The medial septal nucleus (MS) is one of the septal nuclei.

Neurons in this nucleus give rise to the

bulk of efferents from the septal nuclei. A major projection from the medial septal nucleus terminates
in the hippocampal formation.[1]
It plays a role in the generation of theta waves in the hippocampus.[2] Specifically,
the GABAergic cells of the medial septum that act as theta pacemakers target dentate gyrus, CA3,
and CA1 interneurons. Pacemaking MS interneurons express hyperpolarization-activated cyclic
nucleotide-gated (HCN) channels which are likely to promote their pacemaker properties.[3]