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  • Weekly Work Presentation: Sourav Mandal DATE-02.11.2019

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    The document reports on a weekly work presentation by Sourav Mandal dated November 2nd, 2019. It describes several chemical reactions conducted, including reacting an amine with di-tert-butyl dicarbonate to form a BOC-protected amine. A palladium-catalyzed coupling reaction was performed on an iodinated compound that resulted in a product that was both iodine and UV active. Some reactions had to be repeated when full conversion did not occur initially.

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    The document reports on a weekly work presentation by Sourav Mandal dated November 2nd, 2019. It describes several chemical reactions conducted, including reacting an amine with di-tert-butyl dicarbonate to form a BOC-protected amine. A palladium-catalyzed coupling reaction was performed on an iodinated compound that resulted in a product that was both iodine and UV active. Some reactions had to be repeated when full conversion did not occur initially.

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    6 views2 pages

    Weekly Work Presentation: Sourav Mandal DATE-02.11.2019

    Uploaded by

    madhu123iitk
    The document reports on a weekly work presentation by Sourav Mandal dated November 2nd, 2019. It describes several chemical reactions conducted, including reacting an amine with di-tert-butyl dicarbonate to form a BOC-protected amine. A palladium-catalyzed coupling reaction was performed on an iodinated compound that resulted in a product that was both iodine and UV active. Some reactions had to be repeated when full conversion did not occur initially.

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    © All Rights Reserved
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    WEEKLY WORK PRESENTATION

    SOURAV MANDAL
    DATE-02.11.2019

    NH2 NH2
    dry DCM,(BOC) 2O IN DCM O
    24 Hrs,reaction set up in O
    NH2 NH
    ice bath after that it was
    left in RT

    Solvent=Hex:EtOAc-1:1

    After 24hrs of reactionfull conversion does not took place

    N N N
    Pd(II),Cu(I),THF:Et3N,TMS K2CO3,MeOH,2 Hrs
    0
    65 C,6 Hour

    TMS

    SOLVENT-HEXANE FOR BOTH CASES


    N N

    N H H
    I H N N
    N Pd(II),Cu(I),THF:Et 3N,2 Hr,RT
    CH3 + N
    I N
    N
    I

    Both iodine and UV active

    First time the reaction didn’t take place.. So it was repeat ted

    Br Br

    THF,(BOC) 2O,24 Hrs,650C O

    NH2 NH OH

    TMS

    Br
    O
    O
    NH OH
    NH O

    TMS

    O O
    NH
    NH O

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