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What is Biochemistry
➢ Simplest Definition: “Chemistry of the living cell”
➢Uses basic laws of chemistry, biology and physics to explain
processes of living cells
➢Study of life at the molecular level.
Introduction to Biochemistry
ENGR. JEREMIAH EMIER VILLANUEVA
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Quick Review
FUNCTIONAL GROUPS
➢ Lipids
Macromolecules ➢ Commonly known as fats
➢Organic compounds that are not very soluble with water
➢ Used as sources of cellular energy
➢ Components of cell membranes
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Polymers of macromolecules
Polymers of macromolecules
➢ Starch and Cellulose
➢ Polymers of glucose molecules that differ only by how the glucose monomers are
linked.
➢ Proteins/polypeptides
➢ Amino acid monomers linked together
➢ DNA
➢ Heteropolymer of monomeric nucleotides; storage of genetic information
➢RNA
➢ Same as DNA; involved in transfer of the genetic information encoded by DNA
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Quick Review
EUKARYOTIC CELLS
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Cytoplasm/cytosol Cytoskeleton
➢ Viscous aqueous environment (NOT free flowing) ➢ 3-D matrix made up of protein fibers
➢ Contains small molecules, nutrients, salts, soluble proteins
➢ Functions to give cells shape, allows cells to move, guides internal
➢ 20-30% of cytosol is protein – very concentrated organelle movement.
➢ Major cite of cellular metabolism (e.g. glycolysis)
➢ Connects all organelles.
➢ Contains the cytoskeleton
Nucleus
➢ Site of most DNA and RNA synthesis
➢ Storage of genetic information
➢ Bound by a double membrane
➢ Largest organelle
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Lysosomes
➢Internal sacs bound by a single membrane
➢ Responsible for degrading cell components that have become
obsolete for the cell or organism
➢ Internal pH (approx. 5)
➢ Enzymes in lysosomes degrade polymers into their individual
building blocks.
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REDOX reactions
➢ Photosynthesis trap light energy use it as driving energy for the
reactions. (Reduction)
➢ Respiration consume carbohydrates to make use of their energy.
(Oxidation)
Bioenergetics