ABITEC Corporation 800-555-1255

501 W. 1st Ave. +1 614-429-6464

Columbus, OH 43215 www.abiteccorp.com
USA sales@abiteccorp.com

STEROTEX NF ®
Lubricating Dry Binder
LUBRICATING DRY BINDER FOR DIRECT COMPRESSION TABLETING
STEROTEX NF (Hydrogenated Vegetable Oil Type I) functions both as a boundary
lubricant and as a dry binder.  The oleaginous nature of Sterotex NF provides
boundary lubrication to direct-compression tableting blends reducing ejection
force.  Sterotex NF also plastically deforms at relatively low compression pressures
providing increased tablet hardness and reduced tablet friability making it an ideal
dry binder for direct compression tableting operations.

PRIMARY ADVANTAGES:
• Freely flowing
• Plastically deforming at low compression pressures
• Provides boundary lubrication and reduces ejection force
• Economical compared to other dry binders
• Reduced
NUTRI SPERSE effectNUTRI
NUTRI SPERSE on disintegration times compared with magnesium stearate
RI SPERSE NUTRI SPERSE NUTRISPERSE NUTRISPERSE NU-
NUTRI SPERSE
SPERSE NU-
RSE NUTRISP
UTRI SPERSE
RSE NUTRISP
 STEROTEX NF ®

Application 1: Partial Magnesium Stearate Replacement

USP/EP Disintegration Time Ejection Force
600
140

Sterotex NF 0.00% Sterotex NF 0.00% 129.05

124.6
Sterotex NF 0.75% 120 Sterotex NF 0.75%
500 497
Sterotex NF 1.50% 471 Sterotex NF 1.50% 111.25 111.25
USP/EP Disintegraton Time (sec)

469 465 464 106.8

Sterotex NF 2.25%
449
432
433
453 449
100
Sterotex NF 2.25% 102.35
429 426 97.9
400 Sterotex NF 3.00% 403
428
Sterotex NF 3.00% 93.45 93.45
393

Ejection force (N)

380
365 370 84.55
356
80 80.1
329 335
325 75.65
317
300 71.2
62.3
261 62.3
60
57.85
53.4
200
Tablet Manufacturing 44.5
40 Tablet Manufacturing
Formula: Spray-dried Mannitol (85.5%), MCC-102 (9.5%)
Formula: Spray-dried Mannitol (85.5%), MCC-102 (9.5%)
Lubricants (SNF+mgst = 5.0% )
Tablet Weight = 1000mg Lubricants (SNF+mgst = 5.0% )
100
Tablet Press = Manesty Beta Press Tablet Weight = 1000mg
20 Tablet Press = Manesty Beta Press
Press Speed = 50rpm (dwell time 10 msec)
Punches = 0.625" FFBE Type "B" Press Speed = 50rpm (dwell time 10 msec)
Punches = 0.625" FFBE Type "B"
0 0
0 2 4 6 8 10 12 14 16 0 5 10 15 20 25
Hardness (kP) Compression force (kN)

Application 2: Dry Binding

Compaction (5.0% w/w of dry binder) Friability (Dry Binder 5.0% w/w)
18 1

16 Sterotex NF 0.9 Sterotex NF

Copovidone 14.6
Copovidone
14 Hydroxypropyl Cellulose 13.5
14.4
13.9
0.8
Hydroxypropyl Cellulose Tablet Manufacturing
Formula: Spray-dried Mannitol (83.25%), MCC-102 (9.25%)
12.9
0.7 magnesium stearte (2.5%), and dry-binder (5.0%)
12.3 Tablet Weight = 1000mg
12
11.4 Tablet Press = Manesty Beta Press
0.6 Press Speed = 50rpm (dwell time 10 msec)
Friability (%)

10.8
Hardness (kP)

10.4
10 Punches = 0.625" FFBE Type "B"

9.1 0.5 0.465

8.5
8 8.1 0.412
0.4
6.9

6 6.2
5.9
0.3
Tablet Manufacturing 0.236
Formula: Spray-dried Mannitol (83.25%), MCC-102 (9.25%) 0.203
4 magnesium stearte (2.5%), and dry-binder (5.0%) 0.2
0.181
Tablet Weight = 1000mg 0.151 0.144 0.151
0.13
Tablet Press = Manesty Beta Press 0.114
0.087 0.096
2 Press Speed = 50rpm (dwell time 10 msec) 0.1
0.053 0.059
Punches = 0.625" FFBE Type "B"
0
0 0
0 5 10 15 20 0 5 10 15 20 25

Compression Force (kN) Compression Force (kN)

STEROTEX® is a registered trademark of ABITEC Corporation. All information and statements given in this brochure are believed to be accurate at the time of publication. However, neither ABITEC
Corporation nor any of their affiliates make any representations or warranty with respect thereto, including, but not limited to, any results obtained in the processing of the products by customers
or any third party. All information and statements are intended for persons having the required skill and know-how and do not relieve the customer or user from verifying the suitability of infor-
mation and statements given for a specific purpose prior to use of the products. It is entirely the obligation of the customer or user to comply with applicable laws and regulations, and also with all
patent or other intellectual property rights of third parties. ABITEC CORPORATION EXPRESSELY DISCLAIMS ANY REPRESENTATIONS OR WARRANTIES OF ANY KIND, WHETHER EXPRESSED OR IMPLIED,
AS TO THE ACCURACY, CURRENCY, COMPLETENESS AND/OR THE MERCHANTABILITY OR FITNESS OF A PARTICULAR PURPOSE OF ANY INFORMATION CONTAINED IN THIS BROCHURE AND/OR PRODUCT
DESCRIBED OR PROMOTED IN THIS BROCHURE, INCLUDING WARRATNTIES WITH RESPECT TO INFRINGEMENT OF ANY PATENT, COPYRIGHT, OR OTHER RIGHTS OF A THIRD PARTY. We reserve the right to
change product specification and it specified properties of the products without prior notice.

ABITEC CORPORATION | 501 W. First Ave, Columbus, OH 43215 | www.abiteccorp.com