( <1wk: Q 12h; >1wk: Q12hr; IN, CH: Q6hr ) IV, IM. 10 mg , < 5 yr 5 mg). Rectal dose 0.5 mg/kg/dose.
Neonatal and Pediatric Formulary 2012
30TH Edition
Extensively Revised Version
Dr. Heji Al-Zoayed
A secretions clear) then Q1-4 hr for at least 24 hr.
ACYCLOVIR : HSV Encephalitis : 30 mg/kg/24 hr ( 1,500 mg/m 2/24 hr)
÷ Q8 hr IV infusion over 1 hr for 14-21 days
NN ≥ 34 wk : 20 mg/kg/dose IV Q8 hr for 14-21 days
Varicella : 30 mg/kg/24 hr ( 7-10days)
MucuL HSV: IV: 15 mg/kg/day or 750 mg/m 2/day ÷ Q8 hr
PO: 15 mg/kg/dose five times daily : max 1gm/day
(initial: 7-10 days recurrence: 5 days)
ADENOSINE: SVT: NN, IN, CH, 0.05 mg/kg IV push, then ↑ by 0.05
mg/kg Q 2 min till a clinical response occur or a max dose of 0.25
mg/kg or 12 mg achieved
ADRENALINE: CPR (mg/kg/dose): NN: 0.01-0.03mg IV, ETT.
IN, CH: 0.01 mg S.C, IV - 0.1 mg ETT Q3-5min.
IV infusion: 0.1-1 µg/kg/min Neublization (alternative to
racimic epinephrine): 0.5 ml/kg of 1:1000 solution diluted
in 3 ml NS. Max dose > 4 y, 5ml/dose ≤ 4yr, 2.5 ml/dose
Status Asthmaticus : 0.01 mL/kg/dose every 15–20 min; may be
repeated three times if clinically indicated (Conc 1 : 1,000, 1
mg/mL )
ALFACALCIDOL, One - α : 1drop = 0.1µg ).
Prophylaxis : NN : 10-20 µg/day, IN, CH : 10 µg/day PO
Renal failure : 0.1 – 1 mg/day PO
Nutritional Richets without malabsorption : 25 µg/day PO
with malabsorption : 250 – 625 µg/day PO
ALLOPURINOL: CH, 10 mg/kg/day ÷ Q6-12 hr PO max dose
600 mg/24 hr
AMIKACIN: : IN, CH: 15- 22 mg/kg/day ÷ Q8 -12 hr IV, IM
max: 1.5 g/day .
AMINOPHYLLINE: Acute asthma:: LD, 5 mg/kg IV over 20-30
min. Dilute 1ml ( 25 mg ) with 4 ml NS or D5W
MD (mg/kg/hr): 6 wk-6mo: 0.5 mg,
6mo- 1yr : 0.7: 1 mg, 1-9yr: 1 mg, 10-12 yr: 0.9 mg,
CHF or Liver disease: 0.5 mg/kg/hr.
Theophllyine: IN, CH: 12 mg/kg/day ÷ Q6hr PO (if
tolerated, ↑ by 25% Q 3-4 day to 20 mg/kg/day)
Sustaine release tab: initial 3.5mg/kgldose Q12 hr ↑ after
3 days if tolerated to 16 mg/kg/day and after another 3 days
to 20 mg/kg/day
AMOXICILLIN: 20- 25-mg/kg/dose Q12 hr
Otitis media: 80-90 mg/kg/day in 2 divided doses
Ampicillin and Sulbactam : IV : CH ≥ 1 year
Severe infection : 50- 100 mg ampicillin/kg/dose Q 6 hours
Mild-mod infection : 25- 50 mg ampicillin/kg/dose Q 6 hours
Acute Epiglottitis : : IV 25- 50 mg ampicillin/kg/dose Q 6 hours
Peritonsillar and retropharyngeal abscess : 50 mg
ampicillin/kg/dose Q 6 hours
AUGMENTIN, MEGAMOX (based on amoxicillin )
< 3 mo 15 mg/kg/dose Q12hr , > 3 mo : Pneumonia,
sinusitis, severe infection 22.5 mg/kg/dose Q12 hr
Mild to moderate infection : 12.5 mg/kg/dose Q12 hr
Otitis media : 40-45 mg/kg/dose Q 12 hr.
CH > 40 kg : Serious Infections and Respiratory Tract
Infections : 875 mg Q 12 hr
IV Augmentin : NN : 30 mg/kg/dose Q 12 hr
1- 3 mo : 30 mg/kg/dose Q 8 hr
3-mo- 12 yr :30 mg/kg/dose Q 8 hr, , increase to
Q 6 hr with severe infection
AMPHOTERICINE B: 0.25 mg/kg/day qd ↑ by 0.25 mg/kg/day
to1mg/kg/day IV with D5 over 4 hr : 1mlD5 / 0.1mg
AMPICILLIN: Meningitis: NN> 2kg: 50 mg/kg (< 1wk Q8hr,
>1wk Q6hr) IN, CH: 50-75 mg/kg 6hr. IV, IM.
Other Infections: NN: 25 mg/kg/dose: < 1wk: Q12hr, >
1wk: Q 8hr CH, IN: 25-50 mg/kg Q6 hr.
ASPIRIN : Anti-inflamatory : 80-100 mg/kg ÷ Q6 hr
Antithrombotic : 5- 10 mg/kg/day qd
ATENOLOL: 0.8- 2 mg/kg/day ÷ q 24 hr PO
ATROPINE SULFATE: CPR: NN,IN,CH 0.02 mg/kg/dose IV,
ETT Q5 min 2-3 doses min dose 0.1mg, max single dose
0.5 mg . Organophosphorus poisoning: 0.02-0.05 mg/kg
IV Q10-20 min until atrpopine effect ( till excessive
Ac asthma: 50 µg /kg/dose + 3 cc NS nebulization Q6-8 hr
AZITHROMYCIN: 200 mg/5 ml, 250 mg capsules :
Pneumonia, pertussiis : 10 mg/kg PO OD for 5 days 1hr fefore
or 2 hr after food. Acute Otitis media : 30 mg/kg once or 10
mg/kg for 3 days, pharyngitis : 20 mg/kg/dose for 3 days or
12 mg/kg/dose OD for 5 days.
AZTREONAM: 30 mg/ kg/dose IV ( 1wk : < 2kg Q12 hr, 2kg Q8 hr;
> 1wk : < 2 kg Q8hr, > 2kg Q6hr).
IN,CH : 90 -120 mg/ kg /day ÷Q6-8 hr .
B
BACLOFEN: PO 10-15 mg  Q8h  5-15 mg/day every 3-5 days to
40 mg/day; if >8 yr  to 60 mg/day.
BECLOMETHAZONE : Asthma 100-1000 µg /day in 2 devided doses.
Starting doses: Step II : 200 µg Q12 hr
Step III: 300 µg Q 12 hr Step IV: 400 µg Q12 hr.
BROMHEXINE: < 2 yr: 1mg , 2-6 yr: 2 mg., 6-12 yr: 4 mg Q8h
BUDESONIDE: (Pulmicort) 200 µg/puff, neubilization: : 0.25-0.5 mg
Q12h Turbuhaler : 200 - 400 µg Q12 hr. Rhinocort 50 µg/
actuation. CH > 6 yr 2 puffs Q12hr in each nostril.
C Max single dose IM, IV 600 mg.
CALCIUM CARBONATE: (1g salt = 400 mgCa++ ):
Based on Ca++ NN: 50-150 mg/kg/day. IN,CH: 20-65
mg/kg/day ÷ Q6hr PO.
CALCIUM GLUBIONATE: Maintenance / Hypocalcemia : IN, CH: 40-
128 mg Ca++ /kg/day ÷ Q4 6hr PO (1m = 22.5 mg Ca++ ).
NN: 76 mg Ca++ / kg/ day
CALCIUM GLUCEPTATE: 1 gram salt = 82 mg Ca++
CALCIUM GLUCONATE: (1ml = 9 mg of elemental Ca++) IV:
Maintenance /hypocalcemia Ca++ NN: 18-63 mg/ kg/ day ÷
Q6hr IV, PO: 18-72 mg/kg/day mixed in feedings.
IN, CH: 18- 45 mg/ kg/ day IV, PO ÷ Q6hr.
CALCITTOL: Hypoparathroidism: <1 yr-0.04–0.08µg /kg/day 1-5 yr
0.25–0.75 µg /day ≥ 6 yrn 0.25–2 µg /day PO qd
Vit-D dependent rickets : 0.25- 1 µg q qd PO
Vit-D resistantt rickets : Initial : 0.015 µg PO
MD : 0.03 – 0.06 µg/kg PO qd Max dose : 2 µg/day
Hypocalemia during dialysis : 0.25–2 µg /day PO
CKD not on dialysis : Children <3 yr: 10–15 ng/kg/day qd
Children 3 yr): 0.25 – 0.5 µg /day PO qd
Hypocalcemic tetany in premature: 0.03 µg/kg IV qd for 5-12 days
Hypocalcemic in premature PO: 1µg/ qd for 1st 5 days of life.
CARBAMAZIPINE: Initial 10 mg/kg/day PO ÷ Q8-12 hr, increment
Q 1wk till 20-30 mg/ kg/ day .
CAPTOPRIL: NN: 0.1-0.2 mg/kg/dose PO q8hr.
IN, CH: 0.5-6 mg/kg/day ÷ Q8 hr.
CASTOR OIL: IN: 1-5 ml PO OD. CH: 5-15 ml PO OD
CEFADROXIL: (Ultracef) 15 –20 mg/ kg Q 12 hour PO.
CEFDINIR: (Omnicef ) : 6 mo – 12 yr: 14 mg/kg/day q 24 hr or
7mg/kg/day q12 hr PO
CEFIXIME: ( Suprax , 100 mg/5ml ) 8 mg/kg Q 24 hr PO.
CEFAZOLINE: 20 mg/ kg/ dose IV,IM NN (  2 kg : Q12 hr; >
2 kg and >1wk Q8 hr) IN, CH: 50- 100 mg/kg/da ÷ Q8 hr
CEFEPIME: ≥ 2 mo 50 mg/kg/dose Q 12hr, IV, IM
Meningitis, serious infection, neutropenia, cystic fibrosis :
50 mg/kg/dose Q 8 hr
CEFOTAXIME: 50 mg/kg/dose (< 1wk : Q12 h > 1wk & > 2 kg:
Q8hr). IN, CH: Meningitis: 200 mg/kg/day ÷ Q6hr
Others : 100- 150 mg/ kg/day ÷ Q8hr IV, IM.
CEFOXITIN: ( Mefoxin ): NN : 20-40 mg/ kg/ dose
CEFTAZIDIME: NN: 30-50 mg/ kg Q12h. NN > 1wk , IN,
CH : 30-50 mg / kg Q 8h IV, IM.
CEFTRIAXONE:100 mg/ kg/day OD or in 2 divided dosesIV, IM.
CEFUROXIME: (Zinacef ) NN: 30-50 mg/ kg/dose Q12 hr.
IN, CH: 25 - 50 mg/ kg/dose Q 8h IV, IM.
Zinnat : PO 10-15 mg/kg Q12 hr .
CEPHALEXIN: ( Keflex) 25-50 mg/kg/day ÷ Q8 hr PO
Otitis Media : 75-100 mg/kg/day ÷ Q6 hr.
CEPHRADINE: (Velocef) IN, CH: 12.5-50 mg/kg/dose Q6hr IV.
12.5-25 mg/kg/ dose Q6 hr PO.
CETRAZINE (Zyrtec, Zeratazine) : 1 mg/ml
6- 12 mo : 2.5 mg QD 11- 23 mo : 2.5 mg Q12-24 hr
2-5 yr : 2.5 mg Q12-24 hr or 5mg qd ≥ 6 yr : 5-10 mg qd
CHLOROQUINE SULPHATE: Malaria: 10 mg base/kg PO, then
5 mg base/kg 6 hr later, then 5 mg base/kg daily for 2
days. (5 mg base = 8.3 mg salt).
CHLORAL HYDRATE: Sedation 15- 25 mg/kg/dose.
Hyonosis: 50 mg/kg/dose PO, PR Q6-8hr.
Chlorphenarmine ( histop) : 0.35 mg/kg/day ÷ Q 6 hour
CHLOROTHIAZIDE: < 6 mo: 20-40 mg/kg/day ÷ q 12-24 hr PO
> 6 mo: 20 mg/kg/day ÷ Q 12-24 hr PO.
CIMETIDINE: NN,IN: 10-20 mg/ kg/ day ÷q 6hr. CH: 20 -40
mg/kg/day ÷ Q6hr IM, IV (over 20 min), PO.
CIPROFLOXACIN : CH : 7.5-15 mg/kg/dose Q 12 hr PO, IV.
Cystic fibrosis : 20-40 mg/kg/day ÷ Q8-12 hr PO, IV
CLARITHROMYCIN: > 6 mo old, 7.5 mg/kg/ dose Q12hr PO.
CLINDAMYCIN: 5 mg/kg/dose IV,IM NN ( < 1wk : < 2kg: q
12 hr; > 2 kg: Q8 hr) ( > 1wk: < 2 kg: Q8 hr; > 2 kg Q6 hr ).
IN, CH: 30 -40 mg/ kg/day IV, IM ÷ Q6- 8hr.
CLONAZEPAM: 0.01-0.03 mg/ kg/day PO ÷ Q8 hr increase by
0.25-.5 mg/ day Q 3 days to max 0.1-0.2 mg/kg/day.
CLONNIDINE: CH: 5-10 µg/kg/day ÷ q 6-8 hr PO ( ↑ at 5-
7 days intervals to 25 µg/kg/day; max dose is 0.9mg/day).
CLOXACILLIN: (mg/kg/dose, IV) Meningitis: 50 mg. Other
infections: NN 25mg ; IN, CH: 12.5-50mg (< 1wk
q12hr; > 1wk q8hr; IN, CH q6hr ).
PO (Children > 1 mo ): 50–100 mg/kg/day divided q 6
hr up to a maximum of 4 g/day.
COTRIMOXAZOLE: Based on (TMP): Minor infections,
Brucellosis, P. carini prophylaxis: 5 mg/kg/dose Q12 hr.
UTI prophylaxis: 2-4 mg/kg PO OD. Severe infection or P.
carini pneumonia: 5 mg/kg/dose IV, PO Q6hr..
CROMOLVIN NA: Rhinitis 1 spray in each nostril Q6-8hr.
CYCLOPHOSPHAMIDE: Nephrotic syndome :
2mg/kg/day for 8 weeks or 3 mg/kg/day for 12 weeks
CYCLOSPORINE: Nephrotic syndrome 5-6 mg/kg/ day ÷ 12 hr.
D G
DEFEROXAMINE: ( Desferal) Chroinc iron overload:
S.C: 20-40 mg/kg over OD 8hr. Acute iron overload :
IV: 15 mg/kg/hr ( max dose 6g/day).
DEFRASIROX( Exjade ) : 2 yr : 20 – 30 mg/kg/day
DESMOPRESSIN: Enureasis 20 µg (10µg in each nostril ) for 1 wk,
may increase dose in 10 µg increments up to 30-40 µg HS.
Tab : 0.2-0.4 mg at bedtime.
Central DI: 5-30 µg ( 0.05 – 0.3 ml/ day ) / day ÷ qd-bid
PO: Intial 0.05 mg bid, ↑to desired response 0.1 –0.8 mg/day
DESLORATIDINE (Aerius, Neorin): 2.5 mg/ ml, 5 mg tab
6- 11 mo : 1mg OD 12 mo – 5 yr : 1.25 mg OD
6- 11 yr : 2.5 mg OD ≥ 12 yr : 5 mg OD
DEXAMETHASONE: Airway edema: 0.25- 0.5 mg/ kg IV Q6 hr
24 hr before extubation & for 3-4 doses post-extubation.
Meningitis : 0.15 mg/ kg/ dose IV Q6 hr for 16 doses.
Cerebral edema: NN, IN, CH: LD 1.5 mg/kg IV,IM; MD
( NN: 0.2-0.5 mg/kg/day. IN, CH: 1.5 mg/kg/day) ÷ Q 6
hr for 5 days then taper. Croup : 0.6 mg/kg once
Broncial asthma : 0.6 mg/kg OD for 2 days.
DIAZEPAM: Convulsion : 0.3 mg/kg IV. Max dose ( > 5 yr
Sedation / muscle relaxant :
PO :0.12 – 0.8 mg/kg/ 24 hr ÷ Q6- 8 hr
IV : 0.4 -0.3 mg/kg/ dose max 0.6 mg/kg/ 8 hr )
DIAZOXIDE:. Hyperinsulinemia : NN, IN: 8-15 mg/kg/day.
CH: 3-8 mg/kg/day ÷ Q8-12 hr PO.
DIGOXIN: (mg/kg): Total digitalization dose: 1/2,1/4,1/4
( PT: 002- ., full term : 0.02-0.03. IN, CH: 0.025-.04) PO,IV
75% . MD =1/4 of Total Digitilization Dose start 12 hr after
full Total Digitilization Dose.
DICLOFENAC: 1 mg/ kg/ dose q 8hr.
DIMETHINDENE MALEATE (Fenistil ): 0.1 mg/kg/dy ÷ q hr
Syrup: 1mg = 10 ml drops : 1 drop = 0.05 mg 1tab = 1mg
DIPHENYLHYDRAMINE: 1.25 mg/kg/dose q6 hr PO, IV, IM
Max dose 300 mg/24 hr.
DOBUTAMINE: 2.5-40µg/kg/min NN : 2-15 µg/kg/min
DOPAMINE: 5-20 µg/kg/min. 3-5: renal dose (Domaminergic ).
5-15: Cardiotonic dose (β-agonist).
> 15: Pressor dose (α-agonist ).
DOMPERIDONE: Motilium: 0.25-0.5 mg/kg/dose q 6-8 hr
Suppositories: up to 2 yr: 10 mg Q12-6 hr
2-4 yr : 30 mg Q 12 hr 4- 6 yr : 30 mg Q 8 hr
>6 years: 30 mg q 6 hr.
E
ENALPRIL: NN, IN, CH: PO = 0.1-0.5 mg/kg/day ÷ Q12- 24 hr .
IV = 5-10 µg/kg/day ÷ Q8-24 hr
ENALPRIL: NN: 10 mg/kg/dose (< 7 days Q12 hr, > 7days
Q8 hr) PO. CH: 30-50 mg/kg/day ÷ Q6hr PO.
F
FACTOR VIII: Body wt X 0.5 X desired factor VIII level.
Major bleeding: 100%; Moderate bleeding: 50%;
Minor bleeding: 20-30 %.
FAMOTIDINE: IN, CH: 0.5 - 1 mg/kg/dose Q12 hr, PO, IV
FANSIDAR: (Pyrimethamine 25 mg , Sulfadoxine,500 mg )
1–3 yr ½ tab: 4–8 yr 1 tab: 9 yr and older: 2 tab PO OD.
FLUCLOXACILLIN: Adult dose: 250- 1gm Q6hr IV
CH < 2 yr: ¼ adult dose CH > 2 yr: ½ adult dose
FLUDROCORTISONE ACETATE ( Florinef ): 0.05- 0.2 mg/day ÷
Q 12-24 hr PO or 0.1-0.15 mg/m2/ day ÷ Q 12-24 hr PO.
FLUTICASONE PROPIONATE: (Flixotide): Asthma: MDI .
Starting doses : step II : 100 µg Q12 hr,
Step III: 150 µg Q 12 hr Sstep IV : 200- 250 µg Q12 hr
Neublizer: CH ≥ 4 YR : 1000 µg Q12hr for acute asthma
Rhinitis : 1-2 spray ( 50-100 µg) in each nostril QD.
FUROSEMIDE: ( Lasix) NN: (IV,IM 1-2 mg/kg/dose;
PO: 1-6mg/kg/dos) Q12-24hr.
IN,CH: (IV,IM 1-2mg/kg/dose; PO, 1-4 mg/kg/dose) Q6-24 hr
GENTAMICIN, TOBRAMYCIN: NN ≥ 35 wk : 4-5 mg/kg. as single daily
dose infusion over 1 hr IN, CH : 5 -7.5 mg/kg /day ÷ Q8 hr or 5
mg/kg single daily dose IV over 1 hr
GLUCAGON: NN: 0.025-0.3 mg/kg/dose Q20 min PRN
IN, CH : 0.03-0.1 mg/kg/dose ( max 1mg) Q20 min PRN S.C,
IV push, IM.
H
HEPARIN: Anticoagulation : IN, CH : intial 50 U/kg IV bolus
Maintenance : 10-25 U/kg/hr as IV infusion or 50- 100
U/kg/dose Q4hr IV.
Heparin flush: Peripheral IV : 1-2 ml of 10 U/ ml solution Q4hr.
Central IV : 2-3 ml of 100 U/ ml solution Q 4 hr.
HYDRALAZINE: Emergency: IN, CH 0.1-0.2 mg/kg/dose IV, IM Q
4-6 hr PRN ( max, 3.5 mg/kg/day). NN : 0.1-0.5 mg/kg/dose IV,
IM 3-6hr PRN, I increase by 0.1 mg/kg till BP control achieved
or 2 mg/kg given.
MD : NN, IN, CH : : 0.25 – 1 mg/kg/dose PO Q6-8hr .
HYDROCHLOROTHIAZIDE: PO 2-3 mg/ kg /day ÷ Q12h
HYDROCORTISONE: Physilogical replacement: ( CAH) : 15-20
 mg/m2/day ÷ Q8hr PO or 0.25-0.35 mg/kg/day IM.
Acute Adrenal crisis: 100 mg/m 2/dose IV stat, then 25
mg/m2/dose IV q6hr. Anaphylaxis: 5-10 mg/kg/dose IV
Neonatal hypoglycemia: 5mg/kg/dose Q12hr IV, IM.
Status asthmaticus : 1-2 mg/kg Q6 hr for 24 hr, then,
maintenance 0.5-1 mg/kg/dose Q6h
HYDROXYCHLORQUINE: (200 mg tab) 5-6 mg/kg/day ÷ OD
HYOSINE-N-BUTYLBROMIDE: ( Buscupan)
IN:5 mg TID or 7.5 mg suppository Q8-12 hr Q8hr;
1-6 yr: 5-10 mg Q8 hr; > 6 yr 10 mg Q8hr.
I
IBUPROFEN: 6mo–12 yr : Anti-inflammatory : 30–50 mg/kg/day
in 3–4 divided doses .
IMIPENEM: NN 20 mg/ kg /dose IV (1.2-2 kg Q12 hr;  2 kg:
 7 days Q12 hr, > 7 days Q8 hr ).
IN,CH  15 -25 mg/ kg /dose Q6 hr.
IMMUNE-γ-GLOBULIN: ITP : 1g/kg/dose for 1-2 days
GBS: 1g/kg/dose for 2 days. Kawasaki disease: 2g/kg single dose
Immune deficiency: 400- 600 mg/kg/mo IV
IPRATROPIUM BROMIDE:(Atrovent):MDI: IN, CH 4-8 puffs (80- 160
µg) Q 2-4 hr. Nebulization (µg/dose): NN, 25 µg/kg/dose Q8 hr.
IN,CH: Status asthmaticus : 250 μg every 20 min for three doses, then
every 2–4 hr. Nonstaus asthmaticus : : every 4- 6 hours
IPECAC: IN: 1ml/kg/dose PO.
CH: 15-30 ml/dose Q30 min PRN followed by 20 ml/kg water.
IRON: Ferous sulfate (33% F+++ ), Ferous gluconate(12 % F++,
Ferose 10 mg F /1ml . ( Fer-in-sol) l 15 mg F/ 0.6 ml
Maintenance: 1-2 mg of F++/kg/day.
Deficiency: 3-6 mg F++/kg/day ÷ Q 8-12 hr
ISONIAZID: (INH) (mg/kg/dose) : NN, IN, CH
Prophylaxis : 10-15 QD or 20-40 2X/ wk after 1 mo of Rx.
RX : 10-20, QD or 20- 40 2X/ wk with Rifampin.
Prophylaxis : 10-15 QD or 20-40 2X/ wk after 1 mo of Rx.
RX : 10-20, QD or 20- 40 2X/ wk with Rifampin.
K 1 µg/kg/ min. Sedation: IV 0.05 – 0.2 mg/kg loading , then either
KETAMINE: CH : O.5 2 mg/kg/ dose IV, 3-7 mg/kg/ dose
IM, 6- 10 mg/ kg/dose PO, 30 min before the procedure.
KETOTIFEN: 6mo-3 yr: 0.025 mg/kg OD for 5 days then 0.05
mg/kg/day ÷ Q12 hr > 3 yr : 0.mg OD for 5 days then 1 mg QD
L NN : 0.05 mg/kg q 4–8 hr, maximum dose: 0.1 mg/kg. Continuous
LABETALOL: CH, PO: 2 mg/kg/dose Q12 hr. ↑ gradually to 40 mg/kg
/day IV: 0.2- 1 mg/kg/ dose Q10 min PRN (max 20 mg/ dose),
continuous IV infusion 0.4-1 mg/kg/hr ( max, 3 mg/kg/ hr).
LACTULOSE: (ml/day): Portal systemic encephalopathy;
IN: 2.5-10 ml. CH: 40-90 ml PO in 3-4 divided doses.
Chronic constipation: 1ml/kg/dose PO QD-BID
LANSOPRAZOLE: 1-12 yr : GERD, Erosive esophagitis :
< 30 kg : 15 mg OD ≥ 15 kg : 30 mg OD - Max 30mg BID
LEVETIRACEPAM (Keppra ) : PO (Children 4–15 yrs): 10
mg/kg twice daily; by 20 mg/kg/day at 2–wk intervals to
recommended dose of 30 mg/kg twice daily.
LEVOCABASTINE HCl : 2 sprays per nostril Q6, 8 or 12 hr
LIDOCAINE: Antiarrhythmic: LD: 1 mg/kg/dose I.V push(can
repeat in 10 min to desired effect or max 3mg/kg).
MD: 20-50 µg/kg/ min IV infusion.
LORATIDINE: 2-5 yr, 5 mg PO OD ≥ 6 yr: 10 mg PO OD.
LORINASE: 5 mg Loratidine, 60 mg pseudoephidrine sulfate
CH 6-12 yr : > 30 kg : 5 ml Q12hr, < 30 kg : 2.5 ml Q 12 hr
L-THYROXINE: 0- 3mo: 10-15µg/kg qd 3-6 mo:8-10µg/kg qd
6-12 mo: 6-8µg/kg qd PO 1-5 yr: 5-6 µg/kg qd PO
6- 12 yr : 4 6 µg/kg qd PO > 12 yr : 2-3 µg/kg qd PO
M Q10-15 min PRN; continuous IV infusion 0.1-0.5 µg/kg/min .
MAGNESIUM SULFATE: Hypomagnesemia: IV, IM 25-50 mg/kg/dose
(NN Q8hr for 2-3 doses, CH, Q6hr for 3- 4 doses).
CH, Oral 100-200 mg/kg/dose Q6hr.
Daily Maintenance : 30-60 mg/kg/day or 0.25-0.5
mEq/kg/ day IV. Adjunctive therapy for moderate-severe
asthma 50- 75 mg/kg IV ( Max dose 2 gm) in D 5 W over 20 min
every 4–6 hr or 50–75 mg/kg loading dose followed by continuous
infusion at 10–20 mg/kg/hr ( S. level4–5.5 mg/dL ).
MANITOL: Cerebral edema: CH, Initial 0.25g/kg IV over 20-30 min.
MD 0.25-0.5 mg/kg/dose Q4-6 hr PRN ( ±lasix concurrently or 5
min before manitol)
MEFENAMIC ACID: > 6mo IN, CH, 8 mg/kg/dose.
MEFLOQUINE: 25 mg/kg single dose for children > 15 kg.
METHOTREXATE: Intial, 0.25 mg/kg/ wk, ↑ 2-4 wk to max 0.6
mg/kg/wk as single dose on empty stomach.
METHIMAZOLE: Initial: 0.4- 0.6 mg/kg/day ÷ qd-q8 hr
MD: 0.1- 0,3 mg/kg/day ÷ qd-q8hr PO
METHYLPREDNISOLONE: Anti-inflamatory: IV 0.5-2 mg/kg/day ÷ Q6-
12hr Pulse therapy: 30 mg/kg/dose over one hour.
Acute Asthma 1-1.5 mg/kg IV once a day.
Status asthmaticus: Loading dose: 2 mg/kg then 1 mg/kg/dose
Q6 hr for 24-48 hr then 1.5 mg/kg qd
MEROPENAM,: Meningitis: NN, IN, CH: 40 mg/kg/dose Q8 hr
Mod infection: 20 mg/kg/ dose (NN: Q12 hr, IN, CH: Q8 hr
METOCHLOPROMIDE: GER: NN, IN,CH: 0.1-0.2 mg/kg/dose Q8 hr
PO or IV infusion over 30 min. Antiemetic (chemotherapy):
1-2 mg/kg/dose Q2-6 hr IV, IM.
Premedicate with diphenylhydramine to ↓ EPS.
METRONIDAZOLE : Anaerobic infections :
 2kg, > 1wk 15mg/kg/dose Q 12hr IV
 IN, CH : 7.5 mg/kg/dose Q6 hr IV
Clostridium difficle colitis : 7.5 mg/kg/dose Q6 hr PO, IV for 7
days. Amebiasis : 15 mg/kg/dose Q 8 hr for 10 days.
H. pylori: CH 7.5-10 mg/kg/dose Q 12 hr for 2 wk
MIDAZOLAM: IN, CH: Status epilepticus IV load 0.15 mg/kg then
same dose Q 1-2 hr or 1-2 µg/kg/ min.
MONTELUKAST: 6mo – 2 yr: 4 mg granules QD HS
2- 5 yr: 5 mg PO QD HS 6- 12 yr: 5 mg PO QD HS
≥ 12 year : 10 mg PO QD HS
MORPHINE: IV, IM, SC: CH, IN: 0.1-0.2 mg/kg/dose Q 3-4 hr PRN
infusion, sickle cell or cancer pain: 0.02–2.6 mg/kg/hr.
NN : Continuous infusion : 0.01–0.03 mg/kg/hr
MUCOSOLVAN: 2-6 year: 7.5 mg Q8hr <2 year: 7.5mg Q12hr.
N QUINIDINE GLUCONATE: LD 10 mg/kg (max 600 mg) in NS slowly
N-ACETYLCYTEINE: PO: 140 mg/kg loading followed by 70 mg/kg Q4
hr for 17 doses. IV: dilute to 5% with D5: 140 mg/kg loading then
70 mg/kg over 1hr Q4 hr for 12 doses.
NALIDIXIC ACID: CH: 55 mg/kg/ day in 4 divided doses.
Suppressive Therapy : 25-33 mg/kg/day ÷ Q8hr
NAPROXEN: Analgesic: 5-7 mg/kg/day ÷ Q8-12 hr.
Chronic arthritis: - 15 mg/kg/day ÷ Q12 hr.
NIFIDIPINE: Hypertension: IN,CH: 0.25-0.5 mg/kg/ dose Q6hr PO,
SL. Hypertrophic Cardiomyopathy: 0.2-0.3 mg/kg/dose Q8hr.
NITROFURANTOIN: IN,CH: 5-7 mg/kg/day ÷ Q6 hr PO. Max daily
dose 400mg. UTI prophylaxis: 1-2 mg/kg/ dose QHS PO .
O
OMEPRAZOLE: 0.6-3.3 mg/kg/dose PO OD before meal.
P Neublizer: 0.15-0.3 mg (.03 ml) /kg/dose in 3 ml NS Q20 min- 6hr PRN
PARACETAMOL: PO 10-15 mg/kg/dose Q6hr. IV:15 mg/kg/dose Q6hr.
PHENYLEPHRINE: Hypotension, shock: CH: 5-20 µg/kg/dose IV
SVT: 5-10 µg/kg IV over 20-30 sec.
PENICILLIN: : NN: Meningitis: 100,000 U/kg/dose IV
Others: 25,000-50,000 U/kg/dose (< wk: Q12hr ; >1wk Q8hr) .
IN,CH : Meningitis: 75,000 U/kg/dose Q6h.
Other infections: 25,000-100,000 Q6 hr.
PHENOBARBITOL: LD: NN 20 -30 mg/kg give additional 5 mg/kg
Q5 min till cessation of seizure or a total dose of 40 mg/kg
is given. IN & CH: 15 –20mg/kg. may give additional 5 mg/kg
doses Q15-30 min to a max of 30 mg/kg. MD: ( mg/ kg/day ÷
Q12-24 hr): NN: 3-5 mg; IN: 5-6 mg 1-5 yr: 6-8 mg; 6-12 yr:
4-6 mg PO, IV. Sedation: 2 mg/kg/dose
PHENYTOIN: LD: NN 20 mg/kg, IN & CH 15 -18 IV
Maintenance: ( mg/kg/day ÷Q8-12 hr ) : NN: 5-8 mg; > 10 days- 3
yr: 8-10 mg/kg/day; 4-6 yr : 7.5-9 mg/kg/day 7-9 y : 7-8
mg/kg/day; 10-16 y: 6- 7mg/kg/day ÷Q8-12 hr.
Arrhythmia: LD IV push 1.25 mg/kg Q 5 min for 12 doses; total LD
15 mg/kg. MD : PO, IV 2.5-5 mg/kg/dose Q12hr.
PIPRACILLIN: NN ≥ 37 wk: 50 mg/ kg/ dose IV: (< 1wk : Q8hr, > 1
wk : Q6 hr ) IN, CH: 50-75 mg/ kg/dose q 6 hr IV,IM
POTASSIUM KCl: Maintenance: 1-3 mEq/kg/day PO, IV
Hypokalemia: PO 1-4 mEq/kg/day ÷ Q12-24 hr IV, 10-40 mEq/L
of IVF. (1g KCl=13.3 mEq K+ )
PO3, K: ( Elemental PO : mmol/kg/day) NN: 0.5-2 IV, PO .
IN, CH: (PO: 1-3; IV: 0.5-1.5 ) divided. (Ph: 31 mg = 1mmol )
(Injection 1CC = 94 mg Ph, 4.4 mEq K+)
PRAZOCIN: NN, IN, CH: 0.1-0.4 mg/kg/day ÷ Q6 hr PO
PRIMAQUINE: Malaria: 0.3 mg base/kg/day for 14 days.
15 mg base = 26.3 mg salt.
PREDNISONE: Nephrotic syndrome: Initial: 60 mg/m2/day as single
morning dose.
Acute asthma: 1-2 mg/kg/day OD PO for 3-10 days.
PROMETHAZINE: Antihistamine: 0.1 mg/kg/dose Q6 hr during the day
and 0.5mg/kg/dose at bedtime.
Sedative: 0.5-1mg/kg/dose Q6hr PRN PO, IV, IM.
PROPRANOLOL: Tetralogy spells: 0.05-0.1 mg/kg/dose IV, MD 1-6
mg/kg/day PO ÷ q8hr. Hypertension : initial 0.5-1 mg/kg/day ÷
Q6-12 hr may increase dose Q3-5 day. Max dose 8 mg/kg/day
PROPYLTHIOURACIL: Initial 5-7 mg/kg/day ÷ Q8 hr
CH 6- 10 yr : 50 -150 mg/day CH >10 yr :150- 300/ day
PROSTAGLANDIN E: Intial: 0.05 – 0.4 mg/kg/ min
Maintenance dose: 0.01 – 0.4 mg/kg/ min
PYRAZINAMIDE: TB: 35 mg/kg/ day for first 2 mo of Rx.
PYRIDOXINE: Pyridoxine-dependent Seizure:
0.2 – 30 mg/kg/ day mg/day PO, IV,IM
Q WARFARIN: NN, IN, CH: Iinitially 0.2 mg/kg/day PO OD
QUININE SULFATE : Malaria: 25 mg/kg/24 hr ÷ Q8hr for 3–7 days PO.
over 1–2 hr, followed by infusion of 0.02 mg/kg/min
R
RANITIDINE: NN: IV: 1.5 mg/kg loading then after 12 hr start 0.75- 1
mg/kg/dose q 12hr PO 1 mg/kg/dose Q 12 hr
IN, CH: Duodenal/gastric ulcer: PO : 2-4 mg/kg/day ÷ Q12 hr PO
IV: 2-4 mg/kg/day ÷ Q 8-6 hr. GERD/ Erosive ersophagitis: 2-4
mg/kg/day ÷ Q6-8 hr IV PO: 4-10 mg/kg/day ÷ Q12hr
RIFAMPIN: (mg/kg/dose): Prophlaxis, Hib: (NN: 10; IN,CH: 20)
OD for 4 days. Meningooccal: ( NN: 5; IN, CH: 10 ) Q12 hr for 2
days. TB, Brucellosis: 20 mg PO OD.
S References : SNF 2010, Drdrugs 2010, Harriet lane handbook (2009),
SALBUTAMOL: Oral : NN: 0.1-0.3 mg/kg/dose Q8 hr;
CH: < 6 yr, 0.1-0.2 mg/kg/dose; > 6 y r0, 2 mg/dose 6-8.
Continuous, 10–20 mg/hr
IV : 1 µg/kg IV over 15 min0.2 μg/kg/mindose may be increased by
0.1 μg/kg/min increments to clinical improvement or greater than 20%
increase in heart rate
SR tab : 3-12 yr: 4 mg Q12 hr
SALMETEROL: (Serevent ): MDI: 25 µg/puff : 1-2 puffs Q12
SODIUM HCO3: 8.4% : CPR: 2ml/kg Q10-20 min Hyperkalemia: 2ml/kg
IV over 10 min. Others: Wt X 0.3 X base deficit IV .
PO = 1-15 mEq/kg/day ÷ Q8
SODIUM POLYSTERENE SULFONATE:(Kayeoxalate):
NN,IN,CH: 1g/kg/dose in water or D5 PO/PR Q6hr
SPIRONOLACTONE: NN: 1-3 mg/kg/day PO ÷ Q12-24 hr
CH: 1.5 – 3.3 mg/kg/ day PO ÷ Q12-24 hr
T
TAMILFLU: Oseltamivir:Treatment of influenza for 5 days at 12 hr
intervals:CH > 40kg: 75 mg CH 23–40 kg: 60 mg
CH 15–23 kg: 45 mg CH ≤15 kg and ≥1 yr: 30 mg
TOPIRAMATE (Topamax) : ≥ 2 year : 1-3 mg/kg/ dose PO HS for 7
days, max 25 mg/dose. ↑ by 1-3 mg/kg/ day increments at 1-2 wk
interval (as BID) till response.
Usual Maintanence Dose: 2.5 -4.5 mg/kg/ dose Q12 hr
TRAMADOL: ≥1yr: 1-2 mg/kg/dose Q4-6 hr slow IV over 2-3 min.
TAZOCIN, PIPERACILLIN and TAZOBACTAM: IV, dose is based on
Piperacillin component : 2-8 mo: 80 mg/kg/dose Q 8hr, ≥ 9 mo
and < 40 kg:100 mg/kg/dose Q8 hr > 40 kg : 3.375 mg Q Q 6 h
Cystic fibrosis, pseudomonas: 350-450 mg/kg/day ÷ Q 8 hr
V
VALPROIC ACID: 10-15 mg/ kg/ day ÷ Q8-12hr  to 30-60 mg/kg/day
in increments of 5-10 mg/kg/wk 1.75ml=100 mg
VANCOMYCIN: NN: 15 mg/kg/dose IV ( > 2 kg :  1wk Q12h ,
> 1wk Q8h ). IN, CH: Meningitis 15 mg/ kg/ dose Q6-8h .
Other infections : 10 mg/ kg/ dose q6hr
VIGABATRIN: 30-60 mg/kg/day OD- BID
VIT. D2 (Ergocalciferol):Vit.D def Richets: 600,000 units IM once.
VIT D3 : (Cholecalciferol): MD, 400 IU/ day. Nutritional Rickets:
2000-5000 IU/day for 6-12 wk (1 Drop=100 IU)
VIT K1: NN : prophylaxis 1 mg IM, Neonatal hemorragic disease :
1-10 mg/ day IV, IM
Anticoagulant overdose: IV followed by oral , monitor PT till
the patient status normalize. NN, IN : 1-2 mg/dose Q 4-8 hr
PRN, CH : 5-10 mg/dose, PO, IV, IM. May be repeated 12-48
hr after PO dose or 6-8 hr after parenteral dose.
Acute hepatic failure: IN: 1-2 mg CH : 5-10 mg IV,IM
Malabsoprtion: IN, CH: 2.5- 5 mg/ day PO altern. days
W
Maintenance dose: 0.05-0.34 mg/kg/ day PO OD
Z
ZAFIRLEUKAST: 5-11 yr: 10 mg PO BID > 12 yr: 20 mg BID
ZINC: Deficiency: IN, CH: 0.5-1 Mg++/kg/day in 1-3 divided doses.
(Zinc sulfate = 23% Mg ++ ) , (Zinc gluconate = 14.3 % Mg++).
---------------------------------------------------------
Glossary:
PT: Preterm; NN: neonate; IN: Infant; CH: Children;
LD: loading dose; MD: Maintenance dose;
MDI: Meter dose inhaler.
_____________________________________________________
Manual of neonatal care(2008),, Nelson textbook of pediatrics (2007),
Rudolph’s pediatrics (2003), Forfer Textbook of pediatrics(2008),