PATHOPHYSIOLOGY OF ACUTE GASTROENTERITIS

ETIOLOGICAL FACTOR: PREDISPOSING FACTOR:

 Bacterial infection  Age (Infant, Adult)

 Poor Sanitation
 Poor Hygiene
 Diet

Ingestion of contaminated foods

Entry of large amount of pathogen in GIT

Exposure of pathogens to gastric acid

Circulation of Toxins  Intraluminal pressure  Activity organism to  Consumption of

in the body of intestines digestive food nutrients by pathogens

Recognition of toxins Perforating Compres Production of gas by Cellular deprivation of

in the body of sion of product nutrients
intestinal nerve
lining endings

Rapture of Pain Excess gas formation Cellular starvation

capillaries

Hunger Weakness
Bleeding Melena Flatulence

Histamine release Prostaglandin Release of pyrogen

Peristaltic movement Irritation of

hypothalamus
Abdominal pain

Alteration of
Frequency of defecation thermoregulation

Water absorption
Fever
Fluid loss
Watery stool
Dehydration

↓ Urine Poor skin Sunken Thirst Dry mucous

output turgor eyeball membrane