The germ theory of disease states that certain diseases are caused by the growth and reproduction of specific germs or infectious agents within a host body. The germ theory was proposed in the mid-16th century and gained popular acceptance through the work of many scientists during the 17th through 19th centuries. In 1677, Antoni van Leeuwenhoek was surprised to see tiny organisms - which he called ‘animalcules’ - in the droplets of water he was examining. He made no connection with disease, and although later scientists observed germs in the blood of people suffering from disease, they suggested that the germs were an effect of the disease, rather than the cause. This fitted with the then popular theory of spontaneous generation. The observations and actions of Ignaz Semmelweis, Joseph Lister and John Snow would retrospectively be acknowledged as contributing to the acceptance of germ theory. But it was the laboratory researches of Louis Pasteur (1822-1895) in the 1860s and then in 1877 Robert Koch (1822-1895) in the following decades that provided the scientific proof for germ theory. Their work opened the door to research into the identification of disease-causing germs and potential life-saving treatments.
II. Multi Causal Models of Disease
The theory of multi causation is that the contributing causes (behavioural factors, environmental factors) combine together in a random fashion to result in an accident. During accident investigations, there is a need to identify as many of these causes as possible. In reality, the accident model is an amalgam of both the domino and multi causality theories.
The "Epidemiologic Triad"
of infectious disease summarizes the factors that influence an infection, and the measures you might take to combat the infection: