terms of the epigenetic inheritance of traits1, empirical data to support

transgenerational epigenetic inheritance of behavioral traits in mammals are

beginning to accumulate at the level of morphological, behavioral and metabolic
traits2–15os dos vías más respecto a la temática de la negatividad en el Foucault
de la década del cincuenta y principios de la década del sesenta. Además de la vía
nietzscheana, puede rastrearse una vía hegeliana que, a partir del seminario
dictado por Kojève entre los años 1933-1939, produjo una serie de tópicos comunes a
varios autores del pensamiento francés, destacándose principalmente la . We used
olfactory fear conditioning to address when and how the olfactory experience of a
parent might influence their offspring. Specifically, we focused on the olfactory
system, given its wellunderstood molecular biology and neuroanatomy16–18, the
ability to differentially target odorant-receptor pairs in the same modality for
differential and well-controlled behavioral studies, and previous findings that
experience-dependent alterations occur in olfactory neuroanatomy and behavior
following olfactory conditioning19. We examined how specific features of the
parental sensory environment before conception can influence sensory nervous system
structure and function in a cue-specific manner in subsequently conceived F1 and F2
generations. Bisulfite sequencing We examined whether olfactory feaundo momento,
rastreamos las distintas formulaciones sobre lo trágico presentes en los textos
anteriores, donde observamos que el concepto se elabora en relación a las
experiencias de la negatividad y del olvido en el campo de los saberes
psicológicos. Finalmente, daremos cuenta de cómo la reelaboración foucaulteana de
la concepción trágica de Friederich Nietzsche da cuenta de una determinación de la
historia a través de la disputa entre los elementos dionisíacos y apolíneos.
Palabras clave: Foucault; Nietzsche; tragedia; historia; psicología
Abstract: “Michel Foucault and the Tragic Structure. An Early Nietzschean Reading
of Tragedy”. The purpose of this article is to investigate the statute of the
tragic in Michel Foucault’s early texts, especially in the original preface of
Histoire de la folie à l’age classique. It will be argued that in his early reading
of Nietzsche, Foucault elaborates the concept of tragic structure to give
foundation, in epistemic sense, to the historical experiences of madness.
Subsequently, we will trace the different formulations on tragic in Foucault’s
early texts. The concept of tragic appears on these texts as a term to identify the
negativity and of the oblivion in the field of the psychological knowledge.
Finally, we will explain how Foucault re-elaborates Nietzsche’s concept of the
tragic to expose an underlying determinatio to the history. The battle between the
dionysian and apollonian elements defines the status of this experience.
conditioning of the F0 generation leads subsequently conceived adult F1, F2 and
IVF-derived generations to exhibit F0-like behavioral sensitivity toward the F0
conditioned odor, and whether there were neuroanatomical changes at the level of
the main olfactory epithelium (MOE) and olfactory bulb in these generations
(Supplementary Fig. 1). The odors that we used were chosen on the basis of prior
work demonstrating that the M71 odorant receptors (encoded by the Olfr151 gene)
expressed by olfactory sensory neurons (OSNs) in the MOE are activated by
acetophenone20. The use of a chemical mixture that contained compounds very similar
to propanol did not elicit any responses from M71 cells, suggesting that none. F1-
Ace-C57 mice had an enhanced sensitivity to acetophenone (a), but not to propanol
(control odor, b) compared with F1-Home-C57 mice (F1-Ace-C57, n = 16; F1-Home-C57,
n = 13; t test, P = 0.043, t27 = 2.123). (c,d) Responses of M71-LacZ F1 male
offspring conceived after the F0 male was fear conditioned with acetophenone or
propanol. F1-Ace-M71 mice had an enhanced sensitivity to acetophenone (c), but not
to propanol (d), compared with F1-Home-M71, and F1-Prop-M71 mice. In contrast, F1-
Prop-M71 mice had an enhanced sensitivity to propanol (d), but not acetophenone (c)
(F1-Home-M71, n = 11; F1-Ace-M71, n = 13; F1-Prop-M71, n = 9; OPS to acetophenone:
ANOVA, P = 0.003, F2,30 = 6.874; F1-Home-M71 versus F1-Ace-M71, P < 0.05; F1-Ace-
M71 of hem were mated with naive females. Thus, any findings th we obtained were
not the results of extreme phenotype biasing or a previously existing genetic
sensitivity. Both C57Bl/6J and M71-LacZ mice possess the M71 odorant receptor in
their olfactory epithelium21 and both can consequently detect acetophenone. The
main difference between the strains l olfactory sensitivity after F0 conditioning
Fear-potentiated startle (FPS) is a behavioral test to assay for fear learning23.
FPS manifests as an augmented startle responsealma, el tratamiento de los
insensatos, el derecho hospitalario, los establecimientos de beneficencia,
etcétera. En 1958, abandona Uppsala y se instala en Varsovia, Polonia, donde está
encargado de abrir en la Universidad de Varsovia el Centre de Civilisation
Francaise. Allí continúa con la redacción de su tesis, hasta que en diciembre del
mismo año envía el manuscrito a Georges Canguilhem para que lo lea. En octubre de
1959, se traslada a Alemania para dirigir el Instituto Francés de Hamburgo.
Finalmente, el veinte de mayo de 1961, ante un jurado compuesto por Henri Gouhier,
Daniel Lagache y Georges Canguilhem, la tesis es in the presence of the aversive
conditioned cue. In our case, to assay for behavioral sensitivity to an odor, we
used a modified FPS protocol that consists of odor presentation before the startle
stimuli. An odorpotentiated startle (OPS) score is computed, in which an enhanced
OPS reflects a greater startle to the odor relative to control, when the odor is
paired with the startle stimulus. Traditionally, FPS tests have been used to query
the emotional state of the animal and the valence of the stimulus paired with the
startle. It is important to note that we did not use this test as a measure of
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concepto y la “voluntad de poder”, la “fuerza” y la “vida” nietzscheanas. No
obstante, en la obra de Foucault las referencias a Nietzsche son anteriores a la
década del setenta. Durante el periodo arqueológico, Nietzsche es nombrado en cinco
de los seis libros publicados por Foucault (siendo la única excepción Raymond
Roussel, de 1963). También será una referencia constante en sus artículos en torno
a la literatura y a la metodología arqueológica. Más aun, en libros como Histoire
de la folie à l’age classique (1961) y Les mots et les choses (1966) la presencia
de Nietzsche es de vital importancia para comprender sus hipótesis centrales.
Respecto al primero de esos libros, resulta llamativa la ausencia de comentarios
sobre la figura de Nietzsche. Existe una gran cantidad de libros dedicados al
estudio de la presencia de Nietzsche en el periodo arqueológico de Foucault; sin
embargo, los comentarios se suelen limitar a la mención de la presencia de
Nietzsche en Histoire de la folie à l’age classique, pasando por alto la
importancia de la figura del filósofo alemán en dicho libro. Nos sdaasasdasdewre
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