Mapua University {81025-1 Transport Processes in Biological Systems 2 SSEES ay Powe mtr P.otO% 1 Payee manbe, DN Prepared by: HSCabreraMapua University '81025-1 Transport Processes in Biological Systems 2 1 Problem Set 1 Fluid Mechanics in Biological Systems ve: 08-Sep-2018 Reduce the Navier-Stokes equation for cylindrical coordinates to Euler's equation and then to the Bernoull's equation. Then calculate the velocity atthe stenosis throat and the pressure difference between the stenosis throat and the inlet during systole and diastole given the upstream conditions of a velocity of 20 em/s (systole) and 12 ems (diastole), where the left common coronary artery has an axisymmetric constriction because of a plaque buildup. The density of blood is 1050 kg/m’. Assume that there is no difference in height under these conditions mm ~L— ~ Artificial organs within the blood stream are generally associated with flow-induced blood ‘damage, particularly hemolysis of red blood cells (Paul etal, 2003). These damaging effects are known to be dependent on shear forces and exposure times. To determine the correlation between these flow-dependent properties and actual hemolysis, blood Is allowed to flow in a Couette device for study. The location of the plates is at y=0 and at y=h, and the upper plate Is ‘moved with velocity U. Assuming that blood is incompressile and is @ Newtonian fluid, and that the flow is one-dimensional, steady, and varies as a function of height only. Also, there is no pressure gradient. Obtain an equation for the velocity profile of the Couette flow. ‘The pressure difference across an arteriole with length of 100 um and a radius of 35 um is 10 ‘mig Viscosty of blood is 3 ¢P. 2, Calculate the volumetric flow rate within the arteriole. Calculate the change in radius needed to reduce the volumetric flow rate by 5%. What is the vascular resistance? Suppose the flow rate of blood ina coronary artery has been reduced to half its normal value by plaque deposits. ay what factor has the radius of the artery been reduced, assuming no turbulence occurs? Calculate the state fluid pressure inthe skull atthe end of systole. The skull is 35 em above the aorta and thatthe pressure atthe end of systole is 120 mmHg. The density of blood is 1050 kg/m ‘Afermentation tank 1.8 m in diameter and height is stirred by a fla-blade, turbine-type impeller Cf diameter 0.6 m witha rotational speed of 60 rpm. The tank contains a viscous non-Newtonian broth, .= 72,300 cP and p= 1050 kam”. The impeller width is 0.12 m, and the tank contains four bales. A 10x volume scale-up is desired with equal liquid motion needed, 2 Calculate the new dimensions Da, Dt, W, J, HL, and C. b. Calculate the new impeller speed and the power requirements of the mixer. Prepared by: HSCabrera