Professional Documents
Culture Documents
digital
microscopy
IT / ComS edition
Yves Sucaet,
Wim Waelput,
Peter In’t Veld
Financial disclosure
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Prelude
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Topics for today
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PERSONAL BACKGROUND
Who am I (education)?
Education
• 1998-2000: Hogeschool Gent (BE)
– BS Computer Sciences
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Who am I (professional)
Professional
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WHAT IS DIGITAL
MICROSCOPY/PATHOLOGY?
This is not a digital microscope
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Getting started with digital microscopy
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Whole slide imaging (single slide)
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Hardware
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Software stack
Very
large
image!
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How big are these images?
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Network topology at the VUB
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Confusing your end-users (customers)! NOT good!
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What’s the solution?
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Digital microscopy at the VUB
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What does the Pathomation software look like?
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Digital (r)evolution
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HOW DOES IT WORK?
How do the whole slide scanners work?
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Rendering HUGE image files (gigapixel)
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How much data are you transferring?
• It depends
• The original file is about 1GB
– But you only transfer data in packages of 512x512 px
– Optimize the speed of transfer by toggling the
compression ratio
• No impact on diagnostic accuracy!
– Tiles are downloaded in parallel
• Browser initiates 6 parallel downloads
– Tiles 7, 8, 9… are queued
• Optimize tile size for screen size
– Mobile devices vs. 4K screens
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So… how much data ARE you transferring?
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Time taken to serve tiles
Time is milliseconds
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And does it scale?
Number of tiles served within 10 minute timeframe
10 minute intervals
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Facilitating the European Society of Pathology
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BIG IMAGES, BIG DATA, AND DEEP
LEARNING
Once you have image data…
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Pancreas analysis for diabetes research
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Pancreas analysis for diabetes research
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Pancreas analysis for diabetes research
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More advanced: graph theory (Ackermann)
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More advanced: graph theory (Ackermann)
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More advanced: graph theory (Ackermann)
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More advanced: graph theory (Ackermann)
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But what does the graph mean (Ackermann)?
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Deep learning as the new frontier (Van der Laak)
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Another way of looking at deep learning (Van der Laak)
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Do this for histology (Van der Laak)
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Does it work (Van der Laak)?
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Computational pathology as a decision support tool
Tumour
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IN CLOSING
Conclusions
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Continue the conversation
• Email: yves.sucaet@gmail.com
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