Professional Documents
Culture Documents
Pruritus
-Unmyelinated C fibers
-Stimuli: light touch, temperature changes, emotional stress
-Pruritoceptive itch: inflammation, dryness
-Neuropathic itch: post herpetic
-Central neurogenic itch: liver cirrhosis
-Psychogenic itch: parasitophobia
-Itch caused by systemic /internal disease: Chronic kidney disease (most common)
-Internal causes: liver disease, renal failure, hypo/hyperthyroidism, IDA, PV, malignancy
(lymphoma), neuropsychiatric
Xerotic eczema
-background of xerosis
-pruritus occurs before lesions appear
-erythematous patch with accompanying scaling
Pruritus ani
-secondary to contact dermatitis
-hemorrhoids, anal tags
Pruritus scroti
-lichen simplex chronicus
-Pyschogevnic pruritus is the most frequent type
-low potency steroids
Pruritus vulvae
-vaginal candidiasis
-unspecified dermatitis
-lichen sclerosus, lichen planus, psoriasis
Prurigo nodularis
-itchy nodules, usually at the extensors.
-anterior legs
-multiple hyperpigmented nodules topped with excoriations and scaling
Nail
Distal subungual onychomycosis
-most common
-t. Rubrum
-distal nail bed & hyponychium
-secondary involvement of underside of nail plate of fingernails and toenails
White superficial
-can be scraped off
-t.rubrum & t.metangrophytes, cephalosporium, aspergillus, fusarium
-small chalky white spots on nail plate
Candidal onychomycosis
-candida albicans
-"wet workers" (water --> destroy cuticle --> fungi enter)
-paronychia
-fingernails affected
Onychomycosis
-topical: clotrimazole, amorolfine
-systemic antifungals (terbinafine (DOC for dermatophyte onychomycosis), itraconazole,
fluconazole, azoles if candidal)
-precaution: liver disease (LFTs)
Bacterial paronychia
-swelling with pus
-s. Aureus
-mani, pedi
Alopecia areata
-round/oval bald spot
-"broken exclamation mark hair" (distal end is thicker and more pigmented)
-can involve scalp or facial hair
-good prognosis: postpubertal onset
-improve with corticosteroid injections
-poor prognosis: atopic dermatitis, childhood onset, widespread involvement, duration
longer than 5 yrs, onychodystrophy, ophiasis (loss of hair along the temporal and
occipital scalp)
Telogen effluvium
-transient falling of hair due to premature entry into telogen phase
-3 mos after stressful event: pregnancy, fever, surgery, rapid wt loss, drugs
-hair regrowth after 3-6mos
Trichotillomania
-hair pulling disorder
-assoc with OCD
-hair at varying lengths
S. Barbae
-Autoinoculation
-Pustules are superficial
Furuncle
-Nodule with central suppuration, tenderness
-Nape, axilla, buttocks
-DM, atopic dermatitis, any form of immunosuppression
-Tx: warm compress, penicillinase resistant penicillin, I & D if fluctuant
Recurrent Furunculosis
-3 or more episodes per year
-Secondary to staphylococcal carrier state
-Intranasal mupirocin BID for one week every month
-rifampicin 600mg/day dicloxacillin (MSSA) or TMP-SMX (MRSA) × 10 days
-clindamycin 150mg/day x 3 mos
Carbuncle
-2 or more furuncles together
Hansen's dx
*missed slide
Fite faraco stain
Indeterminate leprosy
-Early lesion
-Appears before host make definitive immunologic
-Hypopigmented
TT
-Cell mediated immunity is strong
-Saucer shaped (annular, periphery is elevated)
-Can spontaneously cure
BT
-Immunity is strong enough to restrain infection but insufficient for self-cure.
-No hope for cure
-Satellite lesion or pseudopods
BB
-borderline immunity
-Most unstable
-Swiss cheese appearance
BL
-Inverted saucer shaped
LL
-No cell mediated immunity
-Unrestricted bacillary replication
-Diffuse dermal infiltration
-Widespread nodules or plaques
-Madarosis, saddle nose
Rifampicin
-red urine
-hepatitis
-thrombocytopenia
-psychosis
-decrease effectiveness of systemic steroids
Scrofuloderma
-nodules secondary to direct extension from cervical lymph node
-characteristic cord like scars
-anti-kochs tx
Cellulitis
-ill defined plaque
-staph. aureus or Strep. pyogenes
Bullous cellulitis
-tinea pedis
Erysipelas
-well defined plaque
-grp A strep
Miliaria rubra
-Hot humid climates
-Back, intertriginous areas, popliteal areas
Miliaria crystallina
-Clear superficial vesicles with no inflammatory reaction
-Tight clothing
-No tx, just cold compress
Miliaria pustulosa
-Non follicular pustules (vs folliculitis) bec eccrine sweat glands do no exit thru the pores
Scabies
-Intensely pruritic papular lesion, can come with excoriation, contain mites, eggs or
feces
-Finger webs, axilla, popliteal, axilla, extremities, inguinal
-Sarcoptes scabei var hominis
Obligate human parasitic mite
Burrows in stratum corneum
Live in human for 3 days only
Close contacts
Humans are the only reservoir
Contaminated clothes and beddings
Sensitization: 2-4 wks after onset of infestation
If reinfection: days
-IMPT: nocturnal pruritus, close personal contact, circle of hebra
-Tx: permethrin 5% lotion, sulfur (if pregnant, apply everyday), lindane (with cytotoxicity)
-Prevention: soak linens in very hot water for 15mins or more then dry under the sun,
vacuum all rugs, carpets, furniture, ALL personal contacts should be treated at the same
time, regardless if symptomatic or not, if patient is poor: can pack clothing in garbage
bag for a week (since mites only live for 3 days)
Arthropod bites
-Central punctum
Bed bugs
-Bites in rows
Pediculosis capitis/corporis/pubis
Capitis
-Children
-Secondary inflammation,
-Most common: retroauricular
-Permethrin 1% shampoo, use a fine toothed comb for grooming (use only once), do not
shampoo 24hrs after application, not ovicidal (so repeat after 1 wk)
-secondary impetigo is common.
Corporis
-Mite lays eggs in seams of clothing
-Homeless people with poor hygiene
Acne
-Propionibacterium acne
-Hallmark lesion: Comedone
-can have papules, pustules, nodules, cysts...
-4 features: hyperkeratosis of follicular infundibulum, sebum, propionobacterium acnes,
androgen
A. Microcomedone
B. Comedone
C. Inflammatory papule/ pustule
D. Nodule
First choice in mgt:
*consider physical removal of comedones
Comedonal (blackhead/whiteheads): Topical retinoid: tretinoin, adapalene
Papular/pustular (mild): Topical retinoid + topical antimicrobial: benzoyl peroxide
Papular/pustular (moderate): oral antibiotic + topical retinoid +/- BPO
Nodular (0.5-1 cm, moderate): oral antibiotic + topical retinoid + BPO
Nodular/conglobate (severe): oral isotretinoin
Acneiform
-monomorphic follicular papules/acne
-cause: steroids (oral and topical)
Vascular disorders
Diascope
-test for blanchability
-blanching (dilatation of BV-erythema) vs non blanching (extravasation of RBC-purpura)
-blanching: erythema, sunburn, photosensitivity, urticaria, angioedema,
dermographism, morbilliform drug eruption, EM, exfoliative dermatitis
-Nonblanching: purpura, vasculitis
Sunburn
-erythema, tenderness, blistering
-UVA: aging; UVB causes sunburn; UVC: ozone
-water resistant: 40mins; water proof: 80mins
-spares suncovered areas
Urticaria
-wheals (evanescent: doesn't last >24hrs)
-acute (<6 weeks: food, drugs, infection); chronic (>6 weeks: parasitism, dental caries,
thyroid dx, autoimmune diseases)
-mast cell degradation--> release of histamine
Angioedema
-swelling of subcutaneous layer
-common cause: ACE inhibitors
-ask if there is dyspnea (might have swelling in respiratory passages)
- treatment: epinephrine
Dermatographism
-drawing hehe
Morbilliform reaction
-also called maculopapular rash/exanthem
-most common causes: adverse drug eruption and viral infection
Erythema multiforme
-Dusky center, pale ring, erythematous surrounding (3 layers)
-adult:HSV (1>2)
-child: mycoplasma pneumonia
-minor: 1 mucosal surface
-major: involvement of more than 2 mucosal surfaces
Exfoliative dermatitis
-Generalized erythema and scaling
-psoriasis, atopic dermatitis, eczema, allergic contact, irritant contact dermatitis
Purpura
-flat macule/patch
-petechiae --> purpura --> ecchymoses
-vascular dysfunction, trauma, coagulation disorders, thrombocytopenia
Vasculitis
-hallmark: Palpable Purpura (inflammation of blood vessels)
-secondary to extravasation of RBC from blood vessels
-type 3 hypersensitivity
-confirm dx with biopsy
-advise: exercise, leg elevation
-first line: antihistamine
-colchicine, dapsone
-in children: Henoch Schonlein Purpura (usually preceded by URTI Gr. A Strep)
Seborrheic dermatitis
-scalp: cradle cap
-can involve glabella, nasolabial folds
-yellowish greasy appearance of scales
-recalcitrant seborrheic dermatitis: HIV
-malassezia ovalis
-treatment: mild shampoo for babies, mineral oil 15mins before shampooing,
antifungals, and if with erythema give steroids
Psoriasis
-silvery scales
-goes beyond the hairline
Nummular eczema
-coin shaped, papules and vesicles that coalesce
-NSS compress, antibiotic + steroids
Dyshydrotic eczema
-Tapioca like deep seated vesicles on the lateral hands/feet
-NSS compress, steroids
Intertrigo
-circular patch in flexural areas
-inguinal, inframammary
-candidal intertrigo: satellite pustules(tx: azole)
Inverse psoriasis
-bright red with silvery white scales
-inguinal area + umbilicus
Breast eczema
-areola
Stasis eczema
-medial lower leg
-varicosities, edema
-sign of venous insufficiency
Xerotic eczema
-elderly, pretibial
Tinea manuum
-"1 hand, 2 feet", check inguinal area also
-annular
Tinea capitis
-non inflammatory type: areas of alopecia with broken off hairs (manifest as black dots)
-kerion: boggy inflammatory mass
Tinea cruris
-tx: terbinafine (oral if extensive, OD for 2 weeks)
Tinea facialis
-long septated hyphae with spores
Psoriasis
-sharply marginated, raised, red, plaque with scaly surface
-silvery white scale
-symmetry of lesions
-extensor distribution
-koebner phenomenon: lesions on areas of trauma
-auspitz sign: bleeding upon removal of scales due to dilated capillaries
-pathognomonic: oil spots (nail pitting also seen in alopecia areata)
Plaque Type: scalp, nails, sacrum
Acute guttate: best prognosis; with preceeding strep pharyngitis
Inverse Type
Pustular psoriasis
Erythrodermic psoriasis: can cause exfoliative dermatitis
Psoriatic arthritis
Pityriasis rosea
-Collarette scales, herald patch
-distribution: langer lines,xmas tree
-HHV 6&7
-heals in 4-12 weeks
Tinea versicolor
-hypo/hyper/slightly erythematous
-malassezia furfur
-furfuraceous scales
Syphilis
-primary: chancre
-secondary: maculopapular rash, condyloma lata
-tertiary: gumma
-involvement of palms and soles: syphilis & EM
-great mimicker
Verruca filiformis
-Long slender upward projections
-Papillomatous
Verruca plantaris
-usually found on pressure areas
-most commonly on mid metatarsal areas
-coalesce to form mosaic warts
-differential dx: callus, corn (with exaggerated skin lines, but no black dots)
Verruca plana
-flat topped
-risk factor: sun exposure, autoinoculation by shaving
-Highest rate of spontaneous remission
-koebnerization
Tx for warts
-duofilm
-electrocautery
-cryotherapy
-laser therapy
Molluscum contagiosum
-dome shaped papules with central umbilication
-usually appears in children; can be sexually transmitted
-poxvirus, MCV1
-contact, immunocompromised
-can spontaneously resolve
-inclusion bodies: molluscum bodies or henderson paterson bodies
Treatment: nick curettage, caltarithin
Milia
-white keratinous cysts
-asymptomatic
-in newborns: can resolve spontaneously in weeks
-in elderly: can be due to trauma, blistering diseases, topical occlusive meds
-incise and express the contents
Syringoma
-sweat duct differentiation; skin-colored
-found on cheeks & eyelids
-familial
-recurrence after removal by cauterization or laser therapy
-coalesce to form plaques
Acrochordon/skin tags
-neck, axilla, groin
-can become tender, inflamed or gangrenous when twisted
-common in obese; risk of developing DM: skin tags on top of acanthosis nigricans
velvety plaque
-tx: snip excision
Pustular diseases
Primary lesion: pustule
Pus = INFECTION
Acne vulgaris
-chronic inflammatory disease
-polymorphic: closed comedone (white head), open comedone (black head), pustules,
papules, nodules
-atrophic scars
-face, upper trunk, upper back
-pathophysiology: keratin plug, sebum accumulation, propionobacterium acnes,
hormonal imbalance
Acne congoblata
-Pustules and papules coalesce that form plaques that release serosanguinous material
-tx: oral isotretinoin
Miliaria pustulosa
-non follicular pustules on bedridden patients
-blockage of sweat duct
-areas of predilection: intertriginous areas, back
Folliculitis
-superficial inflammation of hair follicle
-found on hair bearing areas
-multiple lesions: oral antibiotics
Furuncle
-chronic relapsing
-Deeper inflammation nodule hair follicle --> rupture --> nodule with or w/o central
suppuration
Pyogenic Paronychia
-separation of nail fold from nail plate secondary to frequent exposure to water; mani/
pedi; nail biting
Ecthyma
-characteristic sausage shaped ulcers
-staph or strep pyoderma
-shins/dorsal feet
-vesicle/vesiculopustules --> rupture --> ulcer --> heals with scar
-nss compress; antibiotics
Candidal intertrigo
-secondary to maceration of epidermal folds of the neck or intertriginous areas
-satellite pustules
-pruritic
-tx: topical azoles plus mid strength corticosteroids (mometasone) for rapid relief
-recommend: keep area dry, loose clothing, lose weight
Vesicular diseases
Herpes simplex viruses
A. Primary infection: painful ulcers, vesicles
B. Latent phase
C. Recurrence
Herpes zoster
-Grouped vesicles, dermatomal or unilateral; Painful, can be pruritic
-if immunocompromised: disseminated
-chicken pox --> latent(dorsal ganglion) --> herpes zoster
-if no hx of chicken pox, may be due to vaccine or varicella in utero
-herpes zoster ophthalmicus: can cause blindness; Hutchinson's sign (tip of the nose;
involvement of the nasociliary branch of the V1)
-crusting of ALL lesions = non infectious
-Ramsey Hunt (deafness, ipsilateral facial palsy; affects facial and auditory nerves)
-postherpetic neuralgia (sensitization of dorsal neurons, spontaneous activity of afferent
neurons, pain in the absence of damage, more common in elderly)
-antiviral therapy: limit extent, dissemination, prevent post herpetic neuralgia
Tx: acyclovir 800mg/tab 2tab every4hrs for 7days (5 times); valacyclovir 1000mg/tab
1tab TID for 7days
Intraepidermal
-flaccid
-positive nikolsky sign and asboe-hansen's sign
-pemphigus, SJS, SSSS, erythema multiforme
Subepidermal
-tense
-negative nikolsky and asboe-hansen
-bullous pemphigoid, insect bites, SLE
Bullous pemphigoid
-ELDERLY tense blisters; chronic; very PRURITIC
-flexural, nuchal
-autoimmune: IgG Ab (BPAG 1&2)
-histo: eosinophil rich subepidermal blister
-Direct immunofluorescence: detect Ab on BM
-mgt: systemic steroids, azathioprine, dapsone
Pemphigus vulgaris
-Generalized flaccid blisters with ulcers in the oral mucosa; PAINFUL; chronic
-rupture easily so all you see are erosions
-trigger factors: sun-exposure, infections
-intraepidermal area is highlighted on direct immunofluorescence
-Tx: immunosuppressive agents (dapsone, azathioprine), oral corticosteroids
Dermatitis herpetiformis
-Extremely pruritic erythematous papules > vesicles > bullae > crust
-Nape, scapula, extensors, buttocks
-exacerbated by wheat-rich foods
-neutrophils on the dermal papilla
-igA deposition on the dermoepidermal junction
-tx: dapsone & sulfapyridine
-avoid alcohol,beer, cookie crumbs, cookie dough
Bullous impetigo
-Erythematous macules > clear filled bullae on the nostrils > seropurulent discharge >
golden yellow crust
-infectious/contagious
-commonly on nose; disseminated
-staph(most common)/strep
-Tx: 1st gen cephalosporin: cephalexin, MRSA: vancomycin, linezolid; NSS compress
-complications: AGN (grp A strep), SSSS (staph scalded skin syndrome)
SJS
-Hx of drug intake (allopurinol, antipsychotics)
-start as morbiliform eruption
-flaccid vesicle that rupture easily to form erosion, crusting as they heal
-less than 10% of BSA (count areas of detached epidermis like bullae, vesicles,
erosions; not just erythematous areas)
-involvement of mucous membranes: usually oral and conjunctiva (check also GI tract)
-accompanying symptoms: conjunctivitis, oral ulcers, dysuria, dysphagia
-SJS/TEN overlap: 10-30%
-TEN (toxic epidermal necrolysis): > 30%
Vitiligo
-Multiple, Well defined, Depigmented macules and patch
-distribution: focal (often trigeminal), unilateral, vulgaris, universal
-hands and around the mouth ("lip and any tip") are difficult to treat
-white hairs if around eyebrow(
-autoimmune (associated with type1 DM, pernicious anemia, Hashinotos thyroid it's,
Graves' disease, addisons disease, alopecia areata)
-tx: topical steroids
Post inflammatory hypopigmentation/leukoderma
-Eythematous plaques --> white macules
-destruction of melanocytes during the trauma
Melasma (chloasma)
- asian
-hyperpigmentation on cheeks, sunexposed area
-females > males, older
-OCPs, topical application of strong chemicals (maxipeel), sun-exposure
Freckles (Ephelis)
-fair skinned individuals
(*if darker skinned individuals = solar lentigo - do not fade; usually in asians)
-hyperpigmentation
Xanthelasma
-not all have elevated TG, can occur with normal lipids
-most common xanthoma
Xanthoma
-Firm yellow nodules arounds elbows, knees
-Multilobulated masses
-Associated with increased cholesterol
-tuberous xanthoma: super big, appear inflamed and tend to coalesce
-Eruptive xanthoma:
-plane xanthoma: flat macules/slightly elevated plaques with yellowish tan coloration
-advised diet, statins, fibrins, excise if big and affect ADLs but they will recur
Basal cell CA
-most common skin CA; translucent pearly papule/nodule with telangiectasia and rolled
border; friability
-malignant neoplasms from non keratinizing cells that originate in the basal layer of the
epidermis
-elderly > 60 y/o
-males, whites > asians
-sun exposed areas: head (nasal ala) & neck (80%), back, chest, shoulders
-intermittent sun exposure (UV-A&B) usually in childhood, ionizing radiation,
environmental carcinogens, immunosuppression, scars, burns, chronic scarring or
inflammatory dermatoses
-larger lesion with central ulcer and crust = rodent ulcer
-no premalignant skin lesion, appear de novo
-rarely metastasizes, but with prominent tissue destruction, greatest danger is local
invasion
-pathogenesis: mutation of mammalian PTCH gene upregulation of SMO gene
-biopsy at the most indurated border
-histopathologic findings: basaloid cells, peripheral palisading pattern, fibromyxoid
stroma, retraction space
-best tx: surgery (excision - choice), mohs micrographic surgery
-pigmented BCC: most common type in asians
-superficial BCC: trunk, erythematous patch, does not respond well to tx
-morpheaform BCC: aggressive, ivory white
-infiltrative BCC: aggressive
-tx: 4mm margin for nonmorpheaform BCC smaller than 2cm in diameter; 5mm margin if
>2cm diameter; mohs micrographic surgery; curettage for <1cm but can recur on other
areas; cryotherapy; imiquimod (TLR antagonist to boost T helper 1 immunity); 5-FU;
vismodegib (hedgehog pathway antagonist); photodynamic therapy (MAL-PDT);
Radiation therapy
Squamous cell CA
-second most common form of skin CA
-solitary, firm, flash colored keratotic papule tenderness, induration, erosion, scale, or
enlarging diameter
-intense sun exposure, burns, wounds, ulcers, HPV
-sun exposed areas: face, back, legs
-high chance of metastasis
-chemo and radiation is there is lesion left
ABCDs of Melanoma
Asymmetry
Borders are irregular
Color variation (brown, black, pink, red...)
Diameter increased (>6mm) or ugly Duckling sign (atypical lesion)
Elevation/surface change
Acral-lentiginous melanoma
-Most common type of melanoma in asians
-hutchinson's sign: involvement of nail plate + periungual skin
-seen also on plantar surfaces
Amelanocytic melanoma
-mistaken for BCC
-pink/skin colored
-biopsy
Seborrheic keratosis
-Most common benign tumor of the skin
-Oval slightly raised
-Stuck on greasy appearance
-Occur on sunexposed areas or trunk
Scar
Injury > hemostasis > inflammation > remodeling > scar
Keloid
-extension beyond borders of initial injury
-pain, pruritus
-claw-like
-previous trauma, sites of acne, or spontaneous
-areas of high skin tension: chest, upper back
-does not regress, can even become bigger
-intralesional triamcinolone: to soften lesion to reduce pain/pruritus, can flatten but not
always
-emollients, silicone dressings
Skin types
1 - fairest - always burns, never tans
2 - fair - usually burns, rarely tans
3 - dark white - sometimes burns, tans slowly
4 - olive - rarely burns, tans easily
5 - dark - rarely burns, tans profusely
6 - dark brown - never burns, tans darkly black
Blacks and whites have the same number of melanocytes, but blacks have increased
activity of melanosomes that aggregate more melanin