IMPORTANT QUESTIONS OF NERVE AND MUSCLE PHYSIOLOGY FOR 1ST

YEAR MBBS STUDENTS BY DR. ROOMI

Q.1: Define resting membrane potential. How is it generated in a skeletal muscle? 1,4
(UHS 2006, 2007).

Q. 2: Draw strength duration curve. Define the units of excitability and give their clinical
application? What is meant by Utilization time? (2 + 1 + 1 +1 marks)

Q.3: What is Spike Potential? Why Sodium ions cannot pass through Potassium
channels? Give the ionic basis of Absolute refractory period, After depolarization and
After Hyperpolarization. (1 + 1 + 1 +1 +1 marks)

Q. 4: Define REFRACTORY PERIOD and its types. What is its mechanism? Give the
normal value of ABSOLUTE REFRACTORY PERIOD of skeletal muscle?
(2+2+1 )

Q.5: what is sattatory conduction? What are its advantages? which nerve fibers have the
maximum velocity of conduction? (2004 UHS).

Q.6: Explain the impulse conduction along a myelinated nerve fiber.

Q.7: Compare the saltatory & non-saltatory conduction of nerve impulse.

(5 marks)
Q.8: Mr. X fell down and injured his elbow. He consulted a surgeon who told him that
the nerve near his elbow has been damaged. Later on weakness in the muscles of forearm
started. Explain the changes occuring in the nerve fiber when these undergo degeneration.
(2008 S UHS).

Q.9: What is compound action potential? Draw and label it. (2004S UHS).

Q. 10:VWhen sciatic nerve is electrically stimulated, which type of potential record is

obtained? Draw & explain it.

Q.11: What is Walk-along theory & sliding filament model of skeletal muscle
contraction?
(2.5 + 2.5 marks)

Q.12: What is sarcomere? What HISTOLOGIC changes occur in it during the muscle
contraction? 2,3 (2004 S UHS).
Q.13: An unidentified dead body was found in a street. The dead body was having
rigidity. It was handed over to the police. After about 24 hours, rigidity of the dead body
had disappeared.
a. Why was the dead body having rigidity and what is that condition called?
b. Why did the rigidity disappear?
c. What is the forensic significance of this condition?
(3+2 marks)

Q.14: Two different patients present with arterial pH of 7.6 and 7.4 respectively. In
which case tetany may be aggravated more easily and why? (1 + 4 marks)

Q.15: A hyperventilating young girl of 20 years reports to her physician with a typical
position of the hand at the wrist due to spasm of muscles. An I/V injection of a calcium
salt results in remarkable improvement of the girl’s condition.
a. What is the technical name given to this condition of the girl?
b. Why was calcium so effective?
c. What is the role of calcium in muscle contraction? (1+2+2 marks)

Q.16: Draw and label a neuromuscular junction. How is end plate potential produced?
What changes occur in this potential in myasthenia gravis? 2,2,1, (UHS 2005, 2007)

Q.17: A 30 year old lady complained of double vision (diplopia), severe muscle
weakness
& fatigue. She has drooping of eyelids and an enlarged shadow of thymus on
ultrasound.

a. What can be the possible diagnosis of this disturbed physiology?

b. What is the physiological basis of this pathology?
c. What positive finding do you expect in her serum examination?
d. What medicine can alleviate the lady’s complaints?

Q.18: what is end plate potential? How is it produced? How is it affected in myasthenia
gravis? (2004, 2008 UHS). 1+2+2

Q.19: What is the mechanism of action of Post-synaptic neuro-muscular transmission

blockers? Classify them with examples and give their uses. (1 + 3 + 1 marks)

Q.20: Differentiate between Unitary and Multiunit smooth muscle. (5 marks)

Q.21: What is latch phenomenon in a smooth muscle fiber? What is its importance and
how is it regulated? 2,1,2 (2006 UHS).