Data extraction for EBN

A. Clinical question
P- Patients with surgical incision
I- Application of topical antibiotic
C- No application of topical antibiotic
O- The objective was to determine whether the application of topical antibiotics to surgical
wounds that are healing by primary intention reduces the incidence of surgical site infection.
B. Resources searched
 425 Results
C. Identification of research
Item Information about the item
Study ID or code FEU-1, Etc.
Authors and year Author/s names and year of publication
Study subjects Patient’s with wound
Best practices Statements best related to our selected topic

D. Form of data extraction

Study ID Authors & Year Source Publication name Research title
FEU-1 Charles E. Edmiston, American Journal Considering a new
C., Leaper, D., of Infection Control domain for
Spencer, M., Truitt, K., antimicrobial
Fauerbach, L. L., stewardship: Topical
Graham, D. & antibiotics in the open
Johnson, H. B. (2017) surgical wound

FEU-2 Poovelikunnel, T., Journal of Mupirocin resistance:

Gethin, G. & antimicrobial clinical implications
Humphreys, H. (2015) Chemotherapy and potential
alternatives for the
eradication of MRSA
FEU-3 Toussaint, J., Chung, Academic Topical Antibiotic
W. T., Osman, N., emergency Ointment Versus
McClain, S., Raut, V. & medicine Silvercontaining Foam
Singer, A. (2015) Dressing for Second-
degree Burns in Swine
FEU-4 Saco, M., Howe, N., Journal of Topical antibiotic
Nathoo, R. & dermatological prophylaxis for
Cherpelis, B. (2014) treatment prevention of surgical
wound infections from
dermatologic
procedures: a
systematic review and
meta-analysis
FEU-5 Heal C.F., Banks J.L., Chochrane Library Topical antibiotics for
Lepper P.D., preventing surgical site
infection in wounds
 Kontopantelis E. & van healing by primary
Driel M.L. (2016) intention (Review)
FEU-6 Diehr, S., Hamp, A. & CliniCal INquIrIes Do topical antibiotics
Jamieson, B. improve wound
healing?
FEU-7 Phillips, M., HHS Public Access Preventing Surgical Site
Rosenberg, A., Infections: A
Shopsin, B., Cuff, G. Et Randomized, Open-
al. (2015) label Trial of Nasal
Mupirocin Ointment
and Nasal Povidone
Iodine Solution
FEU-8 McHugh, S.M., Collins, Journal of The role of topical
C.J., Corrigan, M.A., antimicrobial antibiotics used as
Hill, A.D.K. & Chemotherapy prophylaxis in surgical
Humphreys, H. site infection
prevention
FEU-9 Lo´pez-Cano, M., Surgical Infections Use of Topical
Kraft, M., Curell, A., Antibiotics before
Puig-Asensio, M., Primary Incision
Balibrea,J., Armengol- Closure to Prevent
Carrasco, M. & Surgical Site Infection:
Garcı´a-Alamino, J.M. A Meta-Analysis
(2019)
FEU-10 Cowling, T. & Jones, S. CADTH Topical Antibiotics for
(2017) Infected Wounds: A
Review of the Clinical
Effectiveness and
Guidelines

E. Study quality assessment

Study Q1 Q2 Q3 Q4 Q5 Q6 Q7 Total %
ID Score
FEU-1 %
FEU-2 %
FEU-3 %
FEU-4 %
FEU-5 %
FEU-6 0.5 0.5 0.5 0 0.5 0.5 0.5 3 43%
FEU-7 0.5 1 1 0.5 0.5 1 1 5.5 79%
FEU-8 1 0.5 0.5 0.5 0.5 0 0 3 43%
FEU-9 1 0 1 0 0.5 0.5 0 3 43%
FEU-10 1 1 0.5 0.5 0.5 0.5 0.5 4.5 64%
 F. Identified best practices
Study ID Authors and year Study subjects Statement of best practice
FEU-1
FEU-2
FEU-3
FEU-4
FEU-5
FEU-7 Phillips, M., patients for Nasal povidone iodine may be
Rosenberg, A., arthroplasty or considered as an alternative to
Shopsin, B., Cuff, G. spine fusion mupirocin in a multifaceted
Et al. (2015) surgery approach to reduce SSI.
FEU-10 Cowling, T. & Jones, patients with Limited and low quality evidence
S. (2017) infected pressure on the use of topical antibiotics for
ulcers infected wounds was identified.

G. Results and discussion of EBN

References: