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ABSTRACT INTRODUCTION
Objective To determine the correlation between placental Placenta previa is a rare but dangerous, sometimes fatal, con-
position at 20–23 weeks and incidence of birth complications dition: it increases maternal, fetal and neonatal morbidity
caused by placental position. and mortality1–3. During pregnancy, placenta previa is one of
Subjects and methods In an ongoing prospective study, the leading causes of third-trimester bleeding4. At delivery,
placental position was determined by transabdominal sono- women with placenta previa have an increased risk of abruptio
graphy as part of anomaly scanning at 20 –23 gestational placentae, Cesarean delivery, fetal malpresentation and post-
weeks, followed by transvaginal sonography in uncertain or partum hemorrhage5. In the United States between 1979 and
suspicious situations. Examination was performed in 9532 1986, 44 maternal deaths were related to placenta previa as an
cases; feedback was obtained from 8650 patients (90.7%). underlying disease, mainly because of bleeding and dissem-
inated intravascular coagulation5.
Results Transabdominal sonography was followed by To prevent severe complications, the accurate and timely
transvaginal scan in 363 of 8650 cases (4.2%). In 8551 cases diagnosis of placenta previa is indispensable. Unfortunately,
(98.9%), we found normal placental position, with the location of placental position produces a diagnostic dilemma:
placenta not reaching the internal os and a Cesarean section on one hand it would be advantageous to be informed about
rate of 17.1% (1458/8551). The incidence of ‘low placental a dangerous placental position as early as possible; on the
position’, with the placenta reaching the internal os was other hand, it is well known that the incidence of so called
0.66% (57/8650), with a Cesarean section rate of 21% (12/ placenta previa decreases with advancing gestational age,
57). In 0.49% (42/8650) of cases, the placenta overlapped especially during the second trimester. Many cases of placenta
the internal os at 20 –23 weeks; Cesarean section because of previa diagnosed during the early second trimester have an
placenta previa or bleeding was performed in 28 of 8650 outcome of normal delivery6. Therefore too early assessment
cases (0.32%). Vaginal delivery was possible in 43% of cases of placental position results in unnecessary patient anxiety7,8.
(13/30), when the overlap did not exceed 25 mm. If the Our aim was to determine the accuracy of placental location
overlap exceeded 25 mm (12 cases), no vaginal delivery was at a 20–23-week anomaly scan in predicting complications
reported. There was no reported case of placenta previa related to placental position at delivery.
missed at the 20–23-week scan.
Conclusion At 20 –23 weeks, a combination of routine
SUBJECTS AND METHODS
transabdominal and indication-based transvaginal loca-
tion of placental position is a powerful tool in predicting In an ongoing prospective study beginning in September
placenta previa at delivery. The advantage of determining 1992, the position of the placenta was registered in 9532 non-
placental position at this stage of pregnancy is a low false- selected consecutive patients undergoing anomaly scanning
positive rate compared to at earlier stages of pregnancy. We at 20–23 gestational weeks in our institution, which serves
conclude that an overlapping placenta at 20 –23 weeks has as one of the referral centers of Berlin. We received feed-
the consequence of a high probability of placenta previa at back concerning the outcome of pregnancies in 8650 cases
delivery. An overlap of 25 mm or more at 20 –23 weeks (91.9%); evaluation was done for these 8650 patients only.
seems to be incompatible with later vaginal delivery. The study group included 255 sets of twins, 19 sets of triplets
Correspondence: Dr R. Becker, Free University of Berlin, University Klinikum Benjamin Franklin, Kurfürstendamm 199, 10719 Berlin, Germany
(e-mail: bedaktari@t-online.de)
Received 8-3-00, Revised 14-12-00, Accepted 9-3-01
and 1 set of quadruplets. Each multiple pregnancy was located by abdominal scan with a normally filled bladder,
counted as one case. We included only pregnancies with a followed by transvaginal scan in uncertain or suspicious sit-
duration of more than 24 weeks; pregnancies terminated uations (n = 363, 4.2%). For evaluation, observations were
because of malformations were excluded from evaluation. divided into three groups:
Most of the patients were delivered in one of the several Group I: ‘normal’ position of placenta: the lower margin
hospitals of the city or the surrounding area. Feedback of of the placenta did not reach the internal os;
information concerning details of delivery including com- Group II: ‘low position’ of placenta: the lower margin of
plications was achieved by return of a form handed out to the the placenta reached the internal cervical os but did not
patient after examination; if omitted, information was overlap (Figure 1);
obtained by telephone contact in most cases with the patient. Group III: ‘overlapping placenta’: the lower margin of the
In 1998 and 1999, this was performed in 958 of 2333 cases placenta overlapped the internal os (Figure 2).
(41%); we therefore estimate the rate of spontaneous return When an overlapping placenta was suspected, the patient
of information in our whole study group to be around 50%. and her physician were informed, and follow up was recom-
The mean age of the patients was 31.1 (15 –46) years. The mended at 28 weeks. Calculations were performed using SAS
mean gestational age was 21.6 weeks. Examinations were (SAS, Heidelberg, Germany). Exact Clopper–Pearson confidence
performed with an Acuson 128 XP10 (Mountain View, CA, intervals were used for the proportions.
USA) ultrasound machine. Transabdominal scans were per-
formed with 4- and 5-MHz probes and transvaginal scans
RESULTS
with 7- or 8.5-MHz probes. Experience of the participating
physicians at the beginning of the study was more than The frequency of different classes of placental position is
2 years of exclusive sonographic work. The placenta was listed in Table 1. The correlation of gestational age and fre-
quency of ‘low’ or ‘overlapping’ placenta is presented in
Table 2. An overview of the frequency of Cesarean sections
in correlation to position of placenta at 20–23 weeks is
shown in Table 3. The frequency of Cesarean section in the
whole study group was 17.3% (1499/8650). Patients with
‘normal placental position’ (Group I) were delivered by
Cesarean section with a frequency of 17.1% (1458/8551). In
‘low position’ (Group II), the frequency was 21% (12/57);
this frequency was not statistically different from that of Group
I (P = 0.38, Fisher’s exact test). In 42 patients we found a
placenta overlapping the internal os containing one set of
twins (Group III). We had occasion to perform follow-up
examinations in 22 of these cases. In six of 22 cases, placental
position had normalized in later phases of pregnancy, all of
20 + 0 to 20 + 6 661 11 1.66
21 + 0 to 21 + 6 3613 44 1.22
Figure 2 Placenta overlapping the internal cervical os by 16.6 mm, 22 + 0 to 22 + 6 3381 35 1.04
visualized by transvaginal sonography at 21 + 1 weeks with a 7-MHz 23 + 0 to 23 + 6 995 9 0.90
probe. P, placenta; large arrow, internal cervical os; small arrows, Overall 8650 99 1.14
cervical channel.
them with an overlap less than 25 mm; 5 of these were delivered There was neither fetal nor maternal death in Group III.
vaginally; one was by Cesarean section because of malpres- One patient with a history of Cesarean section and an overlap
entation. The patient with the greatest amount of overlap and of posterior wall placenta of more than 50 mm experienced
normal delivery had an overlap of 20 mm. The frequency of massive hemorrhage during Cesarean section at 39 weeks
Cesarean section was 69% (29/42) including the one case of and underwent hysterectomy because of placenta increta. In
Cesarean section because of malpresentation (overlap 10 mm another patient, using color Doppler sonography we detected
at 22 + 6 weeks; no overlap at 26 + 6 weeks). In all other overlapping placenta in combination with velamentous inser-
cases, Cesarean section was performed because of placenta tion with an arterial umbilical vessel on the surface of the
previa according to the decision of the responsible physician, overlapping part of the placenta (Figures 4 and 5); she under-
nine of them because of vaginal bleeding between 31 and 39 went emergency Cesarean section following vaginal bleeding
gestational weeks. All patients with an overlap of 25 mm or at home at 32 + 4 weeks. One patient presented with a vas
more delivered by Cesarean section. In patients with pla- previum detected at 23 + 0 gestational weeks (Figure 6); she
centa overlapping less than 25 mm (n = 30), the frequency was admitted to hospital at 30 weeks and delivered by emer-
of Cesarean section because of placenta previa in the sub- gency Cesarean section following vaginal bleeding at 32 + 5
group of 1–10 mm overlap was 43% (6/14) compared to gestational weeks. In all cases, outcome for mother and child
62.5% (10/16) in the subgroup of 11–24 mm (P = 0.46, was favorable and all of the pregnancies of this group had a
Fisher’s exact test). The correlation between degree of duration of at least 31 weeks (Table 4).
placental overlap and sensitivity for Cesarean section
because of placenta previa in Group III (28/42, 67%) is
DISCUSSION
shown in Figure 3. An overview of the duration of pregnancies
in the three groups of different placental position is given in Placenta previa at delivery is a rare condition. Frequencies
Table 4. reported at birth range from 0.14%9 to 0.75%10 with a mean
of 0.38%1,5,8–16. An overview of frequencies of placenta pre-
Table 3 Cesarean section in relation to placental position at 20– via is given in Table 5. In our study group, the incidence of
23 weeks placenta previa at delivery with the consequence of Cesarean
section was 0.32% (28/8650; 95% confidence interval
95% confidence11
Placental position n (%) interval (%)
Table 4 Duration of pregnancy in relation to placental position at 20–
‘Normal’ (Group I) 1458/8551 (17.10) (16.26 –17.87) 23 weeks
‘Low’ (Group II) 12/57 (21.05) (11.38 –33.89)
‘Overlapping’ (Group III) *29/42 (69.05) (52.91–82.39) Duration of pregnancy (weeks)
> 0 –10 mm *7/14 (50.00) (23.04 –76.96)
11–24 mm 10/16 (62.50) (35.44 –84.80) Placental position n Median Range
≥ 25 mm 12/12 (100.00) (73.54 –100.00)
Overall 1499/8650 (17.33) (16.54 –18.14) ‘Normal’ (Group I) 8551 39.0 24–43
‘Low’ (Group II) 57 39.0 32–42
Percentages are based on the total number of patients in the group. ‘Overlapping’ (Group III) 42 38.0 31–41
*Includes one case of Cesarean section because of fetal malpresentation Overall 8650 39.0 24–43
with overlapping placenta at 22 weeks and normal placental position at
control sonography.
ranges, 0.22–0.47%) which lies close below the mean of pub- by the patients according to the information they had received
lished data. The differences of incidence in different study from their physicians in charge. In our opinion this seemed
groups may be due to the higher amount of high-risk preg- to be sufficiently reliable but may bear a small risk of incorrect
nancies in patients of referral hospitals as well as racial and information. With an incidence of 0.32% in our study group
genetic differences. Also, factors like confusing abruption with and 0.38% as the mean of incidence of more than 500 000
placenta previa, quality of outcome information or size of patients (Table 5) our assessment of placenta previa most prob-
study group may be of importance. ably does not include a large amount of incorrect information.
A crucial point in evaluation is the verification of placenta During pregnancy, the frequency of so-called ‘placenta
previa at delivery. In our study group, this was performed by previa’ decreases with increasing gestational age due to an
the responsible physician in the different hospitals of the city. effect described as ‘placental migration’17, caused by the fact
In nine cases, patients were delivered by Cesarean section in that the placenta-free uterine wall grows faster than the placenta-
acute clinical situations of bleeding following the diagnosis of covered area11. This effect was observed in our study group
placenta previa by previous sonograms. In one case, Cesar- with the frequency of ‘low’ or ‘overlapping’ placenta decreasing
ean section was performed because of malpresentation of the from 1.66% at week 20 to 0.90% at week 23 (Table 2).
fetus in a situation where ‘overlapping’ placenta had normal- The consequence of this effect is a higher amount of false-
ized; this case was counted as non-persistence. In 19 cases of positive cases of diagnosis of ‘placenta previa’ in earlier
Cesarean section following overlapping placenta at the 20– phases of pregnancy.
23-week scan, the information of a Cesarean section having An overview of the reported incidence and regression rate
been carried out because of placenta previa was given to us of so-called ‘placenta previa’ is given in Table 6. Incidence
at the time of scan decreased from 2.4% at 12–16 weeks11
to 0.48% at 20–23 weeks, depending on the definition of
‘placenta previa’. Parallel to this effect, the persistence rate
of ‘placenta previa’ until delivery increased from 6.4% at
12–16 weeks11 to 67% at 20–23 weeks.
Before introduction of transvaginal sonography, diagnosis
of placenta previa was difficult and had to rely on indirect
signs16. Since the introduction of transvaginal sonography,
this method has become the gold standard for the diagnosis
of placenta previa in all phases of pregnancy18,19. Performed
accurately, it seems to pose no threat to the pregnancy18–21.
In our study group, one patient with an overlap of 16 mm
reported bleeding in the evening after vaginal examination.
This was possibly due to abruption of the overlapping part
of the placenta following contractions induced by trans-
vaginal sonography; after 8 days in hospital, her pregnancy
Figure 5 Transvaginal sonography (7-MHz probe) of the same situation went on to 40 weeks and ended in a spontaneous delivery.
as in Figure 4 (In Figure 4, fetal head moved to lateral part of amniotic It is still unclear whether accurate diagnosis of placenta
cavity.) with pulsed Doppler of the vas praevium. P, placenta; FH, fetal previa is possible only by routine application of transvaginal
head; large arrow, internal cervical os; small arrows, cervical channel.
sonography9,11. Our experience with the use of transvaginal
sonography only in uncertain or suspicious situations, which
Incidence
Time span Study group (n) n %
Table 6 Incidence of placenta previa at ultrasound, persistence until delivery and incidence at birth
Taipale et al. 199711 6428 12 –16 > 14 mm TV 156/6428 (2.4) 10/156 (6.4) 10/6428 (0.16)
Lauria et al. 199612 > 2910 15–20 ≥ 0 mm TA + TV 31/2910 (1.1) 5/36 (14) 5/ > 2910 (< 0.17)
Rizos et al. 197916 1098 16 –18 > 0 mm TA 58/1098 (5.3) 5/52 (10) 5/1098 (0.46)
Taipale et al. 19989 3696 18–23 > 0 mm TV 57/3969 (1.5) 5/57 (8.8) 5/3696 (0.14)
> 15 mm 27/3969 (0.68) 5/27 (18.5) 5/3696 (0.14)
≥ 25 mm 10/3696 (0.27) 4/10 (40) 4/3696 (0.11)
Present study 8650 20 –23 > 0 mm TA + TV 42/8650 (0.48) *28/42 (67.0) *28/8650 (0.32)
≥ 25 mm 12/8650 (0.14) 12/12 (100) 12/8650 (0.14)
*Excluding one case of Cesarean section because of fetal malpresentation with overlapping placenta at 22 weeks and normal placental position at
control sonography. GA, gestational age; US, ultrasound; P.p. def, definition of placenta previa (degree of overlap over internal os); TA,
transabdominal scan; TV, transvaginal scan.
18 Farine D, Fox HE, Jakobson S, Timor-Tritsch IE. Vaginal ultrasound for 21 Leerentveld RA, Gilberts ECAM, Arnold MJCW, Wladimiroff JW.
diagnosis of placenta previa. Am J Obstet Gynecol 1988; 159: 566–9 Accuracy and safety of transvaginal sonographic placental localization.
19 Farine D, Fox HE, Jakobson S, Timor-Tritsch IE. Is it really a Obstet Gynecol 1990; 76: 759–62
placenta previa? Eur J Obstet Gynecol Reprod Biol 1989; 31: 103–8 22 Smith RS, Lauria MR, Comstock CH, Treadwell MC, Kirk JS, Lee W,
20 Timor-Tritsch IE, Yunis RA. Confirming the safety of transvaginal Bottoms SF. Transvaginal ultrasonography for all placentas that
sonography in patients suspected of placenta previa. Obstet Gynecol appear to be low-lying or over the internal cervical os. Ultrasound
1993; 81: 742 – 4 Obstet Gynecol 1997; 9: 22–4