Scribd Logo
Upload

Welcome to Scribd!

  • Pathophysiology of Cholera PDF

    Uploaded by

    RameshKrishnan
    88 views1 page
    Cholera is caused by ingesting food contaminated with Vibrio cholerae bacteria. Some bacteria survive the stomach's acidity and colonize the small intestine. There, they produce enterotoxins that bind to intestinal cells and stimulate fluid secretion. This leads to a loss of water and electrolytes in diarrhea, potentially causing dehydration, hypovolemic shock, and even death if untreated. Poverty, poor sanitation, malnutrition, and antacid use predispose individuals to cholera infection.

    Original Description:

    Original Title

    306872193-Pathophysiology-of-Cholera (1).pdf

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Cholera is caused by ingesting food contaminated with Vibrio cholerae bacteria. Some bacteria survive the stomach's acidity and colonize the small intestine. There, they produce enterotoxins that bind to intestinal cells and stimulate fluid secretion. This leads to a loss of water and electrolytes in diarrhea, potentially causing dehydration, hypovolemic shock, and even death if untreated. Poverty, poor sanitation, malnutrition, and antacid use predispose individuals to cholera infection.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    88 views1 page

    Pathophysiology of Cholera PDF

    Uploaded by

    RameshKrishnan
    Cholera is caused by ingesting food contaminated with Vibrio cholerae bacteria. Some bacteria survive the stomach's acidity and colonize the small intestine. There, they produce enterotoxins that bind to intestinal cells and stimulate fluid secretion. This leads to a loss of water and electrolytes in diarrhea, potentially causing dehydration, hypovolemic shock, and even death if untreated. Poverty, poor sanitation, malnutrition, and antacid use predispose individuals to cholera infection.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    PATHOPHYSIOLOGY OF CHOLERA

    Precipitating (modifiable):
    Predisposing (non-modifiable):  Long-term antacid use
     Poverty  Improper sanitation
     Environment  Improper food handling
     Blood type O  Malnutrition

    Ingestion of food contaminated with V. cholerae

    Goes to stomach

    Mostly: killed by acidity of the stomach Some: survives and colonize small intestine

    Produces enterotoxins (exotoxin)

    Destruction and irritation of mucosal B subunits of V. cholerae binds to GM1


    lining of small intestine ganglioside receptors (G-protein receptors)

    TENESMUS Hyperactive BS
    A subunit is released into the cell

    Altered bleeding ulceration Abdominal


    digestion & cramps Stimulates adenylate cyclase
    reabsoption

    weakness
    cAMP

    Inhibits Na+ and Cl- absorption by microvilli Secretion of Cl- by the crypt cells

    Water goes out from cell to “rice-watery”


    intestinal lumen DIARRHEA

    Fluid & electrolyte imbalance Dry skin


    Poor skin turgor
    Dry mouth, tongue
    Sunken, glassy eyes
    Dehydration Cold-clammy
    stupor

    Hypovolemic shock Decreased circulating blood volume

    HypoTachyTachy

    Decreased renal perfusion

    Renin release Decreased GFR

    Combines with angiotensinogen Decreased urine output

    Angiotensin I

    Angiotensin I to Angiotensin II by ACE

    vasoconstriction Aldosterone secretion ADH secretion

    @farr_awaaaay

    You might also like