aEKy Phan cau héi ngin binh ena Cau 1. Hay gla tich tal sao née oxy gla dm age du7C PAB.AuaN Khong qué 2/3 thé ti Gau 2:va'3, Trong bal béo “Lead Diversification at the Nenoscale using Liver Microsomes and Quantitative Nuclea Magnetic Resonance Spectroscopy: Application to Posahodiesterase 2 Inhibitors” J. Med. Chem 2040, 6, 3626-3640 tidy cho bidt nhGng thay 68i cu tric ¢6 thé 6 cll@ede dn chét 1411 khi Chat s6 1 duce ti w6imen gan (@anh du va chi thich tryc tiép tren c&u tric Chat $6 4) ‘quantitative NMP x86 ain eu tie tach Hen hop) HPLC eh h08, ya, 1b, it vit tha sinh noe “Téi uu hod chat dn ~lead Kinde bigt ma nhém nghién cu da si dung trong gia! doan optimization’ so voi phurong phap truyén théng thuong duge ding cho gial doan nay. Lipinski 28 gidi thich knd nang ding bang duéng ubng iia oée chat (a), (6), (c). Lau ‘oho cau héi nay. Cau 4-6, Sir dung cac quy t inh va chi st dyn oH i (c) MW: 429,48 gimol LogP = 5,7SEK} 36357759_1522438474527798_2932259831806951424 n.... Eq loa PPM ence chat caer toog | RoNA- 0H ca romana khang sear iniea hieo bon VA Het yoo. HQ = pat i a) a COOH A. (8) va (9) B. (7) va (8) ¢. (8) 0.7) Cu 78: Sy co mat ca nhém OH tal vi tr nao tfong Khung napthacen cila ede tetracyolin Ia nguyén nbn chin iam cho chung bi phn hiy trong moi trong acid? A.c2 B.C4 ©. D.c8 Cau 80: Trong c&u trdc ca cae khang sinh tetrecyclin thisn nhién, nhOm dimethylamin gn trén vj tr nao trong hung tetrahydronaphthacen: A.C4 B.c2 6.08 D.c6 Cau 81: Thubc chéng ddc kim logi nang dye tren 69 ché: ‘A. Trung hea cdc kim loai nang B. Tao tha voi kim logi néng, ngBn edn sy hép thu C. Gay ra cae tae dung dixge lV ngurgc lal v6i tBedung duvoc Ij do kim foal n8ng g@y ra 1D. Tao phic tan trong nude vi kim loei nang, gdp thai enhanh qua dubng then Au 82: Céc phat biBu sau ddy la ding v6) tejconlenin ‘A. Béc tinh. Ong 6 46c tinh trén than hu Yencomy cia BB. Nguén gée: ban tng hop tu vancomycin fn Lu diém fin ve higu qua va tae dung phy CC. Phd khang khudn: chi yéu gram am da ¢& khang D. Céu t20 la mot lipoglycopeptia Cau 83: Nguyén ly cba binh sinh xa “Mo / Te 12.gI? ‘A. "To la chat dann dBu gén voi chét mang ia “Mo Y BB. Ding neutron bin pha dng vi me “Mio #8 tao dng vi phéng xa *To, 6. Ding vi Mo (Tia = 68h) 99 lién tye "Te (Toa Sh) AB duy tt lvong "Te D. Hai dng vi "No va "Te déu phat ra tia garima dng cho may SPECT Cau 84: Knang sinh thuge he tetragycin ding 6iéu iH. Pio: A. Tetracycin B. Tigeeyelin ©. Doxyeylin D. Mineyetin cau 85: Nude ony gid 48 sat trong ode vét throng |8 dung dich hycroperoxyd A. 100 BBV cv D.10v cau 88: DBng vi phéng xe **"Technetium (#"Te) phat a bike xa néo sau Gay? ‘A. Alpha ®. Positron ©.Gamma D.Beta au 87: Chon vi du ve vige mé rong cBu trdc te cht ban sa ‘A, Cocain > Lidocain 8, Mogghin > Methadon C. Acid malonylurea > Phenabarbital of. Apiclin > Oxacilin Cau 88: Trciosan gay hai cho moi rbng vi déc did, NGOAI TRU: ‘A. chuyén hoa trong ty nhién thanh nhing dan guat Gla dioxinch&t doc mau da cam B.trclosan va cac dn xuat chuyn hos it bi phi hu trong moi tnxeng C. tan trong nude D. tich iy trong ode déng vat hu sinh 1 (Cau 89: Gia tr Va (THA tc phan bé) thubng ding a8 tinh ton | ‘A. Ligu odn thidt a dat higu qua oieu tr B. Sinh kha dung olla thudc | C. $6 an ding thube trong ngay D. Kha nang phan bé cia thudc dén co quan | Hinh sau st dung cho céc cau tir 90 dén 92aUEKy a a ae ne 36321479_1522438084527837_7324743393894989824 n... Eq pesos (A. dani Brust ae adeieesinll D. ethanolamin ay 29: 8 ann oi kha nang tndm qua mang cis mt at gat sau day duve st dung ‘A. Bueng kinh phan te 1B. Bhan to leone aw 30: Nystatin ts tube khang nfm ph new. eh tac dung tr "A. Cantica albicans i, Tachophyton EPidermophyton __D. Microsporum Cau 31: Yéut6 nao cd tr nghién ctu thube tr cl ’k. Vi kun sinh san cher C. Vi khuan qua yéu B. V6 linid cua vi hud D. Nan cla vi khudn OF, Cau 32: Mefloquin Mefloquin Ja thude thuge nhém cu tric: 'A.Arylamino-alcol 8, 4 Amino quinolin ¢.4=Qulnoleny! methanol D, &Phenanthten methenol ‘Cau 33: Cau tric co ban olla khang sinh macrolid A. Vong lactam hydroxy héa va két nbi voi cae phan a dyéng qua cau oxy carbon BB. Vong lacton hydroxy héa va ket nf vi eae phan tit duong qua cau oxy ether C. Ving lacton hydroxy héa va két néi voi c4c;phdn tir duéng qua cau carbon D. Vong lactam hydroxy héa va két n6i voi cac phan ti Guéng qua cau oxy ether Cau 34: Saquinavir la thude tr HIV: ‘A. Tac dung theo co ché irc ché enzym saa chép nguot RT B. Tac dung theo oo ché de ché ket cinh HIV va CD, C. Cau tac twang ty base pyrimidin D, Tae dung theo co ené ue ché men protease (Cau 35: Imatinib a thube cibutung thu tac dng tneo coreh ’R. Chat tac dong len thy thé tyrosine kinase B. Chat ending chuyén héa va tveng dBng nuceosia . Khang thé don dong D, Tae anan alkyl héa (Cau 36: Gia tr AUC twang due Ap dng a8 tinh ‘08m ’ Sinh Kha dung cba thube BBS ln ding thude trong naay CC. Lidu cin thigt a8 dat hieu qua gut . Kha nding phan b6 cla thuée an cor quan (Cu 37: Céu tric nao sau day Ia cia on Aco aa