200mg atau 400mg q12h p.o Bagus utk GC
CrCl 10-50: 300mg q24h p.o resisten quinolon
CrCl <10: 200mg q24h p.o
Post HD: 300mg p.o
CEFOPERAZONE 2g q12h i.v Mampu tembus
trak. Biliaris
Ther e i s
 NAMA OBAT DOSIS DEWASA DOSIS ANAK KET
CEFOTAXIME 2g q6h i.v Neonates: Berlawanan jk
CrCl 10-50: 1g q6h i.v 50mg/kg q8-12h i.v digabung sodium
CrCl <10: 1g q12h i.v Anak bicarbonate,
Post HD: 1g i.v 25-50mg/kg q6-8h i.v/i.m metronidazol, atau
aminoglikosida
CEFTAZIDIME 2g q8h i.v Neonates: Berlawanan jk
CrCl 50-80: 1g q12h i.v 30mg/kg/dosis i.v digabung
CrCl 10-50: 1g q24h i.v GA+CA CA Interval vancomycin atau
CrCl <10: 500mg q24h i.v Mggu Hari Jam aminoglikosida
Post HD: 1g i.v ≤29 0-28 12
>28 8
30-36 0-14 12
>14 8
≥37 0-7 12
>7 8

Anak
25-50mg/kg q6-8h i.v/i.m
CEFTRIAXONE 1-2g q24h i.v Neonates: Bergabung dgn lar
Messag er

50mg/kg q8-12h i.v Ca akan timbul

Anak presipitasi vasc.
Sepsis: 50mg/kg q24h i.v/i.m Bgs utk Strep
no God but All oh, and Muhammad is H is

pneumonia di
CAP/CNS
CHLORAM 500mg q6h i.v/p.o Berlawanan jk
PHENICOL digabung
vancomycin,
ampicillin,
erithromisin atau
aminoglikosida

Inaktif di empedu.
CIPRO 400mg q8-12h i.v
FLOXACIN 500-750mg q12h p.o
CrCl 10-50: 400mg q12h i.v
500mg q12h p.o
Ther e i s

CrCl <10: 400mg q12h i.v

500mg q12h p.o
 NAMA OBAT DOSIS DEWASA DOSIS ANAK KET
CLARITHRO 500mg q12h p.o Neonates: Jgn utk aritmia
MYCIN CrCl <10: 250mg q12h p.o Tak boleh
Post HD: 500mg Anak
7,5 mg/kg q12h p.o
CLINDAMYCIN 600-900 mg q8h i.v Neonates:
150-300 mg q6h p.o 5-7,5 mg i.v/p.o
GA+CA CA Interval
Mggu Hari Jam
≤29 0-28 12
>28 8
30-36 0-14 12
>14 8
≥37 0-7 8
>7 6

Anak
5-10 mg/kg q6-8h i.v/i.m
10-30 mg/kg/hr q6-8h p.o
DORIPENEM 500 mg q8h i.v Bagus utk
Messag er

CrCl 50-80: 500mg q8h i.v Pseudomonas &

CrCl 30-50: 250mg q8h i.v Acinetobacter
CrCl 10-30: 250mg q12h i.v MDR
no God but All oh, and Muhammad is H is

ERTAPENEM 1g q24h i.v/i.m Neonates: Krg bagus utk

CrCl<30: 500mg q24h i.v Tak boleh Pseudomonas &
Anak Acinetobacter
15mg/kg q12h i.v (tak boleh
>1g/hr)
ERYTHROMYCIN 1g q6h i.v Neonates: Cek OTPT
500mg q6h p.o 10mg/kg q8h p.o Jgn u aritmia
Anak
10-12,5mg/kg q6-8h p.o
5-12,5mg/kg q6h i.v
FOSFOMYCIN 3g q24h p.o Ab p.o yg dpt u
MDR Pseudo,
Klebsiella,
Acinetobacter di
Ther e i s

cystitis/CAB
 NAMA OBAT DOSIS DEWASA DOSIS ANAK KET
GENTAMICIN 5-7mg/kg q24h i.v Neonates:
CrCl 50-80:2,5mg/kg q24h i.v 4-5mg/kg q24h i.v
120mg q24h i.v Anak
CrCl 10-50:2,5mg/kg q48h i.v 2-2,5 mg/kg q8h i.v/i.m
120mg q48h i.v
CrCl <10: 1,25mg q48h i.v
80mg q48h i.v
IMIPENEM 500mg-1g q6h i.v Neonates: Induksi MRSA-
CrCl 50-80:500mg q6h i.v 20-25mg/kg q12h i.v MDRO
CrCl 10-50: 500mg q8h i.v Anak
CrCl <10: 250mg q12h i.v 15-25 mg/kg q6h i.v
LEVOFLOXACIN 500-750mg q24h i.v/p.o
LINEZOLID 600mg q12h i.v/p.o Neonates:
10mg/kg q12h i.v
Anak
10 mg/kg q8h i.v
MEROPENEM 500mg-1g q8h i.v Neonates: Menghambat
CrCl 25-50: 1g q12h i.v 20mg/kg q12h i.v pelepasan
CrCl 10-25: 500mg q12h i.v Anak endotoxin gr-
Messag er

CrCl <10: 500mg q12h i.v 10 mg/kg q8h i.v (kulit) Satu2nya yg dpt
20mg/kg q8h i.v (intraabd) bolus lebih dr 3-
40mg/kg q8h i.v (meningen) 5mnt
no God but All oh, and Muhammad is H is

MOXIFLOXACIN 400mg q24h i.v/p.o Satu2nya

quinolone utk
B.fragilis
METRONIDAZOLE 1g q24h i.v Neonates: 15mg/kg i.v lalu
500mg q6-8h i.v/p.o 15mg/kg i.v/p.o lalu 7,5mg/kg q6h i.v
CrCl <10: 500mg q24h i.v 7,5mg/kg/dose
250mg q12h p.o GA+CA CA Interval
Mggu Hari Jam
≤29 0-28 48
>28 24
30-36 0-14 24
>14 12
≥37 0-7 24
>7 12
Ther e i s

Anak
5-10 mg/kg q6-8h i.v/i.m
 NAMA OBAT DOSIS DEWASA DOSIS ANAK KET
PIP-TAZO 3,375g q6h i.v Neonates:
CrCl 20-40: 2,25mg q6h i.v Tak boleh
CrCl <20: 2,25mg q8h i.v Anak
100-30mh/kg/hr i.v
TIGECYCLINE 100mg 1dose i.v lalu Bgs u Klebsiella
50mg q12h i.v MDRO dan
Acinetobacter
MDRO.
Jgn u <18th
TMP-SMX 2,5-5mg/kg q6h i.v/p.o Neonates:
CrCl 10-50: 1,25-2,5 mg/kg Tak boleh
q6h i.v/p.o Anak
4-5mg/kg q12h p.o/i.v
VANCOMYCIN 1g q12h i.v Neonates:
CrCl 50-80: 500mg q12h i.v Bcteremi 10mg/kg/dose i.v
CrCl 10-50: 500mg q24h i.v Anak
CrCl<10 : 1g/minggu i.v 10-15mg/kg q6h i.v
Messag er

Edisi 1 : Januari 2012

Hak Cipta : dr Ridha Wahyutomo
Sumber : Antibiotic Essentials Burke A Cunha
Mendell Infectious Disease
no God but All oh, and Muhammad is H is

Clinical Pharmacology Goodman and Gillman

Untuk 3 cahaya hidupku

Nurhasanah
Arina Khaira Rasyidatu Mahya
Annida Khaira Rasyidatu Zahira
Ther e i s

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