Data extraction for EBN

A. Clinical question
P- Patients with surgical incision
I- Application of topical antibiotic
C- No application of topical antibiotic
O- The objective was to determine whether the application of topical antibiotics to surgical
wounds that are healing by primary intention reduces the incidence of surgical site infection.
B. Resources searched
 425 Results
C. Identification of research
Item Information about the item
Study ID or code FEU-1, Etc.
Authors and year Author/s names and year of publication
Study subjects Patient’s with wound
Best practices Statements best related to our selected topic

D. Form of data extraction

Study ID Authors & Year Source Publication name Research title
FEU-1 Charles E. Edmiston, Google American Journal Considering a new
C., Leaper, D., scholar of Infection Control domain for
Spencer, M., Truitt, K., antimicrobial
Fauerbach, L. L., stewardship: Topical
Graham, D. & antibiotics in the open
Johnson, H. B. (2017) surgical wound

FEU-2 Poovelikunnel, T., Google Journal of Mupirocin resistance:

Gethin, G. & scholar antimicrobial clinical implications
Humphreys, H. (2015) Chemotherapy and potential
alternatives for the
eradication of MRSA
FEU-3 Toussaint, J., Chung, Google Academic Topical Antibiotic
W. T., Osman, N., scholar emergency Ointment Versus Silver
McClain, S., Raut, V. & medicine containing Foam
Singer, A. (2015) Dressing for Second-
degree Burns in Swine
FEU-4 Saco, M., Howe, N., Ebsco Journal of Topical antibiotic
Nathoo, R. & dermatological prophylaxis for
Cherpelis, B. (2014) treatment prevention of surgical
wound infections from
dermatologic
procedures: a
systematic review and
meta-analysis
FEU-5 Heal C.F., Banks J.L., Google Chochrane Library Topical antibiotics for
Lepper P.D., scholar preventing surgical site
Kontopantelis E. & van infection in wounds
 Driel M.L. (2016) healing by primary
intention (Review)
FEU-6 Diehr, S., Hamp, A. & Google CliniCal INquIrIes Do topical antibiotics
Jamieson, B. scholar improve wound
healing?
FEU-7 Phillips, M., Google HHS Public Access Preventing Surgical Site
Rosenberg, A., scholar Infections: A
Shopsin, B., Cuff, G. Et Randomized, Open-
al. (2015) label Trial of Nasal
Mupirocin Ointment
and Nasal Povidone
Iodine Solution
FEU-8 McHugh, S.M., Collins, Google Journal of The role of topical
C.J., Corrigan, M.A., scholar antimicrobial antibiotics used as
Hill, A.D.K. & Chemotherapy prophylaxis in surgical
Humphreys, H. site infection
prevention
FEU-9 Lo´pez-Cano, M., Google Surgical Infections Use of Topical
Kraft, M., Curell, A., scholar Antibiotics before
Puig-Asensio, M., Primary Incision
Balibrea,J., Armengol- Closure to Prevent
Carrasco, M. & Surgical Site Infection:
Garcı´a-Alamino, J.M. A Meta-Analysis
(2019)
FEU-10 Cowling, T. & Jones, S. Google CADTH Topical Antibiotics for
(2017) scholar Infected Wounds: A
Review of the Clinical
Effectiveness and
Guidelines

E. Study quality assessment

Study Q1 Q2 Q3 Q4 Q5 Q6 Q7 Total %
ID Score
FEU-1 1 0.5 1 1 0.5 1 1 6 86%
FEU-2 0.5 0.5 0.5 0.5 1 1 0.5 4.0 57%
FEU-3 0.5 0.5 1 0.5 0.5 1 0.5 4.5 64%
FEU-4 1 1 0.5 0.5 0.5 1 1 5.5 79%
FEU-5 1 0.5 0.5 1 0.5 1 1 5.5 79%
FEU-6 0.5 0.5 0.5 0 0.5 0.5 0.5 3 43%
FEU-7 0.5 1 1 0.5 0.5 1 1 5.5 79%
FEU-8 1 0.5 0.5 0.5 0.5 0 0 3 43%
FEU-9 1 0 1 0 0.5 0.5 0 3 43%
FEU-10 1 1 0.5 0.5 0.5 0.5 0.5 4.5 64%
F. Identified best practices
Study ID Authors and year Study subjects Statement of best practice
FEU-1 Charles E. Edmiston, Patients with Survey results indicate that the
C., Leaper, D., open surgical practice of using topical antibiotics
Spencer, M., Truitt, wound intraoperatively, in both irrigation
K., Fauerbach, L. L., fluids and powders, is widespread.
Graham, D. & Given the risks inherent in their use
Johnson, H. B. and the lack of evidence supporting
it, the practice should be
(2017)
monitored and alternative agents,
such as antiseptics, should be
considered.
FEU-2 Poovelikunnel, T.,
Gethin, G. &
Humphreys, H.
(2015
FEU-3 Toussaint, J., Chung, Second degree Deep partial-thickness burns, a
W. T., Osman, N., burn in swine triple-antibiotic ointment enhanced
McClain, S., Raut, V. reepithelialization and reduced scar
& Singer, A. (2015) depth and contraction compared
with a silver-based foam dressing.
This triple-antibiotic ointment
should be considered as a control
for studies evaluating novel topical
burn
therapies.
FEU-4 Saco, M., Howe, N., Patients with of Petrolatum should be used instead
Nathoo, R. & surgical wound of topical antibiotics as a
Cherpelis, B. (2014) infections from prophylactic measure
dermatologic to prevent postsurgical wound
procedures infections in the outpatient
dermatologic setting.
FEU-5 Heal C.F., Banks J.L.,
Lepper P.D.,
Kontopantelis E. &
van Driel M.L.
(2016)
FEU-7 Phillips, M., patients for Nasal povidone iodine may be
Rosenberg, A., arthroplasty or considered as an alternative to
Shopsin, B., Cuff, G. spine fusion mupirocin in a multifaceted
Et al. (2015) surgery approach to reduce SSI.
FEU-10 Cowling, T. & Jones, patients with Limited and low quality evidence
S. (2017) infected pressure on the use of topical antibiotics for
ulcers infected wounds was identified.

G. Results and discussion of EBN

References:

 Saco, M., Howe, N., Nathoo, R., & Cherpelis, B. (2014). Topical antibiotic prophylaxis for
prevention of surgical wound infections from dermatologic procedures: a systematic review and
meta-analysis. Journal of Dermatological Treatment, 26(2), 151–158. doi:
10.3109/09546634.2014.906547

 Toussaint, J., Chung, W. T., Osman, N., Mcclain, S. A., Raut, V., & Singer, A. J. (2015). Topical
Antibiotic Ointment Versus Silver-containing Foam Dressing for Second-degree Burns in
Swine. Academic Emergency Medicine, 22(8), 927–933. doi: 10.1111/acem.12723

 Poovelikunnel, T., Gethin, G., & Humphreys, H. (2015). Mupirocin resistance: clinical implications
and potential alternatives for the eradication of MRSA. Journal of Antimicrobial
Chemotherapy, 70(10), 2681–2692. doi: 10.1093/jac/dkv169

 Edmiston, C. E., Leaper, D., Spencer, M., Truitt, K., Fauerbach, L. L., Graham, D., & Johnson, H. B.
(2017). Considering a new domain for antimicrobial stewardship: Topical antibiotics in the open
surgical wound. American Journal of Infection Control, 45(11), 1259–1266. doi:
10.1016/j.ajic.2017.04.012

 Phillips, M., Rosenberg, A., Shopsin, B., Cuff, G., Skeete, F., Foti, A., … Bosco, J. (2014).
Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin
Ointment and Nasal Povidone-Iodine Solution. Infection Control & Hospital Epidemiology, 35(7),
826–832. doi: 10.1086/676872

 Heal, C., Lepper, P., & Banks, J. (2017). Topical antibiotics to prevent surgical site infection after
minor surgery in primary care. Dermatology Practical & Conceptual, 7(3), 16–20. doi:
10.5826/dpc.0703a03

 Mchugh, S. M., Collins, C. J., Corrigan, M. A., Hill, A. D. K., & Humphreys, H. (2011). The role of
topical antibiotics used as prophylaxis in surgical site infection prevention. Journal of
Antimicrobial Chemotherapy, 66(4), 693–701. doi: 10.1093/jac/dkr009

 López-Cano, M., Kraft, M., Curell, A., Puig-Asensio, M., Balibrea, J., Armengol-Carrasco, M., &
García-Alamino, J. (2019). Use of Topical Antibiotics before Primary Incision Closure to Prevent
Surgical Site Infection: A Meta-Analysis. Surgical Infections, 20(4), 261–270. doi:
10.1089/sur.2018.279