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Erythrocyte Sedimentation Rate (ESR) Also, they can help confirm a diagnosis of

Also Known As certain conditions, including:


 
 Sed Rate  Giant cell arteritis
 Polymyalgia rheumatica
 Sedimentation Rate  Rheumatoid arthritis
 A sed rate test can also help
 Westergren Sedimentation Rate determine the severity of your
inflammatory response and monitor
 Wintrobe Sedimentation Rate the effect of treatment.
 
OVERVIEW Because a sed rate test can't pinpoint the
Sed rate, or erythrocyte sedimentation rate problem that's causing inflammation in your
(ESR), is a blood test that can reveal How you prepare
inflammatory activity in your body. A sed The sed rate is a simple blood test. You don't
rate test isn't a stand-alone diagnostic tool, need to fast before the test.
but it can help your doctor diagnose or
monitor the progress of an inflammatory WHAT YOU CAN EXPECT
disease. A phlebotomist, nurse or medical assistant
will use a needle to draw blood from a vein,
When your blood is placed in a tall, thin most likely a vein in your arm. After the test,
tube, red blood cells (erythrocytes) gradually the site on your arm might be tender for a
settle to the bottom. Inflammation can cause few hours, but you'll be able to resume most
the cells to clump. Because these clumps are normal activities.
denser than individual cells, they settle to
the bottom more quickly. RESULTS
Results from your sed rate test will be
The sed rate test measures the distance red reported in the distance in millimeters (mm)
blood cells fall in a test tube in one hour. that red blood cells have descended in one
The farther the red blood cells have hour (hr). The normal range is 0 to 22
descended, the greater the inflammatory mm/hr for men and 0 to 29 mm/hr for
response of your immune system. women. The upper threshold for a normal
sed rate value may vary somewhat from one
WHY IT'S DONE medical practice to another.
Sed rate tests might be useful when
evaluating unexplained fever, some types of Your sed rate is one piece of information to
arthritis and symptoms that affect your help your doctor check your health. Talk to
muscles. your doctor about what your sed rate results
mean in light of your symptoms and the
results of your other diagnostic tests.
ACCURACY OF TEST RESULTS
A number of conditions can affect the
properties of blood, thereby affecting how
quickly red blood cells sink in a sample of
blood.
So information about inflammatory disease
— what your doctor intends to learn from
the sed rate test — can be obscured by the
influence of other conditions. These
complicating factors include:

 Advanced age
 Anemia
 Pregnancy
 Kidney problems
 Thyroid disease
 Some cancers, such as multiple
myeloma
 Infection

Your doctor will take into account possible


complicating factors when interpreting the
results of your sed rate test.
ECHOCARDIOGRAM A device called transducer is placed
on the patient’s chest and transmits
Echocardiogram, also known as ultrasound waves into the thorax.
echocardiography, or heart ultrasound is a These waves bounce off the
noninvasive, painless test that uses high- structures of the heart, creating
frequency sound waves to visualize the images and sounds that are shown in
shape, size, and movement of the structures a monitor.
of the heart. It is useful to evaluate patients 2. Transesophageal Echocardiogram
with chest pain, enlarged cardiac silhouettes (TOE). It is a special type of
on X-rays, electrocardiogram (ECG) echocardiography that uses an
changes unrelated to CAD, and abnormal endoscope to assist the transducer
heart sounds on auscultation. down to the esophagus where it
produces a more detailed image of
In this test, a transducer directs ultrahigh- the heart than a transthoracic
frequency sound waves toward cardiac echocardiogram.
structure, which reflect these waves. The
echoes are converted to images that are 3. Stress Echocardiogram. An
displayed on a monitor and recorded on a echocardiogram that is performed
strip chart or videotape. Results are while the patient is using a treadmill
correlated with clinical history, physical or stationary bicycle. This type can
examination, and findings from the be used to measure the function of
additional test. the heart both at rest and while
exercising.
The techniques most commonly used in
echocardiography are M-mode (motion 4. Dobutamine Stress Echocardiogram.
mode), for recording the motion and For patients who are unable to
dimensions of intracardiac structures, and exercise on a treadmill, a drug called
two-dimensional (cross-sectional), for dobutamine is given instead through
recording lateral motion and providing the a vein that stimulates the heart in a
correct spatial relationship between similar manner as exercise. This type
structures. of echocardiogram is used to
evaluate coronary artery disease and
The responsibilities of a nurse during measures the effectiveness of cardiac
echocardiography includes explanation of therapeutic regimen.
the procedure to the patient, monitoring
during tranesophageal and stress 5. Doppler echocardiogram. Measures
examinations, and establishing intravenous and assess the blood flow through
access for sonicated saline, microsphere the heart and blood vessels.
contrast, and medication

The different types of echocardiogram INDICATION


are: Echocardiogram is indicated for several
reasons, which includes:
1. Transthoracic Echocardiogram
(TTE). It is the most common type of  Detect and evaluate valvular
echocardiogram and is noninvasive. abnormalities
 Detect atrial tumors The transducer is systematically angled to
 Measure the size of the heart direct ultrasonic waves at specific parts of
chambers the patient’s heart.
 Evaluate chambers and valves in  Record findings.
congenital heart disorders During the test, the screen is observed;
 Diagnose hypertrophic and related significant findings are recorded on a strip
cardiomyopathies chart recorder or a video tape recorder.
 Evaluate cardiac function or wall  Doppler echocardiography.
motion after myocardial infarctions Doppler echocardiography also may be used
 Detect pericardial effusion and mural where color flow stimulates red blood cell
thrombi flow through the heart valves. The sound of
blood flow also may be used to assess heart
PROCEDURE sounds and murmurs as they relate to cardiac
The following are the steps and processes on hemodynamics.
how an echocardiography or
echocardiogram is performed: INTERFERING FACTORS
These are factors that may affect the
 Place patient in a supine position. outcome of echocardiography:
Patient is placed in a supine position and a
conductive gel is applied to the third or Patient doing unnecessary movement during
fourth intercostal space to the left of the the procedure.
sternum. The transducer is placed directly Incorrect placement of the transducer over
over it. the desired test area.
 Transducer is placed Metallic objects within the examination
The transducer directs ultra-high-frequency field, which may hinder organ visualization
sound waves towards cardiac structures, and cause unclear images
which reflect these waves; the transducer Patients who are dehydrated, resulting in
picks up the echoes, converts them to failure to demonstrate the boundaries
electrical impulses, and relays them to an between organs and tissue structures.
echocardiography machine for display. Patients who have a severe chronic
obstructive pulmonary disease have a
 Motion mode is used
significant amount of air and space between
In motion mode (M-mode), a single, pencil-
the heart and the chest cavity. Airspace does
like ultrasound beam strikes the heart and
not conduct ultrasound waves well.
produces a vertical view, which is useful for
In obese patients, the space between the
recording the motion and dimensions of
heart and the transducers is greatly enlarged;
intracardiac structures.
therefore, the accuracy of the test is
 Change in position
decreased.
In two-dimensional echocardiography, a
cross-sectional view of the cardiac structures
NURSING RESPONSIBILITIES
is used for recording the lateral motion and
The following are the nursing interventions
spatial relationship between structures. For a
and nursing care considerations for a patient
left lateral view, the patient is placed on his
undergoing a normal echocardiogram:
left side.
 Transducer is angled.
BEFORE THE PROCEDURE Position the patient on his left side. Explain
The following interventions are done prior that transducer is angled to observe different
and during the study: areas of the heart and that he may be
repositioned on his left side during the
Explain the procedure to the patient. Inform procedure.
the patient that echocardiography is used to
evaluate the size, shape, and motion of AFTER THE PROCEDURE
various cardiac structures. Tell who will The nurse should be aware of these post-
perform the test, where it will take place, procedure nursing interventions after an
and that it’s safe, painless, and is echocardiogram, they are as follows:
noninvasive.
No special preparation is needed. Advise the Remove the conductive gel from the
patient that he doesn’t need to restrict food patient’s skin. When the procedure is
and fluids for the test. completed, remove the gel from the patient’s
Ensure to empty the bladder. Instruct patient chest wall.
to void prior and to change into a gown. Inform the patient that the study will be
Encourage the patient to cooperate. Advise interpreted by the physician. An official
the patient to remain still during the test report will be sent to the requesting
because movement may distort results. He physician, who will discuss the findings with
may also be asked to breathe in or out or to the patient.
briefly hold his breath during the exam. Instruct patient to resume regular diet and
Explain the need to darkened the activities. There is no special type of care
examination field. The room may be given following the test.
darkened slightly to aid visualization on the
monitor screen, and that other procedure
(ECG and phonocardiography) may be NORMAL RESULTS
performed simultaneously to time events in Normal findings of echocardiogram will
the cardiac cycles. reveal the following:
Explain that a vasodilator (amyl nitrate) may
be given. The patient may be asked to inhale For mitral valve: Anterior and posterior
a gas with a slightly sweet odor while mitral valve leaflets separating in early
changes in heart functions are recorded. diastole and attaining maximum excursion
rapidly, then moving toward each other
during ventricular diastole; after atrial
DURING THE PROCEDURE contraction, mitral valve leaflets coming
The following are the nursing considerations together and remaining together during
during echocardiogram: ventricular systole.
For aortic valve: Aortic valve cusps
Inform that a conductive gel is applied to the moving anteriorly during systole and
chest area. A conductive gel will be applied posteriorly during diastole.
to his chest and that a quarter-sized For tricuspid valve: The motion of the
transducer will be placed over it. Warn him valve resembling that of the mitral valve.
that he may feel minor discomfort because For pulmonic valve: Movement occurring
pressure is exerted to keep the transducer in posterior during atrial systole and ventricular
contact with the skin. ejection, cusp moving anteriorly, attaining
its most anterior position during diastole.
For ventricular cavities: Left ventricular
cavity normally an echo-free space between
the interventricular septum and the posterior
left ventricular wall.
Right ventricular cavity: Normally an
echo-free space between the anterior chest
wall and the interventricular septum.

ABNORMAL RESULTS:
Abnormal echocardiogram findings will
show the following:

In mitral stenosis: Valve narrowing


abnormally because of the leaflets’
thickening and disordered motion; during
diastole, both mitral valve leaflets moving
anteriorly instead of posteriorly.
In mitral valve prolapse: One or both
leaflets ballooning into the left atrium during
systole.
In aortic insufficiency: Aortic valve leaflet
fluttering during diastole.
In stenosis: Aortic valve thickening and
generating more echoes.
In bacterial endocarditis: Disrupted valve
motion and fuzzy echoes usually on or near
the valve.
Large chamber size: May indicate
cardiomyopathy, valvular disorders, or heart
failure: small chamber size: may indicate
restrictive pericarditis.
Hypertrophic cardiomyopathy: Identified
by a systolic anterior motion of the mitral
valve and asymmetrical septal hypertrophy.
Myocardial ischemia or infarction: May
cause absent or paradoxical motion in
ventricular walls.
Pericardial effusion: Fluid accumulates in
the pericardial space, causing an abnormal
echo-free space.
In large effusions: Pressure exerted by
excess fluid restricting pericardial motion.
CARDIAC CATHETERIZATION Also note if he's allergic to medications—
Cardiac catheterization reveals defects in the including lidocaine, the local anesthetic
heart chambers, the valves, and coronary commonly used for vascular access.
arteries. Using fluoroscopy, the cardiologist
inserts catheters into one or both sides of the The patient may be instructed to fast for 3 to
heart and measures pressures and cardiac 8 hours before the procedure and withhold
output. The cardiologist also may obtain or decrease the dosages of scheduled
blood specimens for oxygen saturation medications (including insulin,
testing. By injecting contrast media, the antihypertensive drugs, and diuretics). The
cardiologist can further define cardiac physician may prescribe pretreatment
structures, including the coronary arteries, prophylaxis for the patient with a history of
and assess cardiac wall motion. Depending contrast media allergy. Establish two
on the facility and the patient's condition, peripheral venous access sites and infuse
cardiac catheterization may be performed as I.V. fluids as ordered to prevent dehydration.
either an inpatient or an outpatient Obtain specimens for lab tests (complete
procedure. blood cell count, electrolytes, blood urea
nitrogen, creatinine, coagulation studies,
INDICATIONS FOR CARDIAC cardiac biomarkers, and urinalysis). Also
CATHETERIZATION obtain a chest X-ray and an ECG.
Include definitive or suspected myocardial
ischemia, syncope, valvular heart disease, The femoral and brachial arteries are
and acute myocardial infarction (MI). It also common catheter insertion sites, although
may be indicated after an MI, coronary the radial artery also is an option. Assess and
artery bypass graft surgery, or percutaneous mark pulses on the extremity that will be
transluminal coronary angioplasty in used. Have the patient void. (He may wear
patients having recurring symptoms, and his dentures and eyeglasses during the test.)
after a heart transplant to monitor for Administer analgesics and sedatives as
rejection. directed.

GETTING READY DURING THE PROCEDURE


To prepare the patient, teach him about the The test itself lasts 30 minutes to 1 hour, but
procedure and answer his questions. Provide the entire procedure, including
booklets, videos, or other educational tools precatheterization and postcatheterization
to reinforce learning. The cardiologist will care, may take up to 4 hours. Tell the patient
discuss benefits and risks, such as what to expect, including the following
dysrhythmias, bleeding, stroke, or MI. Make points:
sure the patient has provided informed
consent. He'll receive I.V. medication for anxiety and
Assess for allergies, especially significant pain as needed throughout the procedure.
allergies such as a previous anaphylactic The testing takes place in a cool, darkened
reaction to one or more allergens, including room. He'll lie on a special procedure table
contrast media. Ask if he has a history of where X-rays can be taken, either by
asthma, which is associated with an repositioning the table or by moving the X-
increased likelihood of a contrast reaction. ray machine around him. He'll be attached to
equipment for continuous cardiac, BP, and
pulse oximetry monitoring.
He'll be awake throughout the procedure and
may be asked to cough or take a deep breath
at certain times. Tell him to immediately
report any unusual symptoms, such as chest
discomfort or trouble breathing.
When contrast media is injected into the left
ventricle, he may feel warm or flushed for
up to a minute

AFTER THE PROCEDURE


The catheters are removed and bleeding is
controlled with direct pressure or with a
vascular closure device. He'll be
continuously assessed and monitored in a
postcardiac catheterization recovery area.
Depending on his condition and the method
used to stop bleeding, he'll spend some time
on bed rest with the affected extremity
immobilized.

FOLLOW-UP CARE
Assess the patient for nausea or pain
(including back pain from lying still) and
provide medication as indicated. Assess the
catheter insertion site for bleeding or
hematoma with vital signs as ordered.
Instruct him to inform you immediately if he
experiences chest discomfort or other
anginal symptoms. Review the discharge
orders with the patient and family, including
activity restrictions, and educate them about
signs and symptoms of complications,
including MI, stroke, and insertion-site
bleeding or infection. If indicated, inform
the patient that he may need blood urea
nitrogen and creatinine monitoring after
discharge. Finally, instruct him to follow up
with his primary care provider.
ENZYME MARKERS
 brain cancer
WHAT ARE ENZYME MARKERS?  brain injury, stroke, or bleeding in
Enzymes are highly specialized complex the brain
proteins that aid chemical changes in every  pulmonary infarction, which is the
part of the body. For example, they help death of lung tissue
break down food so your body can use it  seizure
effectively. They also help your blood clot.  electroconvulsive therapy
And they’re present in every organ and cell
in your body. Enzymes are necessary for CPK-2 levels rise following a heart attack.
your body to function properly. Increased levels of CPK-2 may also be due
to:
Enzyme markers are blood tests that analyze
specific enzyme activity in the body. Some  open heart surgery
inherited diseases or conditions can cause
 inflammation of the heart muscle
these enzymes to stop working or be less
 heart injury
efficient. Monitoring the rise or fall of
enzyme levels can aid in the diagnosis of a  defibrillation
variety of conditions.  electrical injuries
 chest compressions after cardiac
Your doctor can order a blood test for arrest
enzyme markers, or a routine blood test to
help uncover abnormalities. In some cases, High CPK-3 levels can be a sign of muscle
you may need to take a test multiple times stress, a crush injury, or injury due to:
over the course of several days to measure
changes over time.  muscle damage, dystrophy, or
inflammation
WHAT ARE THE COMMON TYPES  intramuscular injections
OF ENZYME MARKERS?  electromyography, which is a muscle
CPK isoenzymes and nerve function test
The CPK isoenzymes test measures the  recent surgery
creatine phosphokinase (CPK) in the blood.  seizures
CPK enzymes are in the heart, brain, and  strenuous exercise
skeletal muscles. Normal CPK levels vary
by age, gender, and race. HEART ENZYMES
Some heart enzymes slowly enter your
Each laboratory may have minor differences blood if you’ve had a heart attack and your
in reference ranges, as well. In general, a heart is damaged as a result. A general test
CPK level of approximately 200 units per for emergency room patients with heart
liter (U/L) or less is considered normal in an attack symptoms is a test for the presence of
adult. This is the total CPK level in your certain proteins in your blood. A doctor may
body. More specific testing can be done, but check CPK-2, also known as CK-MB. This
this is not routine. marker is highly specific for heart muscle
injury and rises rapidly during a heart attack.
CPK-1 resides mostly in the brain and lungs. Normal CK-MB should be between 5-25
Increased levels of CPK-1 can be due to: international units per liter (UI/L).
article, the important tests are the liver
The preferred marker of heart injury, aminotransferases: alanine aminotransferase
though, is a protein called troponin. (ALT) and aspartate aminotransferase
Troponin should generally be less than 0.02 (AST).
nanograms per milliliter (ng/mL). The level
takes longer to rise than CK-MB, but the ALT is primarily produced by the liver,
protein stays in the bloodstream longer. while AST can be from the liver, cardiac
muscle, skeletal muscle, kidney, and brain.
LIVER ENZYMES A normal ALT level is 29-33 IU/L for men,
Elevated liver enzymes may be due to and 19-25 IU/L for women. A normal AST
inflammation or damaged liver cells. level may range from 10-40 IU/L for men
Usually, elevated liver enzymes are related and 9-32 IU/L for women.
to an acute injury, or a process that occurred
over a short period of time due to: These reference ranges vary from hospital to
hospital. It’s important to compare your liver
prescription medications, such as statins enzyme levels to the reference ranges
over-the-counter (OTC) medications, such provided by the lab.
as acetaminophen (Tylenol)
alcohol consumption
heart failure or heart attack HOW ARE ENZYME MARKER TESTS
liver disease, such as hepatitis, fatty liver PERFORMED?
disease, cancer, and cirrhosis The test is a routine blood test that takes
obesity place in a laboratory. No fasting or special
celiac disease, which is a digestive condition preparation is necessary. But tell your doctor
viruses, such as cytomegalovirus infection; before the test about all prescription and
hepatitis A, B, C, E viruses; mononucleosis; OTC medications and supplements you take.
and Epstein-Barr virus
inflammatory diseases, such as A BLOOD TEST INVOLVES THE
dermatomyositis, pancreatitis, and FOLLOWING STEPS:
gallbladder inflammation A healthcare provider will use an antiseptic
muscular diseases, such as muscular to clean a small area of your arm, usually the
dystrophy or polymyositis inside of your elbow or the back of your
ischemia, or lack of oxygen going to the hand.
liver, such as during cardiac arrest They’ll then wrap an elastic band around
hemochromatosis, which is a disorder in your upper arm to create pressure and make
which there’s too much iron in the blood it easier to access a vein.
underactive thyroid They’ll insert a needle into your vein and
Wilson disease, which is a disorder where blood will flow into a small vial. You’ll
there’s too much copper stored in the body likely feel the stick of the needle or a
physical trauma to the organ stinging sensation.
After filling the vial, the healthcare provider
There are several markers that can be used will remove the elastic band and the needle.
to test liver function. These markers help They’ll place a bandage over the puncture
separate whether or not the injury is to the site and send the blood sample to a lab for
liver parenchyma (liver cells) or to the analysis.
biliary system. For the purposes of this
The procedure should take only a few
minutes.

WHAT ARE THE RISKS ASSOCIATED


WITH ENZYME MARKER TESTS?
Your arm may be sore at the puncture site,
and you might have some mild bruising or
brief throbbing.

Most people have no serious or lasting side


effects from a blood test. Rare complications
include:

 Bleeding
 light-headedness
 fainting
 infection, which is a small risk
whenever the skin is broken
 Contact your doctor immediately if
you have any of these symptoms.

WHAT DO THE TEST RESULTS


MEAN?
Abnormal test results can indicate a variety
of problems from disease to a simple muscle
strain because enzymes are present in every
cell of your body. Your doctor will be able
to determine a proper course of treatment
based on your exact enzyme marker levels
and the symptoms you’re having.
RADIONUCLIDE TESTS see how your heart functions when it has to
Radionuclide tests are one of several types work harder - for example, when you're
of tests performed to assess your heart being more active, or
condition. help diagnose coronary heart disease (CHD).
What happens during a myocardial perfusion
The test that is offered to you will depend on scan?
your condition and symptoms, as well as on
what tests and equipment are available. THERE ARE TWO PARTS TO THE
TEST - STRESS AND REST.
Radionuclide tests are considered safe.
However, during the test you will be For the stress part, you will be given an
exposed to some radiation. injection of a small amount of isotope
(radioactive substance) and be asked to
Every day we are exposed to a small amount exercise on an exercise bike or treadmill. Or,
of radiation which occurs naturally in the you may be given a drug that stimulates
environment. Our risk of cancer can increase your heart to beat faster (this is useful if you
if we're exposed to plenty of radiation, but cannot do much exercise).
the amounts used in these tests are small.
A large camera, positioned close to your
Your doctor will only suggest you have the chest, picks up the gamma rays sent out by
test if he or she feels it's really necessary, the isotope as it passes through your heart.
and if its benefits outweigh any risks. The camera takes pictures of the different
parts of your heart.
TYPES OF RADIONUCLIDE TESTS
There are two types of radionuclide tests: a For the rest part, you will be given a small
myocardial perfusion scan and a amount of isotope while you're resting. The
computerised tomography (CT) scan. There camera will then take the same sort of
are lots of different names for these tests. pictures as before.

The names we mention below are some of Various isotopes are used, including
the more common ones. If the name of your technetium and thallium.
test isn't mentioned here, check with your
doctor or radiographer what your test During the test, the staff will monitor your
involves. heart rate and check your blood pressure.

MYOCARDIAL PERFUSION SCAN WHEN MIGHT I BE OFFERED THIS


This is also known as a thallium scan, MIBI TEST?
scan, MPS or technetium scan. A camera You may be offered this test if you haven't
takes pictures to: previously been diagnosed with CHD and
you go to A&E with chest pain. If the
look at the pumping action of your heart doctors think it's very likely that your chest
look at the flow of blood to your heart pain is caused by CHD this test may be used
muscle to confirm if you have CHD.
You may also be offered this test if you have You may be given a medicine to slow your
CHD and your doctor wants to find out if heart rate down. This is to ensure that the
you'll benefit from having a procedure such doctors are able to get the best possible
as an angioplasty or coronary bypass graft. image of your heart.

CT SCANS (COMPUTERISED How long the test is, depends on the type of
TOMOGRAPHY) scanner used and why you are having the
A CT scan is also known as a CAT scan. It's scan.
a sophisticated type of X-ray, which can
produce detailed images of your heart. It can WHEN MIGHT I BE OFFERED THIS
look at: TEST?
You may be offered a CT scan if doctors are
the pumping action of your heart not entirely sure that your chest pain is
the structure of your heart - its muscle, caused by CHD. So this test is often used to
valves and coronary arteries (the arteries that make sure that you don't have CHD.
supply your heart muscle with blood and
oxygen) If your doctor is reasonably sure that you do
the flow of blood through your heart and have CHD, he or she is more likely to offer
your coronary arteries. you a myocardial perfusion scan or a
A CT scan can see how well your heart is conventional angiogram.
working and can help to diagnose various
heart conditions such as an enlarged heart,
heart valve problems or coronary heart
disease (CHD).

This test can also measure how much


calcium there is in your coronary arteries -
this is called a coronary calcium scan. The
higher your calcium score, the higher your
risk of having CHD. If you have a high or
medium calcium score, you may need
further tests. If you have a low calcium
score, it's unlikely that you have CHD.

WHAT HAPPENS DURING THE


TEST?
You will need to lie on a bed under the CT
scanner. Usually, at the start of the scan,
some dye (called a contrast) will be injected
into your arm. This allows the camera to
easily see the heart's structure and blood
flow. This may cause a warm, flushing
sensation which some people find
unpleasant.

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