KULIAH 2

ASPEK STREOCHEMICAL OBAT TINDAKAN

Asymmetric Molecules Nomenclature

B A
d,l
C * D,L
R,S
D C
isomer

• Molekul memiliki rumus molekul yang

sama tetapi atom-atom disusun berbeda

• Struktur isomer tidak super imposable

 N
H3C

OH
(-) Hydroxy-N-methylmorphinan
antalgin NF
(Levo-Dromoron)
 N N
CH3 H3C

HO OH

(-) Hydroxy-N-methylmorphinan
antalgin NF
(Levo-Dromoron)
 ikatan kimia dan biologi Kegiatan

• Obat-Reseptor Interaksi

k1 k3
D + R DR E
k2

Dimana D = Drug, R = reseptor, DR kompleks = reseptor obat, E = efek

biologis dan k1, k2, Dan k3 = Konstanta laju
Biokimia Building Blocks

Asam amino
COOH COOH
*
H2N C H H C NH2

R R
General Structure General Structure
in Fisher Projection in Fisher Projection
L-Configuration shown D-Configuration shown
S-Configuration shown R-Configuration shown
Tata nama

Asam amino
H3C
R = H-, Glycine (Gly) H2
R = CH3-, Alanine (Ala) R= CH C , Leucine (Leu)
H3C

H2
R= C , Phenylalanine (Phe)

H3C
R= CH , Valine (Val)
H3C
 H2
H3C C
R= CH , Isoleucine (Ile)
H3C

R= HO C , Serine (Ser)
H2

R= HS C , Cystein (Cys)
H2
 H2
C
R= Tryptophan (Trp)
N
H

H2
C
R= , Histidine (His)
N NH
Basa heterosiklik
O O NH2

HN CH3 HN
HN

O N O N
O N H H
H
Thy mine Cytosine
Uracy l
NH2 O
N N
N HN

N N H2N N N
H H
Adenine Guanine
nukleosida
NH2
O O
N
HN HN CH3
O N
O N O N HO

HO HO O
O O
OH R

OH OH R = OH, Cytidine
R = H, Deoxy Cytidine
Uridine Thy midine
 NH2 O

N N
N N

H2N N N
N N

HO HO

O O

OH OH R
R
R = OH, Adenosine R = OH, Guanosine
R = H, Deoxy Adenosine R = H, Deoxy Guanosine