Critical Care >Principles of Neurosciences Critical Care

John M. Oropello, Stephen M. Pastores, Vladimir Kvetan+

Table 48A–1SContinuous infusion anesthetics for RSE and SRSE.

Anesthetic Loading Dose Maintenance Infusion Rate

Start at 0.2 mg/kg/h and increase by 0.2 with every bolus, up to 2.7
MDZ 0.2 mg/kg IV, repeat Q5 min until Szs stop (max 2 mg/kg)
mg/kg/h

5mg/kg IV, repeat Q5 min until Szs stop or BS achieved (max 15 Start at 1.0 mg/kg/h and increase by 0.5-1.0 mg/kg, max 10
PTB
mg/kg) mg/kg/h

2 mg/kg IV, repeat Q5 min until Szs stop or BS achieved (max 10

PRO Start 1 mg/kg/h, max 10 mg/kg/ha
mg/kg)

KET 0.5-2.0 mg/kg, repeat Q5 min until seizures stop (max 4.5 mg/kg) Start 1.2 mg/kg/h and increase by 0.6 mg/kg/h, up to 6 mg/kg/h

MDZ, midazolam; PTB, pentobarbital; PRO, propofol; KET, ketamine; Szs, seizures; BS, burst suppression.

aIf on PRO for more than 48 hours, max rate is 5 mg/kg/h to reduce risk of propofol-related infusion syndrome (PRIS).

Date of download: 02/02/23 from AccessMedicine: accessmedicine.mhmedical.com, Copyright © McGraw Hill. All rights reserved.