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Abstract
Objective: To describe the axial and appendicular skeleton findings of diffuse idiopathic skeletal hyperostosis. To analyze the
role of conventional radiography, computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of this
condition. To discuss the differential diagnosis and diagnostic pitfalls of this disease. Material and methods: The involvement of
vertebral and extravertebral sites including the pelvis, calcaneum, ulnar olecranon, and patella is frequently found in the literature.
The lesions described are the anterior and lateral ossification of the spine, hyperostosis at sites of tendon and ligament insertion,
ligamentous ossification, and periarticular osteophytes. The criteria for the diagnosis of diffuse idiopathic skeletal hyperostosis
involving the spine are: flowing ossification along the anterior and anterolateral aspects of at least four contiguous vertebrae,
preserved intervertebral disc height, no bony ankylosis of the posterior spinal facet joints, and finally no erosion, sclerosis or bony
ankylosis of the sacroiliac joints. Results: The disease has about the same frequency in men (65%) and women (35%); it is most
common in the thoracic spine and occurs less frequently in the lumbar and cervical spine. The disease most commonly presents
in the sixth and seventh decades of life and its estimated frequency in the elderly is 5 – 15%. Signs and symptoms include stiffness
and pain in the back, dysphagia due to direct esophageal compression/distorsion, pain related to associated tendinitis, myelopathy
related to core compression associated to the ossification of the posterior longitudinal ligament, and pain related to vertebral
complications—e.g. fracture/subluxation. Conclusion: While conventional radiography clearly confirms the diagnosis of diffuse
idiopathic skeletal hyperostosis, CT and MRI better detect associated findings (e.g. ossification of the posterior longitudinal
ligament) and complications (e.g. spinal cord compressive myelomalacia). © 1998 Elsevier Science Ireland Ltd. All rights reserved.
tissue cells react by differentiating into osteoblasts. The Lesions are mainly peripheral to the annulus fibrosus
result is osteoproductive fibro-osteogenic changes which and the intervertebral disk. The disk progressively pro-
can take various forms: outgrowths, protuberances, trudes anteriorly and stretches the anterior longitudinal
needle-shaped, spur-like. These reactions are particu- ligament: anterolateral gross calcifications known as
larly important when associated with an ‘osteoblastic enthesophytes or pseudosyndesmophytes are found in
diathesis’, as in DISH, pachydermoperiostosis and a the sites of ligament enthesis.
few other diseases (Table 1). Three radiologic diagnostic criteria are used to assess
Some patients with DISH are asymptomatic but oth- vertebral column involvement and to grade the disease
ers have acute or subacute episodes of ‘periarthritis’ [11–13]:
probably due to phases of activation of the entheso- 1. Rheostotic calcifications closely adherent to the
pathic process, e.g. ‘trochanteritic’, ‘epicondylitic’, anterolateral margins of at least two contiguous
‘epitrochleitic’, ‘shoulder and/or hip periarthritic’ pain. vertebral bodies, with or without associated
Some patients complain of severe symptoms although osteophytes.
there are no objective findings, while others have really 2. Relative sparing of the width of the intervertebral
quite marked functional joint deficit (for example of the disk in the involved segments and no disk
elbow or the cervical spine) with no major subjective degeneration.
signs [6,7]. 3. No bony ankylosis of the interapophyseal joints.
The most common symptoms associated with DISH The distinctive signs of DISH are the so-called ‘pseu-
involved with the spine are rigidity, decreased mobility, dosyndesmophytes’ or ‘hyperostotic spondylophytes’
spinal column pain and dysphagia from esophageal which tend to fuse forming bony bridges [14]. These are
compression. In some, not uncommon and sometimes the consequence of enthesopathies and ossifying perios-
episodic, cases there are symptoms due to irritation toses at the insertions of the anterior longitudinal liga-
(and much more rarely, compression) of nerve roots in ment into the vertebral bodies.
the conjugate vertebral foramina. Spinal cord disorders, A less characteristic feature is the presence of macro-
although even rarer, are also possible [8 – 10]. osteophytes of deforming spondylosis. The so-called
These neurological syndromes are due to obstruction ‘drop ossifications’ are more typical. These ossifications
produced by newly formed bone arising from interapo- often occur in the middle of the disk space, anteriorly
physeal and unco-vertebral joints and ossification of or laterally, sometimes in contact with the margins of
parts of the posterior longitudinal ligament or the the vertebral body—in which case the term ‘gutta
ligamenta flava. cadens’ sign can be used. ‘Bony bridges’ or ‘bony
Radiology demonstrates the degree and extent of the coating’ are seen anteriorly and/or laterally to the verte-
enthesopathic ossification underlying the disease: bral bodies in more advanced disease stages. The entire
changes can be seen in the joints themselves, in peri- spinal column can be involved, even the first two cervi-
and para-articular structures, and in both the cal vertebrae, but the disease is more common and
mesomelic and the rhizomelic skeleton. However, al- more obvious in the middle-low cervical spine and the
though radiologic signs can be found in numerous middle-low thoracic spine. Thoracic spine involvement
peripheral joints, diagnostic certainty is reached from is characteristic, occurring in 95% of patients. Here the
the findings in the spine. hyperostosis is predominantly on the right of the verte-
bral bodies: the aorta pulsation tends to inhibit the
development of osseocalcified formations on the other
side. The whole border of the thoracic spine can be
2. The spine encircled by arches of bony tissue, up to a centimeter
thick, giving a moniliform or scalloped appearance to
Two types of anatomopathologic changes can be the thoracic spine. Lumbar spine neoformations are
found in the axial skeleton: usually more focal, although they may be gross, with
M. Cammisa et al. / European Journal of Radiology 27 (1998) S7– S11 S9
Table 2
Distinctive signs of DISH
Table 3
DISH
A. Idiopathic DISH
B. Secondary DISH due to:
Urate depositing diseases
Pyrophosphate depositing diseases
Hydroxyapatite depositing diseases
Ochronosis
Acromegaly
Other diseases
3. Extra-axial manifestations
bony involvement is much more extensive than might [13] Tsukamoto Y, Onitsuka H, Lee K. Radiologic aspects of diffuse
have been thought from a conventional or digital idiopathic skeletal hyperostosis in the spine. Am J Radiol
1977;129:913 – 8.
examination. [14] Jones MD, Pais MJ, Omija B. Bony overgrowths and abnormal
calcifications about the spine. Radiol Clin North Am
1988;26:1213 – 34.
[15] Albisinni U, Chianura G, Merlini L, Calzolari S, Othsuka K,
References Terayama K. Ossificazione del legamento longitudinale posteri-
ore del rachide lombare. Radiol Med 1988;75:482 – 5.
[1] Weinfeld RM, Olson PN, Maki DD, Griffiths HJ. The preva- [16] Chaabane M, Kheder F, Abid R, et al. Rare causes of ossifica-
lence of diffuse idiopathic skeletal hyperostosis (DISH) in two tion of the posterior common vertebral ligament causing cervical
large American Midwest metropolitan hospital populations. compression. Apropos two cases. J Radiol 1995;76:43 –6.
Skeletal Radiol 1997;26:222–5. [17] Moreno AC, Gonzales ML, Lopez Longo FS, Carreno L, For-
[2] Arlet J, Mazieres B. Hyperostose vertebrale ankylosante de rester DM. Simultaneous occurrence of diffuse idiopathic skele-
Forestier et Rotes Querol ou maladie hyperostosique. Radiol J tal hyperostosis and ankylosing spondylitis. Rev Rhum Engl Ed
CEPUR 1989;9:85 – 92. 1996;63:292 – 5.
[3] McCafferty RR, Harrison MJ, Tamas LB, Larkin MV. Ossifica- [18] Resnick D, Niwayama G. Entheses and enthesopathy. Radiol-
tion of the longitudinal ligament and Forestier’s disease: an
ogy 1983;146:1 – 9.
analysis of seven cases. J Neurosurg 1995;83:13–7.
[19] Dhilmann W. Joints and Vertebral Connections. New York:
[4] Rotes Querol J. Clinical manifestations of diffuse idiopathic
Thieme, 1985.
skeletal hyperostosis (DISH). Br J Rheumatol 1996;5:193 – 1194.
[20] Beyeler C, Lehmann T, Schlapbach P, Gerber NJ, Fuchs WA.
[5] Matteucci BM. Metabolic and endocrine disease and arthritis.
Diffuse idiopathic skeletal hyperostosis (DISH) of the shoulder.
Curr Opin Rheumatol 1995:July:356–358.
A controlled study. Rheumatol Int 1995;15:107 – 10.
[6] Mata S, Fortin PR, Fitzcharles MA, et al. A controlled study of
[21] Vezyroglou G, Mitropoulos A, Kyriazis N, Antomiadis C. A
diffuse idiopathic skeletal hyperostosis. Clinical features and
metabolic syndrome in diffuse idiopathic skeletal hyperostosis. A
functional status. Med Baltim 1997;76:104–17.
controlled study. J Rheumatol 1996;23:672 – 6.
[7] Pappone N, Di Girolamo C, Del Puente A, Scarpa R, Oriente P.
Diffuse idiopathic skeletal hyperostosis (DISH): a retrospective [22] Guo B, Jaovisidha S, Sartoris DJ, et al. Correlation between
analysis. Clin Rheumatol 1996;15:121–4. ossification of the stylohyoid ligament and osteophytes of the
[8] Huang TS, Msu RW, Liao YS, Shih HN, Chen YS. A rare cervical spine. J Rheumatol 1997;24:1575 – 81.
neurological presentation due to ossification of the posterior [23] Scutellari PN, Orzincolo C, Tilotta F. Localizzazioni periferiche
longitudinal ligament of the thoracic spine and ankylosing in corso di iperostosi scheletrica idiopatica diffusa. Radiol Med
spondylitis: case report. Spinal Cord 1997;35:550–3. 1984;70:943 – 8.
[9] Johnsson KE, Petersson H, Wollheim FA. Diffuse idiopathic [24] Scutellari PN, Orzincolo C, Castaldi G. Association between
skeletal hyperostosis (DISH) causing spinal stenosis and sudden diffuse idiopathic skeletal hyperostosis and multiple myeloma.
paraplegia. J Rheumatol 1983;10:784–9. Skeletal Radiol 1995;24:489 – 92.
[10] Ostveen JC, van de Laar MA, Tuynman FH. Anterior at- [25] Kilcoyne RF. Association between diffuse idiopathic skeletal
lantoaxial subluxation in a patient with diffuse idiopathic skele- hyperostosis (DISH) and multiple myeloma. Skeletal Radiol
tal hyperostosis. J Rheumatol 1996;23:1441–4. 1996;25:250.
[11] Resnick D, Niwayama G. Radiographic and pathologic features [26] Lagier R. Spinal hyperostosis in comparative pathology. A
of spinal involvement in diffuse idiopathic skeletal hyperostosis useful approach. Skeletal Radiol 1989;18:99 – 107.
(DISH). Radiology 1976;119:559–68. [27] Marcelli C, Yates AS, Barjon MC, et al. Pagetic vertebral
[12] Resnick D. Degenerative disease of the vertebral column. Radi- ankylosis and diffuse idiopathic skeletal hyperostosis. Spine
ology 1985;156:3 – 14. 1995;15:454 – 9.