BSBO 0002: COMPUTER FUNDAMENTALS AND APPLICATIONS

OBJECTIVES: The objective of this course is that student with life science background will
be familiar with basic knowledge of computers

Credits: 04 Semester I L-T-P: 4-0-0

Module Content Teaching

No. Hours
Introduction: Characteristics, evolution, and generations of computer
systems, Basic Computer Organization: Input, Output, Storage,
Arithmetic Logic Unit, Control Unit, and Central Processing Unit
Number System: Non-positional, Positional, Binary, Octal, and
Hexadecimal, conversion from one number system to another
Computer Code: BCD, EBCDIC, and ASCII
Computer Arithmetic: Binary Addition, Subtraction, Multiplication,
and Division 18
I Processor and Memory: The Central Processing Unit (CPU): Control
Unit, ALU, Instruction Set, and Registers, Processor Speed, Main
Memory, RAM, ROM,PROM, and EPROM, Cache Memory
Computer Software: Relation between Hardware and Software,
System, and Application Software, Logical System Architecture
Computer Languages: Machine, Assembly, and High-level
Language, assembler, Compiler, Linker, and Interpreter (in brief),
General overview of C
Operating System: Functions, measuring system performance,
II Multiprogramming, Multitasking and Multiprocessing, time sharing 24
Database Management System: Introduction of Hierarchical,
Network, Relational, and Object oriented
Computer Networks: Topologies: Star, Ring, Completely connected,
Multi-acces Bus, and Hybrid, Network Type: LAN, WAN, and MAN
The Internet: Email, FTP, and WWW, Uses of Internet
Classification of Computers: Notebook, PCs, Workstations,
Mainframe, and Supercomputers

REFERENCE BOOKS, TEXT BOOKS, CASES:

 Sinha, P.K., Computer Fundamentals, BPB Publication, New Delhi Sixth Edition

Able to use M.S. Office (M.S. Word, M.S. Power point, M.S. Excel and M.S. Access) and
Internet efficiently.
 BSB 6002: GENOMICS AND PROTEOMICS

OBJECTIVES: To expose students with resents advances in the field of Genomics &
Proteomics and their implication in life sciences research.

Credits: 05 Semester VI L–T–P: 5–0–0

Module Teaching
Content
No. Hours
Genomics
Genome sequencing: Shot Gun, Clone Contig, Contig assembly by
chromosomal walking, sequence tagged site; Genetic and Physical
I Mapping, Importance of map in sequence assembly 14
Genome Annotation: identifying genes in a genome sequence,
determining the function of an unknown gene

Proteomics
Chemical classification of amino acids, Principles of protein structure
(Primary, Secondary, Tertiary and Quaternary), dihedral angles (ψ and φ),
Ramachandran Plot
II 14
Studying the Proteome: separation of proteins using 2D Gel,
identification of individual protein using MALDI-TOF, ADME-Tox
properties of drug candidates

Applications of Proteomics & Genomics

Drug Discovery and Development, Microarray Technology,
III Pharmacogenomics, Metagenomics, epigenomics, Chromatin 14
immuneprecipitation sequencing (ChIP), Protein-protein interaction,
Yeast-Two- Hybrid system for protein-protein interaction

Text Book:
 Biotechnology by Dubey, R.C
Reference Books:
 Introduction to Genomics. Arthur Lesk. Oxford University Press
 Brown TA, Genomes by Garland Science.
 Campbell AM & Heyer LJ, Discovering Genomics, Proteomics and
 Bioinformatics by Benjamin Cummings.
 Primrose S & Twyman R, Principles of Gene Manipulation and Genomics by Blackwell.
 Glick BR & Pasternak JJ, Molecular Biotechnology by ASM Press.
 BSB 6007: DRUG DISCOVERY & DEVELOPMENT
OBJECTIVES: The objective of this course is to introduce students the basic process of drug
discovery and various considerations to bring drug in market place

Credits: 02 Semester VI L–T–P: 2–0–0

Module Teaching
Content
No. Hours
Process of Drug Discovery: reductionist target-based approach, Target
Unit-I identification and validation, lead identification: High through-put 10
screening, lead optimization and prioritization: ADME-TOX properties

New strategies in drug discovery: Structure based drug designing,

Unit-II Molecular docking, Computer aided drug designing, chemi-informatics 10
etc

Process of Drug Development: considerations and strategies, cost

estimates, factors for choosing candidates for drug development,
Unit-III preclinical studies (cell-based and animal studies), clinical studies (Phase 10
1, 2, 3)

Text Book:

 Drug Discovery & Development: Traditional Medicine and Ethnopharmacology By

Bhushan Patwardhan

Reference Books:

 Drug Discovery and Development: Technology in Transition By Raymond G Hill

OUTCOME: At the end of this course students will have an understanding of drug discovery
pipeline and its connection with life science