% m

1 0 0 0.001
tiempo (h) S adj (g/L) P adj (g/L) C (g/L) SP adj (g/L) M (g/L)
0 140.0 0.00 1.0 0 0.0
12 118.0 1.36 1.8 19.83 0.0
24 108.5 4.90 4.2 23.35 0.1
36 99.8 9.44 6.8 24.74 0.2
48 92.5 13.08 10.0 24.98 0.5
60 85.9 16.73 11.8 25.90 0.7
72 78.6 21.42 13.8 26.14 1.0
84 73.4 24.53 14.4 27.47 1.2
96 67.0 26.71 15.9 29.85 1.5
108 60.8 30.59 17.7 29.99 1.9
120 55.9 32.55 18.3 32.13 2.2
132 49.0 34.18 19.9 35.26 2.6
144 41.8 38.72 21.3 36.10 3.1
156 36.1 41.29 23.7 36.26 3.7
168 32.0 42.78 25.5 36.48 4.3
180 27.3 44.37 27.4 37.00 4.9
192 21.3 46.32 29.1 38.74 5.6

S P C SP
140.00 0.00 1.00 0.00
116.90 1.38 1.79 19.83
107.54 5.00 4.15 23.35
102.00 9.68 6.78 24.74
92.36 13.56 9.96 24.98
88.81 17.44 11.76 25.90
81.38 22.42 13.84 26.14
75.25 25.74 14.39 27.47
64.26 28.24 15.91 29.85
61.00 32.50 17.71 29.99
55.87 34.74 18.26 32.13
49.00 36.81 19.93 35.26
41.00 41.79 21.31 36.10
37.78 44.98 23.66 36.26
34.89 47.06 25.46 36.48
30.68 49.30 27.40 37.00
25.19 51.90 29.06 38.74

tiempo (h) Yc/s Yp/s Ysp/s Ym/s Yc/s (prom)

 6 0.035909091 0.061750909 0.901363636 0.000976364 0.035909091
18 0.248421053 0.372829474 0.370526316 0.008223158 0.142165072
30 0.302298851 0.521324138 0.159770115 0.016606897 0.195542998
42 0.435616438 0.499452055 0.032876712 0.032054795 0.255561358
54 0.272727273 0.553406061 0.139393939 0.034472727 0.258994541
66 0.284931507 0.642345205 0.032876712 0.039846575 0.263317369
78 0.105769231 0.597638462 0.255769231 0.040823077 0.240810492
90 0.2375 0.340109375 0.372609375 0.04978125 0.24039668
102 0.290322581 0.625706452 0.021822581 0.062148387 0.245944003
114 0.111561866 0.397866126 0.434077079 0.056494929 0.232505789
126 0.243085881 0.237327511 0.455604076 0.063982533 0.233467615
138 0.191666667 0.63085 0.116666667 0.060816667 0.229984203
150 0.412280702 0.450470175 0.028070175 0.109178947 0.244007011
162 0.43902439 0.364312195 0.053658537 0.143004878 0.257936823
174 0.412765957 0.337293617 0.110638298 0.139302128 0.268258766
186 0.276666667 0.325413333 0.29 0.10792 0.26878426
 tiempo (h) S S adj Er Er -
0 140.0 140 0.0 0
12 116.9 118 1.1 0
24 107.5 108.5 1.0 0
36 102.0 99.8 -2.2 2.2
48 92.4 92.5 0.1 0
60 88.8 85.9 -2.9 2.91
72 81.4 78.6 -2.8 2.78
84 75.3 73.4 -1.9 1.85
96 64.3 67 2.7 0
108 61.0 60.8 -0.2 0.2
120 55.9 55.87 0.0 0
132 49.0 49 0.0 0
144 41.0 41.8 0.8 0
156 37.8 36.1 -1.7 1.68
168 34.9 32 -2.9 2.89
180 30.7 27.3 -3.4 3.38
192 25.2 21.3 -3.9 3.89

tiempo (h) P P adj Er Er -

0 0.0 0 0.0 0
12 1.4 1.376778 0.0 0.003222
24 5.0 4.98506 0.0 0.01494
36 9.7 9.643388 0.0 0.036612
48 13.6 13.488288 -0.1 0.071712
60 17.4 17.33416 -0.1 0.10584
72 22.4 22.270528 -0.1 0.149472
84 25.7 25.558686 -0.2 0.181314
96 28.2 28.006196 -0.2 0.229104
108 32.5 32.213098 -0.3 0.286902
120 34.7 34.41132 -0.3 0.32868
132 36.8 36.415386 -0.4 0.394614
144 41.8 41.329704 -0.5 0.460296
156 45.0 44.426356 -0.6 0.553644
168 47.1 46.418408 -0.6 0.641592
180 49.3 48.5602 -0.7 0.7398
192 51.9 51.063072 -0.8 0.836928

Yp/s (prom) Ysp/s (prom) Ym/s (prom) 1

0.9

f(x) = − 5.07127018285023E-07 x³ + 0.00018071957538 x² − 0.020237752841655 x

0.8 R² = 0.975124218083043
 1
0.061750909 0.901363636 0.000976364
0.217290191 0.635944976 0.004599761 0.9

0.31863484 0.477220022 0.008602139 f(x) = − 5.07127018285023E-07 x³ + 0.00018071957538 x² − 0.020237752841655 x

0.8 R² = 0.975124218083043
0.363839144 0.366134195 0.014465303
0.401752527 0.320786144 0.018466788 0.7
0.441851307 0.272801239 0.022030086
0.6
0.464106615 0.270368095 0.024714799
0.44860696 0.283148255 0.027848105 0.5
0.468284681 0.254112069 0.031659248 f(x) = 2.48486725064469E-07 x³ − 9.64606475304975E-05 x² + 0.01165942400942 x
0.461242826 0.27210857 0.034142816 0.4 R² = 0.981485994305275
0.440886888 0.288789979 0.036855517
0.3
0.456717147 0.27444637 0.03885228 f(x) = 2.47644060517756E-07 x³ − 8.12832661683555E-05 x² + 0.008057412896883
0.456236611 0.255494355 0.044262023 R² = 0.925198573361611
0.2
0.449670581 0.241077511 0.051315085
0.442178784 0.232381563 0.057180887 0.1
0.434880943 0.235982716 0.060352082 f(x) = 0.000313863275011 x − 0.000360670202976
0 R² = 0.988724850027133
0 20 40 60 80 100
 Er+ 140.0
0 f(x) = 0.253551601307189 x + 0.892623921568632
R² = 0.986827047061156
1.1 f(x) = 0.001276104374498 x² − 0.803337203302373 x + 130.824282765738
0.9567 R² = 0.991461439819066
120.0
0
0.14
0 f(x) = − 3.50950775068223E-11 x⁶ + 2.5188805139326E-08 x⁵ − 7.05554784152419E-06 x⁴ + 0.000964899454234 x³ − 0.065
100.0 + 0.658144770495777
0 R² = 0.991162930888978
0
2.74
0 80.0
f(x) = − 0.00015205753354 x² + 0.171776745786034 x + 0.869834881320949
0 R² = 0.991008581391504
g/L

0
0.8 60.0
0
0
0 40.0
0

Er+ 20.0
0
0
0
0.0
0 0 20 40 60 80 100 120 140
0
tiempo (h)
0
0 S Polynomial (S) P Linear (P)
C Polynomial (C) SP Polynomial (SP)
0
0
0
0
0
0
0
0
0
0

8 x² − 0.020237752841655 x + 0.968790231217887
8 x² − 0.020237752841655 x + 0.968790231217887

E-05 x² + 0.01165942400942 x + 0.021510323626994

E-05 x² + 0.008057412896883 x + 0.012827471383103

80 100 120 140 160 180 200

 50.00 tiempo (h)
0
12
45.00
24
36
40.00
48
419E-06 x⁴ + 0.000964899454234 x³ − 0.065652292659246 x² + 2.09693605670718 x 60
35.00 72
84
30.00 96
108
120
25.00
132
144
20.00
156
168
15.00 180
192
10.00
Modelo
5.00
S
0
0
0.00
100 120 140 160 180 200 0
0
mpo (h)
1.28E-03
P Linear (P) -8.03E-01
SP Polynomial (SP)
1.31E+02
 dS dp dc dSP Yc/s Yp/s Ysp/s
-0.80299974 0.282 0.17199997 2.09998686 0.214196793 0.351183175 2.615177496
-0.77228 0.282 0.168352 0.893841612 0.217993474 0.365152535 1.157406138
-0.74156 0.282 0.164704 0.263657087 0.222104752 0.380279411 0.355543836
-0.71084 0.282 0.161056 0.002851999 0.22657138 0.396713747 0.004012154
-0.68012 0.282 0.157408 -0.04503938 0.23144151 0.414632712 -0.0662227
-0.6494 0.282 0.15376 0.00735744 0.236772405 0.434246997 0.011329597
-0.61868 0.282 0.150112 0.084968683 0.242632702 0.455809142 0.137338661
-0.58796 0.282 0.146464 0.143983825 0.249105381 0.479624464 0.24488711
-0.55724 0.282 0.142816 0.165567115 0.256291723 0.506065609 0.297119939
-0.52652 0.282 0.139168 0.149569086 0.264316645 0.53559219 0.284071044
-0.4958 0.282 0.13552 0.10823808 0.273336023 0.568777733 0.218309964
-0.46508 0.282 0.131872 0.05993176 0.283546917 0.606347295 0.128863335
-0.43436 0.282 0.128224 0.02282863 0.295202136 0.649231053 0.052556935
-0.40364 0.282 0.124576 0.008639555 0.308631454 0.698642355 0.021404111
-0.37292 0.282 0.120928 0.016319274 0.324273303 0.756194358 0.04376079
-0.3422 0.282 0.11728 0.02577792 0.342723553 0.824079486 0.075329982
-0.31148 0.282 0.113632 -0.00840746 0.36481315 0.905355079 -0.02699198

Derivada
P C SP Potencia S P
0 0 -3.51E-11 6 0 0
0 0 2.52E-08 5 0 0
0 0 -7.06E-06 4 0 0
0 0 9.65E-04 3 0 0
0 -1.52E-04 -6.57E-02 2 0.00256 0
2.82E-01 1.72E-01 2.10E+00 1 -0.803 0.282
1.11E-01 8.70E-01 6.58E-01 0 0 0
 C SP Potencia
0 -2.106E-10 5
0 1.26E-07 4
0 -2.824E-05 3
0 0.002895 2
-0.000304 -0.1314 1
0.172 2.1 0
0 0 0
tiempo (h) S adj (g/L) P adj (g/L) C (g/L) SP adj (g/L)
0 140.0 0.00 1.0 0 1
12 118.0 1.36 1.8 19.83 2
24 108.5 4.90 4.2 23.35 3
36 99.8 9.44 6.8 24.74 4
48 92.5 13.08 10.0 24.98 5
60 85.9 16.73 11.8 25.90 6
72 78.6 21.42 13.8 26.14 7
84 73.4 24.53 14.4 27.47 8
96 67.0 26.71 15.9 29.85 9
108 60.8 30.59 17.7 29.99 10
120 55.9 32.55 18.3 32.13 11
132 49.0 34.18 19.9 35.26 12
144 41.8 38.72 21.3 36.10 13
156 36.1 41.29 23.7 36.26 14
168 32.0 42.78 25.5 36.48 15
180 27.3 44.37 27.4 37.00 16
192 21.3 46.32 29.1 38.74 17

160.0

140.0

120.0

100.0

80.0

60.0

40.0

20.0 f(x) = 3.45117030730421E-06 x³ − 0.001145994582043 x² + 0.245825055899553 x − 0.132053663570692

R² = 0.995113309527474
0.0
0 20 40 60 80 100 120 140 160 180 200

3.45E-06 3 1.04E-05
-1.15E-03 2 -2.29E-03
2.46E-01 1 2.46E-01
-1.32E-01 0 -0.00E+00
 Polino Mod Mio Monod
rc mu C (g/L) rc mu mu
0.2458 0.2458 1.0000 0.2485 0.2485 0.2485
0.2198 0.1228 1.7900 0.1334 0.0745 0.0745
0.1968 0.0474 4.1500 0.2224 0.0536 0.0536
0.1767 0.0261 6.7800 0.2787 0.0411 0.0411
0.1596 0.0160 9.9600 0.3330 0.0334 0.0334
0.1456 0.0124 11.7600 0.3288 0.0280 0.0280
0.1344 0.0097 13.8400 0.3189 0.0230 0.0230
0.1263 0.0088 14.3900 0.2892 0.0201 0.0201
0.1212 0.0076 15.9100 0.2699 0.0170 0.0170
0.1190 0.0067 17.7100 0.2541 0.0143 0.0143
0.1198 0.0066 18.2600 0.2285 0.0125 0.0125
0.1236 0.0062 19.9300 0.2041 0.0102 0.0102
0.1304 0.0061 21.3100 0.1740 0.0082 0.0082
0.1402 0.0059 23.6600 0.1587 0.0067 0.0067
0.1529 0.0060 25.4600 0.1462 0.0057 0.0057
0.1687 0.0062 27.4000 0.1292 0.0047 0.0047
0.1874 0.0064 29.0600 0.1020 0.0035 0.0035

0.3500

0.3000

0.2500

0.2000

0.1500

0.1000
3663570692
0.0500

0 200
0.0000
0 20 40 60 80 100 120 140 160

mu Vs Cs
0.3000

0.2500

0.2000

0.1500
0.2500

0.2000

0.1500

0.1000

0.0500

0.0000
0 2 4 6 8 10 12 14 16
 mod
S Cc mu mu
140.0000 1 14.281777 0.24852797 0.01740175
118.0000 1.79 8.9172423 0.07450537 0.014956
108.5000 4.15 16.0365409 0.05359527 0.0138696
99.8000 6.78 21.6734845 0.04110415 0.01285839
92.5000 9.96 27.7566305 0.03343471 0.01199748
85.9000 11.76 29.3294334 0.02795565 0.01120916
78.6000 13.84 30.8818021 0.02304085 0.010326
73.4000 14.39 29.8440992 0.02009565 0.00968957
67.0000 15.91 30.3343232 0.01696463 0.00889775
60.8000 17.71 31.2914704 0.01434985 0.00812157
55.8700 18.26 30.468863 0.01251104 0.00749787
49.0000 19.93 30.8384827 0.0102418 0.00661897
41.8000 21.31 30.6107094 0.0081668 0.00568541
36.1000 23.66 32.1401671 0.0067067 0.00493714
32.0000 25.46 33.2728864 0.00574212 0.0043938
27.3000 27.4 34.3032058 0.00471432 0.00376561
21.3000 29.06 34.5103797 0.00350954 0.00295526

40.0000

35.0000

30.0000

25.0000

20.0000

15.0000

10.0000

5.0000

0.0000
120 140 160 180 0 20 40 60 80 10

3
𝑟_𝑐=𝐶𝑐 (𝑘_1 𝐶_𝑠)/(1+𝑘_2
K1𝐶_𝑠 )
(Adi) 0.0001417
K2 (L/g) -0.0065727

𝑟_𝑐=𝐶𝑐 (𝑘_1 𝐶_𝑠)/(𝑘_2+𝐶_𝑠 )

K1 (Adi) -0.02155887
K2 (g/L) -152.144476
2 14 16 18 20
 Modif
1/mu 1/mu 1/Cc
57.4654703 4.0236919 0.00714286
66.8636293 13.4218509 0.00847458
72.1001402 18.6583618 0.00921659 m 7057.16302 1000
77.7702193 24.3284409 0.01002004 b 7.05716302 0.1417
83.3508173 29.9090389 0.01081081 ref -46.3846154 53.4417784
89.2127279 35.7709495 0.01164144 7.05716302 0.1417
96.8429521 43.4011737 0.01272265 1/mu max mu max
103.203798 49.7620198 0.01362398
112.387954 58.946176 0.01492537
123.128923 69.6871448 0.01644737
133.37116 79.9293818 0.01789869
151.080898 97.6391197 0.02040816
175.888814 122.447036 0.02392344
202.546443 149.104665 0.02770083
227.593507 174.151729 0.03125
265.561303 212.119525 0.03663004
338.379371 284.937592 0.04694836

400

350

300

250

200

150

100

50

0
0.005 0.01 0.015 0.02 0.025 0.03 0.035 0.04

60 80 100 120 140 160 180

 Ks
mu
dif

0.03 0.035 0.04 0.045 0.05