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Stockley’s drug interactions 11th edition

Article  in  International Journal of Clinical Pharmacy · May 2016

DOI: 10.1007/s11096-016-0325-2

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Int J Clin Pharm
DOI 10.1007/s11096-016-0325-2
BOOK REVIEW
Stockley’s drug interactions 11th edition
J. W. F. van Mil1
Received: 1 May 2016 / Accepted: 17 May 2016
Ó Springer International Publishing 2016
In 2008 and 2014 we reviewed the pocket edition of this
major Reference Book, and were impressed (Pharm World
Science 2008;30:375, Int J Clin Pharm 2014;36:667).
However, the revised version of the real reference book
now also was published, which usually happens every
3 years. Over 1600 pages cite the broad evidence for 4500
interactions, while referring to 27,000 information sources.
The pocket version ‘only’ has 2200 monographs.
The ‘big’ Stockley’s remains ‘the’ famous reference
work that provides concise and rather complete informa-
tion on clinically relevant drug–drug interactions (DDIs). It
provides health care professionals with practical informa-
tion on medicines interactions and their management. The
resource is compiled in close cooperation with the
Martindale team in the publishing division of the British
Royal Pharmaceutical Society, and is also available on-line
via Medicines Complete.
In the new version 350 new monographs were added,
and for this 11th edition the section for anti-diabetic
medicines was revised. The list of medicines that have the
risk of prolonging the QT-interval was updated. Medicines
have been arranged in chapters by therapeutic group.
The section on anticoagulants also has the information
on DOACs, but how to find such information? Like in the
pocket companion it is important to use the index for the
‘parent book’, because for instance the direct acting anti-
coagulants (DOACS) in this book are called ‘Activated
factor X inhibitors’, an unusual term in daily practice.
Looking up the medicine name brings you to the appro-
& J. W. F. van Mil
jwfvmil@planet.nl
1
van Mil Consultancy, Zuidlaren, The Netherlands
priate section. The index covers more than 200 pages! Yet,
the editors warn that one should not only look up the
medicine names, but also the names of the therapeutic
groups.
In the introduction the editors suggest that the advice
concerning the concomitant use of ACE inhibitors and AT-
II antagonist was adapted. Although the evidence for a
pharmacokinetic interaction between such agents is lim-
ited, the Stockley’s still warns for a possible hyperkalemia,
renal failure and hypotension. They follow the advice of
the EMA, and do not recommend combining the two types
of medicines.
On line version
Stockley’s Drug Interactions is still the most indispensable
and authoritative international source of drug interaction
information. But just like all reference books, the online
version of the book is not only easier to handle, but also
easier for searching. Regrettably the price for 1 year use of
the on-line version is double the price of the printed book.
And although we can understand the need to save money
and to consolidate information, health professionals should
preferably use the on-line version which is continuously
updated with the latest information. Additionally one can
find an interaction checker on-line, which simply cannot be
available in printed format.
Conclusion
Stockley’s is still indispensable for the clinical pharmacist.
It is a very reliable publication which is kept up to date. But
for the world to make the best use of the great resource, it is
123

about time to make the on-line version as cheap as the
printed edition, or perhaps even cheaper. That would
enable easier access of the health-professionals to contin-
uously updated information. When it comes to the access to
compiled information, a publisher owned by a pharma-
ceutical society should keep the professional and the
patient in the front of their mind.
123
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Int J Clin Pharm
Full details
Stockley’s Drug Interactions 11th Edition. Edited by Claire
E Preston. Pharmaceutical Press London, 2016. ISBN 978
0 85711 270 5. On-Line price around 500 Euro (£ 395,00)
annually. Printed version of the 11th Edition around 250
Euro (£ 195,00).