I EFFORT TO SUCCESs

CSIR-UGC-NET/JRF GATE-CHEMICALSCIENCES

BIOINORGANIC CHEMSITRY
Time : 45 Minutes
MINORTEST
Date : 22-10-2019
M.M. : 60

INSTRUCTION:

Part-A contains 10 MultipleChoice QuestionSP(MCQ).Each question has 4 choices (a), (b), (c) and
(d), for its answer, out of whiqhFONLY ONE is correct. Foreac correct answer you will be awarded
2 marks. For each incorrecfanswered 0.50 mark will be deducte
Part-B containS10 MultipleChoice Questions (MCQ). Each question has 4 choices (a), (b), (c) and
(d) for its answer, out of which ONE is correct. For each correct answer you will be awarded 4 marks,
For each incorrect ans ered 1 mark will be deducted.
USE OF CALCULATOR IS NOT ALLOWED

Part —A
1. Match column I with column Il.
ColumnI ColumnIl
P. Peroxidase transpo
Q. Ferredoxine C)'torage of iron
R. Hemelythrill (iil)Electro tr sfer
S. Transferrin
I(iv)Oxygen storage
(v) Decomposition fH20
(VI)ScaVenger ofiro
(a) (vi), Q- (iv), R-(i , 9-(ij P- vi), Q - (iii
A(cf6- Q- (iii), R - S- (vi) R- (iii), S- (vi)
2. Match column I with column Il. e
ColumnI ColumnIl
P. Fe(ll), high spin (1) Cytochromes (reduced form)
Q. Fe(ll), low spin (ii) Catalase
R. Fe(lll), high spin (iii)Hemocyanin
S. Fe(lll), low spin (iv) Ascorbate oxidase
(v) Deoxymyoglobin
(vi) Oxyhemerythrjn
(a) P - (vi), Q - (iii), R - (iv), S - (ii) Q- (iii), S- (i)
- (i),S- (iv) Jd)/P - (ii), S -e(vi)
3. Choose the incorrect statement :
Methemerythrin contains an oxo rather than hydroxo bridge and it binds dioxygen
(b) The blue colour ofoxyhemocyanin is due to LMCT
(c) The v stretching frequency in oxyhemocyanin and oxyhemerytherin is 750 cm-I and 845 cm-I

(d) Only homoglobin not hemocyanin bind dioxygen cooperatively

4. The correct order of vo_o in oxy form of hemoglobin, (Hb), Hemocyanin (Hc) and Hemerythrin (Hr) is

(b) Hc>Hr a(c) HC

5. Consider the iron-sulphur proteins and choose the correct option
(a) Oxidise form ofFe;S4 is EPR inactive
-e
(b) Fe4S4and Fess 4 container 4 and 3 labile sulpher respectively
There is slight increase in the Fe-S distance when Fe(lll is reduced to Fe(ll) in ruberdoxine
(d) Fe S2 ferredoxin and ruberodox•lllare paramagnetic and EPR active in oxidised form
6. Consider the following statennents about cytochromes
P. CytOChGme C-oxidare catalyses the conversion to H20.
Q. Both reduced Fe(ll) and oxidized Fe(lll) forms are low spinand C.N. is
R. Cytochrome chain involvers transfer of both electrons and protons across the mitochondrial membrane
Fe(lll) at active site.
S. The cytochrome P-450 enzymes has low spin octahedral
The correct statement(s) is/are
(d) Allofthe above
following regarding nitrogen fixation.
Choose the incorrect statements, among the
reduction ofN2 are transfered to nitrogen by the reduced form offerrodoxins
(a) The electrons required in the
e4Saunits connected by thec teins ligaijdbridge
(b) The Fe protein has two
nitrogen occurs at the o siteofenzyme
(c) The reduction of molecular
reduction ofN2t NI-13 T
This process involve 6e- during
:
8. Consider the follo ing statements
oxidationstate.
P. Ferritin binds e Fe in
strong nd transport it from stomach to bone marrow.
Q. Transferrin binds
is catalys d byceruloplasminin stornach.
R. The oxidation ofFe(II) ions
in distorted octahedral environment.
S. In transferrin Fe(lll) ion is
both helps in storage of iron or Fe(lll).
T. Ferritin and siderophores
Choose the incorrect statement
(b) R, S and T (c) Q, Rand S QandT
(a) P and Q
of following protein.
EPR signal is absent for which
(b) Hemocyanin
(a) Superoxide dismutase
(d) Hemoglobin
Plastocyanin
in the reduction ofN2 to ammonia is
10. The number ofMg ATP's required
(b) 12 16
 3

Part —B
Match the following :

(D Ulcer treatment

(i) Anaemia
R. Sb (ii) Eczema
S. Fe (iv) Imaging agent
(v) Skin filngal infection
(VI)Maniac depression
Ha) P- (vi), Q- (iii), R-(i), s-(ii), T- (iv) (b) P- (iii),Q-(ii), R-(iv), S- T - (i)
(c) P- Q- (v),R-(vi), S- T- (ii) (d) P-(i), Q-(vi), R-(iii), S- (iv), T- (v)
12. Match the type of porphine system in column (A) with their metalloporphyrin in column (B) and type of ring
associated with them in column (C)
Column (A) Column (B) Column(C)
A. Chlorin P. Cytochrolnes (i) Four, 6-mejnbered ring four, 5-me bered ring with
filsecl cyclopentanone ring

B. Porphyrin Q. Vitamin B12 (i) Five,5-membered and t ree, 6-membered ring

C. Corrin R. Ch rophyll (iii) Four, 6-memberedand f ur 5-membered ring
(a) A-P-(i), B C-R-(iii) A(iii),B-Q-(i) C- p-/i))
(c) A -R - (i), B -P -(iii), C=Q—(ii) (d C-R-(i)
13. Match the metal in colum (A) with related compoun s in column (B) with there action in column (C)
Column (A) Column (B) Column (C)
eroxidase (l Electron transfer
Q. Carboxypeptidase (il Hydrolysis of Urea into C02 and NH
3
Urease (i i) Catalyze oxidation fsub rates by H202
S. P ocyanin (i ) Hydrolysis of eptide nd
(a)A-S-(i), B-Q-(iv), -
(b)A-R-(ii), B-P-(i), C-Sr(iii), D-Q-(iv)
(c) A-S-(l)• B- -(iv),C- Q-(iii), D-P-(ii)
D-P-(iii)
14. Which ofthe following is correct concerning the äifference between
hemoglobin and myoglobin
(a) Hemoglobin is a monomericprotein and myoglobin is a terameric
protein
(b) Hemoglobin exhibits a hyperbolic 02 saturation corve
while myoglobin exhibits a
sigmoidal shaped curve
Jcyllemoglobin exhibits cooperative binding of02
while myoglobin does not do so
(d) Hemoglobinexhibitsa higherdegree of02
saturation at all physiologically
partial pressure than
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 15. Identifi incorrectstatement the Zimnrtalboenzynes
or Cd
(a) In SOD. ioncan be replaced by other metals such as Co
CO, addition
(b)
(c) Zn in carFonicanhydrare has Td em ironment ing three histidineresidue
ion
ofdisproportionation ofsuperoxide
_ßå) The carbonic anh>drase increase rate ofequilibrium
16. \l.hich ofthe statement is incorrect?
different environmerl
(a) Mossbauer spectroscopy s that the tv, o Fe(lll) iop.sin oxy hemeryhrin are in

(b) The centre in azurin is trigonal bipyramidal

histidine residues. one S
ÄThe copper centre in plastoc>anin is coordinated to ONON atoms ofinnidazoles of
ofthiol of.steine and one serine O
(d)- In cytoehrome C oxidase act site conlposed ofa herne ax and Cu

17M Consider the follovGngstatement (s) tör tyosinase

A. It isa ironcontainingprotein
B. It catalvzes mo x\ cenation of phenol to diphenol
C. In deoxy form each copper centre is surrounded by three histidineresidue
P
D. It is imol',ed inÄanin synthesis
The correct statement(s) is/are
(a) A and B (b B and C. D (c) A.and D (d) B and C
IS. Consider the followingstatements regarding enzyme ) responsib e for above conversion

o O

(i) It is haem cont iningprotein.

CIDFifth coordination site iSoccupied bycystein ligand.
(iil) Active site contain Ni(IJ) ion.
(W)Fifth coordination site is occupied bygpethtonine.
The correct statement(s) is/are
(a) (i), (iv) (b) (iD,(iil) y (i) and (ii) (d) (iiDand (iv)
19. Consider the folbwing statement(s)
(i) Aldehyde oxidase contain MO at the actice site.
(i) Zn atom incarbonic anhydrase is more acidicthan is carboxypeptidase.
(i) Colour ofcoenzyme B!2isdue to intraligand charge transfer.
Oi) FeaS4ferredoxinacts as two electron transfer agent
The incorrect statement(s) is/are
(a) i iii (b) ii, iv (c) i, iv
Jd)4v only
consider the catalyic for the action ofcytochronr
P -450 enzyne

ROH

11:0

cys

11-0 reduction

211' (RH Fe(P)

What are the oxidation state of re in interrnediate IOrtnedin (l (2 and (5) steps respectively
(a) Ill. Ill, V (d) Il, Ill, IV

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