Waktu (Jam) Cp (µ g/ ml) Log Cp

0.5 5.36 0.729

1 9.95 0.998
2 17.18 1.235
4 25.75 1.411
8 29.78 1.474
12 26.63 1.425
18 19.4 1.288
24 13.26 1.123
36 5.88 0.769
48 2.56 0.408
72 0.49 -0.310
Ditanya …….?
a. Ka, Ke
b.T 1/2 abs, t 1/2 el
c. T maks
d. AUC
e. Vd
f. C maks
g. Cl
Jika Diketahui
Ketersediaan Hayati (F) = 0.8
Dev = 50 mg = 50000 mcg
b= -0.030
a= 1.842
R= 1
slope (b) = -k/2,303
Ke/ K 0.069 Jam-¹
t 1/2 eliminasi = 0.693/K
t 1/2 eliminasi 10.030 Jam
Cp0 Antilog Intersep (a)
Cp0 69.502 µg/ml

t Cp (µg/ml) Cp Ekspoltasi Cp Residual Log Cp Residual

0 0 69.500 69.500 1.842
0.5 5.36 67.143 61.783 1.791
1 9.95 64.866 54.916 1.740
2 17.18 60.541 43.361 1.637

a 1.842
b -0.102
R -1
Slope (K) = -k/2.303
Ka 0.235 Jam-¹
t1/2 = 0.693/Ka
t1/2 Absorbsi 2.950 Jam
AUC = (antilog intersep/k) - (antilog intersep/ka)
AUC 710.096 mcg.jam /ml
t maks = 2.303 * Log (Ka/K) / (Ka - K)
tmaks 7.382 Jam
Dev = 50 mg 50000 mcg
Vd = F*Dev / K*AUC
Vd 815.319 ml
Cmaks = (F*Dev / Vd )* e-ktmaks
Cmaks 29.459 mcg/ml
Cl = (F * Dev) / AUC
Cl 56.330 ml/jam
 t (Jam) Vs Cp (µg/ml)
35
30
25
Cp(µ g/ ml)

20 Column C
f(x) = - 0.275559966x + 19.8526156662
15 R² = 0.3803019805 Linear (Column C)
10
5
0
0 10 20 30 40 50 60 70 80
Waktu ( jam)

t ( jam) vs Log Cp (µg/ml)

(24-72 jam)
1.200
1.000 f(x) = - 0.0298712666x + 1.8417962197
0.800 R² = 0.9999866633
Log Cp (µg/ml)

Column D
0.600
Linear (Column D)
0.400
0.200
0.000
-0.200 20 30 40 50 60 70 80
-0.400
Waktu (Jam)

t (Jam) vs Log Cp Residual

1.850
1.800
f(x) = - 0.1025237112x + 1.8421687868
1.750
ual

R² = 0.9999996102
 t (Jam) vs Log Cp Residual
1.850
1.800
f(x) = - 0.1025237112x + 1.8421687868
1.750
Log Cp Residual
R² = 0.9999996102
1.700 Column E
Linear (Column E)
1.650
1.600
1.550
0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 2.2
Waktu (Jam)