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Complement C3d receptor on microbe Candida albicans
binds C3b/d and reduces
C3b/d-mediated
% Search everythingpolymorph phagocytosis
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Inflammation Induce strong Gonococcus, C. albicans,
inflammatory response, yet HSV, chlamydia
evade consequences
Antibodies (especially IgA) Produce IgA protease Gonococcus
BLOK REPROD…
#Cell-mediated $ MIKROBIOLOGI
immune Antigenic variation; allows Gonococcus, Chlamydia,
response (T cells, re-infection of a given Papillomaviruses (not HSV
lymphokines, natural killer individual with an antigenic or T. pallidum)
cells, etc.) variant T. pallidum, HIV
Poorly understood factors
cause ineffective cell-
mediated immune
response

Host defenses Microbial strategies Examples

Integrity of mucosal
6.2. OK Herpesvirus.pptx
surface
Urine flow (for urethral
infection)
Phagocytes (especially
polymorphs)
Bacterial_STD.pdf
Specific attachment
mechanism
6.3. OK Rubella Rubeola…
Specific attachment;
induce own uptake and
transport across urethral
epithelial surface in
phagocytic vacuole
Infection of urethral
epithelial or subepithelial
cells
Induce negligible
inflammation
Resist phagocytosis
Gonococcus or Chlamydia
to urethral epithelium
Gonococcus
Herpes simplex virus (HSV),
Chlamydia
Treponema pallidum,
mechanism unclear,
perhaps poorly activates
alternative complement
pathway due to sialic acid
coating
Gonococcus (capsule) T.
pallidum (absorbed
fibronectin)