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: 16 Applied Anthropology
Module : 03 Nutrition epidemiology
Development Team
Nutrition epidemiology
Anthropology
Description of Module
Contents:
1. Introduction
2. History of nutritional epidemiology
3. Nutritional deficiency diseases
3.1. Malnutrition
3.1.1. Protein energy malnutrition (PEM)
3.1.2. Kwashiorkor
3.1.3. Marasmus
3.2 Micro-nutrient malnutrition
3.2.1. Iron Deficiency Anaemia (IDA)
3.2.2. Vitamin A Deficiency (VAD)
3.2.2.1. Night Blindness (XN)
3.2.2.2. Conjunctival Xerosis (X1A)
3.3.2.3. Bitot’ Spot (X1B)
3.3.2.4. Corneal Xerosis (X2)
3.3.2.5. Cornea Ulceration (X3A)
3.3.2.6. Keratomalacia (X3B)
3.2.3. Iodine Deficiency Disorders (IDD)
3.2.4. Water soluble vitamin deficiency disorders
3.2.4.1. Thiamine (Vitamin B1) Deficiency Diseases
Nutrition epidemiology
Anthropology
3.2.4.2. Riboflavin (vitamin B12) Deficiency Diseases
3.3. Nutrition and Non Communicable Diseases (NCDs)
3.3.1. Obesity
3.3.2. Type 2 diabetes
3.3.3. Coronary heart disease (CHD)
Learning Objectives:
To understand:
1. Definitions and concepts of nutritional epidemiology.
2. Deficiency diseases due to suboptimal intakes of micronutrients and its dietary management.
3. Non Communicable Diseases (NCDs) due to excessive intakes of macronutrients (over
nutrition) and its dietary management.
Introduction
The word epidemiology comes from two Greek words epi, meaning on or upon, demos, meaning
people, and logos, meaning the study of. Several definitions have been proposed, but the underlying
principles and public health spirit of epidemiology following is define by the following.
“Epidemiology is the study of the distribution and determinants of health-related states or events in
specified populations, and the application of this study to the control of health problems”.
Nutritional epidemiology studies the role of food and nutrition and in relation to disease in human
populations. Nutritional epidemiological research involves the role of food and nutrition in etiology of
diseases, assess and monitor the food consumption and nutritional status of populations, measures to
prevent, control and improvement of health, develop interventions in order to maintain healthy eating
lifestyle and also to analyze the association of nutrition and physical activity in relation to diseases.
Nutrition epidemiology
Anthropology
investigation dates back to more 2000 years ago, when Hippocrates conducted a clinical trial to
observe the cause of a disease and belief in notion that health depends on magical influence. Lind in
1753 observed that scurvy was caused by deficiency of vitamin C when he conducted one of the
earliest clinical trials with lemons and oranges. Milestones in classic epidemiology include John
Snow’s (1813-1858) who studied the spread of cholera due to of polluted water, and suppresses the
outbreaks of the disease 44 years even before the discovery of , the causal agent Vibrio cholera.
Casimir Funk in 1912 investigated that deficiency of substances which he called “vitamins” may cause
diseases such as sprue, beriberi, rickets, pellagra etc.
Another epidemiological investigation of 19th and 20th century include Joseph Goldberger who
observed the occurrence of pellagra among poor relying on as staple diet. He suspected the disease
could be due to nutritional deficiency. It was later identified as deficiency of niacin, a B-complex
vitamin (B3). With the discovery of microorganisms, at the end of the 19th century mark the era of
infectious disease epidemiology. Robert Edward Koch work on the etiology of tubercle bacillus in
1882 resulted in improved environmental conditions and interventions for preventing transmission of
certain microorganisms. Epidemiological observation thus has provided the insight into the diet-
disease relationship and the cause and prevention of diseases. Earlier epidemiologist focused on the
etiology of infectious diseases but since early decades of 20th century, they shifted to chronic disease
and remarkable contribution have made to the understanding of nutrition-related diseases as well. Band
and Dyerberg studied coronary disease in Eskimos and observed that it was uncommon despite their
high fat diet and later found that omega -3 fatty acid from fish oil is responsible for low plasma lipid
level in their diet. Hospital based case control study in 1950 showed that smoking was associated with
lung cancer. So, epidemiology play an increasingly important role and its evolution has led to the
development of specialized areas like environmental, clinical, psychiatric, genetic, occupational within
the epidemiology.
Nutrition epidemiology
Anthropology
is a global burden of diseases in developing countries because of the coexistence of under-nutrition and
related deficiency and infectious diseases along with overweight and obesity, or diet-related non-
communicable diseases as a result of nutritional transition. Nutrition in addition to other factors such as
unhealthy lifestyle and environmental factors influence health and well-being. However, it is important
to realize that nutrition is a major, modifiable, and powerful factor in promoting health, preventing and
treating disease, and improving quality of life.
Nutrition epidemiology
Anthropology
Kwashiorkor
Diet predominantly deficient in protein often leads to kwashiorkor. Although it occurs in older children
and adults, it usually affects children aged 1- 4 years when they are weaned from breast milk to adult
diet. Clinical features of kwashiorkor are growth failure, oedema and mental changes. The main sign is
oedema usually appear first on the feet and leg and eventually spread to hands and faces. Other
symptoms include skin lesions and hypo-pigmentation and in severe cases the epithelium peels off
leaving behind depigmented patches. The hair shows changes in texture and curly hair becomes
straight easily pluckable. Diarrhoea may occur due to secondary infections and defective digestion.
Marasmus
A diet deficient in calories and prolonged starvation results in marasmus. It may also occur due to
chronic infections with marginal food intake. It is more common in children below 2 years of age.
Main cardinal features include severe muscle wasting, growth retardation and loss of subcutaneous fat.
The child appears very thin because most of the muscles mass and fat have been expended to provide
energy. Associated vitamin deficiencies are however very common.
Nutrition epidemiology
Anthropology
Dietary management and prevention
An adequate amount of diet with sufficient calories and a good quality protein should be given. High
energy intakes (150kcal/kg) and high protein intakes (3-4g/kg) are required for rapid recovery. During
infancy and childhood protein requirement is more. In pregnancy protein requirement is increased by
another 15-20 gram per day. Liquid diet either fresh milk or dry skimmed milk powder is
recommended. Eggs are desirable as sources of protein. Vitamins and mineral supplements are
recommended for all malnourished children. Besides, dietary management it is also necessary for
health promotion at community and household level. Promotion of breast feeding, measure to improve
family diet, distribution of supplements, routine immunization of children, and periodic surveillance of
child’s diet should be encouraged. In India, the Integrated Child Development Services (ICDS) is a
major national program providing integrated health and nutrition services to preschool children.
Micro-nutrient malnutrition
It refers to a group of conditions caused by deficiencies of essential minerals and vitamins. The most
common types of micro-nutrient malnutrition in India and in most developing countries include:
Iron Deficiency Anaemia (IDA):
Nutritional anaemia is a major public health problem affecting all sections of the society. It is defined
by WHO as a condition in which the haemoglobin content is low as a result of deficiency of one or
more essential nutrients, regardless of the cause of deficiency. The major cause of nutritional anaemia
is due to deficiency of iron, vitamin B12 and vitamin C. Burden of anemia are not only confined to
pregnant women but affects other segments of the society. Adolescent boys and girls, women in
reproductive years, infants and young children and pregnant women are in vulnerable groups
Prevalence of anemia in India is high due to low dietary intake, poor iron and folic acid intake, poor
bio-availability of iron in phytate fibre-rich Indian diet. NFHS- 3 reported prevalence of anemia as 55
% in women aged 15–49 years, 24% in men aged 15–49 years and 70% among children aged 6–59
months. Deficiency of iron increases incidence of maternal deaths by 20% increases the risk of
premature delivery and low birth weight. According to WHO, 12.8% maternal mortality in Asia are
Nutrition epidemiology
Anthropology
attributed to anaemia. Iron rich supplements are a must for prevention of anaemia. Oral iron or low
dosage of iron, multivitamin supplements, folic acid, vitamin A and zinc are recommended.
Vitamin A Deficiency (VAD):
Vitamin A deficiency with a variety of manifestations is wide spread in the world today. Deficiency of
vitamin A leading to xerophthalmia and night blindness among young children has become a major
public health problem in developing countries including India. The term xerophthalmia
comprehensively includes all ocular manifestations of vitamin A deficiency. The most contributing
factor is due to inadequate of vitamin A or its precursor i.e β carotene. The most vulnerable groups are
the pregnant women and infants born particularly in low income groups. According to the estimates of
NFHS 2, prevalence of night blindness due to low dietary intake of vitamin A in pregnant women was
up to 10-20%. Vitamin a deficiency predominantly occurs in children due to common childhood
infections like diarrhea, measles and infestations like giardiasis and ascariasis. Micronutrient Initiative
(MI) estimates that around 3, 30,000 children in India die due to VAD. More than 4 million children
worldwide exhibit sings of severe deficiency.
Nutrition epidemiology
Anthropology
Corneal Xerosis (X2)
It is characterized by the presence of dry and non wettable cornea and the changes start at the lower
level of the eye.
Cornea Ulceration (X3A)
Cornea Ulceration may occur if corneal xerosis is not treated properly. These ulcers may be circular
and sharply demarcated, initially appear to be shallow and may lead to perforation resulting in
prolapsed of content of eye ball if it becomes deep.
Keratomalacia (X3B)
Keratomalacia is characterized by liquefaction of cornea. Cornea may become soft and may end up in
extrusion of intra-ocular contents or complete atrophy of the eye.
Nutrition epidemiology
Anthropology
1987. The major clinical manifestation of iodine deficiency is goiter, defined by non-inflammatory
enlargement of thyroid gland. For clinical assessments, goiter size is assessed based on the palpation of
thyroid and classified as follows:
Grade 0- No goiter (if it is not visible or palpable, if palpable but the size is less than the distal
phalange).
Grade I- Not visible when the neck is in normal position, but palpable (the size of the enlargement of
gland should be more than the size of the distal phalange of the thumb of the subject).
Grade III- Visible from the minimum distance.
Environmental factors such as environmental iodine deficiency and goitrogens (substances which
interfere with the metabolism of iodine in the body) leads to endemic IDD while intrinsic factors like
hormonal imbalance, failure to synthesis the thyroid hormone contributes to sporadic cases. Iodine
deficiency disorders include a spectrum of disorders such as goiter, retarded physical development,
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Nutrition epidemiology
Anthropology
impaired mental function, juvenile hypothyroidism in children and adolescents, psychomotor defects,
congenital anomalies in foetus.
Prevention of Iodine Deficiency Disorders (IDD)
Fortification of food items with iodine or by direct supplements is a way out. Fortification of food
items like wheat flour, drinking water milk, bread and common salt is still practicing in different parts
of the world. The oldest control measure is to iodize the common salt with potassium iodate. Iodized
oil is also available for oral or intra-muscular injection.
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Nutrition epidemiology
Anthropology
Riboflavin (vitamin B12) Deficiency Diseases
Deficiency of riboflavin is widely prevalent in low income groups of the population in all age groups.
Clinical manifestation of riboflavin deficiency includes ocular symptoms with characteristic itching,
burning, fatigue and eyestrain. Other symptoms are shiny red mucosa of lips with cracking at the
corners of the mouth, known as cheilosis and roughened skin around the mouth and nose. For control
and prevention diet rich in riboflavin such as meats, milk, pulses, and other dairy products are
recommended.
Nutrition epidemiology
Anthropology
high level saturated fats have, together with reduced energy expenditure, contributed to rises in the
incidence of obesity and non communicable diseases. Obesity is associated with other diseases such as
diabetes, cardiovascular diseases, hypertension, cancers and polycystic ovarian diseases. In India,
particularly in urban setting, obesity is emerging as an important health problem. According to NFHS 3
report, 9% of Indian men and 13% of women are overweight or obese.
Dietary prevention for obesity include limited intake of fats, elimination of trans fatty acids, increasing
physical activity level , reducing intakes drinks high in sugars, limited salt consumption, increase
consumption of fruits and vegetables, can prevent unhealthy weight gain.
Type 2 diabetes
Type 2 diabetes often referred to as non insulin dependent diabetes mellitus is characterized by insulin
resistance where the body is unable to utilize the glucose derived from carbohydrates food or glycogen
store in the tissues. Diagnosis of type 2 diabetes usually occurs on the onset of middle adulthood and is
associated with obesity which lead to elevated blood sugar and itself can lead to insulin resistance.
This type of diabetes is the most common type and nearly 90-95% of all diabetic belongs to this
category and is distinguished from type 1 diabetes and gestational diabetes of pregnancy.
There is increasing reports of children with type 2 diabetes and have become serious health issues. It
has been estimated in the adult population that the prevalence of diabetes milletus will raise from 4%
in 1995 to 5.4% in 2025. Obesity is a major risk factor for development of non insulin dependent
diabetes. Approximately type 2 diabetic patients are either found to be overweight or obese and
impaired glucose tolerance is also common in this group. Many epidemiological research revealed that
central obesity as assessed by waist hip ratio (WHR) is associate with higher occurrence of diabetes.
Diet rich in energy dense food such as carbohydrates which contribute to high calorie and enhance
body weight have been associated with diabetes. Other risk factors associated with development of
type 2 diabetes include physical inactivity, diet, increasing age, insulin resistance, ethnicity, family
history of diabetes, genetic factors.
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Nutrition epidemiology
Anthropology
Global prevalence and projections, 2010 and 2030
IGT (Impaired Glucose Tolerance) (20-79 2010 2030
years)
Global prevalence (%) 6.6 7.8
Number of people with diabetes (millions) 285 438
Comparative prevalence 6.4 7.7
Source Link: www. diabetesatlas.org
Weight control, preventing obesity and enhance physical activity level is the most promising approach
of preventing diabetes. It can be achieved by modifying nutrient intake and a healthy life style. Diet
high in plant food is often associated with a lower incidence of diabetes milletus.
Nutrition epidemiology
Anthropology
Consuming high glycaemic index foods are at greater risk of developing CHD. Carbohydrates
mediated their effects by reducing HDL (high density lipoprotein) and increasing triglyceride, plasma
lipids and glycaemia. Consumption of coffee, animal protein and saturated fats is positively associated
with CHD date rate. Many other studies conducted on middle-aged men showed that risk of CHD is
increased by cigarette smoking, high serum cholesterol and high blood pressure.
Replacement of simple sugar and fat with complex carbohydrates containing foods like pulses, whole
cereals, roots, millets, vegetables and fruits is recommended for preventing weight gain, control of high
blood sugar and lipids. High calorie dense food, processed foods, sweetened beverage, deep fried foods
should be avoided. Increasing physical activity level along with dietary modification can reduce
development of cardio-vascular diseases.
Summary
Role of diet and nutrition are important factors for determining, maintenance and promotion of a good
health. Malnutrition remains the most widespread devastating problem affecting the health of children
and continues to dominate the health of world’s poorest nations. There is a global burden of diseases in
developing countries due of the coexistence of under-nutrition and related deficiency and infectious
diseases along with overweight and obesity. For example, India, at present faces a combination of
chronic diseases and communicable diseases where the burden of chronic diseases exceeds that of
communicable diseases. With the economic development, rapid urbanization, food security and
increase health care services in developing countries there has been decline in under nutrition-related
diseases. However, these factors on the other hand have exacerbated the development of chronic
diseases, also known as non communicable diseases (NCDs) due to unhealthy diets, sedentary
lifestyles and lack of physical activity. NCDs are now a major global burden in public health. By 2020,
the burden of NCDs is expected to increase to 57% and it has been projected that in developing
countries, 71% of deaths due to ischaemic heart disease (IHD), 70% of deaths due to diabetes and 75%
of deaths due to stroke will occur.
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Nutrition epidemiology
Anthropology