Professional Documents
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Medically reviewed by Carissa Stephens, RN, CCRN, CPN on August 27, 2018
— Written by Brian Krans and Mariah Adcox
Purpose
PET scan vs. other tests
Risks
Preparation
Procedure
Follow-up and results
Definition
A positron emission tomography (PET) scan is an imaging test that allows your
doctor to check for diseases in your body.
The scan uses a special dye containing radioactive tracers. These tracers are
either swallowed, inhaled, or injected into a vein in your arm depending on what
part of the body is being examined. Certain organs and tissues then absorb the
tracer.
When detected by a PET scanner, the tracers help your doctor to see how well
your organs and tissues are working.
The tracer will collect in areas of higher chemical activity, which is helpful
because certain tissues of the body, and certain diseases, have a higher level of
chemical activity. These areas of disease will show up as bright spots on the PET
scan.
The PET scan can measure blood flow, oxygen use, how your body uses sugar,
and much more.
A PET scan is typically an outpatient procedure. This means you can go about
your day after the test is finished.
In the United States, around 2 million PET scans are performed each year.
Your doctor may order a PET scan to inspect your blood flow, your oxygen
intake, or the metabolism of your organs and tissues. PET scans show problems
at the cellular level, giving your doctor the best view of complex systemic
diseases.
cancer
heart problems
brain disorders, including problems with the central nervous system (CNS)
Cancer
Cancer cells have a higher metabolic rate than noncancerous cells. Because of
this high level of chemical activity, cancer cells show up as bright spots on PET
scans. For this reason, PET scans are useful both for detecting cancer and for:
Heart problems
PET scans reveal areas of decreased blood flow in the heart. This is because
healthy heart tissue will take in more of the tracer than unhealthy tissue or tissue
that has decreased blood flow.
Different colors and degrees of brightness on the scan will indicate different
levels of tissue function, helping you and your doctor decide how best to move
forward. Learn more about the heart PET scan.
Brain disorders
Glucose is the main fuel of the brain. During PET scans, tracers are “attached” to
compounds such as glucose. By detecting radioactive glucose, the PET scan is
able to detect which areas of the brain are utilizing glucose at the highest rates.
Your doctor will look at the scan to see how the brain is working and to check for
any abnormalities. Learn more about the brain PET scan.
PET scans are used to help diagnose and manage many central nervous system
(CNS) disorders, including:
Alzheimer’s disease
depression
epilepsy
head trauma
Parkinson’s disease
How does the PET scan compare to other tests?
PET scans show metabolic changes occurring at the cellular level in an organ or
tissue. This is important because disease often begins at the cellular level. CT
scans and MRIs can’t reveal problems at the cellular level.
PET scans can detect very early changes in your cells. CT scans and MRIs can
only detect changes later, as a disease alters the structure of your organs or
tissues.
Detection of illness at the cellular level gives your doctor the best view of
complex systemic diseases, such as:
When either of these scans is performed in conjunction with a PET scan, they
result in what’s called image fusion. A computer combines the images from the
two scans to create a three-dimensional image, which provides more information
and allows for a more precise diagnosis.
Gallium scans are similar to PET scans in that they involve the injection of
gallium citrate, a radioactive tracer. Gallium scans are typically performed one to
three days after the tracer is administered, so it’s a multiday process.
These scans aren’t as commonly performed for the detection of cancer, though
some forms of the gallium scan are combined with newer tests such as the PET
scan.
The PET scan involves radioactive tracers, but the exposure to harmful radiation
is minimal. According to the Mayo Clinic, the amount of radiation in the tracer is
small, so the risks to your body are low. Still, it’s a good idea to discuss possible
risks with your doctor.
The risks of the test are also minimal in comparison to how beneficial the results
can be in diagnosing serious medical conditions.
It’s possible to have an allergic reaction to the tracer. People who are allergic
to iodine, aspartame, or saccharin should alert their doctor.
Those who can’t have an iodine tracer, typically receive a tracer made up of
diluted barium sweetened with saccharin.
Those most likely to have an allergic reaction to the iodine tracer include people
with:
If you’re receiving a PET–CT scan, additional tracer will be needed. This can be
harmful to people who have kidney disease or who have elevated creatinine
levels from medications they’re already taking.
Other risks
Your doctor will provide you with complete instructions for how to prepare for
your PET scan. Tell your doctor about any prescription, over-the-counter (OTC),
or supplemental medications you’re taking.
A few days before
You may be asked to refrain from strenuous physical activity, such as exercise,
in the 24 to 48 hours preceding the test.
cereal
pasta
bread
rice
milk and yogurt, whether dairy or nondairy
fruit and fruit juices
alcohol
caffeinated beverages
candy, including chewing gum and mints
Hours before
If you’re receiving anesthesia for the procedure, don’t eat or drink anything the
entire morning of your PET scan. Drink only a few sips of water if you need to
take any medications.
If you’re not receiving anesthesia, you’ll still want to refrain from eating anything
for six hours before your scan. Remember to avoid chewing gum or sucking on
hard candy, cough drops, or mints.
You’ll be able to drink water, however, and take any medications as
recommended.
You may be asked to change into a hospital gown. Because metal can interfere
with the testing equipment, you’ll also need to remove any jewelry you’re
wearing, including body-piercing jewelry.
Other considerations
You should also tell your doctor about any medical conditions you have:
If you’re pregnant or believe you could be pregnant, tell your doctor. This test
may be unsafe for your baby.
If you’re breastfeeding, you may need to pump and store your breast milk
24 hours prior to the procedure — you won’t be able to breastfeed for 24
hours after the test.
If you have diabetes, you’ll get special instructions for test preparation
because fasting beforehand could affect your blood sugar levels. You’ll
likely be told to take your normal dose of insulin and eat a light meal 4
hours before you’re scheduled to receive your scan.
Before the scan, you’ll get tracers through a vein in your arm, through a solution
you drink, or in a gas you inhale. Your body needs time to absorb the tracers, so
you’ll wait about an hour before the scan begins.
How long it takes for your body to fully absorb the tracer will depend on the area
of the body being scanned.
While you wait, you’ll want to limit any movement, relax, and try to stay warm. If
you’re undergoing a brain scan, you’ll want to avoid television, music, and
reading.
Next, you’ll undergo the scan, which can last anywhere from 30 to 45 minutes.
This involves lying on a narrow table attached to a PET machine, which looks like
a giant letter “O.” The table glides slowly into the machine so that the scan can
be conducted.
You’ll need to lie still during the scan. The technician will let you know when you
need to remain still. You may be asked to hold your breath for several seconds.
You’ll hear buzzing and clicking noises during the test.
When all the necessary images have been recorded, you’ll slide out of the
machine. The test is then complete.
After the test, you can go about your day unless your doctor gives you other
instructions.
However, because radioactive material will remain in your body for about 12
hours, you’ll want to limit your contact with both pregnant women and infants
during this time.
Drink plenty of fluids after the test to help flush the tracers out of your system.
Generally, all tracers leave your body after two days.
Meanwhile, a trained specialist will interpret the PET scan images and share the
information with your doctor. The results are usually ready for your doctor within
two business days, and your doctor will go over the results with you at your
follow-up appointment.
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