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Name of Drug with Actions Mechanism Indications Side Effects Contraindicatio Nursing Responsibilities
Dosage of Action ns
Hydrocortisone 250 mg IV Corticosteroi Enters target cells Acute adrenal Na & water Latent, healed & WARNING: Give daily before
d Hormones and binds to adrenal retention w/ active TB, herpes 9am to mimic normal peak
cytoplasmic insufficiency, edema & HTN, simplex, chronic diurnal corticosteroids levels
receptors; initiates bilateral hypokalemic nephritis, acute and minimize HPA
man complex adrenalectomy, acidosis, psychosis, suppression.
reactions that are severe shock, susceptibility to Cushing¶s -Space multiple doses evenly
responsible for its acute infections, syndrome, peptic throughout the day.
anti-inflammatory, hypersensitivity increase in ulcer & -Do not give IM injections if pt.
imuunosuppressive reactions, appetite, predisposition to has thrombocytopenic
(glucocorticoid), and overwhelming osteoporosis, thrombophlebitis. purpura.
salt-retaining infections w/ muscle -Rotate sites of IM repository
(mineralcorticoid) severe toxicity, weakness, injections to avoid local
actions. Some SLE in relapse, ocular changes, atrophy.
actions may be aspiration peptic ulcer, -Use minimal doses for
undesirable, pneumonitis & indigestion. minimal duration to minimize
depending on drug other conditions adverse effects.
use. requiring the -Taper doses when
metabolic & anti- discontinuing high-dose or
inflammatory long-term therapy.
actions of -Arrange for increased dosage
hydrocortisone. when pt. is subject to unusual
stress.
-Ensure that adequate amount
of Ca²  is taken if prolonged
administration of steroids.
-Use alternate-day
maintenance therapy with
short-acting corticosteroids
whenever possible.
WARNING: Do not give live
virus vaccines with
immunosuppressive doses of
hydrocortisone.
-Provide antacids between
meals to help avoid peptic

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ulcer.

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Name of Drug with Actions Mechanism Indications Side Effects Contraindicatio Nursing
Dosage of Action ns Responsibilities
Furosemide 40 mg IV Diuretics Inhibits Treatment of Fluid & Latent, healed & -Administer w/ food or milk
reabsorption of edema associated electrolyte active TB, herpes to prevent GI upset.
sodium and w/ CHF, renal & imbalance simplex, chronic -Reduce dosage if given w/
chloride from the hepatic disorders. including nephritis, acute other antihypertensives;
proximal and distal Management of hyponatremia, psychosis, readjust dosage gradually
tubules and oliguria due to hypokalemia & Cushing¶s as BP responds.
ascending limb of renal failure & hypochloremic syndrome, peptic -Give early in the day so
the loop of Henle, insufficiency. Mild alkalosis; ulcer & that increased urination
leading to a to moderate HTN. hyperuricemia. predisposition to will not disturb sleep.
sodium-rich Severe thrombophlebitis. -Avoid IV use if oral use is
dieresis. hypercalcemia. at all possible.
Adjunct to other WARNING: Do not mix
antihypertensive parenteral solution with
agents. highly acidic solutions w/
pH below 3.5.
-Do not expose to light,
which may discolor tablets
or solution; do not use
discolored drug or
solutions.
-Discard diluted solution
after 24hr.
-Refrigerate oral solution.
-Measure and record wt. to
monitor fluid changes.
-Arrange to monitor serum
electrolytes, hydration,
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liver and renal function.

-Arrange for potassium-
rich diet or supplemental
potassium as needed.c
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Name of Drug with Actions Mechanism Indications Side Effects Contraindicatio Nursing
Dosage of Action ns Responsibilities
Cefuroxime 750 mg Antibiotic Bactericidal: Bone & joint GI Hypersensitivity WARNING: Do not mix w/ IV
IV Cephalospori Inhibits synthesis infections, disturbances, to solutions containing
n of bacterial cell osteomyelitis, pseudomembra cephalosporins. aminoglycosides. Powder
wall, causing cell septic arthritis, nous colitis, form, solutions, and
suspensions darken during
death. skin & soft tissue dizziness,
storage.
infections, lower headache, INFUSION: Inject slowly 3-5
resp. tract hypersensitivity mins directly into vein for IV
infections, reactions, local administration, or infuse over
pharyngitis, inj site 30 mins; may be given by
sinusitis, reactions. continuous infusion. Give
gonorrhea, aminoglycosides and
meningitis, otitis cefuroxime at different sites.
media, peritonitis, INCOMPATIBILITIES: Do not
UTI, prophylaxis in mix aminoglycosides and
surgery. cefuroxime in the same IV
solution.

-Culture infection, and arrange

for sensitivity tests before and
during therapy if expected
response is not seen.
-Give oral drug with food to
decrease GI upset and
enhance absorption.
-Give oral tablets to children
who can swallow tablets;
crushing the drug results in a
bitter, unpleasant taste. Use
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solution for children who

cannot swallow tablets.
-Have vitamin K available in
case hypoprothrombinemia
occurs.
-Discontinue if
hypersensitivity reaction
occurs.
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Name of Drug with Actions Mechanism Indications Side Effects Contraindicatio Nursing
Dosage of Action ns Responsibilities
Kalium 2 tabs Electrolytes Replace Hypokalemia. Arrhythmias, Renal -Make sure the powder are
potassium and Prophylaxis Heart block, insufficiency, completely dissolve
maintains during treatment Hypotension hyperkalemia, before giving
potassium level. w/ diuretics. Cardiac arrest
untreated -Monitor renal function.

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Addison¶s
Hyperkalemia after surgery, don¶t give
disease,
Respiratory constriction of the drug until urine flow is
paralysis esophagus &/or established tell patient to
Nausea and obstructive take drug with or after
vomiting , changes in the meals with full glass of
abdominal alimentary tract. water of fruit juice to
pain lessen GI distres

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Name of Drug with Actions Mechanism Indications Side Effects Contraindicatio Nursing
Dosage of Action ns Responsibilities
Paracetamol 500 mg 1 Analgesic, Paracetamol The preparation is In rare cases Anemia, cardiac & -Ask first if the pt. is
tab Antipyreti possesses indicated in hypersensitivity pulmonary hypersensitive to the drug.
c prominent diseases reactions, disease. Hepatic -Should not take longer
antipyretic and manifesting with predominantly or severe renal than 10 days.
analgesic effects. pain and fever: skin allergy disease. -Report any adverse
Its anti- headache, (itching and effects.
inflammatory toothache, mild rash) may c
activity is weak and moderate appear. Long-
and has no postoperative and term treatment
clinical injury pain, high with high doses
significance. The temperature, may cause a
mechanism of infectious toxic hepatitis
action is related diseases and with following
to depression of chills. initial
the prostaglandin symptoms:
synthesis by nausea,
inhibition of vomiting,
specific cell sweating, and
cyclooxygenase, discomfort.
and depression Occasionally a
of the gastrointestinal
thermoregulatory discomfort may
center in the be seen.
medulla
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oblongata.
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