index 0, ID = NP_002063.

2, lenght 359, with 16 features

ID: NP_002063.2
Name: NP_002063
Description: guanine nucleotide-binding protein G(q) subunit alpha [Homo sapiens]
Number of features: 16
/topology=linear
/data_file_division=PRI
/date=21-DEC-2019
/accessions=['NP_002063']
/sequence_version=2
/keywords=['RefSeq', 'MANE Select']
/source=Homo sapiens (human)
/organism=Homo sapiens
/taxonomy=['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata',
'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates',
'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']
/references=[Reference(title='Heterogeneity in Mitogen-Activated Protein Kinase
(MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations',
...), Reference(title='Role of Galphaq in pathogenesis of psoriasis, a new
mechanism about the immune regulation in psoriasis', ...),
Reference(title='Gbetagamma signaling to the chemotactic effector P-REX1 and
mammalian cell migration is directly regulated by Galphaq and Galpha13
proteins', ...), Reference(title='Association of Somatic GNAQ Mutation With
Capillary Malformations in a Case of Choroidal Hemangioma', ...),
Reference(title='Detection of mutations in SF3B1, EIF1AX and GNAQ in primary
orbital melanoma by candidate gene analysis', ...), Reference(title='Molecular
cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene
(GNAQ) and a processed pseudogene', ...), Reference(title='Signal-transducing G
proteins and antidepressant drugs: evidence for modulation of alpha subunit gene
expression in rat brain', ...), Reference(title='Phospholipase C-beta 1 is a
GTPase-activating protein for Gq/11, its physiologic regulator', ...),
Reference(title='The G protein coupled to the thromboxane A2 receptor in human
platelets is a member of the novel Gq family', ...), Reference(title='Purification
and characterization of membrane-bound phospholipase C specific for
phosphoinositides from human platelets', ...)]
/comment=REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL160278.24, BC067850.1 and
AL355535.14.
This sequence is a reference standard in the RefSeqGene project.
On Dec 20, 2003 this sequence version replaced NP_002063.1.
Summary: This locus encodes a guanine nucleotide-binding protein.
The encoded protein, an alpha subunit in the Gq class, couples a
seven-transmembrane domain receptor to activation of phospolipase
C-beta. Mutations at this locus have been associated with problems
in platelet activation and aggregation. A related pseudogene exists
on chromosome 2.[provided by RefSeq, Nov 2010].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
/structured_comment=OrderedDict([('Evidence-Data', OrderedDict([('Transcript exon
combination', 'SRR1803616.64210.1, SRR1803611.79552.1 [ECO:0000332]'), ('RNAseq
introns', 'mixed/partial sample support SAMEA1965299, SAMEA1966682
[ECO:0000350]')])), ('RefSeq-Attributes', OrderedDict([('MANE Ensembl match',
'ENST00000286548.9/ ENSP00000286548.4'), ('RefSeq Select criteria', 'based on
conservation, expression, longest protein')]))])
Seq('MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKST...NLV', IUPACProtein())
Features CDS
1