Aquino was born on 6 January 1812 in Balintawak, Quezon City.

Aquino, daughter of a peasant couple, Juan and Valentina Aquino, never attended school. However,
she was apparently literate at an early age and talented as a singer and performed at local events as
well as at Mass for her Church. She was also often chosen for the role of Reyna Elena during the
"Santacruzan", a processional pageant commemorating Empress Helen's finding of the Cross of
Christ, celebrated in the Philippines in May.
Later in life, she married Fulgencio Ramos, a cabeza de barrio (village chief), and bore six children.
Ramos died when their youngest child was seven and she was left as a single parent for their
children. Aquino continued her life as an hermana mayor active in celebrating fiestas, baptisms, and
weddings. She worked hard in order to give her children an education.
In her native town, Tandang Sora operated a store, which became a refuge for the sick and
wounded revolutionaries. She fed, gave medical attention to and encouraged the revolutionaries with
motherly advice and prayers.
Secret meetings of the Katipuneros (revolutionaries) were also held at her house. Thus she earned
the names "Woman of Revolution", "Mother of Balintawak", "Mother of the Philippine Revolution",
and Tandang Sora (Tandang is derived from the Tagalog word matandâ, which means old). She and
her son, Juan Ramon, were present in the Cry of Balintawak and were witnesses to the tearing up of
the cedulas.
When the Spaniards learned about her activities and her knowledge to the whereabouts of the
Katipuneros, she was interrogated but she refused to divulge any information. She was then
arrested by the guardia civil and was deported to Guam, Marianas Islands, where she and a woman
named Segunda Puentes were placed under house arrest in the residence of a Don Justo Dungca.
After the United States took control of the Philippines in 1898, Tandang Sora, like other exiles,
returned to the Philippines until her death on 19 February 1919, at the age of 107. Her remains were
then transferred to her own backyard (now known as Himlayang Pilipino Memorial Park, Quezon
City).
As a token of gratitude, a Quezon City district and a road were named after Aquino. Her profile was
also placed in the Philippines' five-centavo coin from 1967-92.
She was the first Filipina who appears on a Philippine peso banknote, in this case, a 100-peso bill
from the English Series (1951–66). Tandang Sora Street in the city of San Francisco, California,
United States, is named in her honor.
In 2012, on the celebration of her 200th birthday, the City Government of Quezon City decided to
transfer Aquino's remains from Himlayang Pilipino Memorial Park to the Tandang Sora National
Shrine in Banlat, Quezon City. The city government also declared 2012 to be Tandang Sora Year.
Her descendants carry different surnames, with almost all living in Novaliches and Tandang Sora
districts in Quezon City as well as in Guam (USA) such as Figueroa, Ramos (her husband’s
surname), Geronimo, Eugenio, Cleofas and Apo.