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Hematology Notes
Hematology Notes
Advanced age
Anemia
Pregnancy
Kidney problems
Thyroid disease
Some cancers, such as multiple
myeloma
Infection
ABNORMAL RESULTS:
Abnormal echocardiogram findings will
show the following:
FOLLOW-UP CARE
Assess the patient for nausea or pain
(including back pain from lying still) and
provide medication as indicated. Assess the
catheter insertion site for bleeding or
hematoma with vital signs as ordered.
Instruct him to inform you immediately if he
experiences chest discomfort or other
anginal symptoms. Review the discharge
orders with the patient and family, including
activity restrictions, and educate them about
signs and symptoms of complications,
including MI, stroke, and insertion-site
bleeding or infection. If indicated, inform
the patient that he may need blood urea
nitrogen and creatinine monitoring after
discharge. Finally, instruct him to follow up
with his primary care provider.
ENZYME MARKERS
brain cancer
WHAT ARE ENZYME MARKERS? brain injury, stroke, or bleeding in
Enzymes are highly specialized complex the brain
proteins that aid chemical changes in every pulmonary infarction, which is the
part of the body. For example, they help death of lung tissue
break down food so your body can use it seizure
effectively. They also help your blood clot. electroconvulsive therapy
And they’re present in every organ and cell
in your body. Enzymes are necessary for CPK-2 levels rise following a heart attack.
your body to function properly. Increased levels of CPK-2 may also be due
to:
Enzyme markers are blood tests that analyze
specific enzyme activity in the body. Some open heart surgery
inherited diseases or conditions can cause
inflammation of the heart muscle
these enzymes to stop working or be less
heart injury
efficient. Monitoring the rise or fall of
enzyme levels can aid in the diagnosis of a defibrillation
variety of conditions. electrical injuries
chest compressions after cardiac
Your doctor can order a blood test for arrest
enzyme markers, or a routine blood test to
help uncover abnormalities. In some cases, High CPK-3 levels can be a sign of muscle
you may need to take a test multiple times stress, a crush injury, or injury due to:
over the course of several days to measure
changes over time. muscle damage, dystrophy, or
inflammation
WHAT ARE THE COMMON TYPES intramuscular injections
OF ENZYME MARKERS? electromyography, which is a muscle
CPK isoenzymes and nerve function test
The CPK isoenzymes test measures the recent surgery
creatine phosphokinase (CPK) in the blood. seizures
CPK enzymes are in the heart, brain, and strenuous exercise
skeletal muscles. Normal CPK levels vary
by age, gender, and race. HEART ENZYMES
Some heart enzymes slowly enter your
Each laboratory may have minor differences blood if you’ve had a heart attack and your
in reference ranges, as well. In general, a heart is damaged as a result. A general test
CPK level of approximately 200 units per for emergency room patients with heart
liter (U/L) or less is considered normal in an attack symptoms is a test for the presence of
adult. This is the total CPK level in your certain proteins in your blood. A doctor may
body. More specific testing can be done, but check CPK-2, also known as CK-MB. This
this is not routine. marker is highly specific for heart muscle
injury and rises rapidly during a heart attack.
CPK-1 resides mostly in the brain and lungs. Normal CK-MB should be between 5-25
Increased levels of CPK-1 can be due to: international units per liter (UI/L).
article, the important tests are the liver
The preferred marker of heart injury, aminotransferases: alanine aminotransferase
though, is a protein called troponin. (ALT) and aspartate aminotransferase
Troponin should generally be less than 0.02 (AST).
nanograms per milliliter (ng/mL). The level
takes longer to rise than CK-MB, but the ALT is primarily produced by the liver,
protein stays in the bloodstream longer. while AST can be from the liver, cardiac
muscle, skeletal muscle, kidney, and brain.
LIVER ENZYMES A normal ALT level is 29-33 IU/L for men,
Elevated liver enzymes may be due to and 19-25 IU/L for women. A normal AST
inflammation or damaged liver cells. level may range from 10-40 IU/L for men
Usually, elevated liver enzymes are related and 9-32 IU/L for women.
to an acute injury, or a process that occurred
over a short period of time due to: These reference ranges vary from hospital to
hospital. It’s important to compare your liver
prescription medications, such as statins enzyme levels to the reference ranges
over-the-counter (OTC) medications, such provided by the lab.
as acetaminophen (Tylenol)
alcohol consumption
heart failure or heart attack HOW ARE ENZYME MARKER TESTS
liver disease, such as hepatitis, fatty liver PERFORMED?
disease, cancer, and cirrhosis The test is a routine blood test that takes
obesity place in a laboratory. No fasting or special
celiac disease, which is a digestive condition preparation is necessary. But tell your doctor
viruses, such as cytomegalovirus infection; before the test about all prescription and
hepatitis A, B, C, E viruses; mononucleosis; OTC medications and supplements you take.
and Epstein-Barr virus
inflammatory diseases, such as A BLOOD TEST INVOLVES THE
dermatomyositis, pancreatitis, and FOLLOWING STEPS:
gallbladder inflammation A healthcare provider will use an antiseptic
muscular diseases, such as muscular to clean a small area of your arm, usually the
dystrophy or polymyositis inside of your elbow or the back of your
ischemia, or lack of oxygen going to the hand.
liver, such as during cardiac arrest They’ll then wrap an elastic band around
hemochromatosis, which is a disorder in your upper arm to create pressure and make
which there’s too much iron in the blood it easier to access a vein.
underactive thyroid They’ll insert a needle into your vein and
Wilson disease, which is a disorder where blood will flow into a small vial. You’ll
there’s too much copper stored in the body likely feel the stick of the needle or a
physical trauma to the organ stinging sensation.
After filling the vial, the healthcare provider
There are several markers that can be used will remove the elastic band and the needle.
to test liver function. These markers help They’ll place a bandage over the puncture
separate whether or not the injury is to the site and send the blood sample to a lab for
liver parenchyma (liver cells) or to the analysis.
biliary system. For the purposes of this
The procedure should take only a few
minutes.
Bleeding
light-headedness
fainting
infection, which is a small risk
whenever the skin is broken
Contact your doctor immediately if
you have any of these symptoms.
The names we mention below are some of Various isotopes are used, including
the more common ones. If the name of your technetium and thallium.
test isn't mentioned here, check with your
doctor or radiographer what your test During the test, the staff will monitor your
involves. heart rate and check your blood pressure.
CT SCANS (COMPUTERISED How long the test is, depends on the type of
TOMOGRAPHY) scanner used and why you are having the
A CT scan is also known as a CAT scan. It's scan.
a sophisticated type of X-ray, which can
produce detailed images of your heart. It can WHEN MIGHT I BE OFFERED THIS
look at: TEST?
You may be offered a CT scan if doctors are
the pumping action of your heart not entirely sure that your chest pain is
the structure of your heart - its muscle, caused by CHD. So this test is often used to
valves and coronary arteries (the arteries that make sure that you don't have CHD.
supply your heart muscle with blood and
oxygen) If your doctor is reasonably sure that you do
the flow of blood through your heart and have CHD, he or she is more likely to offer
your coronary arteries. you a myocardial perfusion scan or a
A CT scan can see how well your heart is conventional angiogram.
working and can help to diagnose various
heart conditions such as an enlarged heart,
heart valve problems or coronary heart
disease (CHD).