Drug Data Mechanism of Action Contraindications Adverse Reactions Nursing Responsibilities

Generic Name Pharmacokinetics CNS: seizures, dizziness, Before

Indication headache >assess pts. Infection
Metronidazole Onset: General Indications >watch carefully for edema
PO: uknown IV: immediate >amebic hepatic abscess EENT: Tearing(topical only) because it may cause
Classification Topical: unknown >intestinal amebiasis sodium retention
Pharmacologic Peak : >trichomoniasis GI: abdominal pain, anorexia, >assess skin for severity
Class:Nitroimidazole PO: 1-2 hrs IV: immediate >retractory trichomoniasis nausea and vomiting, areas of local adverse
Topical: 6-10hrs >bacterial infection caused diarrhea, dry mouth, glossitis reactions
Duration: by anaerobic >record number and
PO, IV, Topical: unknown microorganisms Derm: rashes, urticarial, mild character of stools
>to prevent postoperative dryness, skin irritation >assess pt’s and family’s
Therapeutic Class: Therapeutic Effects: infection in contaminated knowledge of drug therapy
Hinders growth of selected colorectal surgery Hemat: leukopenia
organisms, including most >pelvic inflammatory During
anaerobic bacteria and disease Local: Phlebitis at Iv site >give drug with meals to
Antibacterial protozoa minimize GI distress
Antiprotozoal Drug Half Life /Contraindications Neuro: peripheral >to treat trichomoniasis,
>hypersensitivity neuropathy give drug for 7days instead
>hypersensitivity to of 2-g single dose
parabens Misc: superinfection >use only after T.vaginalis
Pregnancy Risk Category: >first trimester of pregnancy has been confirmed by wet
smear
B >tablets may be crushed for
Trade Name Precautions pt’s. with difficult swallowing
>history of blood dyscrasias; >do not use aluminium
Flagyl, Metric 21, Noritade seizures or neurologic needles or hubs, color will
problems turn orange/rust
Patients Dose >severe hepatic impairment
Metronidazole 500mg 1 tab >pregnancy, lactation and After
TID PO children >tell pt. that metallic taste
and dark or red brown urine
Minimum Dose may occur
PO : 250mg TID >instruct pt. to take oral
IV : 100mg /mL form with meals to minimize
reactions
Maximum Dose >instruct to complete full
PO : 750 mg TID 6-10days course of therapy
IV : 100mg/mL Drug interactions >tell pt. not to use alcohol or
>cimetidine drugs that contain alcohol.
Contents >phenobarbital >may cause dizziness/ light
Metronidazole >warfarin headedness
>disulfiram
Availability >fluorouracil
Capsules: 375 mg
Injection: 5mg/mL
Oral suspension: 200mg/5ml
Tablets:
200mg,250mg,400mg,500m
g
Topical gel: 0.75 %,1 %

Routes of administration
PO, IV, Topical