Bio165-2

MULTIPLE CHOICE QUESTIONS

DAVID , MARIA ARIANE; ESTOYA, KAREN M.; BRITANICO GYLE
Molecular Mechanisms for Regulating Mitotic Events

1. The cellular response for steroid hormone receptor pathway signaling

a. mRNA Transcription b. DNA Replication c. Cell Division
d. RNA Translation
2. Class of sex steroid hormone that is synthesized from cholesterol and is secreted
primarily by the ovaries, with contributions from placenta, adipose tissue, and adrenal
glands
a. Testosterone b. Cortisol c. Estrogen d.
Aldosterone
3. The actions of estrogen are mediated through the _______. It regulates transcription
of target genes through binding to specific DNA target sequences.
a. Estrogen Receptor b. Estrogen Complex c. Estrogen Blocker d.
Estrogen Release
4. Type of ER that is dominant among males
a. ERα b. ERβ c. NR3A1 d.
none of the above
5. Region in the ER that is involved in both inter-molecular and intra-molecular
interactions as well as in the activation of gene transcription
a. A/B b. C c. D d. E/F
6. Region in the ER that comprises the E2-binding domain and works, synergistically with
the N-terminal domain in the regulation of gene transcription
a. A/B b. C c. D d. E/F
7. Region in the ER that has a role in receptor dimerization and in binding to chaperone
heat-shock proteins (Hsp).
a. A/B b. C c. D d. E/F
8. Region in the ER that allows ER to dimerize and to bind to the specific ERE sequence
on DNA through its two “zinc finger” structures.
a. A/B b. C c. D d. E/F
9. Short sequence of DNA within the promoter of a gene that is able to bind with the E 2–
ER complex which will result in an enhanced transcription by interacting directly with
coactivator proteins and components of the RNA polymerase II transcription.
a. Estrogen Response Elements b. Hormone Response Elements

c. Estradiol Response Elements d. E2 Response Elements

10. An interaction in which E2-ER complex binds directly to EREs in target gene
promoters.
a. ERE dependent Gene Transactivation Mechanism
b. ERE Independent Mechanism
c. Ligand-Independent Genomic Action
d. Nongenomic Actions of ER
11. Involves the AP1 and SP1 interactions with other transcription factors
a. ERE dependent Gene Transactivation Mechanism
b. ERE Independent Mechanism
c. Ligand-Independent Genomic Action
d. Nongenomic Actions of ER
12. Growth Factors activate Protein Kinase Cascades leading to phosphorylation (P) of
ER at EREs.
a. ERE dependent Gene Transactivation Mechanism
b. ERE Independent Mechanism
c. Ligand-Independent Genomic Action
d. Nongenomic Actions of ER
13. Membrane-associated ERs mediate estrogen actions.
a. ERE dependent Gene Transactivation Mechanism
b. ERE Independent Mechanism
c. Ligand-Independent Genomic Action
d. Nongenomic Actions of ER
14. Type of ER that dominates among females
 a. ERα b. ERβ c. NR3A2 d.
none of the above
15. A process where a single cell divides into two identical daughter cells among
multicelled eukaryotes.
a. Mitosis b. Meiosis c. Binary Fission d.
Prokaryotic Fission
16. The ________ is a double-membrane extension of the rough endoplasmic
reticulum containing many nuclear pore complexes.
a. Nuclear envelope
b. Cell
c. Nucleus
d. Cell membrane

17. During __________, the final step in cell division, the actin and myosin filaments
composing the contractile ring slide past each other to form a cleavage furrow of
steadily decreasing diameter
a. Nuclear fusion
b. Cytokinesis
c. Membrane fusion
d. anaphase

18. Inactivation of MPF toward the end of ______ due to the degradation of cyclin B,
permits the unopposed action of protein phosphatases to dephosphorylate
myosin light chain
a. Anaphase
b. Telophase
c. Centromere
d. mitosis
19. Subsequent fusion of the karyomeres associated with each spindle pole
generates the two daughter-cell nuclei, each one containing a full set of
________
a. Cells
b. Chromosomes
c. Proteins
d. Cytokines

20. ________ function is regulated by the anaphase inhibitor, a protein that is a

target of APC-directed polyubiquitination.
a. Cohesin
 b. MPF Regulator
c. Inhibitor
d. MPK regulator

21. In the late anaphase and telophase stages of _______, APC-mediated

polyubiquitination of cyclin B targets it for destruction
a. Mitosis
b. Meiosis
c. None of the above
d. All of the above

22. A regulated increase in ____activity induces entry into mitosis

a. MPF
b. MPK
c. Telomerase
d. Phosporylase

23. During telophase, microtubule dynamics return to ________conditions

a. Metaphase
b. Interphase
c. Anaphase
d. Telophase

24. During telophase, the chromosomes ________

a. Decondense
b. Condense
c. Reform
d. Are torn apart

25. During telophase the nuclear envelope

a. Decondense
b. Condense
c. Reform
d. Are torn apart

ANSWERS:
1. A
2. C
3. A
4. B
5. A
6. D
7. C
8. B
9. A
10. A
11. B
12. C
13. D
14. A
15. A
16. A
17. B
18. A
19. B
20. A
21. A
22. A
23. B
24. A
25. C