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Typically screening of single urine specimen for many substances by qualitative screening procedure.
However, this procedure only detects drugs of recent use, therefore abstinence for a short duration,
abusing patients. And also it does not differentiate single casual use and chronic abuse.
Drugs of Abuse:
Other common names for methamphetamine include blue, crystal, ice, meth, SHABU, and speed
b. 3,4-methylenedioxy-methamphetamine (MDMA)
Function: hallucinations, empathic and emotional response, euphoria, and increased visual and
tactile sensitivity.
Metabolism: Cytochrome P450 family enzymes play a central role in
the metabolismof MDMA,
Analysis: Routine drug screening by immunoassay, Gas chromatography–mass spectrometry
e. Cocaine:
Function: used as a local anaesthetic and at higher levels functions as a CNS stimulant.
Metabolism: Half life 0.5-1hour with elimination dependent on liver metabolism;
benzoyleegonine (half life 4-7 hours) primary metabolite and filtered by the kidney
Benzoyleegonine is detectable in urine for 3 days following single use and as long as 20 days
following chronic use
Analysis: immunoassays and gas chromatography/ mass spectrometry
f. Opiates
1. Types of Opiates:
a. Naturally occurring: Opium, morphine, codeine
b. Chemically modified: Heroine, dilaudid, oxycodone
c. Synthetic: Demerol, methadone, darvon, talwin, fentanyl
2. Function: Narcotics used for their analgesic, sedative, and anaesthetic properties
3. Metabolism: Respiratory center depressant cause respiratory acidosis
4. Analysis: Immunoassays and gas chromatography/ mass spectrometry
g. Phencyclidine (PCP)
Function: produces stimulant, depressant, anaesthetic, and hallucigonenic effects
Metabolism: Distribute in lipophilic tissue such as brain and adipose tissue; elimination
dependent on it being metabolized by the liver, with 10-15% of the parent compound filtered by
the kidney; detectable in urine for as long as 7-30 days following chronic use
Analysis: Immunoassays and gas chromatography/ mass spectrometry
h. Tranquilizers:
Types of tranquilizers
a. Barbiturates: Phenobarbital (long acting), amobarbital (intermediate acting), and
secobarbital and pentoarbitaa (short acting)
b. Benzodiazepines: Diazepam (valium), chroldiazepoxide (Librium), lorazepam (ativan)
Function: Sedative hypnosis that produce depression of the CNS
Metabolism: Respiratory center depressants causing respiratory acidosis
Analysis: Immunoassays and gas-liquild chromatography