Professional Documents
Culture Documents
IN DEFENSE OF DINGOES
FIXING SCIENCE’S FATAL FLAW
LIFE IN ALIEN OCEANS
SECRETS OF ANCIENT POOP
3D-PRINTED STEEL
CLOTHES THAT FEEL
LIKE CLOUDS
WEEKLY April 25–May 1, 2020
SPECIAL REPORT
HOW TO PROT EC T
YOU R M E N TA L H E A LT H
I N T H E T I M E OF
CORONAV IRUS
Online event:
What we still don’t
know about black holes
Join astronomer Chris Impey
More on the pandemic for a fascinating talk about
8 Why are men more likely black holes on 30 April,
to die? 9 The problem with with the opportunity to
contact-tracing apps 10 Truth ask your questions too
Vol 246 No 3279 about breathing exercises Find out more:
Cover image: Eiko Ojala 10 End-of-life decision-making newscientist.com/events
News Features
14 Antimatter’s nemesis 32 Fixing science’s fatal flaw
Did oscillating neutrinos News The new mathematics that can
kill it off? tell cause and effect apart
Views
The back pages
21 Comment
L E BASKOW/ZUMA WIRE/PA IMAGES. TOP: CHANDRA X-RAY OBSERVATORY CENTER/NASA
24 Letters 53 Feedback
Unusual methods to boost Reverse universe and isolation
the immune system measures: the week in weird
Ways to cope
Lessons from the past can help us deal with the pandemic’s mental health fallout
THERE are still many unknowns potential negative consequences to our For them, advice isn’t enough – they
about how this pandemic will play out. mental health can be avoided if we take must have access to professional
The immediate concern is rightly how good and timely action. psychological help, and we need more
to save lives. But another important Past experience also suggests that ways to deliver this remotely.
question is the effect on the world’s some groups will be hit harder. Existing Experience within the military can
long-term mental health. mental health inequalities within offer useful coping strategies for front-
The future here is unclear and an society will widen, compounded by line healthcare workers. Team leaders
ongoing global research effort to must be primed to identify signs among
monitor and understand the mental “Experience within the military staff that normal levels of distress are
toll is needed. Psychologists are can offer useful coping turning into something more serious.
already tooling up to find answers. strategies for front-line Simple actions, such as a short
In the meantime, one useful way to healthcare workers” conversation during times of acute
break down the problem is to examine stress, can improve long-term mental
the impacts on four groups, as we write the financial insecurity brought on health outcomes.
in our special report (see page 40). These by the pandemic, which, as we saw As we have already learned with the
are the general population, families after Hurricane Katrina in 2005, can threat of this virus to our physical health,
and children, vulnerable people and exacerbate mental health issues. we can’t wait to have all the answers
front-line workers. Past experiences Those with pre-existing mental health before we take action to identify and
of national trauma can be our guide problems are particularly vulnerable at protect those most at risk. Doing so now
and allow us to draw several ideas. a time when they are unlikely to have will help mitigate the impact today, and
First, the good news: many of the access to their normal means of support. for decades to come. ❚
IN A rare display of collaboration, tested positive for the virus – this TraceTogether and governments, how privacy
Apple and Google recently joined would be one way to avoid users is an app is preserved, whether apps are kept
forces to help contact-tracing app trolling the system by falsely claiming developed voluntary and how to also protect
technology work effectively. Such symptoms. In theory, the apps only by the people who might not be able to
apps are attractive to countries store anonymous data temporarily, government install an app – a group that is likely
ASCANNIO/ALAMY
looking to exit lockdown, but without collecting location. of Singapore to include many vulnerable older
there is growing evidence it will Even if it were feasible to get people. The American Civil Liberties
be difficult to make them work. a high number of voluntary Union last week laid out a list
Researchers at the University of installations, there is the big question of principles, including the need
Oxford released a report last week of whether using Bluetooth to people in different rooms could be for an exit strategy for such apps,
that simulated a city of 1 million establish a contact works well, said unnecessarily flagged as having to avoid such systems being
people and found that 80 per cent Katina Michael at Arizona State had contact. The result could be a maintained for “surveillance creep”
of smartphone users in the UK would University and Roba Abbas at the flood of false positives. The Oxford after the epidemic has passed.
need to install a contact-tracing University of Wollongong, Australia, team, which is advising NHSX Nevertheless, many countries
app in order for it to be effective in in a joint email to New Scientist. on its app, say the accuracy with are on the verge of deploying apps.
suppressing an epidemic: that is 56 “How reliable is the system to which Bluetooth can be a useful Germany is expected to release one
per cent of the national population. gather proximity information? The proxy for virus transmission risk
The UK’s chief scientific adviser, range of Bluetooth is much larger is “currently uncertain”. “Bluetooth can vary greatly
Patrick Vallance, has indicated he than 1.5 metres for social A further potential issue is the depending on how people
thinks such apps might have a role distancing,” they said. quality of the data. Michael and hold their phones and
to play in contact tracing, but that it Ross Anderson at the University Abbas said they understand that where they are”
would be a tall order to get 80 per of Cambridge says the range of many apps being considered
cent of UK smartphone owners to Bluetooth can vary greatly depending would record contacts only every imminently, and Australia is working
use them. That is a tough target for on how people hold their phones, 5 minutes, which might mean on one too. One of the most high
the UK’s NHSX, the National Health and whether they are indoors or infectious contacts are missed. profile apps has been Singapore’s
Service digital transformation unit, outdoors. He also points out that Other key issues include the TraceTogether app, built by the city
which is developing such an app. the signals pass through walls, so level of trust between citizens state’s government. But even its
Surveys of 6000 potential app creators admit that it is too early
users in five countries suggest that to tell how effective it is. Moreover,
nearly 74 per cent of UK smartphone “every country will have to develop
users would be willing to install a its own app” because of different
contact-tracing app. The proportion situations and requirements, says
who would do it in reality could be a spokesperson at Pan-European
much lower, though. In Singapore, Privacy-Preserving Proximity Tracing,
only an estimated 17 per cent of a European technology initiative.
the population installed a contact- Anderson says it would be better
tracing app launched last month. to recruit thousands of people to
The principle behind contact- undertake the tracing manually.
tracing apps is fairly simple. Once Vallance says apps should be part
installed, they use Bluetooth of a much broader contact-tracing
low-energy technology to record approach, while the UK health
when a phone has come into close secretary Matt Hancock said last
proximity with anyone else using week that such apps were a “critical”
the app. If either person later reports part of government efforts.
coronavirus symptoms, the other However, the apps can only work
party is notified, so they could amid a broader effort of testing and
self-isolate or seek health advice. An tracing. “Contact-tracing apps are
JOHN LAMPARSKI/GETTY IMAGES
Managing symptoms
DURING the coronavirus pandemic, “widespread health inequities”, disproportionately from ethnic and more likely to live in areas with
people from black, Asian and says Linda Sprague Martinez at minorities – are more likely to have fewer primary care doctors than their
minority ethnic (BAME) backgrounds Boston University’s school of social underlying health problems such as white counterparts.
are being hit particularly hard, work in Massachusetts. heart disease, diabetes and obesity BAME individuals may also be less
according to emerging data. “Communities of colour are that put them at increased risk of able to do social distancing at home.
The most recent figures compiled disproportionately impacted covid-19, says Sprague Martinez. “It’s disproportionately certain groups
by the UK’s Intensive Care National because of racism,” she says. “When we have environmental
Audit and Research Centre suggests
that of nearly 5000 people critically ill
with covid-19 in England, Wales and
“It’s not about people’s biological
make-up. It’s about the conditions
that are created due to racialised
conditions that leave communities
vulnerable, that’s when we see an
increase in chronic disease,” she says.
34%
of adults critically ill with
Northern Ireland whose ethnicity was policies, and how that’s impacted “That’s the result of policies that have covid-19 in England, Wales and
known, 34 per cent were from BAME communities over time.” left those communities marginalised.” Northern Ireland are BAME
backgrounds. But people from such For example, poorer, more In the US, where healthcare isn’t
groups make up only 14 per cent of disadvantaged people – who are universally accessible, studies have that still have to go to work,” says
the population of England and Wales, found that black people miss out Latifa Jackson at Howard University’s
for instance. A pilot drive-through on treatment because of racially college of medicine in Washington DC.
In the US, figures released by covid-19 testing site biased algorithms. They are also In the UK, 18 per cent of black
the Centers for Disease Control in Conyers, Georgia less likely to have health insurance people work in caring, leisure and
and Prevention on 18 April showed other services that are either essential
that of about 120,000 confirmed or jobs that can’t easily be done from
covid-19 cases where race has been home. In the US, less than 20 per cent
specified, 36 per cent were among of black or African-American people
non-white people, who account for can work from home.
23 per cent of the US population. These factors may be
Most were in black or African- compounded by racial bias and
American people, who comprise discrimination in healthcare. Studies
13 per cent of the population, have found that people from BAME
but 30 per cent of all cases. groups may be treated differently
CURTIS COMPTON/ABACA/PA IMAGES
Deep breaths can also increase Breathing in through your nose Advice on social media also Swingwood is concerned that
the amount of oxygen getting is a better idea, says Swingwood. recommends lying on your people who are struggling to breathe
into the body, and the volume of “The nose warms and moistens front once you have completed could try to manage symptoms at
carbon dioxide leaving it, says Ema the air that you take in,” she says. breathing exercises. The idea is to home rather than seek help. “We
Swingwood, chair of the Association “Breathing in dry air isn’t going take pressure off the lungs, which want to make sure that people
of Chartered Physiotherapists to help you.” are located towards your back. are reporting their symptoms and
in Respiratory Care. A hard cough at the end of In a hospital setting, turning getting timely treatments,” she says.
Although taking deep breaths a breathing cycle would help a person over is thought to allow Breathing exercises won’t stop
can be helpful, it isn’t generally clear out mucus, says Niederman. oxygen to reach other parts of people from getting covid-19,
a good idea to inhale through The problem is that most people the lungs. But the decision to turn either. “I don’t think we know
your mouth for them, as the who develop a cough with patients onto their fronts is made completely, but it’s unlikely to cause
doctor in the video does. covid-19 have a dry cough, says only after considering a range of any extra benefit over going for a
Sucking in a big gulp of air Swingwood. For those people, big factors, and doctors monitor how good old walk,” says Swingwood. ❚
can irritate an existing dry cough. coughs are unlikely to be helpful. they respond to the new position. Jessica Hamzelou
Vibrating clothes
evoke the feeling
Volcanic eruption caused
of wearing a cloud by torrential rain
Alice Klein Michael Marshall
WE ARE getting closer to collaboration has observed hints Federico Sanchez and his Over the past decade, hints of
understanding why the universe that CP violation in neutrinos may team at T2K examined about a CP violation in T2K data have been
is made of matter and not be able to make up the difference decade’s worth of data on muon slowly building. “The picture that’s
antimatter. It may be all down (Nature, doi.org/ggr7dw). neutrinos and antineutrinos in this paper has been emerging
to how neutrinos change flavour. There are three flavours of changing flavour, looking for gradually,” says Edward Blucher
Our leading theories tell us neutrino: electron, muon and tau. differences between the at the University of Chicago.
that in the moments after the big As they travel, they can switch, oscillations of the neutrino and “This has been like a photographic
bang, there was an equal amount or oscillate, between flavours. antineutrino beams. The results image that’s been getting sharper
of matter and antimatter. The two The T2K experiment in Japan come close to ruling out total CP and sharper over the last decade.”
annihilate when they meet, which measures those oscillations by symmetry, instead implying that We aren’t yet certain that
means the universe should contain shooting beams of neutrinos there is significant CP violation. neutrino oscillations violate
energy and no matter. Somehow, or antineutrinos 295 kilometres CP symmetry, though. “The most
a significant chunk of matter through the ground and When matter and probable solution is maximal
avoided this fate, and ultimately measuring which flavours are there antimatter meet, CP violation, but we haven’t
turned into stars, planets and at the start and end of the journey. they annihilate disproved all possible ways to get
people. Why this happened is no CP violation,” says Sanchez.
a long-standing mystery. Even if the oscillations do
But there are clues. Theory tells produce the maximum possible
us that for each type of matter amount of CP violation, that
particle there is an antimatter may not be enough to fully
particle that is an exact match explain the imbalance between
apart from having an opposite matter and antimatter.
electrical charge, a concept called “Studying the universe is like
CP symmetry. For matter to have building a building, so you have
survived the early universe, there to understand and measure every
must be other differences between brick,” says Sanchez. “If, in the
MEHAU KULYK/SCIENCE PHOTO LIBRARY
Archaeology
AI can tell who’s years ago. But dog faeces, which Dog faeces often contain looks at all the DNA in a coprolite,
are a similar size and shape, are also human DNA, thanks to dogs’ including that of the microbes living
responsible for common at many archaeological taste for tucking into the turds in the gut, which vary from species
ancient faeces sites. “It is challenging to tell them of other animals, including to species. His team trained a
apart,” says Maxime Borry at the those of humans. On the flip machine learning system dubbed
DOG faeces can still be troublesome Max Planck Institute for the Science side, ancient human faeces often coproID using existing data on
thousands of years after being of Human History in Jena, Germany. contain dog DNA, because eating human and canine microbiomes.
dumped, confusing archaeologists if So his team has developed a dogs was once commonplace in When tested on seven soil
they are mistaken for human waste. method of identifying the source many communities. samples and 13 coprolites, the
Now an artificial intelligence system of ancient stools by sequencing the Because of this, Borry’s method AI was able to name the origin
has been created to discern the two. DNA preserved inside them. You of seven of the faeces samples,
Ancient faeces, or coprolites, can might think that looking for human “Coprolites can tell us and didn’t falsely assign any of the
be a valuable source of information or dog DNA would be enough to about the identity, diet and soil specimens to humans or dogs
about the identity, diet and health reveal the identity of the dumper, health of people who lived (PeerJ, doi.org/dr8x). ❚
of people who lived thousands of but it isn’t that simple. thousands of years ago” Michael Le Page
Interstellar comet
Borisov came from
We’re more negative after
a cold home star five nights of less sleep
Leah Crane Jessica Hamzelou
NICKEL sulphide can transform These chemicals are found in the the connections to carbon fixation The issue is that carbon dioxide
simple chemicals into many of metabolic processes used by all chemistry, which I think is a is fairly unreactive, so minerals
the substances that underpin life. microorganisms, says Huber. good thing to think about,” says like nickel sulphide don’t give
The finding is one of several recent It doesn’t stop there. “Our Joseph Moran at the University enough of a chemical push to
studies indicating that metals can products undergo further of Strasbourg in France. convert it into other substances.
kick-start life-like processes. reactions in the same system”, However, Moran isn’t convinced Huber’s team avoided this
Modern organisms such as mimicking those that take place in that acetylene and carbon problem by replacing carbon
plants convert carbon dioxide into living cells, says Huber. She thinks monoxide are the most likely dioxide with the more reactive
sugars by carrying out intricate that the kind of carbon fixing starting points. “Everyone agrees acetylene and carbon monoxide.
cycles of chemical reactions. reactions we see in plants and carbon dioxide would be present However, in his own research
These reactions are controlled bacteria today could have evolved on the early Earth and we know Moran has used carbon dioxide,
by molecules called enzymes, from these systems. that’s how life gets its carbon mixing it with more potent
which are too complicated to In a 2016 study, Huber’s team today, so that would be the ideal drivers. “In our work we use
have existed when life started. showed that the same mix of feedstock,” he says. metallic iron,” he says. “It’s 80 per
So Claudia Huber at the Technical chemicals can produce fatty lipids, cent of the core of the Earth, and
University of Munich in Germany which could have formed the Nickel sulphide may it’s in meteorites.”
and her colleagues have been outer membranes of the first cells. have helped early life In a series of recent papers,
studying whether other, “They’ve been thinking about get the carbon it needed Moran’s team has shown that
simpler chemicals can make iron converts carbon dioxide
the reactions work. into the chemicals found in many
The researchers began with metabolic processes, and those
two carbon-based chemicals: chemicals then start up simple
carbon monoxide and acetylene. versions of these processes,
Both are thought to have been without the need for enzymes.
present when Earth was young. Huber says Moran and his
They mixed them with nickel colleagues are doing valuable
IAN WALDIE/BLOOMBERG VIA GETTY IMAGES
Technology
The US Army has calls it the largest, fastest and most bunker-busting bombs and adapted the same material when cast or
precise steel printer ever made, it to the printing method, which forged, thanks to its microstructure.
a 3D printer for big enough to print entire parts for lays down layers of powdered A prototype printer is due to be
ultra-strong steel military vehicles, such as hatches. metal and fuses them with a laser. fully operational in the next few
The US Army also had to develop “We weren’t sure if you could months. If it is successful, steel
A GIANT, high-speed 3D printer a new kind of 3D-printing “ink”, print with it,” says McWilliams. parts could be routinely printed
is producing large, ultra-strong or feedstock. “Our big limitation “We did not know if we would get within two to three years, says
steel components and weapons was the feedstock material,” the same properties. In fact, we got McWilliams. Such printers could
for the US Army. It may also have says Brandon McWilliams at the better.” The 3D-printed alloy turned also produce instant spares near
non-military uses. US Army Research Laboratory, out to be 50 per cent stronger than the front line.
The prototype printer, Maryland. “We needed to be able to Being able to print parts on
commissioned from 3D Systems print something with high strength “The 3D-printed steel alloy demand will make it easier to repair
in South Carolina for $15 million, for armoured or ruggedised parts.” is 50 per cent stronger old or obsolete kit, says Connor
can create objects up to a volume His team took a nickel-alloy steel than the same material Myant at Imperial College London. ❚
of 1 by 1 by 0.6 metres. The firm called AF96 that was developed for when cast or forged” David Hambling
after they returned to Earth. All These pull blood back towards the
the astronauts had increased brain feet and could include a human-
volume – including white matter, sized centrifuge that would spin a
grey matter and cerebrospinal person around at high speed, or a
fluid – after returning from space vacuum chamber around the lower
(Radiology, doi.org/dr7h). half of the body. Layal Liverpool
This makes it hard to scale up. the bats to imitate their own calls
Quantum chips “It works for two qubits, but not for Bats copy calls in mini by bribing them with mashed
heat up – a tiny bit a million,” says Menno Veldhorst recording studios banana if they repeated the sound.
at QuTech in the Netherlands. The researchers recorded the
FOR the first time, quantum Veldhorst and his colleagues, BATS can learn to mimic specific bats’ calls, then manipulated the
computer chips have been along with another team led by sounds, which puts them into recordings to lower the frequency.
operated at a temperature above researchers at the University of an elite group of animals. They then repeatedly exposed
-272°C, or 1 kelvin. That may still New South Wales (UNSW) in Ella Lattenkamp at the the bats to different sounds,
seem frigid, but it is just warm Australia, have now demonstrated Max Planck Institute for rewarding the animals whenever
enough to potentially enable a that these qubits can be operated Psycholinguistics in Nijmegen, the they imitated one correctly.
huge leap in their capabilities. at higher temperatures. Netherlands, and her colleagues Within 30 days, all six bats had
Quantum computers are made The UNSW team was able to put six adult pale spear-nosed learned to lower the frequency of
of quantum bits, or qubits, which control the state of two qubits bats in mini recording studios their calls to mimic the recordings
can be built in several ways. One on a chip at temperatures up to equipped with microphones, (Biology Letters, doi.org/ggr7gn).
that is receiving attention from 1.5 kelvin, and Veldhorst’s group speakers and remote-controlled The ability to imitate sounds,
some of the big players consists used two qubits at 1.1 kelvin in feeding devices. They then trained called vocal production learning,
of electrons on a silicon chip. what is called a logic gate, which is rare. Humans can do it, as can
These systems usually function performs the basic operations some birds, as well as elephants,
only below 100 millikelvin, that make up more complex seals, dolphins and whales.
LUTZ WIEGREBE/LUDWIG-MAXIMILIANS-UNIVERSITAT
control. But now researchers at including age, wrinkles, hair One of the AIs the researchers
Adobe have devised AI-controlled colour, hairline, head angle and used was BigGAN, a DeepMind
software that lets you transform facial expression (arxiv.org/ algorithm that has been trained
the objects in images, and adjust abs/2004.02546). on thousands of images
the lighting and perspective, Erik Härkönen at Adobe associated with particular objects
Megadrought due with a few simple controls. Research in Finland and his or animals, such as tools or birds.
to climate change Given a photo of a car, you colleagues built the program The researchers say the work
can use several control sliders using existing algorithms called shows how to create images with
Climate change caused by in the program to adjust its shape generative adversarial networks existing AIs, without needing to
humans turned a moderate and style, background, lighting (GANs). GANs are comprised of train new algorithms. Donna Lu
drought in the US and
Mexico into one of the Microbiome Solar system
driest periods in more
than a millennium. The
drop in rainfall in recent Space rock may have
decades due to climate broken its neck
change may have made
the drought as much as WE NOW have not one but two
47 per cent more severe explanations for how the Kuiper
(Science, doi.org/dr9b). belt object Arrokoth was able to
keep its curious two-lobed shape
Star’s orbit creates despite being hit by a large rock.
spirograph in space A large portion of Arrokoth’s
smaller 15-kilometre-wide lobe
Astronomers have used is taken up by the Maryland
DEEPOL BY PLAINPICTURE
Comment
Dreamy mathematics
Srinivisa Ramanujan’s mathematics seemed to come from a parallel universe
and we are still trying to understand it today, say Ken Ono and Robert Schneider
S
RINIVASA RAMANUJAN received the news that Ramanujan
was a mathematician like had died.
no other. He had almost In the century since
no formal training yet produced Ramanujan’s final letter to Hardy,
some of the most stunning mathematicians have stretched
mathematical results of all time. their collective mind to
This month marks the 100th understand the underlying
anniversary of Ramanujan’s death. theories he didn’t write down.
Yet his extraordinary ideas and In probing the consequences of
remarkable life story are still Ramanujan’s work, Jean-Pierre
highly influential in mathematics, Serre and Pierre Deligne
including in inspiring both of us discovered Galois representations,
to pursue mathematical research. and the latter was awarded a
Ramanujan was born in 1887 Fields medal – a sort of maths
and became obsessed with Nobel prize.
mathematics as a teen. He spent Work in this direction sparked
so much time making original a chain reaction of advances in
discoveries in mathematics that 20th-century mathematics,
he flunked out of college – twice! culminating in the 1995 proof by
In 1913, he sent a now-legendary Andrew Wiles and Richard Taylor
letter to G. H. Hardy, a of the almost 400-year-old
mathematician at the University conjecture known as Fermat’s
of Cambridge. In pages upon pages last theorem.
of dense formulae, Ramanujan The sphere of Ramanujan’s
seemed to report from a parallel influence continues to expand:
universe. He later said he saw the modern fields building on his
equations in his dreams. place in the spheres of art, music, fellow of the Royal Society, in 1918. formulae range from signal
The formulae lacked literature and civil rights. Ramanujan returned to India processing to black hole physics.
explanations. Some were well Over the next five years, in 1919 a national hero, but he It is only in the 21st century that
known, yet presented as original Ramanujan and Hardy was in failing health, diagnosed his mock theta functions have
results; some claims were would introduce a host of with tuberculosis, which is come to be understood and appear
impossible but displayed a wildly groundbreaking ideas in the field now believed to have been a to describe stringy black holes.
creative flair; and some formulae of number theory. From advances misdiagnosis. Reunited with his Contemporary mathematicians
were so breathtaking that Hardy in our knowledge of partitions – family and wife, the 32-year-old are still fleshing out the details
wrote: “They must be true ways to split up numbers, which is number theorist made his most of the theories in Ramanujan’s
because, if they were not true, surprisingly complicated – to the profound discovery, even as his dreams. ❚
no one would have had the powerful circle method that is health worsened.
imagination to invent them.” now a ubiquitous tool for In a letter to Hardy dated
Hardy was beyond intrigued, mathematicians and physicists, 12 January 1920, Ramanujan
and invited Ramanujan to join the pair’s results sent shock waves sketched details of an enigmatic,
him in Cambridge. through mathematics. previously undreamed-of theory
When Ramanujan arrived in the For his advances, Ramanujan of “mock theta functions” – Ken Ono is at the University of
JOSIE FORD
UK, Europe was at the edge of war, became the first mathematician strangely symmetric equations. Virginia and Robert Schneider
and seismic shifts were taking from India to be elected a Before Hardy could reply, he is at the University of Georgia
I
DON’T know about you, eternity in comparison. at least 100 million years, the
but for me, every week of So perhaps cosmic inflation transition to this process will
2020 has felt extremely long, isn’t the best way to maintain begin with a helium flash that
especially since the coronavirus perspective on human timescales, will take place in just a
pandemic has gotten under way. but what about stellar astrophysics few minutes.
As I am not an essential worker, instead? Stars like our sun have We have been stuck in
I am currently spending most of lifetimes of about 10 billion years, lockdown for a lot longer than
my time at home. I try to focus on which is very close to the current this, of course, but at the very
my work on both science and the age of the universe. This scale is least we can say that we won’t be
Chanda Prescod-Weinstein philosophy of science, but then I difficult for humans to fully in social isolation for the time
is an assistant professor of inevitably check the news. Each comprehend. that it takes for the sun to start
physics and astronomy, and update seems to make the week Interesting things can making carbon!
a core faculty member in drag on for longer and longer. happen towards the end of stars’ The helium flash isn’t the
women’s studies at the The reel of bad news may feel lives. They initially shine because only stellar process that can take
University of New Hampshire. like it is never-ending, but one they are “burning” hydrogen – just minutes. When the sun finally
Her research in theoretical of the ways that I have tried to essentially an atomic reaction dies, it will leave behind a remnant
physics focuses on cosmology, keep things in perspective is by that fuses hydrogen atoms known as a white dwarf. This is
neutron stars and particles thinking about the different together to produce helium. a very dense object made of
beyond the standard model timescales on which things This releases energy, some of hydrogen, helium and carbon,
occur in the universe. and when white dwarfs are the by-
As an early universe cosmologist, “You’ve probably product of stars at least 10 times
I know, for example, that cosmic been trying to avoid more massive than the sun,
inflation happened in a fraction they contain a good amount
Chanda’s week people outside of
of a second. Cosmic inflation of of oxygen too.
What I’m reading space-time, the fabric of our your household for These white dwarfs can
I am rereading parts of universe, is one of the first things a couple of white experience instabilities that will
Helen Longino’s Science that ever happened. This was a dwarf pulsations” be familiar to people who have
As Social Knowledge: period in which space-time, like been to the beach: just as an
Values and objectivity the number of cases of covid-19 which we observe as photons, ocean’s waves are partly the result
in scientific inquiry. in many areas when it first got off particles of light. of gravity, white dwarfs experience
the ground, grew exponentially. In the case of the sun, this waves caused by gravity in their
What I’m watching The more space-time there was, process has roughly another interiors. Such waves then cause
My friends and I are the more space-time grew. 5 billion years left to go. If you, pulsations in the brightness of the
holding Zoom parties The rate of space-time like me, have been socially white dwarfs, and these can be
to watch a reality show expansion during inflation was isolating for around five weeks, around two weeks long.
called The Bachelor so quick that it grew faster than this means that the sun still has So one way to think about
Presents: Listen to the speed of light. This might be about 50 billion of your lockdown how long you have spent in
your heart. surprising to hear because we are periods so far left before it physical isolation is to compare
all so used to the idea that nothing reaches the end of its life. it with this phenomenon: so far,
What I’m working on goes faster than the speed of light. Eventually, the sun will start you have probably been trying to
I have been spending a lot This is the case for things that fusing helium into carbon. This avoid contact with people outside
of time learning about the live inside space-time, such as process will begin in our sun your household for only a couple
controversy concerning people, planets and spaceships, when it has about 100 million of white dwarf pulsations.
the unexplained surplus but there is no such limit on years of life left, which is about a It may not be your first
of gamma radiation at the space-time itself. billion times as long as the period instinct to use these references,
centre of the Milky Way. We currently believe that that we have been in isolation for of course. But if you are losing
inflation lasted from around so far. These processes certainly your sense of time or feel as
10-36 to 10-33 seconds after the big put our wait into perspective. though this outbreak is messing
bang. Not only did space-time Yet such prolonged timescales up your natural biorhythms,
grow faster than the speed of aren’t the only ones that are it may help to try and reframe
This column appears light, but this period of expansion relevant to stellar evolution. the timescales involved in terms
monthly. Up next week: was extremely short. A week of Although helium to carbon of cosmic phenomena. It is
Graham Lawton this outbreak is essentially an conversion will continue for helping me, anyway. ❚
Editor’s pick
A down-to-earth way to
boost the immune system?
28 March, p 44
From Liz Berry,
Lydbrook, Gloucestershire, UK
I was fascinated to read Graham
Lawton’s article on improving our
immune system’s fitness. I have
always had a peculiar immune
reaction to pathogens, having never
really been very ill with anything.
Recently, I have started to
consider whether this was due
to my habit of eating earthworms
when I was 4 years old. I distinctly
remember how crunchy they were,
presumably due to the soil passing
through their guts.
I wonder whether exposure to
the microbial life in the soil, which
probably included mycobacteria,
affected my immune system.
Needless to say, my mother wasn’t
pleased with my behaviour.
Difficult or not, wildlife careless about our planet and have mentioned whether it is
climate change, we have failed worth investigating the protective
markets must stay shut
to show enough interest in our effects of applying any of the
When the crisis is over, Letters, 4 April healthcare systems in this age numerous veterinary vaccines
beware the blame game From Evan Bayton, of globalisation. Governments against other coronavirus diseases
28 March, p 23 Moore, Cheshire, UK and social bodies should take the to people.
From Erik Foxcroft, Alistair Litt has a point about the correct decisions for sustainable We now require very substantial
St Albans, Hertfordshire, UK difficulty of banning wild animal development in the same way quantities of vaccine as soon as
David Adam is right to point markets of the sort initially linked as they are making the right possible in order for them to be
out the difference between to the outbreak of covid-19 in choices for health systems effective at the population level.
“the science” of the coronavirus China. However, we should still amid the pandemic. If any of these veterinary products
outbreak and the response of try to end them, as such markets can be effectively adapted, we
the UK government to it. are doing damage in many parts might be able to greatly reduce
Tricky medical choices
Politicians are stressing that of the world. the vaccine deployment time,
their policies are built on the The coronavirus is just the and the race for a vaccine compared with developing one
advice of experts, even when so latest instance of diseases that 4 April, p 12 from scratch.
much about the coronavirus is still jump from animals to us. The From Barry Cash, Bristol, UK
uncertain or unknown, in order to SARS outbreak in the early 2000s Alice Klein reports on the tough
A better way to define
give people more confidence in is another example of this, and medical choices regarding who
government measures. However, also had serious consequences. will get put on ventilators in what constitutes life
the danger is that this could set The threat from potentially deadly health systems overwhelmed Letters, 4 April
those experts up as scapegoats zoonotic diseases is so dangerous by the coronavirus. From Hillary Shaw,
should these steps ultimately that it must be addressed, whatever Yet coverage of this failed to Newport, Shropshire, UK
prove ineffective. the difficulties. mention one special category: Readers such as Bryn Glover
I hope that the UK and the the rich and famous. Would discuss how we should define
rest of the world emerges from the UK’s monarch be denied a life. Could we do so by considering
It is time to redefine our
this epidemic with as few people ventilator because of her age? what it does? Life exists in
dead and seriously debilitated priorities in other ways bounded systems and it locally
as possible. But if it doesn’t, I 4 April, p 10 From Thomas Holland, “reverses” the Second Law of
foresee that some people will From Rajib Saha, Raiganj, India Harrogate, North Yorkshire, UK Thermodynamics by creating
try to blame “experts” and “the Your coverage of the Your articles on the possible order, or lowering entropy.
science” for political failures, environmental effects of prevention or treatment of Within set bounds, living things
echoing reactions we have seen covid-19 lockdowns is timely infection in the covid-19 pandemic decrease entropy by consuming
far too often in recent times. and interesting. Just as we are have been interesting, but none energy, which preserves the
Gege Li
Book
Alien Oceans: The search for
life in the depths of space
Kevin Hand
Princeton University Press
Origin of words
There are fun tales behind where science
terms come from, says David Silverberg
in the first place – or it may have the stories behind how they Watch
just not happened yet. came to be. Biohackers has medical
More generally, is “our kind of Podcast Another head-turning student Mia getting far
life” the only kind of life there is, Science Diction episode takes on the word more than she bargained
or might there be others? WNYC Studios “vaccine”, which was coined for when she tries to
Saturn’s moon Titan has a by British physician Edward get close to a professor
water-ice surface carved and THE word “meme” wasn’t Jenner in the 18th century. she suspects had a
shaped by falling and flowing created to describe things that The story begins with Jenner hand in a family tragedy.
liquid methane. Beneath that icy spread all over the internet. testing the idea that physicians This German thriller is
shell, there probably resides a deep Rather, evolutionary biologist could use cowpox to prevent streaming on Netflix
ocean of liquid water, which could Richard Dawkins coined the the related, but deadly, disease from 30 April.
host life as we know it. But any life term when he was hunting for smallpox. In 1796, he gave
discovered in the liquid methane an idea-focused counterpart cowpox to an 8-year-old boy,
lakes on Titan’s surface would to the concept of a gene. then exposed him to a sample
have a biochemistry completely If animals and plants create of smallpox, itself a violation
different from ours. copies of genes every time they of “about 1000 ethical rules,
We used to think that life could reproduce, what happens when but it went down in history as
only exist in a “Goldilocks zone” cultural phenomena replicate the first official scientifically
dictated by distance from the sun. themselves over and over? documented vaccination”,
Too close, and life would fry; too Dawkins invented a word for says Mayer.
far, and it would freeze. Hand leads this by riffing off the Greek The boy never contracted Read
the reader through today’s more word mimema, which means smallpox, even after Jenner Together: Loneliness,
complex picture, where liquid imitated, and blended it with exposed him to the disease health and what
water is surprisingly common “gene” to create meme. dozens of times. happens when we find
but other limiting factors pertain. This etymological lesson Jenner wrote up his findings connection (Profile)
For example, a lack of rocky comes courtesy of Science in a book called An Inquiry Into sees former US
mantle, or a seabed pressure so Diction, a podcast launched in the Causes and Effects of the surgeon-general Vivek
high that the water there turns March by the New York-based Variola Vaccinae. In Latin, Murthy explore the
to unfamiliar forms of heavy ice, WNYC Studios and the team variola means pustules, and devastating health
could leave an ocean without the behind its main science podcast vacca means something that consequences of social
minerals necessary for life. Or if Science Friday. comes from a cow. isolation and how we
a moon has too circular an orbit, Hosted by Johanna Mayer, So variola vaccine basically can address them.
it won’t provide tidal heating the podcast comes in short refers to cow pustules or
sufficient to keep water on its sharp bites that rarely stretch cowpox, according to Mayer.
surface in a liquid state. beyond 15 minutes, with each Engaging and breezy
In a book that is likely to prove unveiling the origin of science narration, ornamented with
one of the year’s most enthralling words and phrases by telling light sound design, keeps
first-person accounts of a life Science Diction moving at
in science, Hand maps the likely a brisk pace. The words and
limits on life and liveability. phrases being examined will
Equally, he is out to excite us with be familiar to most listeners
the possibilities. Imagine vast and some of the stories will be Listen
FROM TOP: NETFLIX; PROFILE BOOKS; INTEL TECHNIQUES
carbonate chimneys, kilometres too. But having them brought The Privacy, Security,
high, rising above Enceladus’s sea together in a podcast is a more & OSINT Show gives
floor like geological skyscrapers! than pleasant way to spend a a glimpse of daily threats
Imagine geothermally active quarter of an hour. ❚ we don’t notice. In this
rogue planets transporting fish, podcast, Michael Bazzell
squid and octopuses from star to David Silverberg is a freelance uses social media and
star! “Perhaps one is even on its writer based in Canada credit reports to learn
way toward us now,” says Hand. ❚ crucial details about a
One episode of Science Diction person, and tells how to
ROSE WONG
Simon Ings is a freelance culture writer delves into the 18th-century avoid it happening to you.
based in London origins of the word “vaccine”
In Resident Evil 3,
a fictional virus turns
people into zombies
Causing
trouble
The language of science can’t distinguish
between cause and effect. Solving this
problem could put research on firm
foundations, reports Ciarán Gilligan-Lee
I
N THE mid-1990s, an algorithm trained the essential tool to resolve this fatal flaw.
on hospital admission data made a A mantra most scientists can recite in
surprising prediction. It said that people their sleep is that correlation doesn’t imply
who presented with pneumonia were more causation. A simple example illustrates why.
likely to survive if they also had asthma. Data from seaside towns tells us that the more
This flew in the face of all medical knowledge, ice creams are sold on a day, the more bathers
which said that asthmatic patients were are attacked by sharks. Does this mean that ice
at increased risk from the disease. Yet the cream vendors should be shut down in the
data gathered from multiple hospitals interests of public safety? Probably not. A more
was indisputable: if you had asthma, your sensible conclusion is that the two trends
chances were better. What was going on? are likely to be consequences of an underlying
It turned out that the algorithm had missed third factor: more people on the beach. In
a crucial piece of the puzzle. Doctors treating that case, the rise in ice cream sales and shark
pneumonia patients with asthma were passing attacks would both be caused by the rise in
them straight to the intensive care unit, beachgoers, but only correlated to each other.
where the aggressive treatment significantly
reduced their risk of dying from pneumonia.
It was a case of cause and effect being What’s going on?
hopelessly entangled. Fortunately, no changes This analysis seems simple enough. The
were rolled out on the basis of the algorithm. trouble is that the data alone can’t point us
Unweaving the true connection between in the right direction. We need some external
cause and effect is crucial for modern-day knowledge – in this case, that a surge in
science. It underpins everything from the people enjoying the beach on a hot day can
development of medication to the design of adequately explain both trends – to correctly
infrastructure and even our understanding of distinguish correlation from causation.
the laws of physics. But for well over a century, As the data at hand gets more complicated
scientists have lacked the tools to get it right. and less familiar, however, our ability to
Not only has the difference between cause and distinguish between the two falls short.
effect often been impossible to work out from These subtleties were lost on some of
data alone, but we have struggled to reliably the early pioneers of statistics. One notable
distinguish causal links from coincidence. offender was Karl Pearson, an English
Now, mathematical work could fix that for mathematician and prominent eugenicist
good, giving science the causal language that of the early 1900s. Pearson believed the
MICHAEL HADDAD
it desperately needs. This has far-ranging mathematics of correlation was the true
applications in our data-rich age, from drug grammar of science, with causation being
discovery to medical diagnosis, and may be only a special case of correlation, rather than
we care about, we can look only at parts of act as a signature of the underlying causal
the data where the other factors are constant. process, allowing Pearl’s tools to be deployed.
But for each confounding variable we control To put this principle to the test, he and his
for, the corresponding data set gets smaller. colleagues dived into a complex sociological
Eventually, we are left with so little data that question: the true causes of a country’s total
no robust conclusions can be drawn at all. fertility rate. These rates vary dramatically
To overcome these difficulties, Susan Athey around the world, and understanding the
at Stanford University in California and her factors determining them could be a boon
colleagues have developed techniques to for governments seeking to support their
approximate Pearl’s methods while still Shark attacks may rise along populations. By looking for consistent patterns
holding on to as much data as possible. They with seaside ice cream sales, in data from multiple countries, Peters and his
aren’t alone. Tools of this kind are also having but are the two trends linked? colleagues found that mortality rates of young
a big impact in healthcare, an area where children were important drivers of fertility
understanding cause and effect can be rates, a finding that tallied with previous
life-saving. Knowing that a disease is highly To quantitatively compute the effect studies from around the world. “When child
correlated with certain symptoms, or that of treating someone’s symptoms with a mortality is high, families tend to have more
a drug is highly correlated with recovery, certain drug, we need to know that a causal children, even if none of their own children
isn’t enough, and basing medical decisions relationship between that drug and those have died,” says Adrian Raftery, a sociologist
on such information can be dangerous. symptoms exists. The standard approach to and statistician at the University of
Saria is using causal inference to create this is to find out from experts on the subject. Washington in Seattle. “This may be proactive,
tools to help doctors make decisions by But getting this causal knowledge from to try to make sure that they do have a family.”
comparing the effect of different medical experts can be difficult and takes time, Bareinboim is very excited about the
actions. However, working with medical data says Radinsky. The approach she and her group’s ability to obtain causal insights from
comes with challenges. “We may be reflecting collaborators have taken to streamline observational data alone. “When that work
back biases that are not the true underlying this process is to mine causal relationships came along, it was amazing,” he says. Peters
phenomena in nature,” she says. For example, from medical papers that actually verified and his collaborators are now using the
unequal access to treatment means that their existence through experiments. By invariance principle to paint a causal picture
the US spends less money caring for black applying this causal knowledge to drug of biosphere and atmosphere interactions,
patients than for white patients. Some repurposing – using existing medicines with potentially dramatic consequences
algorithms conclude from such data that in new ways – they have already found new for our understanding of climate change.
black patients are healthier than equally treatments for hypertension and diabetes. But like Pearson’s statistical analysis over
sick white patients, which is patently false. a century ago, it isn’t a silver bullet. To truly
For Kira Radinsky at the Technion-Israel disentangle cause, effect and correlation,
Institute of Technology, causal understanding Learning from the data scientists will always need extra contextual
is key to a more equitable health system. This is a fruitful and powerful approach, information. Without knowing how
“If you don’t understand the causal processes, but not every field has a large collection of beachgoers behave, for instance, or how
you are susceptible to bias in the data,” she online research papers with proven causal doctors treat people with pneumonia if they
says. “As soon as you do understand them, links just waiting to be exploited. This has have asthma, no analysis in the world could
you can clean out the bias.” led researchers in other disciplines to correctly parse even the largest data set.
This highlights one problem that causal wonder if causal relationships could be “The problem is the data-generating process,”
inference can’t solve. Before Pearl’s techniques discovered from purely observational data. says Athey, “not the limits of our brains.” ❚
can be employed, the causal relationships need The age-old difficulty of distinguishing
to be known. Left to analyse shark attack and ice correlation from causation would seem
cream sales data, for example, they wouldn’t to rule this out. Yet a new generation of Ciarán Gilligan-Lee is a senior
be able to determine the connection between researchers bold enough to investigate researcher at University College
the two without knowing that an increase in the problem is starting to realise that it London and Babylon Health.
beachgoers could explain both trends. might not be as impossible as it sounds. Follow him @quantumciaran
B
Y JANUARY, when the world turned its a huge task that could take decades – even if reared from pups to be pets, to help with
attention to Australia’s bush-fire crisis, major fires don’t erupt again. hunting and to act as guards. On reaching
Murray Ings had been battling blazes However, amid efforts to restore Australia’s maturity, however, these “camp dingoes” are
near his home in the hills of northern New native fauna, one animal is expected to thought to have gone into the bush to breed.
South Wales for months. A third-generation continue dying. Dingoes, a type of semi-wild, This mutually beneficial relationship
forestry worker and volunteer firefighter, Ings primitive dog, are widely considered pests, the between people and predators ended abruptly
worked shifts of up to 16 hours, sometimes threat they pose to livestock trumping their with the mass arrival of European settlers in
through the night, in apocalyptic conditions. status as a native species. Yet there is mounting 1788. Dingoes were the most obvious threat
It got so hot, the sand in the soil melted to evidence that these apex predators play a key to their livestock, being one of just two large,
glass, causing the ground to shine. “That’s a role in maintaining ecological balance. They land carnivores in Australia. The other, the
furnace,” says Ings. But what he remembers might even be as central to restoring the bush thylacine, was confined to Tasmania by that
most vividly is the “haunting, piercing” as wolves have been in rewilding Yellowstone time and was eventually hunted to extinction,
screams of dying animals. “It’s the worst national park in the US. But for that to happen, as far as we know. “Dingoes were painted as a
sound you can ever hear,” he says. Australians will need to put an end to centuries villain quite early on,” says ecologist Thomas
With the fires now extinguished, parts of of bad blood with their native canid. Newsome at the University of Sydney. In the
the native forest on Ings’s property resemble It was thought that people brought the 1880s, a barrier known as the “dingo fence” was
a wasteland. “In areas, we’ve lost the whole lot: ancestors of the dingo to Australia from South- built along some 5600 kilometres to protect
all the trees, all the animals,” he says. That’s East Asia around 5000 years ago, although new the south-eastern corner of the continent.
just on his 500 hectares. Across south-east evidence hints at a different origin story (see It is still maintained today, at an annual cost
Australia, some 19 million hectares burned. “What is a dingo?”, page 38). Regardless of how of A$10 million (£5 million). As a pest control
The federal government has set out a multi- and when they arrived, dingoes were quickly effort, it is without parallel, says Newsome.
million-dollar restoration programme. It is integrated into Aboriginal communities, More recently, the dingo’s public image has
Every dog
has its day
Conserving Australia’s dingo, a predator reviled for
centuries, could be key to restoring fire-ravaged flora
and fauna, finds Elle Hunt
lots of politics, history,” he says. “It’s deeply wolves to continental Europe. Australia has government and industry effort, funded by
intertwined.” never come close. meat, wool and livestock bodies – has led the
Attitudes towards the dingo are certainly Across Australia, the killing of dingoes is response, in coordination with state and
mixed. The vast majority of Australians, living permitted – and in some states mandated territory-specific strategies. The plan estimates
on a sliver of highly urbanised coastline, under pest control laws – in the name of that wild dogs cost the agricultural sector
may have romantic notions of it as an iconic exterminating “wild dogs” that roam the A$89 million annually. Its coordinator,
national species. But in rural communities, bush, preying on livestock and native animals. Greg Mifsud, describes the dingo as “simply
anti-dingo sentiment still runs deep. In legislation, the term wild dogs is applied a wild-living dog, a predator that attacks, >
maims and kills”. However, he adds, the plan
acknowledges the environmental and cultural
Maintaining
mental health in the
time of coronavirus
From social isolation to working on the front line,
covid-19 is posing serious challenges to mental health.
Moya Sarner asks the experts how we can protect ourselves
A
FTER weeks of complete social isolation, enduring disruption in their routine and
Italy has undergone what psychiatrist having to distance themselves from friends and
Paolo Brambilla calls “a social families. They may also suffer the losses of loved
experiment that has never been done before”. ones. It is important to consider the longer-
The country has suffered a massive death toll term implications of this emergency for mental
from the coronavirus, and has endured one health.” In a survey published last week in The
of the strictest lockdowns in the world. The Lancet Psychiatry, people in the UK reported
effects on the nation’s psyche will be profound, increased anxiety, depression and stress, and
says Brambilla, who is at the University of Milan. concerns about isolation. These were larger
This month saw half of the world’s population worries than the prospect of having covid-19.
enter some form of confinement, and many Taking these psychological costs seriously
people are facing the biggest threat to their is critical, says Sandro Galea, a physician and
health and livelihood in recent history. epidemiologist at Boston University in the US.
“We are seeing the spread of a virus, but “The mental health impact is the next wave of
we have also, from the very beginning, been this event, and I am worried that we’re not
seeing the spread of fear as well,” says Aiysha talking about it enough,” he says. “These issues
Malik, a psychologist at the World Health are very real.” It isn’t too soon to start to tackle
Organization. As well as having to wrap our the fallout, says Malik. “Countries need to
heads around the threat of the virus itself, prepare for how they’re going to address
public and personal life has changed beyond mental health and psychosocial support, now.”
recognition. The actions we have had to take to How do we do that? In many respects, the
curb the spread of disease have left some of us situation is unprecedented, so we are dealing
struggling to cope with a lack of childcare while with the unknown. But there are ways to begin
working, a loss of income, separation from to make sense of things. Results are coming in
family and friends, and serious health fears. from studies and reviews turned around at
For others, it has meant working on the front breakneck speed. We can also ground our
line, facing potentially traumatic experiences thinking in previous research on the
and making tough moral decisions. Whatever psychology of epidemics and quarantine, in
our situation, it’s time to look at what we can all the response to past events, including terrorist
do to limit the toll on our mental well-being. attacks and natural disasters, and in theories of
“People are facing a novel, threatening and trauma and resilience. On the following pages,
unpredictable experience,” says psychiatrist we ask those working in mental health to share
Andrea Danese at King’s College London. “At their understanding of the situation, and to
the same time, people are losing important offer their advice on how we can protect
coping strategies for stressful situations, ourselves and our loved ones. >
It is important to be honest
and acknowledge your
emotions, and it’s important
for parents to be open and
honest with their children.
What isn’t helpful is panic.
Be factual, explain what the
risk is, and what can be done
to reduce it. Be responsive –
answer questions when they’re
asked, and use words and more frightening,” she says. “This leaves
ideas that your children can parents in a state of perpetual anxiety, and that “Young adults in
understand. Parents are good
at this, because they have lots
means they have to dig really deep in order to
be able to manage their own anxiety, and in
the US reported
of practice. order to be able to manage their children’s.” much more
Added to this there is the impact of the
Andrea Danese, psychiatrist,
King’s College London lockdown, including the closure of schools frequent feelings
Allow the chaos for a bit
for most children, which leaves families
feeling untethered. “What is having a really
of loneliness
and then start to develop a important impact on every family’s mental than older
structure in the home, so that health is the complete change in structure,”
the children feel sane and safe, says Labuschagne. “Parents are now having to people”
and the parents feel sane and re-establish different sorts of routines – and
safe. Understand that this when you’re anxious about a risk you cannot
structure will be organic, see, and about being able to pay bills, that is a
which is a polite way of saying tall order.”
that it is likely to go tits up at Children and teenagers may be
some point. And go easy on disproportionately affected by ongoing events,
yourself: this pandemic is says Danese. There are several reasons for this.
unprecedented. The prime “Starting from biology, their brains are still
minister didn’t get this right developing, and they may be less able to control
straight away, and neither their emotional responses, whether to events
will we. they perceive as traumatic or to worrying
Nicola Labuschagne, clinical thoughts and uncertainty,” he says. “They may
psychologist, Anna Freud National struggle with the alarming and sometimes
Centre for Children and Families, conflicting messages on the news. And, even
London
more than the rest of us, they have had an
unprecedented disruption of their normal
experiences like education and socialising.”
Young people are also feeling the effects
MONEYSHARMA/AFP/GETTY IMAGES
There are several ways to help reduce
these risks and strengthen the resilience
of healthcare workers. “Evidence from both
military and non-military studies shows that
the way people treat their staff is absolutely
critical in determining whether they develop
mental health problems,” says Greenberg.
“Equally as important is whether staff seek
help early to try to rectify mental health
problems if they develop. It’s inevitable that
staff will feel stressed, because it is a difficult
situation – but we mustn’t let those early signs
“During a crisis teams. From events like the 2017 fire in
London’s Grenfell Tower that left 72 dead
of distress develop into moral injuries and front-line staff and the 2005 bombings in the city that killed
mental health disorders.” 52 people, we know that front-line staff don’t
Once problems have been identified, it is want to share, want in-depth psychological work during or
relatively easy for supervisors to step in, he
says. Actions might include altering someone’s
connect and immediately after a crisis, but “to share,
connect and make contact”, she says.
duties to give them some respite. Even just a
5-minute chat with a colleague can help after
make contact” Greenberg agrees that bonds between
team members is key. “Some are saying that
a difficult experience. Greenberg cites a study hospitals are at breaking point, that healthcare
by the Israeli military showing that the more workers face an impossible task. But with
such practices were applied when soldiers good leadership and good camaraderie – and
were having an acute stress reaction during the right equipment – you can come through
the 1982 Lebanon war, the better their mental situations that might be described as
health was 20 years later. “What we need is for impossible, and not only do a good job and
supervisors, managers and colleagues to be survive, but also experience something we call
looking out for each other,” he says. “We need post-traumatic growth. A feeling that you did
people to actively monitor those who are well despite the circumstances. That you feel
providing the front-line services.” proud to be a healthcare worker.” ❚
This kind of thinking ties up with that of
Lydia Hartland-Rowe, a psychotherapist at Need a listening ear? UK Samaritans: 116123
the Tavistock and Portman NHS Foundation (samaritans.org). Visit bit.ly/SuicideHelplines
Trust in London. She is helping to coordinate for hotlines and websites for other countries
a project to support the well-being and mental
health of 52,000 health and social care staff in
London during the coronavirus crisis. This Moya Sarner is a freelance
consists of online resources, brief and relevant writer based in London
podcasts, and email and telephone support for
managers so that they can better support their
Q2 / 2020
Value of Vaccines Read more in next week's New Scientist and online at www.healthawareness.co.uk
Laetitia Bigger
Director
Vaccines Policy, IFPMA
Page 48
© G AV I / 2 0 1 9/ I SA AC G R I B ER G
48 | Read more at healthawareness.co.uk MEDIAPLANET
NEXT WEEK’S
ISSUE
Beyond childhood:
“Vaccines are our best
weapons against pandemics” the case for
Thomas M. File (JR., M.D., MSC FIDSA)
President, Infectious Disease Society of America
life-course
@HealthawarenessUK @MediaplanetUK @MediaplanetUK Please recycle
immunisation Laetitia Bigger
The power of T
he global population to antibiotics becoming gradually
continues to age. In 2020, less effective against resistant
children under five years bacteria. It is critical to increase
will be outnumbered by the uptake and coverage of existing
immunity
course approach to immunisation
(LCI) promotes individual and Creating a healthy and
population health, and emphasises prosperous society
the prevention of disease. So, what The World Health Organization
exactly is a life-course approach (WHO) estimates the global
Unlike typical medicines, vaccines have the to immunisation? ‘The life-course yearly return on investments to
incredible superpower of protecting whole Dr Tonia Thomas approach to immunisation vaccination is 12-18%6. For every
communities rather than just the individual. Vaccine Knowledge recognises the role of immunisation €1 invested, the government gets
Project Manager,
as a strategy to prevent disease and back €4.02 of economic revenue.
This is vital for protecting vulnerable people Oxford Vaccine
Group maximise health over one’s entire A greater vaccine uptake contributes
in our communities, such as cancer patients. life, regardless of an individual’s to a positive impact on education,
age and includes all populations.’2 workforce productivity, and
Worldwide, vaccines save ultimately an increased GDP.
W
e are acutely aware of As well as protecting this 3% between two and three million Therefore, LCI reduces the burden
the devastating impact of people, vaccines protect those lives each year.3 Immunisation is on healthcare services, promotes
cancer can have on a who are temporarily vulnerable to considered one of the most effective healthy ageing and addresses
person and their family. infections, like babies who are too public health achievements of health risks like infectious diseases
But we often fail to relay that some young to be vaccinated, pregnant modern society. However, until and AMR, which impact the global
cancer treatments can severely women, and the elderly. recently, the target has only economy. LCI is thus recognised
weaken the immune system. While concerned children under five years a cost-effective intervention.8
many of us are forthcoming with The societal benefits of choosing of age, and little focus has been Harnessing the benefit of
fundraising and support campaigns to vaccinate given beyond infancy. As research LCI will require policy changes
for cancer patients, we must also As a society we must realise that has shown, pregnant women, and innovative approaches.
remember to donate the invaluable those of us who are healthy have adolescents, older adults, people A report from The Health Policy
power of community immunity. the privilege of choosing whether with certain chronic conditions, Partnership supported by IFPMA9
Community immunity (or ‘herd or not to be vaccinated, but at caregivers, healthcare professionals, showcases important lessons
immunity’) is achieved when a cost to those around us. By and vulnerable and marginalised from six countries who are in
enough people in the community choosing not to protect ourselves communities, face an increased risk different stages of implementing
are vaccinated against a disease, and our comwmunities, we are of contracting vaccine-preventable LCI. It identifies five key policy
rendering it unable to spread. For endangering the lives of those diseases and can greatly benefit areas which, if accomplished,
example, measles requires 95% of who are not fortunate enough from an LCI approach.4 While would lead to building healthier
people to be vaccinated to ensure to have this choice. this is recognised at global level, communities and nations with a
that it cannot spread if introduced progress within individual strong vaccination foundation – a
to the community. Sources: 1: Babady, N. (2016). Laboratory countries has been slow. foundation of primary healthcare.
In the UK, we are close to this Diagnosis of Infections in Cancer
for the first dose of the measles, Patients: Challenges and Opportunities. How can LCI benefit References: 1: (World Health Organization),
mumps and rubella (MMR) vaccine, Journal of Clinical Microbiology, 54(11), communities as a whole? 2: (IFPMA; Health Policy Partnership,
but, for the second dose, we have pp.2635-2646. 2: Files.digital.nhs.uk. Improving immunisation rates in 2019), 3: (Delany, Rappuoli, & Gregorio,
only reached a level of 86.4% (2018- (2019). Childhood Vaccination Coverage the community has the potential 2014), 4: (IFPMA; Health Policy
19). Now, the vulnerable people Statistics England, 2018-19. [online] to protect vaccinated individuals Partnership, 2019, p. 12), 5: Ibid p 4, 6, 9, 6:
in our communities are at risk. Available at: https://files.digital.nhs. and vulnerable populations, like (Andre, et al., 2008), 7: (Supporting Active
Accounting for approximately three children and immunocompromised Ageing Through Immunisation (SAATI)
uk/4C/09214C/child-vacc-stat-eng-2018-
people in every 100 among us, this individuals, who are at high risk Partnership, 2013), 8: (IFPMA; Health
19-report.pdf [Accessed 9 Feb. 2020]. 3:
includes those undergoing cancer of infections. Investing in an LCI Policy Partnership, 2019, p. 13), 9:
Varghese, L., Curran, D., Bunge, E., Vroling,
treatment, those with autoimmune approach on a health system level (IFPMA; Health Policy Partnership, 2019)
diseases such as Crohn’s, ulcerative H., van Kessel, F., Guignard, A., Casabona, can support universal health
colitis or rheumatoid arthritis, and G. and Olivieri, A. (2017). Contraindication coverage by reaching people who
those living with organ transplants of live vaccines in immunocompromised may not have access to primary
or HIV. These people are already patients: an estimate of the number of healthcare services by providing
struggling with life-long conditions, affected people in the USA and the UK. infrastructure. An important
and now they are also at risk of Public Health, 142, pp.46-49. feature and benefit of LCI is the
contracting measles and other indirect impact of some vaccines
infectious diseases. Worse still, on antimicrobial resistance (AMR).
these individuals are more likely Increased uptake of AMR-related
to develop complications, need vaccines throughout the life course,
hospital care, and are more likely Read more at as a complementary tool to mitigate Read more at
to die from infections. healthawareness.co.uk the threat of AMR, is essential due healthawareness.co.uk
MEDIAPLANET Read more at healthawareness.co.uk | 49
50 | Read more at healthawareness.co.uk MEDIAPLANET
© M A N I T C H A I D EE
Pneumonia: the
preventable health
crisis the world
has neglected
Every year, 800,000 children die of pneumonia, a
well-known but often-neglected disease. Though
Keith Klugman
effective treatment and preventive vaccines Director, Pneumonia,
exist, pneumonia remains the leading infectious Bill & Melinda Gates
affordable as generic
D
espite the high death
toll, bacterial pneumonia
G
eneric medicines – budget Making vaccines more health or development priorities.
versions of brand-name affordable for all Pneumococcal conjugate vaccines There are encouraging signs of
drugs – are often quite Since 2000, Gavi, the Vaccine have had major success in high- progress. Indonesia announced in
literally a lifesaver because Alliance, has been working to make income countries January that it would make PCV
they are affordable. Vaccines are vaccines accessible and affordable One particularly important tool part of its routine immunisation
just as critical, protecting against through innovative financing in the fight against pneumonia are programme and committed to
infectious diseases such measles mechanisms such as committing pneumococcal conjugate vaccines vaccinating four million children
and polio, yet we don’t have cheap to the purchase of a vaccine still in (PCV), which have reduced rates each year. Rolling PCVs out in a
generics for vaccines. development, thereby reassuring the of severe pneumonia by more than country like Indonesia, with a large
This is because the biological manufacturers that a market exists. half in the high-income countries population and a high burden of
nature of vaccines means the pro- However, newer vaccines can that have used them for nearly two pneumonia, is a major step forward.
cesses of manufacture, licensing be more complex – for example, decades. But, while this important
and regulation are vastly different pneumococcal conjugate vaccines, tool exists, many communities Pneumonia prevention must
to medicines, leading to high fixed which protect against diseases like in low- and middle-income be a priority
costs in development. pneumonia – and this can make countries still don’t have access Reducing deaths from pneumonia
Since a vaccine can be the them more costly. to the vaccines, leaving millions in the long-term will require putting
difference between life and death While funding programmes can of children without protection pneumonia at the top of the global
for billions of people, pushing for lower the costs for poorer countries against this deadly disease. agenda and keeping it there.
change in the factors that keep by subsidising the vaccines, ideally Thankfully, a new vaccine will High-burden countries must
vaccine prices high is crucial. the cost to produce the vaccines soon be on the market that will make protecting children from
would be lower in the first place. help reduce this disparity and make pneumonia through well-function-
Developing a vaccine never PCVs available to more children. ing primary healthcare systems
gets cheaper How to drive down vaccine costs The availability of this vaccine will a top priority.
So why can we have generic drugs Uncertainties about vaccine help alleviate one of the biggest Donor governments must
but not vaccines? Manufacturers demand can mean manufacturers barriers to sustainable access to continue to generously fund
of generic drugs and medicines increase prices to ensure they get a PCVs that countries face – price. organisations like Gavi to ensure
need to follow the same chemical return on their investment sooner A new pneumococcal vaccine countries have the support they
recipe as the brand-name version, rather than later. Introducing from the Serum Institute of India need to introduce PCVs and sustain
but they don’t necessarily need to greater certainty of demand can was recently approved for use by their use in every community.
test the generics on people to see therefore lower costs. the World Health Organization To create a world free of prevent-
whether they respond to them the Investing in ways of improving and is expected to be 30% cheaper able disease, we must ensure every
same way. biological standards and assays for low-income countries than child can access these life-saving
A vaccine, however, is consid- to speed up investigation or existing vaccines. vaccines – no matter where they live.
ered to be a new biological entity, proof-of-concept could lower
and must be tested on people, costs too, as could new platform Lower-priced vaccines REFERENCES:
which is costly and time-consum- technologies to accelerate R&D and With the support of organisations 1. Policy Cures Research. G-FINDER 2019:
ing. With vaccines, manufacturers better regulatory science for faster like Gavi, the Vaccine Alliance, Neglected Disease Research and Devel-
may have to repeat trials for any approvals. These shifts along the poor countries will be better placed opment: Uneven Progress, Jan 2020.
innovation they want to make, value chain of vaccine production than ever before to introduce https://s3-ap-southeast-2.amazonaws.
adding to costs. would ultimately help lead to these vaccines into their routine com/policy-cures-website-assets/app/
Along each step of production, cheaper vaccines for those who immunisation programmes. Gavi uploads/2020/01/30100951/G-Finder-
hundreds of quality control steps need them most. helps increase access to vaccines 2019-report.pdf
are needed, raising costs and in low-income countries and has
increasing timelines for produc- already supported 59 low-income
tion. All of this can send the cost Read more at countries to introduce PCVs, reach-
of vaccine production soaring. healthawareness.co.uk ing more than 183 million children.
The back pages
Puzzles Feedback Twisteddoodles Almost the last word The Q&A
A quick crossword, Reverse universe and for New Scientist Why do some people Madeleine Goumas
a Diffy squares puzzle isolation measures: A cartoonist’s take sneeze repeatedly? on the strange appeal
and the quiz p52 the week in weird p53 on the world p53 Readers respond p54 of gulls p56
ELENA SHASHKINA/ALAMY
The traditional method begins
with milk, but using condensed
What you need milk speeds up the process.
Can of condensed milk Condensed milk is milk in which
or about 60 per cent of the water
Milk has been evaporated, and sugar
Sugar has been added. Evaporated
milk is similar but unsweetened, Science of cooking online
so it won’t work for this. All projects are posted at
Remove the label and put the newscientist.com/cooking Email: cooking@newscientist.com
tin on its side in a large pot and
cover with water. Then simmer
it for 2 to 3 hours, depending on when sugar molecules break apart cooking time can achieve
how dark you like your caramel. and generate a range of other browning even at 100°C.
It is crucial the tin is submerged flavour compounds. This happens You can also make dulce de leche
the whole time because this only for sucrose – table sugar – at the more traditional way, with a
stops overheating causing a temperatures above 170°C. litre of milk and 250 grams of sugar,
pressure build-up and a potential Just as with caramelised onions, gently simmered on the stove. This
explosion. Liquid water won’t which I covered a few weeks ago, takes many hours but can be sped
exceed 100°C, so a submerged tin the chemical process here is the up with a teaspoon of bicarbonate
won’t get hotter than this either. Maillard reaction. This occurs of soda, which raises the pH,
When the time is up, use tongs when sugars react with amino accelerating the Maillard reaction.
to take the tin out of the water. acids, the components that make Even so, it may take 2 hours,
Make sure you let the tin cool up proteins, which are abundant and needs frequent stirring.
completely before opening it, or in milk. The products are a range Alternatively, try cajeta, a
else hot dulce de leche could shoot of flavoursome compounds. version made with goat’s milk,
out. The sweetened milk will have Maillard reactions happen which needs a mere 45 minutes or
turned into a thick brown paste at lower temperatures than so of simmering. Goat’s milk is
that you can spread on toast or caramelisation, but are quite lower in lactose than cow’s milk,
spoon on to fruit or ice cream. slow until you get to about 120°C. so it is less likely to burn, and has a
Next week Strictly speaking, the reaction In condensed milk, the high higher concentration of various
The science of responsible isn’t caramelisation. concentration of compounds amino acids, which confer thermal
the perfect stir-fry This term describes what happens for reactions and the prolonged stability and umami taste. ❚
Quick crossword #56 Set by Richard Smyth Quick quiz #48 Puzzle set by Rob Eastaway
0 0
2 In differential calculus, 9 1 1 8
velocity is the first derivative 0 0
6 5
of displacement with respect 1
to time, and acceleration the 12 9
second. What is the third?
Diffy is a subtraction game. You choose
3 Adipose tissue is an four whole numbers between 1 and 12
orotund way of describing and write them on the corners of a square.
which feature of our bodies? Then, you find the difference between
numbers at neighbouring corners and write
4 The bacterium Bordetella the answer at the midpoint (see above).
pertussis is responsible Join the midpoint numbers to form
for which respiratory a diamond, then repeat the process until
infection that is especially you end with four zeroes in a square
common in young children? (which always happens, eventually).
In the example, there are five squares,
ACROSS 5 In the northern climes but with the right starting numbers you
9 Furthest distance from molecules through a of Canada, where would can get more than five. Your challenge
which a sound may be membrane into a region you be if you had wandered is to find whole numbers between
heard (8,7) of greater concentration (7) into a muskeg? 1 and 12 that will do this.
10 Type of electric battery (3,4) 21 Duck, Somateria • You are a high achiever if you get more
12 Pertaining to mollissima (5) Answers below than six Diffy squares.
the open sea (7) 23 See 3 Down • You are a genius if you get 10 Diffy
13 Fruit of Ficus carica (6,3) 24 Instrument that squares.
15 Sense (5) measures current (7)
16 Mathematical notation, also 25 Online commentator (7) Cryptic Answer next week
known as Reverse Polish (7) 28 Selenographic location Crossword #29
18 Net movement of solute reference (5,10) Answers