DRUG DOSAGES PICU/PHDU/PEADS-ONCO/PEADS-GEN

INFUSIONS

SEDATION & RELAXATION

Midazolam 0.05-0.1mg/kg/hr
Morphine 0.05-0.1mg/kg/hr
Atracurium 0.5-1mg/kg/hr
Cisatracurium 0.06-0.18mg/kg/hr
Dexmedetomidine 0.2-0.7 mic/kg/hr
Rocuronium 1 mg/kg/hr
Pancuromium 0.1mg/kg/hr
Vecuronium 0.1mg/kg/hr
Fentanyl 1-3 mic/kg/hr
Thiopental 1-5 mg/kg/hr
Propofol 1-3 mg/kg/hr
CNS
Valproic acid 3-5mg/kg/hr
Midazolam 2-27mic/kg/min(status)
Thiopental 3-5 mg/kg/hr
CVS
Dopamine 5-10mic/kg/min
Epinephrine 0.01-0.05mic/kg/min
0.01-0.3mic/kg/min
Norepinephrine 0.03-0.3 mic/kg/min
Dobutamine 1-10mic/kg/min
Milrinone 0.3-0.8 mic/kg/min
Vasopressin 0.2units/kg/hr
Nitroglycerine 0.5-7 mic/kg/min
Sodium nitroprusside 0.5-10mic/kg/min
Lasix 0.1-0.4mg/kg/hr (CHF)
1 mg/kg/hr (AKI)
Amiodarone 5-15mic/kg/min
Lidocaine 20-50 mic/kg/min
Labetalol 0.5-3 mg/kg/hr
Phenylephrine 0.1-2 mic/kg/min
Max.4 mic/kg/min)
Prostaglandin 0.01-0.1 mic/kg/min
OTHERS
Terbutaline 1-14 mic/kg/min
Aminophylline 1 mg/kg/hr
Hypertonic saline 0.1-1 ml/kg/hr
1ml/age[yrs]/hr)
Insulin 0.1-0.3mic/kg/min
CaCl2 10-30mg/kg/hr
Tranexamic acid 1-10mg/kg/hr
15-25mg/kg/day
Load 10mg/kg/dose then 1-2mg/kg/hr
Heparin 20 units kg/hr
Octreotide 1 mic/kg/hr (max 50mic/hr
Omeprazole 2-4mg/kg/day
0.1mg/kg/hr max.8mg/hr
INTERMITTENT
RELAXATION
Atracurium 0.5-1mg/kg/dose
Succinylcholine 1-2 mg/kg/dose (max 150 mg)
Pancuronium 0.1 mg/kg/dose
SEDATION & ANALGESIA
Ketorolac 0.5 mg/kg/dose q8hrly (CI- ICB, AKI)
Ketamine 0.5-2 mg/kg/dose
Paracetamol 40-60mg/kg/day q4-6hrly(max 60mg/kg –
4g/day
Clonazepam PO 0.01-0.03mg/kg/day divided in BID/TDS

Pethidine 0.5mg/kg/dose q4-6hrly

Nelbuphine 0.2 mg/kg/dose q4-6hrly
Morphine 0.02 – 0.05 mg /kg/dose q2-6 hrly
Tramadol 1mg/kg/dose q8hrly

CVS:
Adenosine 100 mic/kg/dose ( x2)
Atropine 0.02 mg/kg/dose (min 0.1mg;
max 0.5-1 mg)
Amiodarone 5 mg/kg (Antiarrhythmic)
Amlodipine 0.1-0.3 mg/kg/dose q24hrly
(max 10 mg/day)
Captopril 0.05-0.3 mg/kg/dose q8hrly
Digoxin 5-10 mic/kg/dose
Dispirin 5 mg/kg/dose q24hrly (Antiplatelet)

Enalapril
Epinephrine
Hydralazine
Lidocaine
Magnesium sulphate
Phenytoin
Satolol
STEROIDS
ASTHMA : Methyl prednisolone
Hydrocortisone
CROUP: Dexamethasone
MENINGITIS: Dexamethasone
TBM: Dexamethasone
POST EXTUBATION: Dexamethasone
PULSE: Methyl prednisolone
ARDS: Methyl prednisolone
Physiologic replacement
Hydrocortisone
PREDNISOLONE
Adrenal Insufficiency
Hydrocortisone (solu-cortif)
Severe Stress
Hydrocortisone
Anti-emetic: (chemo-induce )
Dexamethasone
Cerebral Edema :
Dexamethasone
ITP : Pulse Therapy with
DEXAMETHASONE
Spinal Cord Injury
Methyl Prednisolone
Enteric fever : Dexamethasone
80-100 mg/kg/day q6hrly (Kawasaki)
0.1-0.5mg/kg/day q12-24hrly
0.01mg/kg/dose
0.1-0.5 mg/kg/dose q4-6hrly (max 20
mg/dose)
1 mg/kg/dose (max 3 mg/kg)
25-50 mg/kg/dose (max 2 gms) torsades de
pointes
1.25 mg/kg q5min (max 15mg/kg)
2-5 mg/kg/day (320-480mg/day)
2 mg/kg load then 2 mg/kg/day q6hrly
8 mg/kg load then 8 mg/kg/day q6hrly
0.6 mg/kg/dose
0.15mg/kg/dose q6hrly (48hrs)
4 mg/kg/day (max 16 mg) q6hrly
0.5 mg/kg/dose q6hrly (48hrs)
25-30mg/kg/dose QD (max 1 grm)
2 mg/kg/day q6hrly
PO : 12-18mg/m2/24hr divided Q8H
PO :2.5-3.5mg/m2/24hr divided Q12H
50mg/m2/stat then 25-100mg/m2/24H as a
continues infusion
25-100mg/m2/24H as a continues infusion
Or 25mg/m2/dose I/M Q6H
Loading dose : 10mg/m2 (max:20mg)
Subsequent : 5mg/m2/dose Q6h
LD : 1-2mg/kg/dose
MD : 1-1.5mg/kg/day divided Q6H
Iv 20-25mg/m2/dose for 4 days
30mg/kg bolus over 15mint
45mint later
5.4mg/kg/hr for 23 hours as a continues infusion

should be initiated within 8hrs Of injury
LD:2MG/KG

 MD 1mg/kg total 9dose 6H

OSMOTHERAPY
Mannitol 0.5-1 mg/kg (push)
3% Hypertonic saline 2-5 ml/kg/dose q8hrly

HEMATOLOGY
DDAVP 0.3 mic/k/dose (max 20 mic/dose)
Enoxaparin 1 mg/kg/dose q12hrly
Tranexamic acid 10 mg/kg/dose q6-12hrly(max 1gm/dose)
Cryoprecipitate 1 unit/5 kg
Platelets 1 unit/5 kg
Factor VIIa 90 mic/kg/dose
FFP 10ml/kg
Pack cells 10ml/kg
CNS
Dexamethasone 0.3-0.5 mg/kg/day q6hrly (Raised ICP)
Lidocaine 1-2 mg/kg/dose (raised ICP in intubation)
Lorazepam IV/PO 0.05-0.1 mg/kg/dose q1hrly prn
Phenobarbital 15-20 mic/kg load the 3-5 mg/kg HS
Phenytoin 15-20 mg/kg load then 7 mg/kg/day Q12H
Epival 15-20mg/kg load then 10-20 mg/kg/dose q8h
If Divalproic acid use then administerd in BD
dose i-e 10-30mg/kg/dose BD
Lerace 15mg/kg/dose q6h max.60mg/kg/day
PO 10-15mg/kg/dose BID
Topiramate 1-3mg/kg/day QHS for 7day (max.25mg)
Maintance :5-9mg/kg/day Divided BD
Lacosamide 1-2mg/kg/day BD
Max:4-5mg/kg/dose
Diazepam 0.1-0.3mg/kg/dose

GIT
N Acetylcystiene for FHF I/V 150mg/kg over 1 hr then
I/V 50 mg/kg over 4 hrs then
I/V 100 mg/kg over 16 hrs
PO 70mg/kg q4hrly 17 doses
Kayhexalate 0.5-1 gm/kg/dose q4-6hrly (max 30-60g/dose
Dimenhydrinate 1 mg/kg/dose q4-6hrly (max 50 mg/dose)
Domperidone 0.1-0.5mg/kg/dose q8hrly
Glycopyrolate 5-10 mic/kg/dose q6hrly
Lactulose 1ml/kg/dose q8-24hrly (max 30 ml/dose)
Omeprazole 0.7-1.4mg/kg/day q12-24hrly
Ranitidine 2-6 mg/kg/day q6-12hrly (max 50 mg/dose)
Sucralfate 40-80mg/kg/day q6hrly(max 1 gm/dose)
Ondansetron 0.15mg/kg/dose q8hrly
RENAL
Acetazolamide: PO 5-10mg/kg/day q8-24hrly (max 1gm/day)
Lasix 1-2 mg/kg/day q6-8hrly
Metolazone 0.2-0.4mg/kg/day q12-24hrly (max
10mg/dose)
Spironolactone 1-3 mg/kg/day q12-24hrly
Vasopressin 0.0003-0.002 units/kg/dose (DI)
ANTIBIOTICS
Acyclovir: Neonates 20mg/kg/dose Q8H
Child:
10mg/kg/dose q8hrly (immunocompetent pt)
750-1500mg/m2/day q8hrly (immunocompromised
pt)
Augmentin Iv 30 mg/kg/dose q8hrly
PO 25-50mg/kg/day or severe
80-90mg/kg/day (in S.pneumonia
resistance)
Amphotericin B : 0.5 mg/kg/dose QD (day1) then 1
mg/kg/dose QD
Azithromycin 10 mg/kg/dose q24hrly(3DAYS)
10mg/kg stat then 5mg/kg/day for four days
Cefazolin 50-150 mg/kg/day q8hrly (max 6 gm/day)
Cefotaxime (m) 200mg/kg/day q6hrly (max 8 gm/day)
Others 100-150 mg/kg/day q8-6hrly (max
6gm/day)
Cefoperazone+sulbactum Mild infection 20-40mg/kg/day
Moderate infection 60-80mg/kg/day
Severe infection 100-150mg/kg/day
Cefpodoxime Proxtil PO: 10mg/kg/day divided 12-24H
Ceftazidime Mild-Moderate Infection 90-120mg/kg/day
 Cyctic fibrosis & Meningitis 50mg/kg/dose
Q8H
Cefuroxime IV 75-150mg/kg/day Q8H
PO 20-30mg/kg/day Q12H
Ceftriaxone (m) 100mg/kg/day q12-24hrly (max 2
gm/dose)
Others 65-75mg/kg/day q24hrly (max 2
gm/day)
Ciprofloxacin 20-30mg/kg/day q12hrly (max 400mg/dose)
Levofloxicin PO/IV : 10mg/kg/dose OD
Clarithromycin 15 mg/kg/day q12hrly
Erythromycin 10mg/kg/dose Q12H
Ertapenem 15mg/kg/dose Q12H (max500mg/dose)
Clindamycin 30-40 mg/kg/day q8hrly

Cloxacillin 100-200 mg/kg/day q6hrly

Metronidazole 30 mg/kg/day q8hrly
Meropenem (m) 40mg/kg/dose q8hrly (max 6 g/day)
Others 20mg/kg/dose q8hrly
Imipenem- 15-25mg/kg/dose Q6h (max 1g/dose)
Pip/Tazocin 300mg/kg/day q8hrly (max 4.5 gm/dose)
Fluconazole 6-12 mg/kg/day QD
Voriconazole Empirical dose : 9mg/Kg/dose BD
Itraconazole 3-5mg/kg/day divided Q12-24H
Ketoconazole 3-6mg/kg/day OD
Collistin (IV)15000-25000/KG/DOSE Q8HRLY
(Neb ) 1.2 million-2.25million iu per/day
divided 3 doses 0r 50-70mg/day (6.25-8.75lac
IU/day )

Vancomycin (m) 60mg/kg/day q8-6hrly

Others 45 mg/kg/day q8hrly
Tiecoplanin 10mg/kg/dose 1st 3dose at Q12H Then OD
Linezolid 10mg/kg/dose Q8H-Q12H (MAX 1.2g/day)
Anti-
Anti-Hypertensive agent
Amlodpine PO 0.1mg/kg/dose initially max 5mg
May increase upto 0.6mg/kg/day maximum
20mg/day (10 mg bid)
Atenolol PO 0.5-1mg/kg/dose OD-BID
Carvedilol PO 0.015-0.2mg/kg/24H divided in BD
Captopril PO 0.3-0.5mg/kg/dose MAX.2MG/KG/DOSE
Clonidine PO 5-10mic/kg/day divided in BD/TDS
Diltiazem PO 1.5-2MG/KG/DAY divided in tds/qid
Esmolol 500mic/kg stat
50-250mic/kg/min as cont. infusion
Hydralazine 0.1-0.2mg/kg/dose Q4-6H (max.20mg/dose)
Labetalol PO :1-3MG/KG/DAY
IV :
intermittent dose= 0.2-1mg/kg/dose
infusion dose =0.4-1mg/kg/hr (max3mg/kg/hr)
Linsopril PO 0.07-0.1mg/kg/dose OD
Losartan PO 0.7MG/KG/DOSE OD
Methyl-dopa PO = 10mg/kg/day in Q6-12H
IV = 2-4mg/kg/dose
Metoprolol PO 1-2mg/kg/day divided in BID
Propronalol PO 0.5-1MG/KG/24H divided in 6-12H
Sildenafil (pulmonary HTN) PO 0.25-2MG/KG/DOSE Q6-8H

VITAMINS
Vit A PO 50,000-200,000IU/DOSE
Vit B1 (THIAMIN)
BERIBERI IV-IM : 10-25MG/DOSE OD
PO : 10-50MG/DOSE OD

Wernicki’s encephalopathy 100MG IV STAT
50-100MG/DAY

Vit B2 (RIBOFLAVIN)
Vit B3 ( NIACIN)
Vit B6 (PYRIDOXINE)
Vit B12 (Cynocobalmmin)
Vit C ( Ascorbic Acid)
Vit D2 ( Ergocalciferol)
Vit D3 (Cholecalciferol)
Vit E (a-tocopherol)
Vit k (Phytonadione )
2.5MG-10MG/24HR OD
50-100MG/DOSE TID
5-25MG/24HR
100MCG/DAY
100-300MG/24HR OD
400-800 iu/day
25-OH vit D= 4000-8000 iu/day
Malabsorption =10,000-25,000 iu/day
200-800 iu/day
10 iu/kg
Cystic fibrosis : 5-10iu/kg/day max 400iu
Iv 1-2mg/day or
age will be the dose max 10mg
OTHERS
L-Carnitine 50-100 mg/kg/dose q6-12hrly (max
300mg/kg/day)
Clemastine 0.025mg/kg/dose q6-8hrly
Calcium gluconate 100-400 mg/kg/day q6hrly (max 1 gm/dose)
Baclofen 10-20mg/24H
Pralidoxime Intermittent dose 20-50mg/kg/dose
Continues infusion 10-20mg/kg/hr

Raza Ullah (Rph)

Critical Care Clinical Pharmacist
The Indus Hospital Karachi