NEWS RELEASE

NULINE PHARMACEUTICALS presents a new algorithm to treat tooth hypersensitivity

July 1, 2010

Parsippany, New Jersey—Nuline Pharmaceuticals, LLC announces the introduction of

REME•SENSE™ (dipotassium oxalate 3%) TOOTH DESENSITIZER, an Rx Class II medical device now
available in the U.S. REME•SENSE™ was introduced globally in 2008. It is presently sold in 16 countries,
ranging from England and the European Union to Asia and Africa. Nuline expects to launch REME•SENSE™
in Canada and other countries later this year or by early 2011.

Tooth hypersensitivity is an exaggerated response to sensory stimuli that usually cause no response in a
normal healthy tooth.1 Except for sensitivity associated with tooth bleaching or other tooth pathology, the
primary underlying clinical cause of tooth hypersensitivity is dentin tubules exposed to the oral environment.2

It is estimated that dentinal hypersensitivity affects 57% of the world’s population.3 The prevalence of
dentinal hypersensitivity has been reported to occur in more than 40 million people in the U.S.,
encompassing over 14% of all dental patients or up to 30% of adults at some point during their lifetime.4
Women may be affected more often than men. Up to 75% of patients who have had their teeth
professionally whitened have dentinal hypersensitivity.5 Length of exposure, concentration, and pH
of the bleaching agent will factor into the degree of hypersensitivity.3

REME•SENSE™ presents the dental profession with a unique system to treat tooth hypersensitivity.
Treatment can be initiated in the dental office, a prescription given to the patient, and treatment then
can be continued at home.

REME•SENSE™ provides a tray and impregnated foam strips that offer:

• A pressure gradient that is higher compared to a conventional solution or gel application

• An active ingredient proven to reduce hypersensitivity that is embedded in a foam matrix and
is released in a sustained and controlled manner

Rx Only
REME•SENSE™ (dipotassium oxalate 3%) offers the patient the following features and benefits:

• Immediate relief following a 10-minute application

• Unique, easy to use tray and impregnated foam strips

• Affords up to a month’s protection

• Non-abrasive application

• Available for in-office and at-home (Rx) use

REME•SENSE™ contains dipotassium oxalate, which reacts with calcium ions in the mouth to
form calcium oxalate crystals. These crystals occlude exposed dentin tubules, alleviating hypersensitivity.
Potassium ions have also been shown to modify nerve excitability, thus reducing the pain response.6

Competing products already in the marketplace include OTC desensitizing toothpastes that take
3 to 4 weeks of use before offering varied results and require continual daily use. Products used in
the dental office include burnishing pastes and products requiring air drying, problems for the patient
whose teeth are already sensitive.

REME•SENSE™ is available in a professional size for distribution directly to the dental office and an
Rx 3-month supply for distribution through pharmacies.

References:
1. Bizhang M. Heinrich-Henle Univ., Dept of Operative & Preventive Dentistry, Feb 2008.
2. Walters PA. J Contemp Dent Pract. May 2005, Vol 6, Number 2.
3. Jacobsen PL, Bruce G. Clinical dentin hypersensitivity. J Contemp Dent Pract. 2001,2:1-5.
4. Addy M. Etiology & clinical implications of dentine hypersensitivity. Dent Clin of N Amer. 1990;34;503-514
5. Haywood VB. Dentin hypersensitivity: bleaching and restorative considerations for successful management. Int Dent J. 2002.
6. Greenhill JD, Pashley DH. The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. J Dent Res. 1981;60:686-98.

Rx Only

Contact: 1-877-NULINE1 (685-4631) WWW.NULINEPHARMA.COM

© 2010 NuLine Pharmaceuticals, LLC NLP-500-0022 Patents Pending
REME•SENSE™ is a registered trademark of Sylphar N.V.