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Abstract: Multiple techniques exist to remove uroliths from each section of the urinary tract. Minimally invasive methods for
removing lower urinary tract stones include voiding urohydropropulsion, retrograde urohydropropulsion followed by dissolution
or removal, catheter retrieval, cystoscopic removal, and cystoscopy-assisted laser lithotripsy and surgery. Laparoscopic cysto-
tomy is less invasive than surgical cystotomy. Extracorporeal shock wave lithotripsy can be used for nephroliths and ureteroliths.
Nephrotomy, pyelotomy, or urethrotomy may be recommended in certain situations. This article discusses each technique and
gives guidance for selecting the most appropriate technique for an individual patient.
N
ew, minimally invasive techniques for removing preventive measures.7 Surgical removal of partial or com-
uroliths have been developed or have become more pletely obstructing ureteroliths that do not pass within 24
readily available in veterinary medicine. TABLE hours may be prudent.8 A staged approach to surgery can be
1 summarizes the advantages and disadvantages of each considered if uroliths are found at multiple sites in the upper
method, the number and type of uroliths for which each is urinary tract. The reversibility of renal dysfunction depends
appropriate, and necessary equipment for each. on completeness and duration of obstruction. Studies in
Uroliths can be eliminated by physical removal, and cer- dogs have shown variable and permanent decreases in renal
tain types can be dissolved. Indications for physical removal function after 7 days of acute ureteral obstruction, with no
include obstruction of the urethra, renal pelvis, or ureters; improvement after 40 days of obstruction,8 although there
failure of dissolution therapy; and unacceptable clinical are reports of improvement after 70 days in people,9 and we
signs associated with urolithiasis, such as recurrent urinary have observed improvement in cats after 70 days.
tract infections or pollakiuria.1–3 The benefits of physical All methods of stone removal should be followed by imag-
removal of cystic calculi include rapid resolution, definitive ing to confirm complete urolith removal. Appropriate man-
diagnosis of urolith type (via quantitative urolith analysis), agement to prevent regrowth of uroliths is recommended.
and reduced risk of urinary obstruction.4 In asymptomatic
patients, removal of cystic calculi is not mandatory, particu- Nonsurgical Techniques
larly if there are relative contraindications to anesthesia or Voiding urohydropropulsion is used to evacuate small uro-
surgery.5 If a urolith is suspected to be composed of struvite, cystoliths by flushing them out through the urethra (BOX
urate, or cystine, medical dissolution can be attempted if 1).10–12 A general guideline is that this technique can be used
no indication for more immediate removal is present. There to remove uroliths <5 mm in diameter from male and female
are no effective medical dissolution protocols for calcium dogs weighing more than 8 kg, uroliths <3 mm from female
oxalate uroliths. cats and small dogs, and uroliths ≤1 mm in diameter from
The decision to remove nephroliths or ureteroliths is
more complicated than the decision to remove cystic or
urethral calculi. Nephroliths are commonly detected in cats RELATED ARTICLES
with chronic kidney disease, but in most cases, they do not
cause progression of renal dysfunction, and nephrotomy is • Diagnosis of Urolithiasis, August 2008
generally not recommended.6 Nephroliths and ureteroliths • Urate Urolithiasis, October 2009
should be physically removed if they are causing obstruc- • Calcium Oxalate Urolithiasis, November 2009
tion to urine flow, progressive deterioration in renal function, • Feline Struvite Urolithiasis, December 2009
or recurrent urinary tract infection or are enlarging despite
Ureterotomy Ureter Any size, All Rapid resolution of Risk of urine leakage; Yes Surgical;
small number obstruction postoperative swelling magnifying loupes
or stricture may cause or operating
obstruction; multiple microscope in cats
uroliths increase risks
Nephrotomy Kidney Any All No special Temporary decrease in Yes Surgical
equipment renal function
Ureteral stent Ureter Large number All May be only option Stents not readily available, Yes Surgical;
difficult to place intraoperative
fluoroscopy
Lower Urinary Tract
Voiding Bladder, Small size, All No surgery Risk of obstruction with Sedation or Catheter
urohydropropulsion urethra any number larger uroliths anesthesia
Retrograde Urethra Small size All Avoids urethrotomy Does not remove uroliths Sedation or Catheter
hydropropulsion anesthesia
Cystoscopic Bladder Small size, All No surgery Only small uroliths Yes Rigid cystoscope
evacuation any number removed
Laser lithotripsy Bladder, Medium All No surgery Limited availability; may Yes Rigid or flexible
urethra size; small take longer than cystotomy cystoscope; laser
to moderate if large urolith burden lithotripter
number
Laparoscopic- Bladder Any All Less invasive than Same procedure duration Yes Rigid cystoscope
assisted cystotomy standard cystotomy as standard cystotomy
with skilled operator
Cystotomy Bladder Any All Rapid, readily Bigger incision than Yes Surgical
available laparoscopic-assisted
cystotomy
Urethrotomy Urethra Any All Removes uroliths Risk of stricture Yes Surgical
resistant to other
techniques
Urethrostomy Urethra Any All Decreases risk of Increased long-term risk of Yes Surgical
future obstruction infection
in dogs with
recurrent urolith
formation
Upper and Lower Urinary Tract
Dissolution Bladder, Any Struvite, No anesthesia or Not applicable to all urolith No None
kidney urate, surgery types; takes weeks to
cystine months for resolution
Box 1 Box 2
8. Express the urinary bladder (apply digital pressure • Inject saline through the catheter until resistance is felt
dorsally and cranially to induce micturition; if the by the person performing the injection. This dilates the
bladder is pushed toward the pelvic canal, a kink section of urethra between the two sites of occlusion.
can form in the distal urethra, preventing passage of • Rapidly release the pressure in the pelvic urethra (but
uroliths). not distal urethra) while continuing to inject saline.
This flushes the urolith into the bladder.
9. Repeat steps 2 through 8 until uroliths are no longer
being expelled. Females
10. Use imaging to evaluate the success of the • With rectal palpation or vaginal palpation (preferred),
procedure (consider cystoscopy or double-contrast occlude the distal urethra around the catheter.
cystography to evaluate small uroliths that may • Inject saline through the catheter.
remain; only a lateral exposure is needed).
• Gently manipulate the urolith to move it toward the
bladder lumen.
male cats.10 Larger uroliths have been removed with this • Repeat as needed to move all uroliths into the bladder.
technique in some situations; removal is more likely to be • Monitor bladder size during the procedure to prevent
successful for uroliths with smooth contours than for uro- overdistention.
liths with irregular contours.10 Voiding urohydropropulsion
should not be used in patients with a urethral obstruction
and is not ideal for patients that have recently undergone Catheter-assisted retrieval of uroliths through a urinary
bladder surgery. Anesthesia is not needed in all animals catheter (BOX 3) is mainly used to collect small cystic calculi
but facilitates performing the procedure. Agents that pro- for diagnostic purposes (mineral analysis). Anesthesia may
vide analgesia and muscle relaxation are recommended.10 not be needed, depending on the patient.3,12
Antibiotics should be used for 3 to 5 days after the procedure Cystoscopic retrieval has been described for small uro-
is performed to prevent iatrogenic urinary tract infection. liths or urolith fragments after lithotripsy; the latter may be
Retrograde urohydropropulsion (BOX 2) does not remove aspirated through the rigid cystoscope sheath after the tele-
uroliths from the urinary tract; rather, it relocates them from scope has been removed. This technique allows retrieval of
the urethra to the bladder, where they can be dissolved by larger uroliths than does catheter assistance but is limited
medical therapy or removed via cystotomy or laser litho- by the inner diameter of the cystoscope sheath. An Ellik
tripsy techniques.3,13 evacuator (Bard Urologic Division, Covington, GA) aids
FIGURE 1
Percutaneous cystolithotomy.
The cystoscope sheath being placed into the bladder through the small abdomi-
nal incision. (Courtesy of Dr. Allyson Berent, Animal Medical Center, New York
City. Used with permission of the Journal of the American Veterinary Association View of bladder via cystoscope with stone bas-
[JAVMA]) ket in view. (Used with permission of JAVMA)
cium oxalate uroliths are more difficult to fragment than hours but may take several weeks to months to clear the
canine calcium oxalate uroliths.21 upper urinary tract.14 The amount of renal damage induced
Using a wet lithotripter, successful fragmentation of in cats by wet lithotripters causes an unacceptable decline
nephroliths was achieved in 90% of dogs after one or two in renal function, but successful resolution of ureteroliths in
treatments in one study.20 Retreatment was necessary in cats has been accomplished with dry lithotripters.20,22,23
about 30% of these patients, compared with a retreatment Transient hematuria is common after ESWL.22 Transient
rate of about 50% after lithotripsy using a dry lithotripter.14,20 increases in creatinine occurred in half of dogs treated with
Fragments begin to move out of the renal pelvis within 24 ESWL but remained within the normal range in one report.14
Nephrotomy/Pyelotomy/Ureterotomy References
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Small Animal Practice. Philadelphia: WB Saunders; 1995:1003-1007. lodged in the urethra back to the bladder for surgical
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3 CE
CREDITS CE Test This article qualifies for 3 contact hours of continuing education credit from the Auburn University College of Veterinary
Medicine. To take individual CE tests online and get real-time scores, visit Vetlearn.com. Those who wish to apply this credit to fulfill
state relicensure requirements should consult their respective state authorities regarding the applicability of this program.
1. Effective medical dissolution protocols b. multiple small cystic calculi. d. laparoscopic cystotomy
do not exist for ____ uroliths. c. a large number of small to moderate-
a. struvite sized calculi. 8. In two studies, after standard surgical
b. calcium oxalate d. a small urolith lodged in the urethra. cystotomy, calculi were inadvertently
c. urate left behind in ____ of dogs.
d. cystine 5. The least invasive way to remove a a. 0%
single, large calcium oxalate cystic cal- b. 20%
2. Removal of cystic calculi is not recom- culus involves c. 50%
mended when a. voiding urohydropropulsion. d. 80%
a. a patient has clinical signs associated b. retrograde urohydropropulsion.
with cystic calculi. c. cystoscopy-assisted laser lithotripsy. 9. In one study, a year after nephrotomy
b. a patient has urinary tract infection. d. surgical cystotomy. in healthy cats, single-kidney GFR was
c. a definitive diagnosis of urolith compo- decreased by
sition is desired. 6. Surgical cystotomy may be more rapid a. 0%.
d. cystic calculi are noted incidentally in than cystoscopy with laser lithotripsy for b. 10% to 20%.
an asymptomatic patient. removing c. 50%.
a. a single large cystic calculus. d. 80%.
3. Voiding urohydropropulsion is ideal for b. multiple small cystic calculi.
removing c. a large number of moderate to large- 10. Based on studies in dogs, complete
a. a large cystic calculus. sized calculi. return of renal function becomes less
b. multiple small cystic calculi. d. a urolith lodged in the urethra. probable if an obstructing ureterolith is
c. a large number of moderate-sized to not removed within _____ day(s).
large calculi. 7. Which method of urolith removal would a. 1
d. a urolith lodged in the urethra. be most appropriate for a dog with a high b. 7
anesthetic risk? c. 30
4. Retrograde urohydropropulsion is ideal a. voiding urohydropropulsion d. 90
for b. laser lithotripsy
a. a large cystic calculus. c. ESWL