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Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
FORMULATION (KRISI5) CREAM OF THE COMBINATION OF BETEL Commented [u1]: Pakai template yang sudah disediakan jurnal
Commented [u2]: Langsung bahasa latin
LEAF AND LEAF DELIMA AS ANTI-AGING AND ANTI-ACNE
Commented [u3]: leaves
Commented [u4]: bahasa latin diikuti leaves
Abstract
The appearance of wrinkles which become one of the signs of aging, and acne
on the face are the factors most disturbing beauty of the face. Aging is triggered by free
radicals in the body, this occurs due to oxidative processes. Unlike the pimples that
appear on the face, one of which is caused by the activity of bacteria that cause acne is
Propionibacterium acnes. Many Indonesian natural materials that have potential in the
field of beauty and good bioactive components that have not been used optimally.
Pomegranate leaves (Punica granatum L) have been studied have a high antioxidant
because it contains elagat acid in high amounts, while the betel leaf (Piper betle L. ) has
antibacterial activity against Propionibacterium acnes bacteria that cause acne. Topical
preparations of anti-aging and anti-acne already widely circulated in the market in the
form of a cream, because it is considered to have aesthetic appeal greater because it is
not greasy and the ability to absorb into the skin at the time of basting. The purpose of
this research is to produce a cream which is effective as an anti-aging and anti-acne that
can be produced for cosmetic preparations so that consumers can feel two facial care
benefits in one product at an affordable price. Because it is considered to have aesthetic
appeal greater because it is not greasy and the ability to absorb into the skin at the time
of basting. The purpose of this research is to produce a cream which is effective as an
anti-aging and anti-acne that can be produced for cosmetic preparations so that
consumers can feel two facial care benefits in one product at an affordable price. The
method used in anti-aging test is using a skin analyzer and moisture checker and for
Formulation KRISI5:
Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
anti-acne is agar diffusion method using paper pencadang by measuring the diameter of
growth inhibition against Propionibacterium acnes bacteria. Commented [u5]: Ringkas menjadi 200 kata saja. Terdiri dari
latar belakang dan tujuan, metode, hasil dan kesimpulan
Keywords : Anti-acne, anti-aging, pomegranate leaf, betel leaves Commented [u6]: leaves
1 INTRODUCTION
Has a beautiful face and naturally became one of happiness and is one of the factors Commented [u7]: paragrafnya tidak masuk seperti ini
Commented [u8]: Having
to increase the confidence of every woman. In this modern era, women are required to
Commented [u9]: natural
look beautiful so that directs women to try to get the perfect beauty. Commented [u10]: become
The appearance of wrinkles which become one of the signs of aging, and acne on Commented [u11]: therefore
the face are the factors most disturbing beauty of the face. Aging is triggered by free
radicals in the body. This occurs due to oxidative processes. The use of anti-aging
antioxidant-containing compound is an effort that is often done to prevent or at least the
age of aging naturally (Ardhie, 2011). Commented [u12]: cara menulis rujukan mengunakan angka.
Jadi ini angka 1
Antioxidants are one of the compounds that can neutralize and reduce free radicals
and inhibit the oxidation of cells thereby reducing the occurrence of cell damage, such
as premature aging (Heranani and Raharjo, 2005). Commented [u13]: 2
Unlike the pimples that appear on the face, one of which is caused by the activity of
bacteria that cause acne is Propionibacterium acnes. Required to eliminate or prevent Commented [u14]: revise
aesthetic appeal to have a greater because it is not greasy and the ability to absorb into
the skin at the time of application of (Ansel, 1989).
Based on the above, it is necessary to do research that is able to identify the
potential of the combination of pomegranate leaf and betel leaf as an anti-aging and
anti-acne creams formulated in dosage forms.
2 RESEARCH METHODS Commented [u20]: EXPERIMENTAL
2.4.1 Sampling
Sampling was done by purposive ie without comparing with other regions.
Pomegranate leaf samples (Punnica granatum) taken from Jalan Rambutan Sentang
Village, District East Range, Asahan, North Sumatra. Samples of betel leaf (Piper betel
L) were taken from Padangsidimpuan, Padangsidimpuan District of North, North
Sumatra. Commented [u25]: Masukkan ke material. Tidak perlu nama
jalan hanya daerahnya saja atau kabupaten
2.4.2 Identification of Samples
Formulation KRISI5:
Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
nipagin 0.1 g
sodium metabisulfite 0.1 g
Perfume 3 drops
Distilled water ad 100 ml Commented [u31]: jadikan satu kalimat
Cream C: Formula 2
Cream D: Formula 3
Cream E: Formula 4
3.5.4 Evaluation of the stability of the preparations
Evaluation of the stability of the preparation is done during 4 weeks of storage,
preparation of cream stored at room temperature and observed changes in odor, color
and rupture of the emulsion. The results of the evaluation of the stability of each
parameter can be seen in:
observation After
finished
No.
1 Cream
A - - - 1- week
- - -2 weeks
- - -3 weeks
- - - 4 weeks
- -
2 B - be made
- - - - - - - - - - - - - -
3 C x- y- z - x- y- z- x- y- z- x- y- z- x- y- z-
4 D - - - - - - - - - - - - - - -
5 E - - - - - - - - - - - - - - -
Commented [u34]: perbaiki
Commented [u35]: mana hasil uji klinisnya?
observations and observations on storage for 4 weeks.
Cream E: F4
x: Discoloration
y: Change of odor
z: Rupture emulsion
-: No changes
√: There is a change
Volunteer
Irritation
reactions
I II III IV V VI VII VIII IX X
Irritation 0 0 0 0 0 0 0 0 0 0
Itchy 0 0 0 0 0 0 0 0 0 0
Rude 0 0 0 0 0 0 0 0 0 0
120
F4
100
80 F3
60 F2
40
20 F1
0 Blanko
Kondisi Minggu 1 Minggu 2 Minggu 3 Minggu 4
awal
Time
Figure 1. Graph the results of measurements of water content (moisture) in facial skin
form a group of volunteers, the cream of pomegranate leaf extract and Daub betel for 4
weeks
Commented [u45]: Tidak perlu pakai judul
Persentasion of water content Sesuaikan dengan gambar di atas
10
water content (%)
F4
5 F3
F2
0
Blanko F1 F2 F3 F4 F1
Formula Blanko
Formulation KRISI5:
Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
Figure 2. Graph recovery percentage of water content (moisture) in skin form a group
of volunteers, pomegranate leaf extract cream and betel leaf for 4 weeks.
2. Evenness
Evenness
45
40
35
30
Evenness
Blanko
25
20 F1
15
F2
10
5 F3
0
F4
Kondisi minggu 1 minggu 2 minggu 3 minggu 4
awal
Figure 3. Fineness measurement Time
result graph (Evenness) on the skin form a group of
volunteers, pomegranate leaf extract cream and betel leaf for 4 weeks for 4 weeks.
Persentasion of evenness
25
20
Evenness (%)
Blanko
15
F1
10
F2
5
0 F3
Blanko F1 F2 F3 F4 F4
Formula
Figure 4. Graph recovery percentage of water content (moisture) in facial skin form a
group of volunteers, pomegranate leaf extract cream and betel leaf for 4 weeks
3. Pore
Pore
35
30
25
20 Blanko
pore
F1
15
F2
10
F3
5 F4
0
Kondisi awal Minggu 1 Minggu 2 Minggu 3 Minggu 4
time
Formulation KRISI5:
Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
Figure 5. Graph pore on the skin form a group of volunteers, pomegranate leaf
extract cream and betel leaf for 4 weeks.
Persentasion of pore
70
60
50
Blanko
pore (%)
40
F1
30
F2
20
F3
10
0 F4
Blanko F1 F2 F3 F4
Figure 6. Graph recovery percentage
Formulapore on the skin form a group of volunteers,
pomegranate leaf extract cream and betel leaf for 4 weeks.
Spot
50
45
40
35
30 Blanko
Spot
25
20 F1
15 F2
10
5 F3
0
F4
Kondisi Minggu 1 Minggu 2 Minggu 3 Minggu 4
awal
Figure 7.Graph the results of measurement spots on the skin form a group of
Time
volunteers, cream extract, pomegranate leaf extract cream and betel leaf for 4 weeks.
Persentasion of spot
60
50
40 Blanko
Spot (%)
30 F1
20 F2
10 F3
0 F4
Blanko F1 F2 F3 F4
Formula
Formulation KRISI5:
Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
Figure 8. Graph recovery percentage spots on the skin form a group of volunteers,
pomegranate leaf extract cream and betel leaves after 4 weeks.
45
Wrinkle
40
35
30
Blank
Wrinkle
25 o
20 F1
15
10 F2
5
0
Figure 9. Kondisi
Graph the results
Minggu of measurements
1 Minggu 2 Minggu 3 of wrinkles
Minggu 4 at the group of volunteers
awal Time cream and betel leaf sselama 4 weeks.
face blank, pomegranate leaf extract
Persentasion of wrinkle
45
40
35
Wrinkle (%)
30 Blanko
25
F1
20
15 F2
10 F3
5
F4
Figure0 10. Graph recovery percentage wrinkles on the skin form a group of
Blanko F1 F2 F3 F4
volunteers, pomegranate leaf extract cream and betel leaves after 4 weeks.
Formula
4. CONCLUSION
Formulation KRISI5:
Cream Of The combination of Betel Leaf And Leaves Pomegranate As Anti-Aging and Anti-
Acne
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