Resultado de La Clasificación

ID Name CAS No.
ID501 2-(Dimethylamino)ethyl methacrylate 2867-47-2

ID502 n-Butyl methacrylate 97-88-1
(Z)-2'-methylacetophenone 4,6-dimethyl-2-
ID503 89269-64-7
pyrimidinylhydrazone
Methyl 3-chloro-5-(4,6-dimethoxy-2-
ID504 pyrimidinylcarbamoylsulfamoyl)-1- 100784-20-1
methylpyrazole-4-carboxylate
ID505 3-methyl-1,5-di(2,4-xylyl)-1,3,5- 33089-61-1
triazapenta-1,4-diene
ID506 N-methyldithiocarbamic acid 144-54-7
6-methyl-1,3-dithiolo[4,5-b]quinoxalin-2-
ID507 one 2439-01-2
ID508 3-Methylpyridine 108-99-6
ID509 S-1-methyl-1-phenylethyl 1- 61432-55-1
piperidinecarbothioate
ID510 O-3-tert-butylphenyl N-(6-methoxy-2-
pyridyl)-N-methylthiocarbamate 88678-67-5
ID511 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-
one; Methoxsalen 298-81-7
ID512 Tris(2-chloroethyl) phosphate 115-96-8
ID513 Tris(dimethylphenyl) phosphate 25155-23-1
ID514 2-Amino-5-nitrobenzonitrile 17420-30-3
ID515 p-Aminophenol 123-30-8
ID516 3'-Amino-4'-methoxyacetanilide 6375-47-9
ID517 4-Allyl-1,2-dimethoxybenzene 93-15-2
2-ethylamino-4-isopropylamino-6-
ID518 methylthio-1,3,5-triazine 834-12-8
5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-
ID519 50-06-6
pyrimidinetrione; Phenobarbital
ID520 2,4-Xylenol 105-67-9
2-(4-chloro-6-ethylamino-1,3,5-triazin-2-
ID521 yl)amino-2-methylpropiononitrile 21725-46-2
ID522 1-Chloronaphthalene 90-13-1
O-6-Chloro-3-phenyl-4-pyridazinyl S-n-
ID523 octyl thiocarbonate; Pyridate 55512-33-9
ID524 alpha-cyano-3-phenoxybenzyl 2,2-dichloro- 63935-38-6

1-(4-ethoxyphenyl)cyclopropanecarboxylate
(S)-alpha-Cyano-3-phenoxybenzyl 3-(2,2-
dichlorovinyl)-2,2-dimethyl-cis-
ID525 cyclopropanecarboxylate; alpha- 67375-30-8
Cypermethrin
ID526 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6- 83121-18-0
difluorobenzoyl)urea
2,2-Dichloro-N-[2-hydroxy-1-
ID527 (hydroxymethyl)-2-(4- 56-75-7
nitrophenyl)ethyl]acetamide;
Chloramphenicol
ID528 2,4'-dichloro-alpha-(5-pyrimidinyl)benzhydryl
alcohol 60168-88-9
ID529 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol- 79983-71-4

1-yl)-2-hexanol
Disodium 4-amino-3-[4'-(2,4-
ID530 diaminophenylazo)-1,1'-biphenyl-4-ylazo]- 1937-37-7
5-hydroxy-6-phenylazo-2,7-
naphthalenedisulfonate; C.I. Direct Black 38
Disodium 2,2'-vinylenebis[5-(4-morpholino-
ID531 6-anilino-1,3,5-triazin-2- 16090-02-1
ylamino)benzenesulfonate]; C.I. Fluorescent
260
Mixture of 2,4-dinitro-6-octylphenyl
crotonate and 2,6-dinitro-4-octylphenyl
ID532 crotonate (octyl=1-methylheptyl,1- 131-72-6
ethylhexyl,1-propylpentyl); Dinocap; DPC
ID533 2,3-Dihydro-6-propyl-2-thioxo-4(1H)- 51-52-5
pyrimidinone; Propylthiouracil
ID534 p-Divinylbenzene 105-06-6
ID535 m-Divinylbenzene 108-57-6
ID536 o-Divinylbenzene 91-14-5
ID537 5,5-Diphenyl-2,4-imidazolidinedione 57-41-0
ID538 1,4-Dibromobutane 110-52-1
ID539 1,3-Dibromopropane 109-64-8
ID540 Dibenzyl ether 103-50-4
ID541 Thioacetamide 62-55-5
ID542 Iron carbonyl 13463-40-6
ID543 Tellurium dioxide 7446-07-3
ID544 Trichloroacetonitrile 545-06-2
ID545 Sodium 1,1'-biphenyl-2-olate 132-27-4
ID546 m-Nitroaniline 99-09-2
5'-[N,N-Bis(2-acetyloxyethyl)amino]-2'-(2-
ID547 bromo-4,6-dinitrophenylazo)-4'- 3618-72-2
methoxyacetanilide
ID548 Phenanthrene 85-01-8
ID549 Diisobutyl phthalate 84-69-5
ID550 tert-Butyl hydroperoxide 75-91-2
N-propyl-N-[2-(2,4,6-
ID551 trichlorophenoxy)ethyl]imidazole-1- 67747-09-5
carboxamide
ID552 p-Bromophenol 106-41-2
ID553 3-Bromo-1-propene; Allyl bromide 106-95-6
ID554 Hexadecyltrimethylammonium bromide 57-09-0
ID555 Benzothiazole 95-16-9
Methyl 2-(4,6-dimethoxy-2-pyrimidinyloxy)-
ID556 6-[1-(methoxyimino)ethyl]benzoate 136191-64-5
Methyl 3-(4-methoxy-6-methyl-1,3,5-
ID557 79277-27-3
triazin-2-ylcarbamoylsulfamoyl)-2-thenoate
ID558 4,4'-Methylenebis(N,N-dimethylaniline) 101-61-1
ID559 4,4'-Methylenebis(2- 6864-37-5
methylcyclohexaneamine)
ID560 (Z)-2-chloro-1-(2,4,5-trichlorophenyl)vinyl 22248-79-9
dimethyl phosphate
ID561 Tris(2-ethylhexyl) phosphate 78-42-2
ID562 Sodium azide (Na(N3)) 26628-22-8
ID563 Propanenitrile, 2-hydroxy-2-methyl- 75-86-5
ID564 Ammonia 7664-41-7
ID565 2-Chloroethanol 107-07-3
ID566 Zinc chloride 7646-85-7
ID567 Hydrochloric acid 7647-01-0
ID568 Thionyl dichloride 7719-09-7
ID569 Phosphoryl trichloride 10025-87-3
ID570 Chlorine 7782-50-5
ID571 Phosphorus (yellow) 12185-10-3
ID572 chlordane , pur 57-74-9
ID573 Hydrogen peroxide 7722-84-1
ID574 Formic acid 64-18-6
ID575 chloroacetaldehyde 107-20-0
ID576 Chloroprene 126-99-8
ID577 germanium tetrahydride 7782-65-2
ID578 Phosphorus pentachloride 10026-13-8
ID579 Ethyl acetate 141-78-6
ID580 Phosphorous trichloride 7719-12-2
ID581 Borane, trifluoro- 7637-07-2
ID582 Lead, tetraethyl- 78-00-2
ID583 calcium cyanide 592-01-8
ID584 Parathion 56-38-2
ID585 dioxathion 78-34-2
ID586 Ethane, 1,2-dibromo- 106-93-4
ID587 Dibromochloropropane 96-12-8
ID588 diborane(6) 19287-45-7
ID589 Dimethylamine 124-40-3
ID590 Demeton-methyl 8022-00-2
ID591 Parathion, methyl- 298-00-0
ID592 paraquat-dimethylsulfate 2074-50-2
ID593 Ethane, bromo- 74-96-4
ID594 Hydrobromic acid 10035-10-6
ID595 Oxalic acid 144-62-7
ID596 Bromine 7726-95-6
ID597 Nitric acid 7697-37-2
ID598 Potassium hydroxide 1310-58-3
ID599 Sodium hydroxide 1310-73-2
ID600 Lead distearate 1072-35-1
GHS Classification
ID501 2-(Dimethylamino)ethyl methacrylate
CAS 2867-47-2 Date Classified: Aug. 22, 2006 (Environmental Hazards: Mar. 31, 2006)
Physical Hazards Reference Manual: GHS Classification Manual (Feb. 10, 2006)
Hazard class Classification symbol signal word hazard statement Rational for the classification
1 Explosives Not applicable Containing no chemical groups with explosive properties
2 Flammable gases Not applicable Classified as "liquid" according to GHS definition
3 Flammable aerosols Not applicable Not aerosol products
4 Oxidizing gases Not applicable Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 The flash point is 74degC (open cup flash test) (NFPA (13th, 2002)), which is classified into "Category 4."
7 Flammable solids Not applicable Classified as "liquid" according to GHS definition
8 Self-reactive substances and Not classified
No data available, though containing unsaturated bonds (olefin). Classified into Division 6.1 (UN#2522) (UN Recommendations on the Transport of
mixtures Dangerous Goods)
9 Pyrophoric liquids Not classified Classified into Division 6.1 (UN#2522) (UN Recommendations on the Transport of Dangerous Goods)
10 Pyrophoric solids Not applicable Classified as "liquid" according to GHS definition
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available.
mixtures
12 Substances and mixtures, which
in contact with water, emit Not applicable Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
flammable gases
13 Oxidizing liquids Not applicable Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified Classified into Division 6.1 (UN#2522) (UN Recommendations on the Transport of Dangerous Goods)
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the LD50 value of 1,550mg/kg calculated from the testing data of rat LD50 (oral route) of 1,751mg/kg, 2,659mg/kg and 1,550mg/kg (SIDS
(2003)).
1 Acute toxicity (dermal) Classification not possible Insufficient data available
1 Acute toxicity (inhalation: gas) Not applicable Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (inhalation: Category 1 Based on the rat LC50 (4 hour inhalation) value of 0.62mg/L (equivalent to 95ppm) (SIDS (2003)) was lower than 90% of the saturated vapour
vapour) concentration (2,480ppm) under a saturated vapour pressure of 250Pa (20degC), the substance was considered as "vapour containing substantially
no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (inhalation: dust, Classification not possible No data available

mist)
2 Skin corrosion / irritation Category 1A-1C Based on the description in the report on rabbit skin irritation tests (SIDS (2003)): "Severe erythema, edema and necrosis were observed
immediately post-dosing. These symptoms persisted for 72 hours. The present substance was thus considered to have a potential for skin
corrosivity." Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further
subclassification is needed.
3 Serious eye damage / eye Category 1 Based on the description in the report on rabbit eye irritation tests (SIDS (2003)): "within 2 hours of application, all treated animals exhibited severe
irritation corneal, iris and conjunctival damage. The present substance was thus considered to have a potential for eye corrosivity."
4 Respiratory/skin sensitizer Respiratory sensitizer: No data available

Respiratory sensitizer: Skin sensitizer: Based on the description in the report on guinea pig skin sensitization tests performed in accordance with OECD 605 (SIDS (2003)):
Classification not possible "There was no evidence of skin reactions induced by sensitization," "Negative." Also based on the description in the report on guinea pig skin
Skin sensitizer: Not classified sensitization tests evaluated according to Maximization Method (CERI Hazard Data 2001-55 (2002)): "No evidence of sensitization."
5 Germ cell mutagenicity Not classified Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell
mutagenicity tests in vivo (micronucleus tests), described in Report by the Ministry of Health, Labour and Welfare (1998), SIDS (2003) and CERI
Hazard Data 2001-55 (2002).
6 Carcinogenicity Classification not possible No data available

7 Toxic to reproduction Category 2 Based on the evidence of underfeeding of the offspring probably due to impaired nursing functions of maternal animals (though maternal behaviours
were observed) and increased neonatal mortality at doses producing parental toxicity, described in Report by the Ministry of Health, Labour and
Welfare (1998), CERI Hazard Data 2001-55 (2002) and SIDS (2003).
8 Specific target organs/systemic Category 3 (narcotic effects) Based on the evidence from animal studies including "reduced locomotor activity and sedation" (SIDS (2003)).
toxicity following single exposure
9 Specific target organs/systemic Insufficient data available
toxicity following repeated Classification not possible
exposure
10 Aspiration hazard Classification not possible No data available
Environmental Hazards
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 72 hours ErC50=9mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1997).
environment (acute)
11 Hazardous to the aquatic Since there was rapidly degrading (it was hydrolyzed to methacrylic acid (the decomposition by BOD: 91%) and to N,N-dimethyl-N-ethanolamine (the
environment (chronic) Not classified - - - decomposition by BOD: 60.5%) (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.97 (PHYSPROP Database
(2005))), it was claasified into Not classified.
GHS Classification
ID502 n-Butyl methacrylate
CAS 97-88-1 Date Classified: Aug. 22, 2006 (Environmental Hazards: Mar. 31, 2006)
6 Flammable liquids Category 3 The flash point is 41degC (ICSC (2000)), which is classified into "Category 3." Those containing stabilizers are classified into Class 3 (UN#2227) (UN
Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though containing unsaturated bonds (olefin). Those containing stabilizers are classified into Class 3
mixtures (UN#2227) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 290degC (ICSC, 1999).

mixtures
flammable gases
16 Corrosive to metals Classification not possible No data available. Those containing stabilizers are classified into Class 3 (UN#2227) (UN Recommendations on the Transport of Dangerous Goods).
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of 16,000mg/kg representing the lower of the two testing data, 16,000mg/kg and 20,000mg/kg (CERI Hazard
Data 2001-49 (2002)).
1 Acute toxicity (dermal) Not classified Based on the rabbit LD50 (dermal route) value of 11,300mg/kg (CERI Hazard Data 2001-49 (2002)).
1 Acute toxicity (inhalation: Classification not possible No data available

vapour) Not classified Because the rat LC50 (inhalation) value of 28.5mg/L (equivalent to 4,810ppm) (CERI Hazard Data 2001-49 (2002)) exceeded the saturated vapour
1 Acute toxicity (inhalation: dust,
mist) concentration (2,790ppm) under a saturated vapour pressure of 282Pa (25degC), the substance was considered as "mist exposure," and the
obtained LC50 exceeded the upper limit value of Category 4 (5mg/L) by more than 2.5 fold.
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (4 hour application) (CERI Hazard Data 2001-49 (2002)): "Mild irritation."
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests evaluated according to the Draize scheme (CERI Hazard Data 2001-49 (2002)):
irritation "Mild irritation."
4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

Classification not possible Skin sensitizer: Classification not possible due to the insufficiency of data. No evidence of skin sensitization was observed in guinea pig skin
Skin sensitizer: Classification sensitization tests evaluated according to Maximization Method and Split Adjuvant Method (CERI Hazard Data 2001-49 (2002)), whereas PATTY
not possible (4th, 2001) and EU Risk Phrase (R43) suggest a potential for sensitization.
5 Germ cell mutagenicity Not classified Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, negative data on somatic cell
mutagenicity tests in vivo (micronucleus tests), described in Report by the Ministry of Health, Labour and Welfare (1998), CERI Hazard Data 2001-49
(2002) and NTP DB (Access on Mar., 2006).

7 Toxic to reproduction Category 2 Based on the evidence of decreased numbers of corpora lutea and implantation sites observed at doses causing parental toxicity, described in
Report by the Ministry of Health, Labour and Welfare (1998) and CERI Hazard Data 2001-49 (2002).
8 Specific target organs/systemic Category 3 (respiratory tract Based on the evidence from animal studies including "respiratory irritation" (ECETOC JACC36 (1996)).
toxicity following single exposure irritation)
9 Specific target organs/systemic Based on the evidence from animal studies including "atrophy of the red pulp of spleen" (Report by the Ministry of Health, Labour and Welfare
toxicity following repeated Category 2 (spleen) (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
exposure
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 96 hours LC50=5570microg/L of the fish (Oryzias Latipest) (MOE Risk Assessment vol. 2 (2003) and others.).
environment (acute)
11 Hazardous to the aquatic Not classified - - -
Since there was rapidly degrading (the decomposition by BOD: 88% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low
environment (chronic) (log Kow=2.88 (PHYSPROP Database, 2005)), it was claasified into Not classified.
GHS Classification
ID503 (Z)-2'-methylacetophenone 4,6-dimethyl-2-pyrimidinylhydrazone
CAS 89269-64-7 Date Classified: Dec. 18, 2006 (Environmental Hazards: Mar. 31, 2006)
1 Explosives Being a hydrazine compound, the substance contains chemical groups with explosive properties, but its oxygen budget is calculated at -245, that is
Not classified "Not classified."
2 Flammable gases Not applicable Classified as "solid" according to GHS definition

4 Oxidizing gases Not applicable Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible Classification not possible due to lack of data
8 Self-reactive substances and
Classification not possible Classification not possible due to lack of data, though being a hydrazine compound containing chemical groups with explosive properties.
mixtures
9 Pyrophoric liquids Not applicable Classified as "solid" according to GHS definition
10 Pyrophoric solids Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat at 60degC for a month
Not classified (Agricultural Chemical Registration Data)
11 Self-heating substances and Classification not possible Classification not possible due to lack of data
mixtures
flammable gases
13 Oxidizing liquids Not applicable Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable Organic compounds containing no oxygen, fluorine or chlorine
16 Corrosive to metals Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 173.9degC (Agricultural Chemical
Classification not possible Registration Data)).
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 642mg/kg (Agricultural Chemical Registration Data (1991)).
1 Acute toxicity (dermal) Not classified Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1991)).
1 Acute toxicity (inhalation: gas) Not applicable Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.

vapour) Classification not possible Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >3.8mg/L (4 hours) (Agricultural Chemical
mist) Registration Data (1991)).
2 Skin corrosion / irritation Category 3 Based on the evidence of mild irritation with a Draize score of 1.6, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data
(1991)).
3 Serious eye damage / eye Category 2A Based on the evidence of reversible irritation, with effects persisting for up to day 16, observed in rabbit eye irritation tests (Agricultural Chemical
irritation Registration Data (1991)).

Classification not possible Skin sensitizer: No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler method (Agricultural Chemical
Skin sensitizer: Not classified Registration Data (1991)).
5 Germ cell mutagenicity Not classified Based on negative data in in vitro studies (chromosome aberration tests, reverse mutation tests and DNA repair tests) and mouse in vivo
micronucleus tests (Agricultural Chemical Registration Data (1991, 1994)).
6 Carcinogenicity Classification not possible Classification not possible in the absence of existing classification, though tumor formation was found in rat carcinogenicity studies (Agricultural
Chemical Registration Data (1991)).
7 Toxic to reproduction Not classified Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit
teratogenicity studies (Agricultural Chemical Registration Data (1991)).
8 Specific target organs/systemic Based on the evidence from animal studies including "reduced locomotor activity," "abnormal gait," "muscle flaccidity," "convulsions," and
toxicity following single exposure Category 2 (nervous system) "tremors" (Agricultural Chemical Registration Data (1991)). These effects were observed at dosing levels within the guidance value ranges for
Category 2.
9 Specific target organs/systemic Insufficient data available.
exposure
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 48 hours EC50=6.2mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2000).
environment (acute)
11 Hazardous to the aquatic Category 2 Environment -
Toxic to aquatic life with Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2.98(PHYSPROP Database, 2005)), since there was no
environment (chronic) long lasting effects rapidly degrading (BIOWIN), it was classified into Category 2.
GHS Classification
ID504 Methyl 3-chloro-5-(4,6-dimethoxy-2-pyrimidinylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though being a sulfonyl compound containing chemical groups with self-reactive properties.
mixtures
10 Pyrophoric solids Classification not possible Classification not possible due to lack of data
mixtures
flammable gases
14 Oxidizing solids Cannot be classified though being organic compounds containing oxygen bound to elements other than carbon and hydrogen
Classification not possible

16 Corrosive to metals Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 175.5-177.2degC (Agricultural Chemical
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of 7,758mg/kg (Agricultural Chemical Registration Data (1990)).

vapour) Not classified Based on the rat LC50 (inhalation route) value of >6.0mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data
mist) (1990)).
2 Skin corrosion / irritation Not classified Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1990)).
3 Serious eye damage / eye Not classified In rabbit eye irritation tests, the treated animals exhibited a mean Draize score of 0.7, and were fully recovered (Agricultural Chemical Registration
irritation Data (1990)).

Classification not possible Skin sensitizer: No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical
5 Germ cell mutagenicity Not classified Based on negative data in in vitro studies (chromosome aberration tests, reverse mutation tests and DNA repair tests) and mouse in vivo
6 Carcinogenicity Not classified There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration
Data (1992)).
teratogenicity studies (Agricultural Chemical Registration Data (1990, 1991, 1993)).
8 Specific target organs/systemic Classification not possible Insufficient data available

exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 14 days EC50=0.042ppb of the aquatic plant (Lemna Gibba) (AQUIRE, 2003).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning
Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=-0.02(PHYSPROP Database, 2005)), since there was no rapidly degrading
environment (chronic) with long lasting effects (BIOWIN), it was classified into Category 1.
GHS Classification
ID505 3-methyl-1,5-di(2,4-xylyl)-1,3,5-triazapenta-1,4-diene
7 Flammable solids Classification not possible Classification not possible due to lack of data, though classified as flammable according to ICSC (2004)
8 Self-reactive substances and Not applicable Containing no chemical groups with explosive or self-reactive properties
mixtures
10 Pyrophoric solids Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural
Not classified Chemical Registration Data)
11 Self-heating substances and Not classified Stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 370mg/kg (Agricultural Chemical Registration Data).
1 Acute toxicity (dermal) Classification not possible Classification cannot be determined, though the available rat dermal study reported the LC50 value of >1,600mg/kg (Agricultural Chemical
Registration Data).

vapour)
1 Acute toxicity (inhalation: dust, Not classified Based on the rat LC50 (inhalation route) value of 65mg/L (4 hours) (Agricultural Chemical Registration Data).
mist)
2 Skin corrosion / irritation Not classified Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data).
3 Serious eye damage / eye Not classified In rabbit eye irritation tests, the treated animals exhibited a mean Draize score of 0.8 at 24 hours, and were fully recovered within 7 days
irritation (Agricultural Chemical Registration Data).

Classification not possible Skin sensitizer: Based on positive results in guinea pig skin sensitization tests employing the Maximization method (Agricultural Chemical Registration
Skin sensitizer: Category 1 Data).
5 Germ cell mutagenicity Not classified Based on negative data in in vitro assays (chromosome aberration tests, reverse mutation tests and unscheduled DNA synthesis tests) and in vivo
assays (mouse dominant lethal tests and unscheduled DNA synthesis tests on rat stem cells) (Agricultural Chemical Registration Data).
6 Carcinogenicity Not classified There was no treatment-related increase in tumor incidence observed in carcinogenicity studies in rats, mice and dogs (Agricultural Chemical
Registration Data).
teratogenicity studies (Agricultural Chemical Registration Data).
8 Specific target organs/systemic Based on the evidence from animal studies including "ataxia," "hyperexcitability" and "tremors" (Agricultural Chemical Registration Data (year
toxicity following single exposure unknown)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
Category 2 (nervous system)
9 Specific target organs/systemic Based on the human evidence: "The present substance may adversely affect the central nervous system and liver" (ICSC (1994)). Also based on the
toxicity following repeated evidence from animal studies: "ataxia, increased nasal secretion, polyuria, body tremors, and coma were observed. Hematological examinations
exposure showed reductions in packed cell volume, hemoglobin, red cells, and plasma protein concentrations in blood," and "seminiferous tubular degeneration
Category 2 (central nervous was seen" (JMPR (1998)), "changes in the prostate, seminal capsule, Cowper cyst and accessory gland" (RTECS (2006)). The effects on
system, liver, blood system, experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (prostate, testicular appendage) and Category 2
testes, prostate, testicular (central nervous system, testes and blood system). However, ICSC and RTECS are assigned a priority rating of 2, the effects on the prostate and
appendage) testes are classified into Category 2.
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 96 hours LC50=0.552mg/L of the fish (Carp) (Agricultural Chemical Registration Data, 2003).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.5 (PHYSPROP
environment (chronic) with long lasting effects Database, 2005)), it was classified into Category 1.
GHS Classification
ID506 N-methyldithiocarbamic acid
2 Flammable gases Not applicable (ammonium Classified as "solid" according to GHS definition. The free acid cannot be classified due to lack of data.
salt)
4 Oxidizing gases Not applicable (ammonium Classified as "solid" according to GHS definition. The free acid cannot be classified due to lack of data.
salt)
5 Gases under pressure Not applicable (ammonium Classified as "solid" according to GHS definition. The free acid cannot be classified due to lack of data.
salt)
6 Flammable liquids Not applicable (ammonium Classified as "solid" according to GHS definition. The free acid cannot be classified due to lack of data.
salt)
mixtures
9 Pyrophoric liquids Not applicable (ammonium Classified as "solid" according to GHS definition. The free acid cannot be classified due to lack of data.
salt)
mixtures
flammable gases
13 Oxidizing liquids Not applicable (ammonium Classified as "solid" according to GHS definition. The free acid cannot be classified due to lack of data.
salt)
16 Corrosive to metals Classification not possible Classification not possible due to lack of data
Health Hazards
1 Acute toxicity (dermal) Classification not possible Classification cannot be determined, though the available rat dermal study reported the LD50 value of >628mg/kg (Agricultural Chemical Registration
Data (1984)).

vapour)
Acute toxicity (inhalation: dust, Category 4 Based on the rat LC50 (inhalation route) value of 1.98mg/L (4 hours) (Agricultural Chemical Registration Data (1984)).
1
mist)
2 Skin corrosion / irritation Category 1C Based on the evidence of destruction of skin tissues observed in rabbit skin irritation tests (24 hour application) (Agricultural Chemical Registration
Data (1987)).
3 Serious eye damage / eye Category 1 Due to the fact that rabbit skin corrosivity potential is classified as Category 1C.
irritation

Skin sensitizer: Category 1 Data (1984)).
5 Germ cell mutagenicity Not classified Based on negative data in in vitro reverse mutation tests (Agricultural Chemical Registration Data (1979)), in vivo micronucleus tests on mouse bone
marrow cells and in vivo unscheduled DNA synthesis tests on rat stem cells (Agricultural Chemical Registration Data (2002)), though in vitro
chromosome aberration tests showed positive (Agricultural Chemical Registration Data (1993)).
6 Carcinogenicity Not classified There was no treatment-related increase in tumor incidence observed in carcinogenicity studies in rats and mice (Agricultural Chemical Registration
Data (1996)).
7 Toxic to reproduction Not classified Based on no evidence of adverse effects on reproduction or offspring development observed in rat reproduction studies and rat/rabbit teratogenicity
studies (Agricultural Chemical Registration Data (1993, 1995, 1996)).
8 Specific target organs/systemic Based on the evidence from animal studies including "reduced locomotor activity," "salivation," "prone position," and "tonic convulsions"
toxicity following single exposure Category 1 (nervous system) (Agricultural Chemical Registration Data (1984)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organs/systemic In the available animal studies, "increased liver weight and centrilobular hepatocellular hypertrophy" were found. These effects were observed at
toxicity following repeated Category 2 (liver) dosing levels within the guidance value ranges for Category 2.
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 72 hours EbC50=0.062mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2005).
environment (acute)
Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.15(Existing Chemical Safety Inspections Data, )), since there was no
environment (chronic) with long lasting effects rapidly degrading (the decomposition by BOD: 6%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.
GHS Classification
ID507 6-methyl-1,3-dithiolo[4,5-b]quinoxalin-2-one
mixtures
mixtures
flammable gases
14 Oxidizing solids Not applicable Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)

Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of >3,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data).
1 Acute toxicity (dermal) Classification not possible Classification cannot be determined, though the available rat dermal study reported the LC50 value of >500mg/kg (Agricultural Chemical Registration
Data).

vapour) Category 4 Based on the rat LC50 (inhalation route) value of 2.16mg/L (4 hours) (Agricultural Chemical Registration Data).
mist)
2 Skin corrosion / irritation Not classified Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data).
3 Serious eye damage / eye Category 1 Based on the evidence of moderate to severe eye irritation, with effects persisting for at least 14 days of observation in rabbit eye irritation tests
irritation (Agricultural Chemical Registration Data).

Skin sensitizer: Category 1 Data).
5 Germ cell mutagenicity Not classified Based on negative data in in vitro reverse mutation tests and mouse in vivo micronucleus tests, though in vitro chromosome aberration tests showed
positive (Agricultural Chemical Registration Data).
6 Carcinogenicity Not classified There was no treatment-related increase in tumor incidence observed in mouse carcinogenicity studies (Agricultural Chemical Registration Data).
teratogenicity studies (Agricultural Chemical Registration Data).
8 Specific target organs/systemic In single dose toxicity studies in chickens, "flaccid paralysis without sensory loss (generally, neuromuscular block), somnolency (general suppression
toxicity following single exposure Category 2 (nervous system) of activity), and convulsions" (RTECS (2003)) were found. These effects were observed at dosing levels within the guidance value ranges for
Category 2.

exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 48 hours EC50=0.015mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.78(PHYSPROP Database, 2005)), since there was no rapidly degrading
environment (chronic) with long lasting effects (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.
GHS Classification
ID508 3-Methylpyridine
CAS 108-99-6 Date Classified: Sep. 20, 2006 (Environmental Hazards: Mar. 31, 2006)
6 Flammable liquids Category 3 The flash point is 38degC (c.c.) (ICSC (2000)), which is classified into "Category 3." Classified into Class 3 and Packing Group III (UN#2313, Picoline)
(UN Recommendations on the Transport of Dangerous Goods).
mixtures
9 Pyrophoric liquids Not classified Classified into Class 3 (UN#2313, Picoline) (UN Recommendations on the Transport of Dangerous Goods).

mixtures
flammable gases
13 Oxidizing liquids Not applicable Organic compounds containing no oxygen, fluorine and chlorine
16 Corrosive to metals Not classified Classified into Class 3 (UN#2313, Picoline) (UN Recommendations on the Transport of Dangerous Goods).
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 400mg/kg representing the lower of the two testing data, 400mg/kg and 800mg/kg (CERI-NITE Hazard
Assessment No.29 (2005)).
1 Acute toxicity (dermal) Category 3 Based on the rabbit LD50 (dermal route) value of 800mg/kg representing the lower of the two testing data, 800mg/kg and 2,000mg/kg (PATTY (4th,
2000)).
1 Acute toxicity (inhalation: Category 3 Based on the LC50 value of 1,300ppm calculated from the rat LC50 (4 hour inhalation of vapour) value of 5.03mg/L representing the lower of the
vapour) two testing data of 5.03mg/L and 12.8mg/L (CERI-NITE Hazard Assessment No.29 (2005)) was lower than 90% of the saturated vapour
concentration (7,970ppm) under a saturated vapour pressure of 805Pa (6.05mmHg) (25degC) (CERI Hazard Data 2001-52 (2002)), the substance was
considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.

mist)
2 Skin corrosion / irritation Category 1A-1C Based on the evidence of "corrosion" from rabbit skin irritation tests (4 hour application) (CERI-NITE Hazard Assessment No.29 (2005)). Although
classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage / eye Category 1 Classified as Category 1 in accordance with the technical guideline, given the fact that the substance is classified into Category 1A-1C for "2. Skin
irritation corrosion / irritation."

Classification not possible Skin sensitizer: "No evidence of skin sensitization" was obtained in guinea pig skin sensitization tests (CERI Hazard Data 2001-52 (2002)). However,
Skin sensitizer: Classification classification is not possible, with only one set of data showing "negative" available.
not possible
5 Germ cell mutagenicity Not classified Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, negative data on somatic cell
mutagenicity tests in vivo (micronucleus tests), described in NTP DB (Access on May 2006), CERI-NITE Hazard Assessment No.29 (2005) and CERI
Hazard Data 2001-52 (2002).
6 Carcinogenicity Classification not possible Classification not possible based on expert judgment in the absence of existing classification, though CERI Hazard Data 2001-52 (2002) provides
some toxicity data.
7 Toxic to reproduction Classification not possible No data available

8 Specific target organs/systemic Based on the human evidence including "autonomic disorder such as reduced tension of the vascular smooth muscles, decreased blood pressure and
toxicity following single exposure Category 1 (nervous system), bradycardia, increased pilomotor reflex, impaired thermoregulatory functions, and symptoms of polyneuropathy" (CERI-NITE Hazard Assessment
Category 3 (narcotic effects, No.29 (2005)), "autonomic disorder, bradycardia, hypotension, impaired thermoregulatory functions, mild central nervous system disorder" (PATTY
respiratory tract irritation) (4th, 2000)), "the substance, in the form of fume, irritates the respiratory tract" (ICSC (J) 1999).
9 Specific target organs/systemic Based on the human evidence including "increased alanine aminotransferase/aspartate aminotransferase activity indicative of hepatotoxicity, and
toxicity following repeated bilirubinemia" (CERI-NITE Hazard Assessment No.29 (2005)), "increased activity of hepatic enzymes (SGOT and SGPT) was observed in humans
exposure Category 1 (liver) subject to prolonged exposure" (PATTY (4th, 2000)).
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life
It was classified into Category 3 from 24-72 hours ErC50=15mg/L of the algae (Selenastrum) (CERI/NITE Hazard Assessment Report (preliminary
environment (acute) version), 2006).
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life Although acute toxicity was Category 3 and the bio-accumulation potential was low (BCF<29(Existing Chemical Safety Inspections Data)), since
environment (chronic) with long lasting effects there was no rapidly degrading (the decomposition by BOD: 3%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.
GHS Classification
ID509 S-1-methyl-1-phenylethyl 1-piperidinecarbothioate
CAS 61432-55-1 Date Classified: Nov. 20, 2006 (Environmental Hazards: Mar. 31, 2006)
7 Flammable solids Classification not possible No data available
mixtures
10 Pyrophoric solids Classification not possible No data available
11 Self-heating substances and Classification not possible Test method applicable to liquid substances are not available (melting point: 39degC, (SRC (2006)), test temperature: 140degC).
mixtures
flammable gases
14 Oxidizing solids Not applicable Organic compounds containing oxygen (but not fluorine and chlorine), with oxygen bound to carbon and hydrogen (but not to other elements)

16 Corrosive to metals Classification not possible Classification not possible due to lack of data on substances with melting points of <55degC (melting point: 39degC, SRC (2006))
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 945mg/kg (RTECS (20006)).
1 Acute toxicity (dermal) Not classified Based on the rat LD50 (dermal route) value of >5,000mg/kg (RTECS (2006)).

vapour) Classification not possible Classification not possible due to the insufficiency of data.
mist)
2 Skin corrosion / irritation Classification not possible No data available
3 Serious eye damage / eye Classification not possible No data available
irritation

Classification not possible Skin sensitizer: No data available
Skin sensitizer: Classification
not possible
5 Germ cell mutagenicity Classification not possible No data available

8 Specific target organs/systemic No data available
exposure
11 Hazardous to the aquatic Classification not possible - - - No data available
environment (acute)
environment (chronic)
GHS Classification
ID510 O-3-tert-butylphenyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate
mixtures
11 Self-heating substances and Test method applicable to liquid substances are not available (melting point: 86.3-88.2degC (Agricultural Chemical Registration Data), test
mixtures Classification not possible temperature: 140degC).

flammable gases

Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1988)).
1 Acute toxicity (dermal) Not classified Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1988)).

vapour) Not classified Based on the rat LC50 (inhalation route) value of >6.52mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration
mist) Data (1988)).
3 Serious eye damage / eye Not classified Based on the evidence of conjunctival injection with a score of 1 at 1 hour after instillation; 0.2 at 24 hours; the effects cleared up by 72 hours in all
irritation affected animals (Agricultural Chemical Registration Data (1988)).

5 Germ cell mutagenicity Not classified Based on negative data in in vitro assays (reverse mutation tests, chromosome aberration tests and DNA repair tests) and mouse in vivo
6 Carcinogenicity Classification not possible Based on a judgment made by experts in the absence of existing classification, though some data are available on carcinogenicity studies in rats and
mice.

Classification not possible In a rat inhalation study, one test animal exhibited accumulation of whitish foamy fluid in the trachea, and dark reddening and edematous changes of
the lung.

exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 72 hours EbC50=0.0977mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
environment (acute)
GHS Classification
ID511 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one; Methoxsalen
7 Flammable solids Classification not possible Classification not possible due to lack of data, though classified as flammable according to HSDB (2006).

Classification not possible Classification not possible due to lack of data, though containing unsaturated bonds (olefin)
mixtures
11 Self-heating substances and Classification not possible No data available
mixtures
flammable gases
16 Corrosive to metals Classification not possible Test methods applicable to solid substances are not available
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 420mg/kg representing the lower of the two testing data, 420mg/kg and 791mg/kg (CERI Hazard Data
2000-36 (2001)).
1 Acute toxicity (dermal) Classification not possible No data available
1 Acute toxicity (inhalation: gas) Not applicable Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.

vapour) Classification not possible No data available
mist)
irritation

not possible
5 Germ cell mutagenicity Category 2 Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo,
and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in NTP DB (Access on May 2006) and CERI Hazard Data
2000-36 (2001).
6 Carcinogenicity Category 1A Due to the fact that the substance is classified as Group 1 (8-Methoxypsoralen (Methoxsalen) [298-81-7] plus ultraviolet A radiation) by IARC
(1999) and Category K (Methoxsalen with Ultraviolet A Therapy (PUVA)) by NTP (2005).

8 Specific target organs/systemic Based on the evidence from animal studies including "spasm, altered locomotor activity, ataxia" (RTECS (2005)). The effects on experimental
toxicity following single exposure Category 2 (nervous system) animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organs/systemic Based on the evidence from animal studies including "hyperplasia of the renal tubular epithelium, chronic nephritis,
toxicity following repeated Category 2 (kidneys, thyroid inflammation/ulceration/hyperplasia of the proventricular mucosal epithelium, and hyperplasia of the follicular epithelium in the thyroid gland" (CERI
exposure gland) Hazard Data 2000-36 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
11 Hazardous to the aquatic Classification not possible - - - Classification not possible due to lack of data
environment (acute)
GHS Classification
ID512 Tris(2-chloroethyl) phosphate
6 Flammable liquids Not classified The flash point is 216degC (open cup flash test) (Sax (11th, 2004))
mixtures
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 602degC (Sax, 11th, 2004).

mixtures
in contact with water, emit Not classified Stable to water (water solubility: 5g/L (20degC), BUA20 (1987))
flammable gases
Oxidizing liquids Classification not possible due to lack of data, though being organic compounds containing oxygen bound to elements other than carbon and
13 Classification not possible hydrogen
16 Corrosive to metals Classification not possible No data available
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the LD50 value of 542mg/kg calculated from the testing data of rat LD50 (oral route) of 200mg/kg (CERI Hazard Data 98-22 (1999)),
501mg/kg, 430mg/kg, 794mg/kg, 1,230mg/kg, 1,410mg/kg, 1,150mg/kg and 3,600mg/kg (CERI-NITE Hazard Assessment No.205 (2004)).
1 Acute toxicity (dermal) Not classified Based on the rabbit LD50 (dermal route) value of > 28,500mg/kg (CERI Hazard Data 98-22 (1999)).

vapour)
1 Acute toxicity (inhalation: dust, Classification not possible Insufficient data available
mist)
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 98-22 (1999) and CERI-NITE Hazard Assessment No.205
(2004)): "mild irritation," "mild erythema."
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 98-22 (1999)): "Mildly irritating."
irritation

Classification not possible Skin sensitizer: "No evidence of skin sensitization" was obtained in Buehler Tests on guinea pigs (CERI-NITE Hazard Assessment No.205 (2004)).
Skin sensitizer: Classification However, classification is not possible, with only one set of data showing "negative" available.
not possible
5 Germ cell mutagenicity Category 1B Based on positive data on multi-generation mutagenicity tests (dominant lethal tests), described in IARC 71 (1999), CERI-NITE Hazard Assessment
No.205 (2004), NTP DB (Access on May 2006) and EHC 209 (1998).
6 Carcinogenicity Not classified Due to the fact that the substance is classified as Group 3 by IARC (1999).
7 Toxic to reproduction Category 2 Based on the evidence of decreased numbers of live fetuses per litter and testicular effects at parental toxic doses (or in the absence of data on
general toxicity) in rat teratogenicity studies and continuous breeding studies, described in MOE Risk Assessment vol. 1 (2002) and EHC 209 (1998).
8 Specific target organs/systemic Based on the evidence from animal studies including "piloerection and salivation, hunchback position (in all treated animals), abnormal gait, lethargy,
toxicity following single exposure labored respiration, blepharoptosis and paleness of extremities," "dose-dependent increase in rearing and tremor (wet dog shakes)" (CERI-NITE
Category 1 (nervous system), Hazard Assessment No.205 (2004)), "(treated animals) convulsed within 60-90 hours and had extensive loss of CA1 hippocampal pyramidal cells
Category 3 (narcotic effects) when examined after 7 days, suggesting long-term impairment of some brain functions" (EHC 209 (1998)). The effects on experimental animals were
observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organs/systemic Based on the human evidence: "Clinical signs included weakness in arms and abdominal muscles and abnormalities in electromyogram and nerve
toxicity following repeated conduction velocities" (NICNAS (2001)). Also based on the evidence from animal studies including "dose-dependent increase in the incidence of
exposure hyperplasia of the renal tubular epithelium (renal cortex convoluted tubules); degeneration and necrosis of neurocytes in the brain stem and
Category 1 (nervous system) cerebrum, reactive gliosis, hemorrhage, mineral deposition, pigmentation or hemosiderin deposition, local lesions in the cerebrum and thalamus"
Category 2 (kidneys) (CERI-NITE Hazard Assessment No.205 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value
ranges for Category 2.
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life It was classified into Category 3 from 96 hours LC50=90mg/L of the fish (Goldfish) (CERI/NITE Hazard Assessment Report, 2004).
environment (acute)
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life Although acute toxicity was Category 3 and the bio-accumulation potential was low (BCF=5.1(Existing Chemical Safety Inspections Data)), since
environment (chronic) with long lasting effects there was no rapidly degrading (the decomposition by BOD: 4%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.
GHS Classification
ID513 Tris(dimethylphenyl) phosphate
6 Flammable liquids Not classified The flash point is 232degC (Hawley (14th, 2001))
mixtures
9 Pyrophoric liquids Not classified The substance is primarily used as incombustible material, plastics and hydraulic fluids, and therefore considered not to be pyrophoric when in
contact with air at ordinary temperatures (HSDB, 2006).
mixtures
in contact with water, emit Not classified Stable to water (water solubility: 0.002wt% (85degC), Hawley (14th, 2001))
flammable gases
Oxidizing liquids Classification not possible due to lack of data, though being organic compounds containing oxygen bound to elements other than carbon and
13 Classification not possible hydrogen
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) values of >25,000mg/kg (CERI Hazard Data 2001-28 (2002)) and >20,000mg/kg (CERI-NITE Hazard Assessment
No.24 (2005)).

mist)
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.24 (2005)): "Slight erythematous responses
persisted by 72 hours."
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.24 (2005)): "At 1 hour, with and without
irritation rinsing, treated animals experienced mild to moderate irritation with conjunctival edema" that was completely reversible within 24 hours.

not possible
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo mutagenicity tests and no positive data on in vitro mutagenicity tests (several indices), described in NTP
DB (Access on May 2006), CERI-NITE Hazard Assessment No.24 (2005) and CERI Hazard Data 2001-28 (2002).

8 Specific target organs/systemic Based on the evidence from animal studies: "ataxia and neuropathological changes, suggesting that tris(dimethylphenyl) phosphate induces
toxicity following single exposure neurotoxicity" (CERI-NITE Hazard Assessment No.24 (2005)). The effects on experimental animals were observed at dosing levels within the
Category 2 (nervous system) guidance value ranges for Category 2.
exposure
Since a potential that relevant toxicity was indicated in the water solubility (0.89mg/L (PHYSPROP Database (2005)) of this substance could not be
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life denied from 48 hours EC50=5.9mg/L of the crustacea (Daphnia magna) (MOE Eco-Toxicity Tests of Chemicals (1997)), it was classified into
environment (acute) Category 1.
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (BCF=466.4(Existing Chemical Safety Inspections Data, )), since there was no
GHS Classification
ID514 2-Amino-5-nitrobenzonitrile
1 Explosives Classification not possible
Classification not possible due to lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups
with its oxygen budget calculated at -142).
Classification not possible Classification not possible due to lack of data, though containing nitro groups with explosive properties
mixtures
mixtures
flammable gases
Classification not possible due to lack of data, though being organic compounds containing oxygen bound to elements other than carbon and
14 Oxidizing solids Classification not possible
hydrogen
Health Hazards
1 Acute toxicity (oral) Category 5 Based on the rat LD50 (oral route) value of 3,884mg/kg (RTECS (2006)).
mist)
irritation

not possible

exposure
environment (acute)
GHS Classification
ID515 p-Aminophenol
7 Flammable solids Not classified Classified as flammable according to HSDB (2006). Classified into Division 6.1 (UN#2261 (o-, m-, p-)) (UN Recommendation on the Transport of
Dangerous Goods).
Not applicable Containing no chemical groups with explosive or self-reactive properties
mixtures
10 Pyrophoric solids Not classified Although classified as flammable, the substance does not catch fire easily (HSDB, 2006). Classified into Division 6.1 (UN#2512 (o-, m-, p-)) (UN
Recommendations on the Transport of Dangerous Goods).
mixtures
flammable gases
Health Hazards
1 Acute toxicity (dermal) Not classified Based on the rabbit LD50 (oral route) value of > 8,000mg/kg representing the lower of the two testing data, > 8,000mg/kg (IUCLID (2000)) and >
16,000mg/kg (RTECS (2006)).

vapour) Category 4 Based on the rat LC50 (inhalation of dust/mist) value of 1.48mg/L (IUCLID (2000)).
mist)
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (RTECS (2006) and IUCLID (2000)): "Mild," "slightly irritating." The substance is
thus considered a mild skin irritant.
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (RTECS (2006) and IUCLID (2000)): "Mild," "slightly irritating." The substance is
irritation thus considered a mild eye irritant.
4 Respiratory/skin sensitizer Respiratory sensitizer: Based on the description in HSDB (2003) of the human health effects: "The substance induces contact dermatitis and
Respiratory sensitizer: bronchial asthma."
Category 1 Skin sensitizer: Due to the fact that the substance is classified as a "Skin Sensitizing Substance" by the Japanese Society for Contact Dermatitis.
Skin sensitizer: Category 1
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on in vitro mutagenicity tests (several indices),
described in NTP DB (Access on May 2006), and Report by the Ministry of Health, Labour and Welfare (1997).
6 Carcinogenicity Classification not possible Classification not possible based on expert judgment in the absence of existing classification, though PATTY (4th, 1999) presents toxicity data.
7 Toxic to reproduction Category 2 Based on the evidence of a significant increase in the incidence of exencephalia and malformation of the limbs, tail and eye in the pups observed in
teratogenicity studies with Syrian hamsters using intraperitoneal injection, described in PATTY (4th, 1999) (though no data are available regarding
parental toxicity). Also based on the evidence of maternal toxicity and teratogenicity observed in rat teratogenicity studies using the oral route of
exposure, described in Teratology (1986).
8 Specific target organs/systemic Category 1 (blood system) Based on the human evidence: "p-Aminophenol induces methemoglobinemia" (PATTY (4th, 1999)).
9 Specific target organs/systemic Based on the human evidence: "p-Aminophenol produces nephrotoxicity; induces methemoglobinemia" (PATTY (4th, 1999)). Also based on the
toxicity following repeated evidence from animal studies including "dark brown urine was observed; urinalysis revealed an increase in epithelial cells; a band of white colored
exposure tissue was present at the corticomedullary junction; basophilic renal tubules were found" (Report by the Ministry of Health, Labour and Welfare
Category 1 (kidneys, blood (1997)), "dose-dependent nephrosis was noted in both sexes at weeks 13 and 27, and in males that had been kept away from the test material at
system) week 7 during the recovery period" (PATTY (4th, 1999)).
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 72 hours ErC50=0.1mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1996).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (BCF=46(Existing Chemical Safety Inspections Data, )), since there was no rapidly
environment (chronic) with long lasting effects degrading (the decomposition by BOD: 6%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.
GHS Classification
ID516 3'-Amino-4'-methoxyacetanilide
mixtures
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 110-110.5degC (PRTR Chemicals DB, NITE, 2006), test temperature:
mixtures 140degC).
flammable gases
Health Hazards
1 Acute toxicity (oral) Classification not possible No data available

mist)
irritation

not possible

"Though being an Existing Chemical, the substance was considered to possess a mutagenic potential as defined under the Labor Safety and
Sanitation Law."

8 Specific target organs/systemic Classification not possible No data available
exposure
environment (acute)
GHS Classification
ID517 4-Allyl-1,2-dimethoxybenzene
6 Flammable liquids Not classified The flash point is 99degC (c.c.) (NFPA (13th, 2002))
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though containing unsaturated bonds (olefin)
mixtures
9 Pyrophoric liquids Not classified Stable to air, heat and light (HSDB, 2006); not pyrophoric when in contact with air at ordinary temperatures

mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 1,179mg/kg (PATTY (4th, 1999)).

vapour)
mist)
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (PATTY (4th, 1999)): "Slightly irritating."
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (PATTY (4th, 1999)): "Slightly irritating."
irritation

Classification not possible Skin sensitizer: According to the description in HSDB (2002) of human health effects, a Maximization test showed no indication of sensitization in
Skin sensitizer: Classification humans. However, classification is not possible, with only one set of data showing "negative" available.
not possible
mutagenicity tests in vivo (micronucleus tests), described in NTP DB (Access on May 2006).
6 Carcinogenicity Category 1B Based on expert judgment in the absence of existing classification, though NTP TR491 (2000) presents toxicity data and the substance is classified
as Category R by NTP (2005).
7 Toxic to reproduction Classification not possible Insufficient data available

9 Specific target organs/systemic Based on the evidence from animal studies including "hepatocellular hypertrophy, oval cell hyperplasia, bile duct hyperplasia (females), cystic
toxicity following repeated degeneration, neuroendocrine cell hyperplasia and atrophy of the glandular stomach," "increased platelet counts; increased serum activities of
exposure alanine aminotransferase and sorbitol dehydrogenase indicative of hepatocellular lesions; increased incidences of adrenal gland cortical hypertrophy
Category 2 (liver, stomach, and/or cytoplasmic alteration in the submandibular gland occurred," "the incidences of lesions of the glandular stomach were increased" (NTP
blood system, adrenal, TR491 (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
submandibular gland)
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life It was classified into Category 3 from 96 hours LC50=14mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals, 2003).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since there was rapidly degrading (the decomposition by BOD: 89% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low
GHS Classification
ID518 2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-triazine
mixtures
11 Self-heating substances and Test method applicable to liquid substances are not available (melting point: 88-89degC (Agricultural Chemical Registration Data), test temperature:
mixtures Classification not possible 140degC).

flammable gases
16 Corrosive to metals Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 88-89degC (Agricultural Chemical
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 1,405mg/kg (Agricultural Chemical Registration Data (1969)).

vapour)
1 Acute toxicity (inhalation: dust, Not classified Based on the rat LC50 (inhalation route) value of >5.17mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration
mist) Data (1991)).
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (exposure duration unknown) (PATTY (4th, 1999)): "Slight irritation." The
substance is thus considered a mild irritant.
3 Serious eye damage / eye Category 2B Based on the descriptions in the reports on rabbit eye irritation tests: "Mild irritation" (PATTY (4th, 1999)) and "Mild" (RTECS (2006)).
irritation
4 Respiratory/skin sensitizer Respiratory sensitizer: No data available

Respiratory sensitizer: Skin sensitizer: Based on the description in the reports on skin sensitization tests in animals (species unknown) (PATTY (4th, 1999)): "Non-
Classification not possible sensitizer." Also based on the description in the report on guinea pig maximization tests (IUCLID (2000)): "not sensitization."
Skin sensitizer: Not classified
5 Germ cell mutagenicity Not classified Based on negative data in in vitro reverse mutation tests, in vitro chromosome aberration tests and in vivo host mediated reverse mutation tests in
mice (Agricultural Chemical Registration Data (1979, 1989, 1998)).
Data (1988, 1992)).
teratogenicity studies (Agricultural Chemical Registration Data (1988, 1992)).
8 Specific target organs/systemic Based on the evidence from animal studies including "ataxia," "salivation," "reduced locomotor activity," "sedation," "abnormal gait," and
toxicity following single exposure Category 2 (nervous system) "lacrimation" (Agricultural Chemical Registration Data (1969, 1986)). These effects were observed at dosing levels within the guidance value ranges
for Category 2.
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 96 hours EbC50=0.0062mg/L of the algae (Skeletonema) (ECETOC TR91, 2003).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (BCF=11(Existing Chemical Safety Inspections Data, )), since there was no rapidly
GHS Classification
ID519 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; Phenobarbital
mixtures
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 3 Based on the rat LD50 (oral route) value of 162mg/kg (IARC 79 (2001)).
vapour)
mist)
irritation

not possible
5 Germ cell mutagenicity Category 1B Based on the absence of data on multi-generation mutagenicity tests and positive data on germ cell mutagenicity tests in vivo (chromosome
aberration tests), described in IARC 79 (2001) and NTP DB (Access on May 2006).
6 Carcinogenicity Category 2 Due to the fact that the substance is classified as Group 2B by IARC (2001).
7 Toxic to reproduction Category 2 Based on the evidence of cleft palate and abnormal behaviour of the offspring observed in teratogenicity studies with mice and rats, described in
IARC 79 (2001) (though no data are available regarding parental toxicity).
8 Specific target organs/systemic Category 3 (narcotic effects) Based on the evidence from animal studies including "somnolence" (RTECS (2006)).
9 Specific target organs/systemic Based on the human evidence: "Sedation is the most common side effect of exposure to phenobarbital in humans. Overdosage of phenobarbital
toxicity following repeated leads to nystagmus and ataxia," "In the patient, T4 level was decreased whereas T3 and TSH responses to thyrotropin-releasing hormone were
exposure within the normal range" (IARC 79 (2003)), "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to
phenobarbital that was prescribed for presumed febrile seizures," "phenobarbital induced a hypersensitivity state consisting of tubulointerstitial
Category 1 (nervous system, nephritis, exfoliative dermatitis and hepatitis" (HSDB (2002)). Also based on the evidence from animal studies: "the liver of the test animal showed
thyroid gland) an occurrence of moderate to severe hypertrophy of centrolobular hepatocytes," "serum T4 and T3 levels were decreased, whereas TSH production
Category 2 (liver, kidneys) was increased," "mild to moderate follicular hypertrophy of the thyroid gland and moderate hepatocellular hypertrophy occurred" (IARC 79 (2003)).
The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. Since the priority rating of the
study reporting the effects on the liver and kidneys in humans is 2, these effects are classified into Category 2.
11 Hazardous to the aquatic Not classified - - - It was classified into Not classified from 96 hours LC50=484mg/L of the fish (Fathead Minnows) (HSDB, 2004).
environment (acute)
Since it was not water-insolubility (the water-solubility =1110mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into
environment (chronic) Not classified.
GHS Classification
ID520 2,4-Xylenol
7 Flammable solids Not classified Classified as flammable according to HSDB (2006). Classified into Division 6.1 (UN#2261 Xylenol (solid)) (UN Recommendation on the Transport of
Dangerous Goods).
Not applicable Containing no chemical groups with explosive or self-reactive properties
mixtures
10 Pyrophoric solids Not classified Not pyrophoric when in contact with air at ordinary temperatures (flash point: 599degC (ICSC, 2004))
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 25.4-26degC (ICSC, 2004), test temperature: 140degC).
mixtures
flammable gases
16 Corrosive to metals Not classified Classified into Division 6.1 (UN#2261 Xylenol (solid)) (UN Recommendation on the Transport of Dangerous Goods).
Health Hazards
1 Acute toxicity (oral) Category 5 Based on the rat LD50 (oral route) value of 2,300mg/kg representing the lower of the two testing data, 3,200mg/kg (RTECS (2006)) and 2,300mg/kg
(HSDB (2003)).
1 Acute toxicity (dermal) Category 4 Based on the rat LD50 (dermal route) of 1,040mg/kg (RTECS (2006)).
1 Acute toxicity (inhalation: gas) Not applicable Due to the fact that the substance is "liquid" or "solid"according to the GHS definition and inhalation of its gas is not expected.

vapour)
Acute toxicity (inhalation: dust, Classification not possible No data available
1
mist)
2 Skin corrosion / irritation Category 1A-1C Based on the description in ICSC (J) (2003) of the human health effects: "Corrosive to the skin, respiratory tract and eye." Although classified into
Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage / eye Category 1 Based on the description in ICSC (J) (2003) of the human health effects: "Corrosive to the skin, respiratory tract and eye."
irritation

Classification not possible Skin sensitizer: Based on the description in ICSC (J) (2003): "Repeated or prolonged contact may cause a skin sensitization reaction."
DB (Access on June 2006).

8 Specific target organs/systemic Category 2 (respiratory Corrosive to the skin, respiratory tract and eye; oral ingestion results in corrosion; inhalation of aerosols may lead to pulmonary edema (ICSC (J)
toxicity following single exposure organs) (2003)). Since the priority rating of the referenced study is 2, these effects are classified into Category 2 (respiratory organs).
9 Specific target organs/systemic Based on the evidence from animal studies: "at final sacrifice in the mid-dose female group, BUN levels were significantly higher than controls,"
toxicity following repeated Category 2 (kidneys, nervous "lethargy, prostration and ataxia in males and females" (IRIS (1990)). The effects on experimental animals were observed at dosing levels within the
exposure system) guidance value ranges for Category 2.
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 48 hours EC50=4.2mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 2001).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since there was rapidly degrading (the decomposition by BOD: 91% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low
GHS Classification
ID521 2-(4-chloro-6-ethylamino-1,3,5-triazin-2-yl)amino-2-methylpropiononitrile
7 Flammable solids Not classified Non-flammable (ICSC (2004))
mixtures
10 Pyrophoric solids Not classified Non-flammable (ICSC (2004))
11 Self-heating substances and Not classified Non-flammable (ICSC (2004))
mixtures
flammable gases
14 Oxidizing solids Not applicable Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)

Not classified Registration Data)). Assigned to Division 6.1 (UN#2763 Triazine Pesticide, solid, toxic (ICSC (2004))) (UN Recommendations on the Transport of
Dangerous Goods)
Health Hazards

vapour) Classification not possible Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >0.809mg/L (4 hours) (Agricultural
mist) Chemical Registration Data (1983)).
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (24 hours, occluded) (PATTY (4th, 1999)): "Mildly irritating."
3 Serious eye damage / eye Category 2A Based on the description in the report on rabbit eye irritation tests (PATTY (4th, 1999)): "Mild to moderate irritation" and "severe irritation following
irritation instillation of 90% formulation, which took about two weeks to resolve." The substance is thus considered a moderate irritant.

Classification not possible Skin sensitizer: No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler method (Agricultural Chemical
5 Germ cell mutagenicity Not classified Based on negative data in in vitro assays (reverse mutation tests, chromosome aberration tests and unscheduled DNA synthesis tests) and in vivo
assays (mouse chromosome aberration tests, dominant lethal tests and unscheduled DNA synthesis tests) (Agricultural Chemical Registration Data
(1983, 1996, 1997)).
Data (1983, 1996)).
8 Specific target organs/systemic Category 3 (Narcotic effects) Based on the evidence from animal studies including "lethargy" (RTECS (2003)).
9 Specific target organs/systemic Based on the evidence from animal studies including "acute renal failure, acute renal tubular necrosis, and myocardiosis including myocardial
toxicity following repeated infarction" (RTECS (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1
Category 2 (kidneys, heart) (kidneys) and Category 2 (heart). Since the referenced study (RTECS (2003)) is assigned a priority rating of 2, these effects are classified into
exposure
Category 2.
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from ErC50=20microg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.22(PHYSPROP Database, 2005)), since there was no rapidly degrading
environment (chronic) with long lasting effects (BIOWIN), it was classified into Category 1.
GHS Classification
ID522 1-Chloronaphthalene
mixtures
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures (flash point: >558degC (NFPA, 13th, 2002))

mixtures
flammable gases
13 Oxidizing liquids Not applicable Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 1,540mg/kg (CICAD 34 (2001)).
mist)
2 Skin corrosion / irritation Category 2 Based on the description in HSDB (2003) of the human health effects: "It is an irritant to the skin." Although classified into Category 2-3 in the
absence of data regarding the degree of irritation, the substance should be placed in Category 2 from the viewpoint of safety.
3 Serious eye damage / eye Category 2A-2B Based on the description in HSDB (2003) of the human health effects: "It is an irritant to the eyes." Although classified into Category 2A-2B in the
irritation absence of data regarding the degree of irritation, the substance should be placed in Category 2 from the viewpoint of safety if further
subclassification is needed.

not possible
DB (Access on June 2006) and CICAD 34 (2001).

8 Specific target organs/systemic Category 2 (systemic Based on the human evidence: "Symptoms may include... headache, fatigue, vertigo and anorexia" (HSDB (2003)).
toxicity following single exposure toxicity)
9 Specific target organs/systemic Based on the human evidence: "chloracne may develop after chronic exposure" (HSDB (2003)).
toxicity following repeated Category 2 (skin) Since the priority rating of the referenced study is 2, these effects are classified into Category 2 (skin).
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 96 hours LC50=0.37mg/L of the crustacea (Mysid Shrimp)) (CICAD34, 2001).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (BCF=442(Existing Chemical Safety Inspections Data, )), since there was no
GHS Classification
ID523 O-6-Chloro-3-phenyl-4-pyridazinyl S-n-octyl thiocarbonate; Pyridate
mixtures
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 27degC (Merck, 13th, 2001), test temperature: 140degC).
mixtures
flammable gases
14 Oxidizing solids Not applicable Organic compounds containing oxygen and chlorine (but not fluorine), with the oxygen and chlorine bound to carbon and hydrogen respectively (but
not to other elements)
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the LD50 value of 1,694mg/kg calculated from the testing data of rat LD50 (oral route) of 1,970mg/kg (RTECS (2006)), 4,690mg/kg,
3,588mg/kg and 1,431mg/kg (IUCLD (2000)).
1 Acute toxicity (dermal) Category 5 Based on the rabbit LD50 (dermal route) value of 3,400mg/kg (RTECS (2006)).
1 Acute toxicity (inhalation: Classification not possible Insufficient data available

vapour) Classification not possible Insufficient data available
mist)
2 Skin corrosion / irritation Category 2 Based on the description in the report on rabbit skin irritation tests (IUCLD (2000)): "Irritating" (though the severity of the effects is unknown).
3 Serious eye damage / eye Not classified Based on the description in the report on rabbit eye irritation tests (IUCLD (2000)): "Not irritating."
irritation

Classification not possible Skin sensitizer: Based on the descriptions in the report on the guinea pig Maximization test and Open epicutaneous test (IUCLD (2000)):
Skin sensitizer: Category 1 "Sensitizing."

exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 48 hours EC50=0.83mg/L of the crustacea (Daphnia magna) (IUCLID, 2000).
environment (acute)
GHS Classification
ID524 alpha-cyano-3-phenoxybenzyl 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylate
6 Flammable liquids Classification not possible Classification not possible due to lack of data
mixtures
9 Pyrophoric liquids Classification not possible Classification not possible due to lack of data
11 Self-heating substances and Classification not possible Test method applicable to liquid substances are not available (test temperature: 140degC).
mixtures
flammable gases
13 Oxidizing liquids Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other
Not applicable elements)

16 Corrosive to metals Classification not possible Classification not possible due to lack of data
Health Hazards
1 Acute toxicity (inhalation: gas) Not applicable Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected.

3 Serious eye damage / eye Not classified Based on no evidence of irritation observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1986)).
irritation

5 Germ cell mutagenicity Not classified Based on negative data in in vitro assays (reverse mutation tests, chromosome aberration tests and somatic cell mutation tests) and mouse in vivo
micronucleus tests (Agricultural Chemical Registration Data (1986)).
6 Carcinogenicity Classification not possible Classification not possible in the absence of existing classification, though some data on animal studies are available.
studies (Agricultural Chemical Registration Data (1986)).
8 Specific target organs/systemic Category 2 (testes, In inhalation studies in animals, "testicular atrophy and millet-sized brown spots in the testes," and "slight hepatoid degeneration of the lung" were
toxicity following single exposure found (Agricultural Chemical Registration Data (1986). These effects were observed at dosing levels within the guidance value ranges for Category 2.
respiratory organs)

exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 48 hours EC50=0.27mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
environment (acute)
GHS Classification
ID525 (S)-alpha-Cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cis-cyclopropanecarboxylate; alpha-Cypermethrin
mixtures
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 78-81degC (HSDB, 2006), test temperature: 140degC).
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 2 Based on the LD50 value of 40mg/kg calculated from the testing data of rat LD50 (oral route) of 79mg/kg (MOE Risk Assessment vol. 4 (2005)),
40mg/kg, 80mg/kg and 368mg/kg (EHC 142 (1992)).

vapour) Classification not possible Insufficient data available
mist)
2 Skin corrosion / irritation Category 2 Based on the description in the report on rabbit eye irritation tests (EHC 142 (1992)): "Mildly irritating."
3 Serious eye damage / eye Category 1 Based on the description in the report on rabbit eye irritation tests (EHC 142 (1992)): "Severe eye irritant," "The vascularization of the cornea and
irritation iritis were considered to be irreversible." The substance is thus considered to have irreversible effects on the eye and thus classified as Category 1.
The effects induced may differ depending on the type of formulation (such as "EC" and "SC").

Classification not possible Skin sensitizer: The results of guinea pig Maximization tests and Buehler tests reported in EHC 142 (1992) suggest no evidence of skin sensitization,
Skin sensitizer: Classification whereas the substance is considered positive for sensitization according to EU Risk Phrase. These inconsistent data do not allow the presence or
not possible absence of sensitization to be determined, and thus classification is not possible.
mutagenicity tests in vivo (chromosome aberration tests), described in EHC 142 (1992).

7 Toxic to reproduction Classification not possible Classification is not possible since no data are available regarding adult reproduction, though no definitive evidence of pup reproductive toxicity was
observed in any of the teratogenicity studies with rats and rabbits, described in MOE Risk Assessment vol. 4 (2005).
8 Specific target organs/systemic Based on the evidence from animal studies: "clonic convulsions, piloerection, salivation and splayed hind-leg gait were found" (EHC 142 (1992)),
toxicity following single exposure "ataxia, dyspnea, salivary gland dysfunction" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the
9 Specific target organs/systemic Based on the human evidence: "The substance induces neurotoxicity that affects the axons of the peripheral and central nervous systems via
toxicity following repeated sodium channels" (MOE Risk Assessment vol. 4 (2005)). Also based on the evidence from animal studies including "ataxia and abnormal gait,
exposure hyperactivity, hunchback position, elevated ALAT/ASAT levels," "decreased hemoglobin level and increased platelet counts; increased lymphocyte
counts and decreased acidophile counts in males; decreased mean red blood cell volume and mean corpuscular hemoglobin, and increased blood level
Category 1 (nervous system) of urea in females" (MOE Risk Assessment vol. 4 (2005)), "abnormal gait and hypersensitivity were observed; decreases in protein and increases in
Category 2 (blood system, urea levels were observed in both sexes" (EHC 142 (1992)). The effects on experimental animals were observed at dosing levels within the guidance
liver) value ranges for Category 1 (nervous system) and Category 2 (liver, blood system).
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 48 hours EC50=0.0003mg/L of the crustacea (Daphnia magna) (EHC142, 1992).
environment (acute)
GHS Classification
ID526 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea
mixtures
10 Pyrophoric solids Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat at 40degC for two months
Not classified (Agricultural Chemical Registration Data)
mixtures
flammable gases
14 Oxidizing solids Not applicable Organic compounds containing fluorine, chlorine and oxygen bound to carbon and hydrogen (but not to other elements)

Health Hazards

vapour)
1 Acute toxicity (inhalation: dust, Not classified Based on the rat LC50 (inhalation route) value of >5.0mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data
mist) (1996)).
3 Serious eye damage / eye Not classified Based on the evidence of mild irritation occurring immediately after exposure, with effects clearing up by 24 hours, observed in rabbit eye irritation
irritation tests (Agricultural Chemical Registration Data (1996)).

5 Germ cell mutagenicity Not classified Based on negative data in in vitro studies (reverse mutation tests, forward mutation assay, chromosome aberration tests, DNA repair tests and
unscheduled DNA synthesis tests) and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1996)).
Data (1987, 1996)).

9 Specific target organs/systemic Based on the evidence from animal studies including "moderate centrilobular hepatocellular necrosis" (JMPR (1994)). The effects on experimental
toxicity following repeated Category 1 (liver) animals were observed at dosing levels within the guidance value ranges for Category 1.
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 48 hours EC50=2.28microg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data,
environment (acute) 2003).
Very toxic to aquatic life Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.56 (PHYSPROP
GHS Classification
ID527 2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; Chloramphenicol
Classification not possible Classification not possible due to lack of data, though containing nitro groups with explosive properties.
mixtures
mixtures
flammable gases
Classification not possible due to lack of data, though being organic compounds containing oxygen bound to the elements other than carbon and
14 Oxidizing solids Classification not possible
hydrogen
Health Hazards

vapour)
mist)
3 Serious eye damage / eye Classification not possible Insufficient data available
irritation

not possible
5 Germ cell mutagenicity Category 1B Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), positive data on germ cell mutagenicity tests in vivo
(chromosome aberration tests) and somatic cell mutagenicity tests in vivo (chromosome aberration tests), and the absence of data on germ cell
genotoxicity tests in vivo, described in IARC 50 (1990) and IARC 10 (1976).
6 Carcinogenicity Category 1B Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2A by IARC (1990).
7 Toxic to reproduction Category 2 Based on the evidence of pup malformation including hydrocephalus and cleft palate observed in rat teratogenicity studies, described in IARC 10
(1976) (though no data are available regarding parental toxicity).

9 Specific target organs/systemic Based on the human evidence: "a case report of a 5-yr-old child who developed aplastic anemia and died of acute myeloblastic leukemia 1 year after
toxicity following repeated chloramphenicol was therapeutically administered," "a case of a 63-yr-old man who developed bone marrow suppression 4 months after
exposure chloramphenicol was administered at a dose of 12g" (IARC 10 (1976)), "other adverse effects of prolonged administration included skin eruption,
Category 1 (bone marrow, gastrointestinal disorder and nervous system damage" (IARC 50 (1990)), "there is symmetrical loss of ganglion cells from retina and atrophy of fibers
nervous system, digestive in optic nerve," "cardiovascular collapse with cardiomyopathic changes and impaired left ventricular function was documented by echocardiography"
organs) (HSDB (2005)). Since the priority rating of the referenced study reporting the effects on the heart in humans is 2, these effects are classified into
Category 2 (heart) Category 2.
11 Hazardous to the aquatic Not classified - - - It was classified into Not classified from 48 hours EC50=345000microg/L of the crustacea (Daphnia magna) (AQUIRE, 2003).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since it was not water-insolubility (the water-solubility =2500mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into
GHS Classification
ID528 2,4'-dichloro-alpha-(5-pyrimidinyl)benzhydryl alcohol
mixtures
11 Self-heating substances and Test method applicable to liquid substances are not available (melting point: 116degC (Agricultural Chemical Registration Data), test temperature:

flammable gases
14 Oxidizing solids Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other

16 Corrosive to metals Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 116degC (Agricultural Chemical
Health Hazards
3 Serious eye damage / eye Category 2B Based on the evidence of mild irritation of the eye, which was fully reversed by 72 hours, observed in rabbit eye irritation tests (Agricultural Chemical

5 Germ cell mutagenicity Not classified Based on negative data in in vitro studies (reverse mutation tests, forward mutation assay, chromosome aberration tests, DNA repair tests,
unscheduled DNA synthesis tests) and in vivo studies (chromosome aberration tests on hamster bone marrow cells and rat dominant lethal tests in
vivo) (Agricultural Chemical Registration Data (1977, 1979, 1980, 1982, 2005)).
Data (1981, 1985)).
7 Toxic to reproduction Category 2 Based on the evidence of "decreased female fertility," "dystocia," "decreased delivery rate," "prolonged gestation period" and "decreased pup
viability" at doses causing reduced parental body weight gain observed in rat reproduction studies (Agricultural Chemical Registration Data (1986)).
8 Specific target organs/systemic Based on the evidence from animal studies including "reduced locomotor activity," "blepharoptosis," "ataxic gait," "spastic gait," "sedation," "prone
toxicity following single exposure or lateral position," "panting" and "gasping" (Agricultural Chemical Registration Data (1980)). These effects were observed at dosing levels within
Category 2 (nervous system) the guidance value ranges for Category 2.
9 Specific target organs/systemic Based on the evidence from animal studies including "fatty infiltration of the liver and hepatocellular hypertrophy," "renal tubular hyaline cast" and
toxicity following repeated "hypertrophy of adrenal fasciculata cells" (Agricultural Chemical Registration Data (1980)). These effects were observed at dosing levels within the
exposure Category 2 (liver, kidneys, guidance value ranges for Category 2.
adrenal)
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from ErC50=5.1mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2005).
environment (acute)
11 Hazardous to the aquatic Category 2 Environment - Toxic to aquatic life with Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=3.6(PHYSPROP Database, 2005)), since there was no
environment (chronic) long lasting effects rapidly degrading (BIOWIN), it was classified into Category 2.
GHS Classification
ID529 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-hexanol
mixtures
11 Self-heating substances and Test method applicable to liquid substances are not available (melting point: 84-86degC (Agricultural Chemical Registration Data), test temperature:

flammable gases

Health Hazards

vapour)
Acute toxicity (inhalation: dust, Not classified Based on the rat LC50 (inhalation route) value of >5.9mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data
1
mist) (1990)).
3 Serious eye damage / eye Category 2B Based on the evidence of mild irritation, which was fully reversed by day 7, observed in rabbit eye irritation tests (Agricultural Chemical Registration
irritation Data (1990)).
4 Respiratory/skin sensitizer Respiratory sensitizer:

Respiratory sensitizer: No data available
Skin sensitizer: Based on positive results in guinea pig skin sensitization tests employing the Maximization method (Agricultural Chemical Registration
Classification not possible Data (1990)).
5 Germ cell mutagenicity Not classified Based on negative data in reverse mutation tests in bacteria, gene mutation tests on mouse lymphoma cells and mouse in vivo micronucleus tests
(Agricultural Chemical Registration Data (1990)).
Data (1990)).
8 Specific target organs/systemic Category 2 (systemic Based on the evidence from animal studies including "reduced locomotor activity," "dehydration," "low body temperature," "lack of stability" and
toxicity following single exposure "respiratory failure" observed at dosing levels within the guidance value ranges for Category 2 (Agricultural Chemical Registration Data (1990)).
toxicity)
9 Specific target organs/systemic Based on the evidence from animal studies including "hepatocellular hypertrophy," "hepatocellular necrosis" and "adrenal cortical vacuolization"
toxicity following repeated Category 2 (liver, adrenal) (Agricultural Chemical Registration Data (1990)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
exposure
environment (acute)
GHS Classification
ID530 Disodium 4-amino-3-[4'-(2,4-diaminophenylazo)-1,1'-biphenyl-4-ylazo]-5-hydroxy-6-phenylazo-2,7-naphthalenedisulfonate; C.I. Direct Black 38
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though being sulfonyls, containing chemical groups with self-reactive properties
mixtures
10 Pyrophoric solids Not classified Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is used as dyestuffs for the textile, leather, resin
and flooring applications, and resin filler, etc. (HSDB, 2006).
11 Self-heating substances and
Classification not possible No data available
mixtures
in contact with water, emit Not classified Stable to water (soluble, HSDB (2006))
flammable gases
14 Oxidizing solids Classification not possible Classification not possible due to lack of data, though being organic compounds containing oxygen bound to the elements other than carbon and
hydrogen.
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of 7,600mg/kg (RTECS (2006)).

mist)
3 Serious eye damage / eye Category 2A Based on the description in the report on rabbit eye irritation tests (RTECS (2006)): "Moderate."
irritation

not possible
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on mutagenicity tests in vitro (several indices),
described in IARC 29 (1982) and NTP DB (Access on June 2006).
6 Carcinogenicity Classification not possible Classification not possible based on expert judgment in the absence of existing classification (except EU Risk Phrase), though IARC 29 (1982)
presents toxicity data.
7 Toxic to reproduction Category 2 Based on the evidence of total resorptions observed at doses causing maternal death, described in IARC 29 (1982).

9 Specific target organs/systemic Based on the evidence from animal studies: "9 of surviving rats had bladder mucosal hyperplasia, whereas 8 had hepatic hyperplasia" (IARC 29
toxicity following repeated Category 2 (bladder, liver) (1982)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
exposure
11 Hazardous to the aquatic Not classified - - - It was classified into Not classified from 96 hours LC50>180000microg/L of the fish (Fathead Minnows) (AQUIRE, 2003).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since it was not water-insolubility (the water-solubility =3000mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into
nate; C.I. Direct Black 38
GHS Classification
ID531 Disodium 2,2'-vinylenebis[5-(4-morpholino-6-anilino-1,3,5-triazin-2-ylamino)benzenesulfonate]; C.I. Fluorescent 260
7 Flammable solids Not classified Non-flammable (ICSC, 2002)
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though being sulfonyls, containing chemical groups with self-reactive properties
mixtures
10 Pyrophoric solids Not classified Non-flammable (ICSC, 2002)
11 Self-heating substances and Not classified Non-flammable (ICSC, 2002)
mixtures
in contact with water, emit Not classified Stable to water (water solubility: 5mg/L (25degC), HSDB (2006))
flammable gases
hydrogen.
Health Hazards
1 Acute toxicity (oral) Classification not possible Insufficient data available

vapour)
mist)
2 Skin corrosion / irritation Classification not possible The results in rabbit eye irritation tests reported in IUCLD (2000) suggest that the substance is "not irritating." However, classification is not
possible, with only one set of data available.
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (RTECS (2006) and IUCLID (2000)): "Mild," "slightly irritating." The substance is
irritation thus considered a mild eye irritant.

Classification not possible Skin sensitizer: Insufficient data available
not possible

exposure
Since it was suggested from 96-hour LC50>44mg/L of the fish (Oryzias Latipest) (MOE Eco-Toxicity Tests of Chemicals, 1997) that relevant
environment (acute) toxicity is not indicated in the water solubility (5mg/L(PHYSPROP Database, 2005)) of this substance, it was classified into Not classified.
11 Hazardous to the aquatic Not classified - - - Although it is water-insolubility and acute toxicity was not reported within the aqueous solubility concentrations and there was no rapidly degrading
environment (chronic) (BIOWIN), since the bio-accumulation (BCF=28 (Existing Chemical Safety Inspections Data)) was low, it was classified into Not classified.
GHS Classification
ID532 Mixture of 2,4-dinitro-6-octylphenyl crotonate and 2,6-dinitro-4-octylphenyl crotonate (octyl=1-methylheptyl,1-ethylhexyl,1-propylpentyl); Dinocap; D
CAS 131-72-6 Date Classified: Oct. 23, 2006 (Environmental Hazards: Mar. 31, 2006)
Classification not possible due to lack of data on decomposition energy, though the substance contains nitro groups with its oxygen budget
calculated at -184. According to ICSC (2004), Dinocap (mixing ratio of isomers unknown) may decompose when heated above 32degC.
6 Flammable liquids Classification not possible Classification not possible due to lack of data, though Dinocap (mixing ratio of isomers unknown) is classified as flammable by ICSC (2004).
8 Self-reactive substances and Classification not possible due to lack of data, though the substance contains nitro groups with explosive properties. According to ICSC (2004),
mixtures Classification not possible Dinocap (mixing ratio of isomers unknown) may decompose when heated above 32degC.
9 Pyrophoric liquids Classification not possible No data available. Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is widely used as fungicides,
acaricides, etc. for fruits, vines, vegetables and house plants (Dinocap, mixing ratio of isomers unknown (HSDB, 2006)).
mixtures
flammable gases
13 Oxidizing liquids Classification not possible Classification not possible due to lack of data, though being organic compounds containing oxygen bound to the elements other than carbon and
hydrogen.
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the LD50 value of 829mg/kg calculated from the rat LD50 (oral route) of 980mg/kg, 950mg/kg, 1,190mg/kg (HSDB (2006)) and 766mg/kg
(RTECS (2006)).
1 Acute toxicity (dermal) Not classified Based on the rabbit LD50 (dermal route) value of 9,400mg/kg (RTECS (2006)).
1 Acute toxicity (inhalation: Category 1 Based on the rat LC50 value of 24ppm (4 hours), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.36mg/L (4 hours) (RTECS
vapour) (2006)), was lower than the saturated vapour concentration (52,800ppm) under a saturated vapour pressure of 0.00533mPa (25degC) (Howard
(1997)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.

mist)
2 Skin corrosion / irritation Category 2 Based on the description of the human health effects (exposure duration unknown) (HSDB (2006)): "They are only moderately irritating to the skin
and mucous membranes."

irritation

Classification not possible Skin sensitizer: Based on the description of the human health effects (HSDB (2006) and ICSC (J) (1997)): "Skin sensitization: positive."
mutagenicity tests in vivo (chromosome aberration tests), described in JMPR (1989) and JMPR (1998).
6 Carcinogenicity Classification not possible Classification not possible based on expert judgment in the absence of existing classification, though some toxicity data are available.
7 Toxic to reproduction Category 1B Based on the evidence of increased pup mortality and fetal malformation (cleft palate, abnormal inner ear) at non-parentally toxic doses in mouse
teratogenicity studies, described in JMPR (1989).

9 Specific target organs/systemic Based on the evidence from animal studies: "necrosis was found in the liver" (JMPR (1998)), "histological changes were noted in the liver and
toxicity following repeated Category 1 (liver) kidneys" (HSDB (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2.
exposure Category 2 (kidneys)
environment (acute)
xyl,1-propylpentyl); Dinocap; DPC
GHS Classification
ID533 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; Propylthiouracil
mixtures
mixtures
flammable gases
Health Hazards

mist)
irritation

not possible
5 Germ cell mutagenicity Classification not possible Classification is not possible due to the insufficiency of data. No data are available on multi-generation mutagenicity tests and germ cell mutagenicity
tests in vivo, whereas a somatic cell mutagenicity study in vivo (chromosome aberration test) showed negative results (NTP DB (Access on June
2006) and IARC 79 (2001)). However, the latter test was exceptional in that it was conducted ex vivo using the thyroid gland and therefore cannot
serve as an adequate basis for the classification.
6 Carcinogenicity Category 2 Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2B by IARC (2001).
7 Toxic to reproduction Category 2 Based on the evidence of reduced cerebral neocortex volume and abnormal behaviour in the pups observed in rat teratogenicity studies, described in
IARC 79 (2001) (though no data are available regarding parental toxicity).

9 Specific target organs/systemic Based on the human evidence (patients given doses of propylthiouracil): "Agranulocytosis is the most common side effect; rare but severe side
toxicity following repeated effects include hepatitis, angitis and drug induced lupus syndrome," "Propylthiouracil has been widely used in the treatment of hyperthyroidism;
exposure Category 1 (thyroid gland, patients tend to develop hypothyroidism due to inappropriate management of dosage regimens" (IARC 79 (2001)). Also based on the evidence from
blood system, liver, animal studies: "Both serum T3 and T4 levels are decreased; hyperplasia of the follicular epithelial cells has been reported" (IARC 79 (2001)). The
cardiovascular system, skin) effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
environment (acute)
GHS Classification
ID534 p-Divinylbenzene
mixtures
10 Pyrophoric solids No data available. The isomer mixtures including m- and o- (mixing ratio unknown) have the flash point of 500degC (ICSC (1999)) and are considered
Classification not possible non-pyrophoric when in contact with air at ordinary temperatures. p-divinylbenzene per se is also regarded non-pyrophoric when in contact with air
at ordinary temperatures, and therefore "Not classified."
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 31degC (Lide, 84th, 2003), test temperature: 140degC).
mixtures
flammable gases
Health Hazards

vapour)
1
mist)
irritation

not possible

Classification not possible Refer to GHS classification of divinylbenzene isomer mixtures (ID_0231, CAS 1321-74-0).
toxicity following repeated Classification not possible Refer to GHS classification of divinylbenzene isomer mixtures (ID_0231, CAS 1321-74-0).
exposure
environment (acute)
GHS Classification
ID535 m-Divinylbenzene
6 Flammable liquids No data available. The isomer mixtures including p- and o- (mixing ratio unknown) have the boiling point of 195degC and the flash point of 76degC
(open cup flash test) (ICSC (1999)), whereas the boiling point of m-divinylbenzene is 199.5degC (HSDB (2006)). According to some studies, "a good
linear relationship is found between the flash points and the boiling points of the homologues, which indicates that the substance with a low boiling
Classification not possible point generally has a low flash point" (Safety of Hazardous Substances, 2004). Based on this, the flash point of m-divinylbenzene is considered to
exceed 76degC, which can be included in "Category 4."

mixtures
9 Pyrophoric liquids No data available. The isomer mixtures including p- and o- (mixing ratio unknown) have the flash point of 500degC (ICSC (1999)) and are considered
Classification not possible non-pyrophoric when in contact with air at ordinary temperatures. m-divinylbenzene per se is also regarded non-pyrophoric when in contact with air
at ordinary temperatures, and therefore "Not classified."

mixtures
flammable gases
13 Oxidizing liquids Not applicable Organic compounds containing no oxygen, fluorine or chlorine
Health Hazards

vapour)
mist)
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (RTECS (2006)): "Mildly irritating."
irritation

not possible

toxicity following single exposure Refer to GHS classification of divinylbenzene isomer mixtures (ID_0231, CAS 1321-74-0).
exposure
10 Aspiration hazard Category 1 Based on the fact that the substance is a hydrocarbon and has a dynamic viscosity of 1.17mm2/s (20degC).
environment (acute)
GHS Classification
ID536 o-Divinylbenzene
6 Flammable liquids No data available. The isomer mixtures including p- and m- (mixing ratio unknown) have the boiling point of 195degC and the flash point of 76degC
(open cup flash test) (ICSC (1999)), whereas the boiling point of o-divinylbenzene is 178.5degC (HSDB (2006)). According to some studies, "a good
linear relationship is found between the flash points and the boiling points of the homologues, which indicates that the substance with a low boiling
Classification not possible point generally has a low flash point" (Safety of Hazardous Substances, 2004). Based on this, the flash point of o-divinylbenzene is considered to be
lower than 76degC, which can be included in "Categories 4, 3 or 2."

mixtures
9 Pyrophoric liquids No data available. The isomer mixtures including p- and m- (mixing ratio unknown) have the flash point of 500degC (ICSC (1999)) and are considered
Classification not possible non-pyrophoric when in contact with air at ordinary temperatures. o-divinylbenzene per se is regarded non-pyrophoric when in contact with air at
ordinary temperatures, and therefore "Not classified."

mixtures
flammable gases
Health Hazards

vapour)
mist)
irritation

not possible

toxicity following single exposure Refer to GHS classification of divinylbenzene isomer mixtures (ID_0231, CAS 1321-74-0).
exposure
environment (acute)
GHS Classification
ID537 5,5-Diphenyl-2,4-imidazolidinedione
mixtures
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 1,635mg/kg (IUCLID (2000)).

vapour)
mist)
irritation

not possible
5 Germ cell mutagenicity Category 1B Based on positive data on multi-generation mutagenicity tests (dominant lethal tests), described in NTP DB (Access on June, 2006), NTP TR404
(1993) and IARC 66 (1996).
7 Toxic to reproduction Category 1A Based on the human evidence of reproductive toxicity, described in IARC 66 (1996) and NTP TR404 (1993).
8 Specific target organs/systemic Based on the human evidence: "acute oral overexposure to the material causes irreversible cerebellar atrophy, according to some studies" (IARC 66
toxicity following single exposure Category 1 (nervous system) (1996)).
9 Specific target organs/systemic Based on the human evidence (patients receiving doses over a long period of time): "Gingival hyperplasia is a major disorder associated with
toxicity following repeated phenytoin. In addition, hepatic necrosis and a decrease in peripheral blood lymphocyte counts have been reported; hyperplasia of heterotype cells of
exposure lymph node has also been noted" (IARC 13 (1973)), "long-term ingestion of phenytoin adversely affects the nervous system," "clinically significant
Category 1 (nervous system, gingival growth was noted" (IARC 66 (1996)). Also based on the evidence from animal studies including "dose dependent hypertrophy of
gingiva, liver, lymph node) centrolobular hepatocytes was observed" (NTP TR404 (1993)). The effects on experimental animals were observed at dosing levels within the
guidance value ranges for Category 2.
environment (acute)
GHS Classification
ID538 1,4-Dibromobutane
6 Flammable liquids Not classified The flash point is 110degC (Dean (15th, 1999))
mixtures
9 Pyrophoric liquids Classification not possible No data available
mixtures
flammable gases
Health Hazards

mist)
irritation

not possible
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo mutagenicity tests and no positive data on in vitro mutagenicity tests (several indices).

exposure
environment (acute)
GHS Classification
ID539 1,3-Dibromopropane
6 Flammable liquids Category 3 The flash point is 54degC (Dean (15th, 1999)), which is classified into "Category 3."
mixtures
mixtures
flammable gases
Health Hazards

mist)
irritation

not possible
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on in vitro mutagenicity tests (several indices).
8 Specific target organs/systemic Based on the evidence from animal studies including "salivation, reduced locomotor activity, abnormal gait, prone position and lateral position"
toxicity following single exposure (Report by the Ministry of Health, Labour and Welfare (2003)). The effects on experimental animals were observed at dosing levels within the
9 Specific target organs/systemic Based on the evidence from animal studies including "decreases in the red blood cell counts, hemoglobin, hematocrit, and lymphocyte fraction ratio
toxicity following repeated and increases in the reticulocyte ratio and segmented neutrophil fraction ratio; increases in ASAT, ALAT, gamma-GTP, albumin, total cholesterol,
exposure Category 2 (blood system, phospholipids," (Report by the Ministry of Health, Labour and Welfare (2003)). The effects on experimental animals were observed at dosing levels
liver) within the guidance value ranges for Category 2.
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 96 hours LC50=7.8mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals, 2003).
environment (acute)
11 Hazardous to the aquatic Category 2 Environment - Toxic to aquatic life with Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2.37(PHYSPROP Database, 2005)), since there was no
environment (chronic) long lasting effects rapidly degrading (the decomposition by BOD: 48%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.
GHS Classification
ID540 Dibenzyl ether
mixtures
9 Pyrophoric liquids Not classified Dibenzylether is commonly used as a perfume solvent (HSDB, 2006), and thus considered non-pyrophoric when in contact with air at ordinary
temperatures.
mixtures
flammable gases
16 Corrosive to metals Classification not possible No data available. Dibenzylether is commonly used as a perfume solvent (HSDB, 2006), and therefore unlikely to be corrosive to metals.
Health Hazards

vapour)
mist)
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (RTECS (2006)): "Mildly irritating" (though the results are not those of four hour
application).
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (RTECS (2006)): "Mildly irritating."
irritation

not possible
5 Germ cell mutagenicity Classification not possible Classification not possible due to the insufficiency of data (no data available on in vivo mutagenicity/genotoxicity tests)

exposure
It was classified into Category 1 from 48 hours EC50=0.77mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals (1995) and
Very toxic to aquatic life others.).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity is Category 1 and bio-accumulation is low (BCF=429(Existing Chemical Safety Inspections Data, )), since there was no
GHS Classification
ID541 Thioacetamide
7 Flammable solids Classification not possible Classification not possible due to lack of data, though classified as "flammable" by ICSC (2004).
mixtures
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 113-116degC (ICSC, 2004), test temperature: 140degC).
mixtures
flammable gases
Health Hazards
vapour)
mist)
irritation

not possible
and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in RTECS (2006) and NTP DB (Access on June, 2006).
7 Toxic to reproduction Classification not possible Insufficient data available.

8 Specific target organs/systemic Based on the human evidence: "Several people developed degenerative changes in the liver" (HSDB (2003)). Also based on the evidence from animal
toxicity following single exposure studies including "hepatitis (hepatocyte necrosis)" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the
Category 2 (liver) guidance value ranges for Category 1. Since the priority rating of the referenced studies (both in animals and humans) are 2, the substance is
classified into Category 2 (liver).
9 Specific target organs/systemic Based on the evidence from animal studies: "Mild to moderate cirrhosis was observed" (IARC 7 (1974)). The effects on experimental animals were
toxicity following repeated Category 1 (liver) observed at dosing levels within the guidance value ranges for Category 1.
exposure
environment (acute)
GHS Classification
ID542 Iron carbonyl
6 Flammable liquids The flash point is -15degC (ICSC (2004)) and the boiling point is 103degC, which is classified into Category 2. Classified into Class 3 and Division 6.1
Category 2 (UN#1994) (UN Recommendation on the Transport of Dangerous Goods).

mixtures
9 Pyrophoric liquids Not classified based on the "Technical Guideline of GHS Classification of Physical Hazard" (Mar.10, 2006) since the substance is Classified into
Class 3 and Division 6.1 (UN#1994) by the UN Recommendation on the Transport of Dangerous Goods, though it has the flash point of 50degC (ICSC
Not classified (2004)) and may be pyrophoric when in contact with air, which could be classified into "Category 1."

mixtures
in contact with water, emit Not classified Stable to water (insoluble, ICSC (2004))
flammable gases
13 Oxidizing liquids Not classified
Classified as a powerful reducing agent by ICSC (2004), though being inorganic compounds containing oxygen

15 Organic peroxides Not applicable Not organic compounds
16 Corrosive to metals Not classified Classified into Class 3 and Division 6.1 (UN#1994) (UN Recommendation on the Transport of Dangerous Goods).
Health Hazards
1 Acute toxicity (oral) Category 2 Based on the rat LD50 (oral route) value of 25mg/kg representing the lower of the two testing data, 25mg/kg (RTECS (2006)) and 40mg/kg (IUCLID
(2000)).
1 Acute toxicity (dermal) Category 2 Based on the LD50 value of 105mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 56mg/kg (RTECS (2006)), 240mg/kg,
250mg/kg and 170mg/kg (males) (IUCLID (2000)).
1 Acute toxicity (inhalation: Category 1 Based on the rat LC50 (4 hours) value of 0.32mg/L (equivalent to 40ppm), calculated from the testing data of rat LC50 (inhalation of vapour) of
vapour) 0.91mg/L (30 min) (equivalent to 115ppm) (ATSDR (2001)), was lower than 90% of the saturated vapour concentration (46,000ppm) under a saturated
vapour pressure of 35torr (25degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard
values expressed in ppm.

mist)
2 Skin corrosion / irritation Not classified Based on the description in the report on rabbit skin irritation tests (4 hour application) performed in accordance with OECD Test Guideline (IUCLID
(2000)): "Not irritating."
3 Serious eye damage / eye Not classified Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Test Guideline 405 (IUCLID (2000)): "Not
irritation irritating."
not possible
5 Germ cell mutagenicity Classification not possible Classification not possible due to the insufficiency of data (no data available on in vivo mutagenicity/genotoxicity tests)

8 Specific target organs/systemic Based on the human evidence including "liver and kidney damage; central nervous system degeneration" (HSDB (2005)), "pathological lesions
toxicity following single exposure Category 1 (respiratory including hepatization of the lung, vascular disorder and central nervous system degeneration" (PATTY (4th, 1999)), and the evidence from animal
organs, nervous system, studies: "clinical symptoms following exposure include respiratory depression, cyanosis, tremor and motor paralysis" (ACGIH (7th, 2001)). The effects
cardiovascular system) on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Since the referenced studies for the effects
Category 2 (liver, kidneys) on human liver and kidneys are assigned a priority rating of 2, these effects are classified into Category 2.
9 Specific target organs/systemic Based on the description in ICSC (J) (1995): "The substance adversely affects the liver, inducing hepatic dysfunction." Also based on the evidence
toxicity following repeated from animal studies: "Treatment-related histopathological changes occurred in the lung; a slight but significant increase in carboxyhemoglobin was
exposure Category 2 (liver, blood detected" (IUCLID (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
system, respiratory organs) However, the substance is classified into Category 2 since the priority rating of referenced studies is 2.
11 Hazardous to the aquatic Not classified - - - Since it was suggested that relevant toxicity is not indicated within the water solubility (100mg/L (IUCLID (2000)) of this substance in spite of 48
environment (acute) hours EC50=130mg/L and EC0=62.5mg/L of the crustacea (Daphnia magna) (IUCLID (2000)), it was classified into Not classified.
11 Hazardous to the aquatic Not classified - - - Since it was not water-insolubility (the water-solubility =100mg/L (IUCLID, 2000)), and acute toxicity was low, it was classified into Not classified.
GHS Classification
ID543 Tellurium dioxide
7 Flammable solids Considered non-flammable because tellurium, which can be produced by burning tellurium (Te) in air, is a stable oxide existing in nature as a mineral
Not classified (Chemical Dictionary, 1994).
mixtures
10 Pyrophoric solids Considered non-flammable because tellurium, which can be produced by burning tellurium (Te) in air, is a stable oxide existing in nature as a mineral
Not classified (Chemical Dictionary, 1994).
11 Self-heating substances and Not classified Tellurium oxide is considered non-flammable because it is obtained by burning tellurium (Te) in air and it is a stable oxide occurring in nature as a
mixtures mineral (tellurite) (Chemical Dictionary, 1994).
in contact with water, emit Not classified Stable to water (insoluble, Lide (84th, 2003))
flammable gases
14 Oxidizing solids Classification not possible Classification not possible due to lack of data, though being inorganic compounds containing oxygen
15 Organic peroxides Not applicable Not organic compounds

Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of >5,000mg/kg (RTECS (2004)).

vapour)
mist)
irritation

not possible

7 Toxic to reproduction Category 2 Based on the evidence of adverse effects on pup development (malformation and fetal death), described in RTECS (2006) (though no data are
available regarding parental toxicity).
8 Specific target organs/systemic Insufficient data available.
Classification not possible Refer to "Tellurium" (ID_0236, CAS_13494-80-9).
9 Specific target organs/systemic Based on the evidence from animal studies including "effects on the parasympathetic nervous system, muscle contraction/twitching" (RTECS
toxicity following repeated (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
exposure Category 2 (nervous system)
Refer to "Tellurium" (ID_0236, CAS_13494-80-9).
Since it was suggested that relevant toxicity is not indicated in the water solubility (6.7mg/L(Merck 13th, 2001)) of this substance, according to from
environment (acute) 96-hour LC50>1000000microg/L of the fish (Fundulus Heteroclitus) (AQUIRE (2003)), it was classified into Not classified.
11 Hazardous to the aquatic May cause long lasting
Since although acute toxicity is not reported within the aqueous solubility concentrations, it was a metallic compound, and the underwater action
environment (chronic) Category 4 - - harmful effects to
aquatic life was unknown, it was classified into Category 4.
GHS Classification
ID544 Trichloroacetonitrile
6 Flammable liquids Classification not possible No data available
mixtures
mixtures
flammable gases
13 Oxidizing liquids Not applicable Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
Health Hazards
1 Acute toxicity (oral) Category 3 Based on the rat LD50 (oral route) value of 250mg/kg (RTECS (2003).
1 Acute toxicity (dermal) Category 4 Based on the LD50 value of 1,300mg/kg, converted from the testing data of rabbit LD50 (dermal route) of 900microL/kg (RTECS (2003)), using
specific gravity of 1.44 (25degC/4degC).

vapour)
mist)
2 Skin corrosion / irritation Category 2 Based on the description in the report on rabbit skin irritation tests (24 hour application) (RTECS (2003)): "Severe irritation was observed."
3 Serious eye damage / eye Category 2A Based on the description in the report on rabbit eye irritation tests (RTECS (2003)): "Severe irritation was observed." The substance was thus
irritation considered a severe eye irritant.

not possible
mutagenicity tests in vivo (micronucleus tests), described in IARC 52 (1991), EHC 182 (1996) and NTP DB (Access on June, 2006).
6 Carcinogenicity Not classified Due to the fact that the substance is classified as Category 3 by IARC 71 (1999).
7 Toxic to reproduction Category 1B Based on the evidence of fetal toxicity and teratogenicity at non-parentally toxic doses, described in IARC 52 (1991) and EHC 182 (1996).
8 Specific target organs/systemic Category 3 (narcotic effects) Based on the evidence from animal studies including "lacrimation, somnolency (reduced locomotor activity), and dyspnea" (RTECS (2003)).
exposure
environment (acute)
GHS Classification
ID545 Sodium 1,1'-biphenyl-2-olate
mixtures
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 78degC (Gangolli, 2nd, 1999), test temperature: 140degC).
mixtures
in contact with water, emit Not classified Stable to water (water solubility: 1.10*10^(6)mg/L (25degC), Howard (1997))
flammable gases
hydrogen.
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 1,000mg/kg representing the lower of the two testing data, 1,000mg/kg and 1,600mg/kg (DFGOT Vo.2
(1991)).

vapour)
mist)
2 Skin corrosion / irritation Category 1A-1C The results of rabbit skin irritation tests (24 hour application) suggest the evidence of "mild or severe irritation" (RTECS (2006)). Although classified
into Category 1A-1C since the pH of 1% aqueous solution may exceed 11.5 (normally in the range of 11.2 to 11.6) (DFGOT Vol.2 (1991)), the
substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage / eye Category 1 Because the pH of 1% aqueous solution may exceed 11.5 (normally in the range of 11.2 to 11.6) according to DFGOT Vol.2 (1991).
irritation

not possible
5 Germ cell mutagenicity Not classified Based on negative data on multi-generation mutagenicity tests (dominant lethal tests) and the absence of data on germ/somatic cell mutagenicity
tests in vivo, described in IARC 73 (1999) and NTP DB (Access on June, 2006).
6 Carcinogenicity Category 2 Due to the fact that the substance is classified as Group 2B by IARC (1999).
7 Toxic to reproduction Classification not possible Classification not possible due to the insufficiency of data (no data available on reproduction of parental animals).
8 Specific target organs/systemic Based on the evidence from animal studies including "narcotic effects, decreased respiratory rate" (DFGOT vol.2 (1991)), "altered locomotor
toxicity following single exposure Category 3 (narcotic effects) activity," "ataxia, respiratory depression, decreased body temperature" (RTECS (2006)).
exposure
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 48 hours EC50=3.8ppm of the crustacea (Daphnia magna) (AQUIRE, 2003).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since there was rapidly degrading (o-phenylphenol was caused by dissection in the water (the decomposition by BOD: 66%) (Existing Chemical Safety
environment (chronic) Inspections Data)) and the bio-accumulation was low (log Kow=0.59 (PHYSPROP Database (2005))), it was claasified into Not classified.
GHS Classification
ID546 m-Nitroaniline
1 Explosives Classification not possible due to lack of data, though the substance contains nitro groups with its oxygen budget calculated at -151. According to
Bretherick (J) (5th, 1998), the kick-off temperature is 213degC, whereas the decomposition energy is 1.882kJ/g (280-380degC), which can be
Not classified classified as "Explosives." Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).

7 Flammable solids Insufficient data available, though classified as flammable(HSDB (2006)) and the powder or granules, when mixed with the air, may cause dust
Not classified explosion (ICSC (2004)) . Classified into Division 6.1 (UN#1661(o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
8 Self-reactive substances and Not classified with the kick-off temperature of 213degC (Bretherick (J) (5th, 1998)), though the substance contains nitro groups with explosive
mixtures Not classified properties. Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).

10 Pyrophoric solids Not classified
Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
11 Self-heating substances and

Classification not possible Test methods applicable to liquid substances are not available (melting point: 114degC (ICSC, 2002), test temperature: 140degC).
mixtures
flammable gases
14 Oxidizing solids No data available, though being organic compounds containing oxygen bound to the elements other than carbon and hydrogen. Classified into Division
Not classified 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).

Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 535mg/kg representing the lower of the two testing data, 535mg/kg and 540mg/kg (SIDS (1995)).

mist)
2 Skin corrosion / irritation Classification not possible Some human epidemiological studies provide evidence of skin irritation potential (PATTY (4th, 1999)): "The substance is rapidly absorbed through
intact skin, and irritates the skin, eye and mucous membranes." However, classification is not possible since the severity of the effects is not
presented.
3 Serious eye damage / eye Classification not possible Some human epidemiological studies provide evidence of eye irritation potential (PATTY (4th, 1999)): "The substance is rapidly absorbed through
irritation intact skin, causing irritation of the skin, eye and mucous membranes." However, classification is not possible since the severity of the effects is not
presented.

not possible
and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in Report by the Ministry of Health, Labour and Welfare
(1994), NTP DB (Access on June, 2006) and SIDS (1995).

7 Toxic to reproduction Category 2 Based on the indication of a potential of parturition or lactation disorder at doses inducing parental toxicity, described in Report by the Ministry of
Health, Labour and Welfare (1994).
8 Specific target organs/systemic Based on the human evidence: "Acute exposure can cause methemoglobinemia, cyanosis" (HSDB (2003)). Also based on the evidence from animal
toxicity following single exposure studies including "increased methemoglobin and sulfhemoglobin levels in blood" (HSDB (2003)). The effects on experimental animals were observed
Category 2 (blood system) at dosing levels within the guidance value ranges for Category 2. The priority rating for the referenced study for human effects is 2.
9 Specific target organs/systemic Based on the human evidence: "Chronic exposure can cause liver damage" (HSDB (2003)), "may adversely affect the blood system, forming
toxicity following repeated methemoglobin" (ICSC (J) (2001)). Also based on the evidence from animal studies including "cyanosis, methemoglobinemia, testicular atrophy and
exposure Category 2 (liver, blood hepatocyte swelling" (Report by the Ministry of Health, Labour and Welfare (1994)). The effects on experimental animals were observed at dosing
system, testes) levels within the guidance value ranges for Category 2.
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life It was classified into Category 3 from 24 hours EC50=36mg/L of the crustacea (Daphnia magna) (SIDS, 1995).
environment (acute)
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life Although acute toxicity was Category 3 and the bio-accumulation potential was low (BCF=3(Existing Chemical Safety Inspections Data)), since there
environment (chronic) with long lasting effects was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.
GHS Classification
ID547 5'-[N,N-Bis(2-acetyloxyethyl)amino]-2'-(2-bromo-4,6-dinitrophenylazo)-4'-methoxyacetanilide
Classification not possible Classification not possible due to lack of data, though containing nitro groups with explosive properties
mixtures
mixtures
flammable gases
hydrogen.
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of >5,000mg/kg (RTECS (1998)).

mist)
irritation

not possible

exposure
environment (acute)
GHS Classification
ID548 Phenanthrene
mixtures
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the mouse LD50 (oral route) value of 700mg/kg representing the lower of the two testing data, 700mg/kg and 1,000mg/kg (EHC 202
(1998)).

mist)
irritation

Classification not possible Skin sensitizer: Based on the description in the report on human epidemiological studies (PATTY (4th, 1999)): "Mild allergen," "photosensitizing to
Skin sensitizer: Category 1 the skin," though the results of animal skin sensitization studies reported in EHC 202 (1998) suggest "no evidence of contact sensitization caused by
(photosensitizer) phenanthrene."
mutagenicity tests in vivo (micronucleus tests and chromosome aberration tests), described in NTP DB (Access on June, 2006) and IARC 32 (1983).
6 Carcinogenicity Not classified Due to the fact that the substance is classified as Category D by EPA (1990) and Category 3 by IARC (1987).

exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 72 hours ErC50=0.64mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1997).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Since the acute toxicity was Category 1 and it had no rapidly degrading (the decomposition by BOD: 54% (Existing Chemicals Safety Check Data)),
environment (chronic) with long lasting effects and it had the bio-accumulation (log Kow=4.46(PHYSPROP Database, 2005)), it was classified into Category 1.
GHS Classification
ID549 Diisobutyl phthalate
6 Flammable liquids Not classified The flash point is 185degC (ICSC (2001))
mixtures
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures (flash point: 400degC (ICSC, 2001))
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of ca.10,400mg/kg representing the lower of the two testing data, ca.10,400mg/kg (IUCLID (2000)) and
15,000mg/kg (RTECS (2006)).
1 Acute toxicity (dermal) Not classified Based on the guinea pig LD50 (dermal route) value of 10,000mg/kg (RTECS (2006)).

vapour)
mist)
2 Skin corrosion / irritation Not classified Based on the description in the report on rabbit skin irritation tests performed in accordance with OECD Test Guideline 404 (IUCLID (2000)): "Not
irritating."
3 Serious eye damage / eye Not classified Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Test Guideline 405 (IUCLID (2000)): "Not
irritation irritating."

not possible
5 Germ cell mutagenicity Classification not possible Classification not possible due to lack of data on in vivo tests.
7 Toxic to reproduction Classification not possible Insufficient data available.
8 Specific target organs/systemic Category 3 (narcotic effects, Based on the evidence from animal studies including "coma, respiratory tract irritation" (RTECS, (2006)).
toxicity following single exposure respiratory tract irritation)
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 96 hours LC50=0.9mg/L of the fish (Fathead Minnows) (ECETOC TR91, 2003).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Although acute toxicity was Category 1 and there was rapidly degrading (the decomposition by BOD: 98%(Existing Chemical Safety Inspections
environment (chronic) with long lasting effects Data)), since there was bio-accumulation (log Kow=4.11 (PHYSPROP Database (2005)), it was classified into Category 1.
GHS Classification
ID550 tert-Butyl hydroperoxide
Classification not possible due to lack of data on the kick-off temperature and decomposition energy, though being a peroxide with its oxygen budget
calculated at -195. Heating may cause an explosion according to HSDB (2006).
6 Flammable liquids Category 2
Because of a lack of data on the flash point. The substance can be classified into Category 2 or 3 with the flash point of <27degC (c.c.) (NFPA (13th,
2002)) and the boiling point of 89degC (decomposition) (Lide (84th, 2003)), and is placed in "Category 2" from the viewpoint of safety.
8 Self-reactive substances and Classified as "organic peroxides" though being a peroxide containing chemical groups with explosive properties. Classified into Division 5.2 by the UN
mixtures Not applicable Recommendation on the Transport of Dangerous Goods (UN numbers (3103, 3105, 3107, 3109) are given only to those diluted according to their
concentrations and proportions of diluents; tert-butyl hydroperoxide in neat liquid is prohibited for transport and thus has no UN number).
9 Pyrophoric liquids Classification not possible Classification not possible due to lack of data, though heating may cause a fire according to HSDB (2006).
mixtures
flammable gases
hydrogen, and classified as a powerful oxidant according to HSDB (2006).
15 Organic peroxides Type classification is not possible due to lack of data, though organic compounds containing -O-O- structure, with active oxygen quantity calculated
at 35.5%, that is, "Organic peroxides." Organic peroxides permitted for transport are assigned general entries by the UN Recommendation on the
Transport of Dangerous Goods. As for tert-butyl hydroperoxide, only those diluted are given UN numbers (3103, 3105, 3107, 3109), subclassified into
Type A "Type C," "Type D," "Type E" and "Type F" according to their concentrations and proportions of diluents. Since those undiluted are interpreted as
"Type A" (prohibited for transport), tert-butyl hydroperoxide (in neat liquid) is classified as "Type A" by GHS classification. Those diluted are
assigned to Division 5.2 (UN#3103 Organic peroxides Type C (liquid), UN#3105 Organic peroxides Type D (liquid), UN#3107 Organic peroxides Type E
(liquid) and UN#3109 Organic peroxides Type F (liquid )) by the UN Recommendation on the Transport of Dangerous Goods.
16 Corrosive to metals No data available. Under the UN Recommendation on the Transport of Dangerous Goods, those diluted substances classified as "Organic peroxides"
need to be labeled with the subsidiary risk label of "Corrosive Substances." However, the category includes skin corrosivity, and it is unclear
Classification not possible whether the substance is classified as "metal" corrosive (UN numbers of those in solution: UN#3103 Organic peroxides Type C (liquid), UN#3105
Organic peroxides Type D (liquid), UN#3107 Organic peroxides Type E (liquid) and UN#3109 Organic peroxides Type F (liquid)).
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 560mg/kg (SIDS (1995)).
1 Acute toxicity (dermal) Category 3 Based on the LD50 value of 470mg/kg representing the lower of the two testing data, rabbit LD50 (dermal route) of 628mg/kg (SIDS (1995)) and rat
LD50 (dermal route) of 470mg/kg (PATTY (4th, 1999)).
1 Acute toxicity (inhalation: Category 3 Based on the rat LC50 (inhalation of vapour) value of 502ppm (PATTY (4th, 1999)) was lower than 90% of the saturated vapour concentration
vapour) (27,000ppm) under a saturated vapour pressure of 2.7kPa (20degC), the substance was considered as "vapour containing substantially no mist" and
was classified based on standard values expressed in ppm.
mist)
2 Skin corrosion / irritation Category 1A-1C Based on the description in the report on rat skin irritation tests (PATTY (4th, 1999)): "Causes very strong irritation." Although classified into
3 Serious eye damage / eye Category 1 Based on the description in the report on rat eye irritation tests (PATTY (4th, 1999)): "Causes very strong irritation." Also based on the description
irritation in ICSC (1999) of human health effects: "redness, pains and deep burn." The substance is thus considered corrosive to the eye.
not possible
5 Germ cell mutagenicity Category 2 Based on negative and positive data on multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo
(chromosome aberration tests), and the absence of data on germ cell mutagenicity tests in vivo, described in SIDS (1995), DFGOT Vol. 3 (1992) and
NTP DB (Access on June, 2006). The results of dominant lethal tests were not based on the sound knowledge, whereas the positive data on
chromosome aberration tests in vivo were considered not to be definitive. However, all the in vitro tests (Ames assay, chromosome aberration assay,
mouse lymphoma) were positive for mutagenicity, and therefore the substance is classified into Category 2.
6 Carcinogenicity Classification not possible Insufficient data available

7 Toxic to reproduction Not classified Based on no evidence of adverse effects on parental reproduction and pup development in combined studies and teratogenicity studies, described in
SIDS (1995).
8 Specific target organs/systemic Based on the evidence from animal studies: "clinical signs including hypoactivity and lacrimation...loss of righting reflex...signs of hematuria" (PATTY
toxicity following single exposure Category 2 (nervous system, (4th, 1999)) , "hypoactivity...loss of righting reflex, lacrimation...hematuria" (IUCLID (1999)), "methemoglobinemia or carboxyhemoglobin," "cyanosis"
(RTECS (2006)), "decreased respiratory rate and apnea" (IUCLID (1999)). The effects on experimental animals were observed at dosing levels within
blood system, respiratory the guidance value ranges for Category 2 (nervous system, blood system) and Category 1 (respiratory organs). However, the referenced study for the
organs) respiratory effects has a priority rating of 2, which does not meet the criteria for 1b (3) specified in the "Technical Guideline for GHS Health Hazard
Category 3 (narcotic effects) Classification," therefore these are classified into Category 2.
9 Specific target organs/systemic Category 1 (kidneys) Based on the evidence from animal studies including "reticulocytopenia, increased bilirubin level, and nephrosis" (SIDS (1995)). The effects on
toxicity following repeated experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (kidneys) and Category 2 (blood system).
exposure Category 2 (blood system)
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 3 day ErC50=2.1mg/L of the algae (Selenastrum) (IUCLID, 2000).
environment (acute)
Toxic to aquatic life with Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=1.8(Existing Chemical Safety Inspections Data)), since
environment (chronic) long lasting effects there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.
GHS Classification
ID551 N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide
mixtures
11 Self-heating substances and Test method applicable to liquid substances are not available (melting point: 38.5-41.0degC (Agricultural Chemical Registration Data), test
mixtures Classification not possible temperature: 140degC).

flammable gases

16 Corrosive to metals Classification not possible due to lack of data on the substances with melting points of <55degC (melting point: 38.5-41.0degC (Agricultural Chemical
Health Hazards

vapour)
Acute toxicity (inhalation: dust, Classification not possible Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >2.16mg/L (4 hours) (Agricultural Chemical
1
3 Serious eye damage / eye Not classified Based on the evidence of mild irritation occurring immediately after exposure, with effects resolving by 24 hours, observed in rabbit eye irritation
irritation tests (Agricultural Chemical Registration Data (1996)).

not possible
5 Germ cell mutagenicity Not classified Based on negative data in reverse mutation tests in bacteria, in vitro DNA repair tests, in vitro chromosome aberration tests, gene mutation tests on
mouse lymphoma cells, in vitro unscheduled DNA synthesis tests, mouse in vivo micronucleus tests and mouse dominant lethal tests (Agricultural
Chemical Registration Data (2003)).
6 Carcinogenicity Not classified Due to the fact that the substance is classified as Category C by EPA (1997).
7 Toxic to reproduction Category 2 Based on the evidence of "a decreased number of live-born pups with an increase in the stillbirth rate" and "decreased postnatal viability" at doses
causing a reduction in parental body weight gain observed in rat 2-generation reproduction studies. Also based on the evidence of "incomplete
ossification of the sternum/vertebral arch" and "a decreased number of live fetuses/tendency of increased fetal mortality" at parentally toxic doses
observed in rat teratogenicity studies (Agricultural Chemical Registration Data (2003)).
8 Specific target organs/systemic Based on the evidence from animal studies including "central nervous system depressant effects, hunchback position, increased salivation,
toxicity following single exposure hypothermia, ataxia, bradypnea, lacrimation, tremors and convulsions" (JMPR (2001)), "effects on the prostate, seminal capsule, Cowper cyst and
accessory gland" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category
Category 2 (nervous system, 1 (accessory reproductive organs) and Category 2 (nervous system). Since the referenced study for the accessory reproductive organs (RTECS
accessory reproductive (2006)) is assigned a priority rating of 2, these effects are classified into Category 2.
organs)
9 Specific target organs/systemic Based on the evidence from animal studies including "lipogenesis of perilobular hepatocytes," "periportal vacuolization," and "increased fatty-
toxicity following repeated droplet deposition in hepatocytes" (Agricultural Chemical Registration Data (1996)). These effects were observed at dosing levels within the
exposure Category 2 (liver) guidance value ranges for Category 2.
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 72 hours ErC50=1.54mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
environment (acute)
Toxic to aquatic life with Since acute toxicity was Category 2, there was no rapidly degrading (BIOWIN) and there was bio-accumulation (log Kow=4.1(PHYSPROP Database,
environment (chronic) long lasting effects 2005)), it was classified into Category 2.
GHS Classification
ID552 p-Bromophenol
mixtures
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the mouse LD50 (oral route) value of 523mg/kg (RTECS (2006)).

mist)
irritation

not possible

6 Carcinogenicity Classification not possible Insufficient data available
7 Toxic to reproduction Category 2 Based on the evidence of adverse effects on pup development (increased postimplantation loss) at doses at which maternal toxicity is unknown,
described in RTECS (2006).
exposure
environment (acute)
11 Hazardous to the aquatic Category 2 Environment - Toxic to aquatic life with Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=25(Existing Chemical Safety Inspections Data)), since
environment (chronic) long lasting effects there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.
GHS Classification
ID553 3-Bromo-1-propene; Allyl bromide
6 Flammable liquids The flash point is -1degC (c.c.) (NFPA (13th, 2002)) and the boiling point is 71degC, which is classified into "Category 2." Classified into Class 3 and
Category 2 Division 6.1 (UN#1099) (UN Recommendation on the Transport of Dangerous Goods).

8 Self-reactive substances and No data available, though containing unsaturated bonds (olefin). Classified into Class 3 and Division 6.1 (UN#1099) (UN Recommendation on the
mixtures Not classified Transport of Dangerous Goods).
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures (flash point: 295degC (NFPA, 13th, 2002))
mixtures
flammable gases
16 Corrosive to metals Not classified
Classified into Class 3 and Division 6.1 (UN#1099) (UN Recommendation on the Transport of Dangerous Goods).
Health Hazards
1 Acute toxicity (inhalation: Category 3 Based on the LC50 value of 3.5mg/L (equivalent to 710ppm) representing the lower of the LC50 values (4 hours) of 3.5mg/L and 7.1mg/L, calculated
vapour) from the testing data of rat LC50 (inhalation of vapour) of 10mg/L (30 min) and 10mg/L (2 hours) (RTECS (2006)), was lower than 90% of the
saturated vapour concentration (187,000ppm) under a saturated vapour pressure of 142 mmHg (25degC) (equivalent to 18.9 kPa), the substance was
considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.

mist)
2 Skin corrosion / irritation Category 1A-1C Based on the description in the report on human epidemiological studies (HSDB (2006)): "Causes severe skin burn." Although classified into
3 Serious eye damage / eye Category 1 Based on the description in the report on human epidemiological studies (HSDB (2006)): "Causes severe eye burn."
irritation

not possible
mutagenicity tests in vivo (micronucleus tests), described in NTP DB (Access on June, 2006).

8 Specific target organs/systemic Category 3 (respiratory tract Based on the human evidence including "respiratory irritation" (HSDB (2003)).
toxicity following single exposure irritation)
exposure
environment (acute)
GHS Classification
ID554 Hexadecyltrimethylammonium bromide
mixtures
mixtures
flammable gases
Health Hazards

mist)
2 Skin corrosion / irritation Category 2 Based on the description in the report on mouse skin irritation tests (CERI-NITE Hazard Assessment No.206 (2005)): 0.5, 1 and 2 hour application
"caused moderate irritation of the skin."
3 Serious eye damage / eye Category 2A Based on the data on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.206 (2005)): "Causes strong irritation."
irritation

not possible
and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in CERI-NITE Hazard Assessment No.206
(2005).
7 Toxic to reproduction Category 2 Based on the evidence of a decreased number of live borns and decreased viability index on day 3 observed at doses producing parental toxicity in
mouse and rat teratogenicity studies, described in CERI-NITE Hazard Assessment No.206 (2005).
8 Specific target organs/systemic Category 1 (heart, blood Based on the human evidence including "unstable blood pressure and heart ischemia, methemoglobinemia" (CERI-NITE Hazard Assessment No.206
toxicity following single exposure (2005)).
system)
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 96 hours EC50=30microg/L of the blue algae (Microcystis) (MOE Risk Assessment vol. 3, 2004).
environment (acute)
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life Since the acute toxicity was Category 1 and it had no rapidly degrading (the decomposition by BOD: 0% (Existing Chemicals Safety Check Data)), and
environment (chronic) with long lasting effects it had the bio-accumulation (BCF=741 (Existing Chemicals Safety Check Data)), it was classified into Category 1.
GHS Classification
ID555 Benzothiazole
6 Flammable liquids Not classified The flash point is 107degC (c.c.) (IUCLID (2000))
mixtures
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 380mg/kg representing the lower of the two testing data, 492mg/kg and 380mg/kg (PATTY (4th, 2000)).
1 Acute toxicity (dermal) Category 2 Based on the rabbit LD50 (dermal route) value of 126mg/kg representing the lowest of the testing data, 630-1,000mg/kg and 126-200mg/kg
(PATTY (4th, 2000)).

vapour)
mist)
2 Skin corrosion / irritation Category 3 Based on the description in the report on rabbit skin irritation tests (exposure duration unknown) (PATTY (4th, 2000)): "Slightly irritating."
3 Serious eye damage / eye Category 2B Based on the description in the report on rabbit eye irritation tests (PATTY (4th, 2000)): "Slightly irritating."
irritation

not possible
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo tests and no positive data on in vitro mutagenicity tests (several indices), described in NTP DB (Access on
June 2006) and PATTY (4th, 2000).

exposure
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life It was classified into Category 3 from 48 hours EC50=19mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1997).
environment (acute)
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life Although acute toxicity was Category 3 and the potential was low (BCF=7.5(Existing Chemical Safety Inspections Data)), since there was no rapidly
GHS Classification
ID556 Methyl 2-(4,6-dimethoxy-2-pyrimidinyloxy)-6-[1-(methoxyimino)ethyl]benzoate
mixtures
10 Pyrophoric solids Considered non-pyrophoric when in contact with air at ordinary temperatures; both trans- and cis- isomers are stable to heat (up to 150degC)
Not classified (Agricultural Chemical Registration Data).
11 Self-heating substances and Not classified Not classified; both trans- and cis- isomers are stable to heat (up to 150degC) (Agricultural Chemical Registration Data).
mixtures
flammable gases
14 Oxidizing solids Classification not possible Cannot be classified, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen

Health Hazards
1 Acute toxicity (dermal) Not classified Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality at this level (Agricultural Chemical Registration
Data (1995)).

vapour) Not classified Based on the rat LC50 (inhalation route) value of >5.5mg/L, together with the absence of mortality at this level (Agricultural Chemical Registration
mist) Data (1995)).
2 Skin corrosion / irritation Category 3 Based on test data from rabbit skin irritation studies (Agricultural Chemical Registration Data (1995)): "Caused mild irritation which persisted for up
to 72 hours."
3 Serious eye damage / eye Category 2B Based on test data from rabbit eye irritation studies (Agricultural Chemical Registration Data (1995)): "Caused only mild irritation to the eye, which
irritation cleared up within 7 days."

5 Germ cell mutagenicity Not classified Based on negative data in in vitro reverse mutation tests, in vitro DNA repair tests and micronucleus tests in mice and rats (Agricultural Chemical
Registration Data (1995)), though in vitro chromosome aberration tests showed positive.
6 Carcinogenicity Not classified The available carcinogenicity studies in rats and mice provide no evidence of treatment-related incidence of tumor formation, reported in Agricultural
Chemical Registration Data (1995).
studies (Agricultural Chemical Registration Data (1995)).
8 Specific target organs/systemic Based on the evidence from animal studies including reduced locomotor activity, prone position, lacrimation, and blepharoptosis (Agricultural
toxicity following single exposure Category 3 (narcotic effects) Chemical Registration Data (1991)).
9 Specific target organs/systemic No symptoms or signs referable to specific target organs were observed at dose levels within the guidance value ranges for Category 2 in the
toxicity following repeated Classification not possible available subacute toxicity studies in rats and dogs (Agricultural Chemical Registration Data (1992, 1994)).
exposure
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life It was classified into Category 3 from ErC50=73.9mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2003).
environment (acute)
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=2.84(PHYSPROP Database, 2005)), since there was no
environment (chronic) with long lasting effects rapidly degrading (BIOWIN), it was classified into Category 3.
GHS Classification
ID557 Methyl 3-(4-methoxy-6-methyl-1,3,5-triazin-2-ylcarbamoylsulfamoyl)-2-thenoate
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though being a sulfonyl compound containing chemical groups with self-reactive properties.
mixtures
10 Pyrophoric solids Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural
Not classified Chemical Registration Data)
11 Self-heating substances and Not classified Stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
mixtures
flammable gases
14 Oxidizing solids Cannot be classified though being organic compounds containing oxygen bound to elements other than carbon and hydrogen

Health Hazards
1 Acute toxicity (dermal) Not classified Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with absence of mortality (Agricultural Chemical Registration Data (1997)).

vapour) Not classified Based on the rat LC50 (inhalation route) value of >7.9mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data
mist) (1997)).
2 Skin corrosion / irritation Category 3 Based on the evidence of mild irritation reactions which cleared up by 48 hours, observed in rabbit skin irritation tests (Agricultural Chemical
Registration Data (1997)).
3 Serious eye damage / eye Not classified In rabbit eye irritation tests, mild irritation occurred immediately after instillation, with effects fully reversible within 24 hours (Agricultural Chemical

5 Germ cell mutagenicity Not classified Based on negative data in reverse mutation tests in bacteria, in vitro chromosome aberration tests, mouse in vivo micronucleus tests (Agricultural
Chemical Registration Data (1997, 2005)).
Data (1997)).

exposure
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life It was classified into Category 3 from 72 hours EbC50=14.5mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
environment (acute)
11 Hazardous to the aquatic Category 3 - - Harmful to aquatic life Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=1.56(PHYSPROP Database, 2005)), since there was no
environment (chronic) with long lasting effects rapidly degrading (BIOWIN), it was classified into Category 3.
GHS Classification
ID558 4,4'-Methylenebis(N,N-dimethylaniline)
mixtures
11 Self-heating substances and Classification not possible Test methods applicable to liquid substances are not available (melting point: 90-91degC (Merck, 13th, 2001), test temperature: 140degC).
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 5 Based on the rat LD50 (oral route) value of 3,160mg/kg (IARC 27 (1982)).

mist)
irritation

not possible
5 Germ cell mutagenicity Classification not possible No data are available on in vivo studies. When tested in vitro, the substance was only slightly positive in gene mutation tests (reverse mutation assay
and mouse lymphoma assay) and negative in chromosome aberration tests, described in NTP DB (Access on June 2006), IARC 27 (1982) and DFGOT
Vol. 1 (1990). Classification is not possible since the results obtained are not sufficient to include the substance in Category 2.
6 Carcinogenicity Category 2 Due to the fact that the substance is classified as Category R by NTP (2005) and Category B2 by EPA (1990).
exposure
environment (acute)
GHS Classification
ID559 4,4'-Methylenebis(2-methylcyclohexaneamine)
6 Flammable liquids Not classified The flash point is 173degC (c.c.) (IUCLID (2000))
mixtures
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures (flash point: 275degC (IUCLID, 2000)).
mixtures
flammable gases
Health Hazards
1 Acute toxicity (oral) Category 4 Based on the rat LD50 (oral route) value of 550mg/kg (SIDS (2005)).
1 Acute toxicity (inhalation: Category 1 Based on the rat LC50 value of 0.003ppm (4 hours), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.40mg/L, 0.42mg/L and
vapour) 0.44mg/L (SIDS (2005)), was lower than 90% of the saturated vapour concentration (80ppm) under a saturated vapour pressure of 0.08kPa (20degC)
(SIDS (2005)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in
ppm.

mist)
2 Skin corrosion / irritation Category 1A-1C Based on the description in the report on rabbit skin irritation tests (SIDS (2005)): "Corrosive." Although classified into Category 1A-1C, the
substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage / eye Category 1 Based on the description in the report on rabbit eye irritation tests (SIDS (2005)): "Corrosive."
irritation

Classification not possible Skin sensitizer: Based on the description in the report on a skin painting test and a Maximization test in guinea pigs (SIDS (2005)): "Not sensitizing."
Skin sensitizer: Not classified
5 Germ cell mutagenicity Classification not possible Based on the absence of data on in vivo mutagenicity tests and no positive data on in vitro mutagenicity tests (several indices), described in SIDS
(2005).
7 Toxic to reproduction Not classified Histopathological changes, such as seminiferous tubular atrophy, were observed at doses producing general toxicity in repeated dose toxicity studies
and teratogenicity studies with rats (SIDS (2005)). However, SIDS attributes these changes to the indirect effects of general toxicity of a severe
degree.
8 Specific target organs/systemic Based on the evidence from animal studies including "sedation, laboured breathing, dyspnea, spasm, arrhythmia, cardiac fibrillation, proteinuria, kidney
toxicity following single exposure Category 2 (nervous system, damage" (BUA 143 (1996)), "corrosive to the respiratory tract; inhalation of aerosols may result in pulmonary edema" (ICSC (J) (2002)). The effects
heart, kidneys, respiratory on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. However, the referenced studies are
organs) assigned a priority rating of 2, the effects are classified into Category 2.
9 Specific target organs/systemic Based on the evidence from animal studies including "vacuolar degeneration of the nasal mucosa and olfactory epithelium, elevated GOT/GPT,
toxicity following repeated Category 1 (kidneys) decreased hemoglobin level/mean corpuscular hemoglobin concentration (MCHC), and mild renal tubular nephrosis" (SIDS (2001)), "histological
exposure Category 2 (respiratory changes in the liver, red blood cell, white blood cell, kidneys, adrenal and heart" (SIDS (2001)). The effects on experimental animals were observed at
organs, liver, blood system, dosing levels within the guidance value ranges for Category 1 (kidneys) and Category 2 (respiratory organs, liver, blood system, adrenal, heart).
adrenal, heart)
environment (acute)
Toxic to aquatic life with Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=6(Existing Chemical Safety Inspections Data)), since there
environment (chronic) long lasting effects was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.
GHS Classification
ID560 (Z)-2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate
8 Self-reactive substances and Classification not possible Classification not possible due to lack of data, though containing unsaturated bonds (olefin).
mixtures
11 Self-heating substances and Classification not possible Test method applicable to liquid substances are not available (melting point: 97-98degC (Merck (13th, 2001)), test temperature: 140degC).
mixtures
in contact with water, emit Not classified Stable to water (water solubility: 11ppm (Merck (13th, 2001)))
flammable gases
14 Oxidizing solids Cannot be classified, though being organic compounds containing oxygen (but not fluorine and chlorine) bound to elements other than carbon and
Classification not possible hydrogen.

16 Corrosive to metals Classification not possible Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 97-98degC (Merck (13th, 2001))).
Health Hazards
1 Acute toxicity (dermal) Category 4 Based on the rat LD50 (dermal route) value of 1,500mg/kg (RTECS (2006)).

vapour)
mist)
irritation

not possible
5 Germ cell mutagenicity Classification not possible Insufficient data available

6 Carcinogenicity Not classified Due to the fact that the substance is classified as Group 3 by IARC Suppl 7 (1987).
8 Specific target organs/systemic Based on the evidence from animal studies including "somnolency (general suppression of activity)" (RTECS (2006)).
Category 3 (narcotic effects)
9 Specific target organs/systemic Classification not possible due to the insufficiency of data.
exposure
11 Hazardous to the aquatic Category 1 Environment Warning Very toxic to aquatic life It was classified into Category 1 from 48 hours EC50=1.9ppb of the crustacea (Daphnia magna) (AQUIRE, 2003).
environment (acute)
11 Hazardous to the aquatic Although acute toxicity was Category 1 and bio-accumulation was low (BCF=62 of (Z)-2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate;
Very toxic to aquatic life tetrachlorvinphos (Existing Chemical Safety Inspections Data)), and there was no rapidly degrading (the decomposition by BOD of (Z)-2-chloro-1-
environment (chronic) Category 1 Environment Warning with long lasting effects (2,4,5-trichlorophenyl)vinyl dimethyl phosphate; tetrachlorvinphos: 0% (Existing Chemical Safety Inspections Data)), it was classified into Category 1.
GHS Classification
ID561 Tris(2-ethylhexyl) phosphate
6 Flammable liquids Not classified The flash point is 170degC (ICSC (1999))
mixtures
9 Pyrophoric liquids Not classified Not pyrophoric when in contact with air at ordinary temperatures (flash point: 370degC (ICSC, 1999)).
mixtures
in contact with water, emit Not classified Stable to water (water solubility: 0.6mg/L (24degC), SRC (2006)).
flammable gases
hydrogen.
Health Hazards
1 Acute toxicity (oral) Not classified Based on the rat LD50 (oral route) value of 37,000mg/kg, >10,000mg/kg and >36,800mg/kg (EHC 218 (2000)).
1 Acute toxicity (dermal) Not classified Based on the rabbit LD50 (dermal route) value of 18,400mg/kg (CERI-NITE Hazard Assessment No.207 (2004)).

vapour)
1
mist)
2 Skin corrosion / irritation Category 2 Based on the description in the report on rabbit skin irritation tests performed in accordance with OECD Guideline 404 (EHC 218 (2000)): "Moderate
irritation was noted." The substance is considered corrosive given the evidence of crust formation, and thus classified into Category 2.
3 Serious eye damage / eye Category 2A-2B Based on the description in the report on rabbit eye irritation tests (EHC 218 (2000)): "Doses up to 0.05mL produced slight conjunctivitis, while
irritation doses of 0.1 and 0.5mL produced moderate conjunctivitis which cleared up in 24 hours." Although classified into Category 2A-2B as the
classification for skin irritation is Category 2, the substance should be placed in Category 2A from the viewpoint of safety if further subclassification
is needed.

not possible
mutagenicity tests in vivo (micronucleus tests, chromosome aberration tests), described in NTP DB (Access on June 2006), EHC 218 (2000) and
CERI-NITE Hazard Assessment No.207 (2005).
6 Carcinogenicity Classification not possible Classification not possible based on expert judgment in the absence of existing classification, though some data are available on carcinogenicity
studies with mice and rats.
9 Specific target organs/systemic Classification not possible since there are no symptoms reported that can be used for assessment.
exposure
environment (acute)
GHS Classification
ID562 Sodium azide (Na(N3))
CAS 26628-22-8 Date Classified: Mar. 23, 2006
1 Explosives Not classified - - - Not classified in UNRTDG Class: 1 and Subsidiary risks Class, though containing azido groups.
2 Flammable gases Not applicable - - - Solid (GHS definition)
3 Flammable aerosols Not applicable - - - Not aerosol products
4 Oxidizing gases Not applicable - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - Solid (GHS definition)
7 Flammable solids Classification not - - - Individual literature citations vary about a flammable. The data with tests defined by the United Nations is not found. It is
possible not classified into the United Nations class 4.1.
8 Self-reactive substances and Type G - - - Not classified in UNRTDG Class: 4.1, but Class: 6.1 (though containing azido groups)
mixtures
9 Pyrophoric liquids Not applicable - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - Non-pyrophoric at a room temperature
11 Self-heating substances and Not classified - - - No data available on self-heating
mixtures
in contact with water, emit Not classified - - - Hydrogen azide is not generated when it melts in neutral waters.
flammable gases
13 Oxidizing liquids Not applicable - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - Inorganic substance
16 Corrosive to metals Classification not Although there is information that it corrodes aluminum strongly, there is no experimental data of the metal corrosion
possible - - - rate. It is not classified into a class 8 according to UNRTDG, either.
Health Hazards
Skull and
1 Acute toxicity (oral) Category 2
crossbones
Danger Fatal if swallowed Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 45mg/kg; REFERENCE SOURCE: DFGOT vol.20 (2003)
1 Acute toxicity (dermal) Skull and Fatal in contact with
Category 1 Danger Since rabbit percutaneous LD50 value was 20mg/kg (ACGIH (2001)), it was set as Category 1.
crossbones skin
1 Acute toxicity (inhalation: gas) Not applicable - - - Solid (GHS definition)
1 Acute toxicity (inhalation: Classification not - - - The steam pressure at normal temperature (1 Pa) is less than rat inhalation LC50 (37mg/m3) (RTECS (2004)).
vapour) possible
1 Acute toxicity (inhalation: dust, Classification not It cannot taxonomic according to lack of information. The information on RTECS (2004) is not clear in a chemical
mist) possible - - - exposure forms. (a dust, cracked gas)
2 Skin corrosion / irritation Causes severe skin
Category 1C Corrosion Danger burns and eye It judged to be "Category 1C" from corrosivity in animal test result and 4 hour contact (DFGOT vol.20 (2003)).
damage
3 Serious eye damage / eye Causes serious eye
irritation Category 1 Corrosion Danger Since skin corrosivity was Category 1C, the eye was also set to "category 1."
damage
4 Respiratory/skin sensitizer Respiratory
sensitization:
Classification not (Respiratory (Respiratory (Respiratory
possible; Skin sensitization)-; (Skin sensitization)-; sensitization)- With no sufficient information about causing sensitivity.
sensitization: sensitization)- (Skin ; (Skin
Classification not sensitization)- sensitization)-
possible
5 Germ cell mutagenicity Although there are positive results from in vitro microbial mutagenicity tests, the in vitro mutagenicity tests in mammalian
cells are negative and also there are no data from in vivo tests in mammals. So it was decided that the substance "could
Classification not - - - not be classified". It is considered that the strong mutagenicity is peculiar to microorganisms and plants. (DFGOT vol.20
possible (2003))
Category 2, which was based on the in vivo results in muscids, was also suggested in some comments from the experts,
but in the end it was concluded that the substance could not be classified.
6 Carcinogenicity Not classified - - - Since it was judged with A4 by ACGIH, it was set as "Outside of Category."
7 Toxic to reproduction Classification not - - - No data available
possible
8 Specific target organs/systemic Cause damage to
toxicity following single exposure Category 1 (circulatory Health hazard Danger organs (circulatory Since there is a large number of examples about hypotension (be used as therapeutic agents) and suspected the side
system) effects to its respiratory organs, digestive organ, etc. So it was classified into "Category 1."
system)
9 Specific target organs/systemic Causes damage to
toxicity following repeated organs (circulatory Since increased sensitivity was seen in some patients when it was used for treatment for high blood pressure for humans
exposure Category 1 (circulatory Health hazard system, liver)
Danger through prolonged over a long-term (ACGIH (2001)) , and the effects on the liver was seen with the given dose below 10mg/kg-day in an
system, liver)
or repeated animal experiments, it was classified in "Category 1."
exposure
10 Aspiration hazard Classification not
possible - - - No data available
11 Hazardous to the aquatic Very toxic to
environment (acute) Category 1 Environment Warning aquatic life It was classified into Category 1 from 96-hour LC50=0.7mg/L of fishes (Bluegill) (HSDB, 2004).
11 Hazardous to the aquatic Very toxic to Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (direct measurement (HPLC): 1%
environment (chronic) Category 1 Environment Warning aquatic life with long (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow<=0.3 (existing chemical
lasting effects safety inspections data).
GHS Classification
ID563 Propanenitrile, 2-hydroxy-2-methyl-
CAS 75-86-5 Date Classified: Jun. 20, 2006 (Environmental Hazards: Mar. 31, 2006)
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases Not applicable - - - Liquid (GHS definition)
4 Oxidizing gases Not applicable - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning Combustible liquid Flash point: 74degC, Boiling point: 95degC
7 Flammable solids Not applicable - - - Liquid (GHS definition)
8 Self-reactive substances and Not applicable - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
mixtures
9 Pyrophoric liquids Not classified - - - Flash point: 685degC and UNRTDG: Class6.1
10 Pyrophoric solids Not applicable - - - Liquid (GHS definition)
11 Self-heating substances and Classification not
mixtures possible - - - Test methods applicable to liquid substances are not available
in contact with water, emit Not applicable - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
flammable gases
13 Oxidizing liquids Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but
Not applicable - - -
not to other elements).
14 Oxidizing solids Not applicable - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - Containing no -0-0- structure
16 Corrosive to metals Classification not
possible - - - No data available on corrosion to metals
Health Hazards
1 Acute toxicity (oral) SPECIES: Rat
Skull and ENDPOINT: LD50
Category 2 crossbones Danger Fatal if swallowed VALUE: 0.017ml/kg (15.8mg/kg)
REFERENCE SOURCE: ACGIH (2001)
Category 1 crossbones Danger skin It was set as Category 1 from rabbit LD50 = 0.017ml/kg (reduced value: 15.8mg/kg) (ACGIH (2001)).
1 Acute toxicity (inhalation: gas) Not applicable - - - Liquid (GHS definition)
1 Acute toxicity (inhalation: Classification not - - - There is no data for LC50 value, and it cannot be classified. (Since there is a description that with 62.5ppm of inhalation
vapour) possible exposure, 2 out of 6 rats died (ACGIH (2001)), it is supposed to be Category 1.)
1 Acute toxicity (inhalation: dust, Classification not
mist) - - - No data available
possible
2 Skin corrosion / irritation Classification not - - - No data available
possible
3 Serious eye damage / eye
irritation Category 2 - - - Based on data that there was irritation with a rat, it was set as Category 2(CICAD 61 (2004)).

sensitization:
possible; Skin sensitization)-; (Skin sensitization)-; sensitization)- No data available
possible
5 Germ cell mutagenicity Although there is a result that the substance does not induce mutagenicity in chromosome aberration or change in rat
Classification not
possible - - - bone-marrow cells in vivo (CICAD 61(2004)), the test is not for mammals. So it was decided that the substance could not
be classified.
6 Carcinogenicity Classification not
possible - - - There is no data against carcinogenic properties and rating administrative information.
7 Toxic to reproduction Suspected of
Category 2 Health hazard Warning damaging fertility or Since there is abnormality in scaffold of child in administration dose causing maternal toxicity to pregnancy hamster
the undorn child (ACGIH (2001)), it is classified into the Category 2.
8 Specific target organs/systemic Due to the description that "it caused the headache, paralysis, sense of exhaustion, bilious vomiting, and walk difficulty,
toxicity following single exposure and after the symptoms such as cyanosis, coma, and evanescen disturbance of mouth opening, it takes 10 days for
Category 1 (central Cause damage to recovering with no sequelae" in the example of an accident in human transdermal exposure (ACGIH (2001)), it was
nervous system, Health hazard Danger organs (central classified into Category 1 (central nervous system, circulatory system). The effects of circulatory organ systems, such as
circulatory system) nervous system, tachycardia, respiratory distress, respiratory paralysis are observed also in dermal exposure of guinea pigs at 1.5ml
circulatory system) (weight equivalent: 1395mg/kg (it corresponds to the 1000 - 2000mg/kg in guidance value of Category 2 in rat and
rabbit.)).
toxicity following repeated
exposure Category 1 (liver, organs (liver, It was classified in Category 1 by that which has a case of liver and the kidney with the value (5mg/(kg)) of a rat (PATTY
kidneys) Health hazard Danger kidneys) through (5th, 2001)).
prolonged or
repeated exposure
- - - No data available on chemical pneumonia
possible
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 48-hour EC50=0.13mg/L of Crustacea (Daphnia magna) (SIDS, 1997).
aquatic life
11 Hazardous to the aquatic Since rapidly degrading (completely degraded <60 mg/L (SIDS, 1997)), and less bio-accumulative (log Kow=-0.03
environment (chronic) Not classified - - - (PHYSPROP Database, 2005)).
GHS Classification
ID564 Ammonia
CAS 7664-41-7 Date Classified: Apr. 20, 2006 (Environmental Hazards: Mar. 31, 2006)
1 Explosives Not applicable - - - Gas (GHS definition)
2 Flammable gases Category 1 - Danger Extremely flammable Flammable range with air is 15-28 vol% (GESTIS-database on hazardous substances, 2nd, 1993)
gas
4 Oxidizing gases Not classified - - - UNRTDG No.1005, Class: 2.3, Subsidiary risks Class: 8
5 Gases under pressure Contains gas under
Liquefied gas Gas cylinder Warning pressure; may Critical temp: 132.4degC (Merck, 13th, 2001)
explode if heated
6 Flammable liquids Not applicable - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - Gas (GHS definition)
8 Self-reactive substances and Not applicable - - - Gas (GHS definition)
mixtures
9 Pyrophoric liquids Not applicable - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - Gas (GHS definition)
11 Self-heating substances and Not applicable - - - Gas (GHS definition)
mixtures
in contact with water, emit Not applicable - - - Gas (GHS definition)
flammable gases
13 Oxidizing liquids Not applicable - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - Gas (GHS definition)
16 Corrosive to metals Classification not - - - Test methods applicable to gas substances are not available
possible
Health Hazards
1 Acute toxicity (oral) Classification not There is the report of the death in humans after ammonia solution ingestion (EHC 54 (1986)). But it is not gas data, it is
- - -
possible not considered as the basis of the categories.
1 Acute toxicity (dermal) Classification not
- - - Classification not possible due to lack of data
possible
1 Acute toxicity (inhalation: gas) Category 4 Exclamation mark Warning Harmful if inhaled It was considered as Category 4 based on rat LC50 = 4608.7ppm (4-hour equivalent) (EHC 54 (1986)).
1 Acute toxicity (inhalation: Not applicable - - - Gas (GHS definition)
vapour)
1 Acute toxicity (inhalation: dust, Not applicable - - - Gas (GHS definition)
mist)
2 Skin corrosion / irritation
Causes severe skin Necrosis was observed in skin irritation test with ammonia solution on rabbits (IUCLID 2000). As for humans, there is a
Category 1A-1C Corrosion Danger burns and eye report of a remarkable stimulation, chemical burns, etc. on contacts with ammonia gas (DFGOTvol.6 (1992)), and it is
damage regarded as a skin irritant also in the state of gas (IUCLID 2000). From what mentioned above, it was classified as
Category 1A-1C.
3 Serious eye damage / eye Conjunctival edema is observed ammonia postexposure to eye of rabbit (EHC 54 (1986)). If a burned is caused, the
irritation
irreversible influence of eyeball adhesion, the ulcers and perforations of a cornea, permanent corneal cloudings, iritis, etc.
Category 1 Corrosion Danger Causes serious eye is admitted (EHC 54 (1986), IUCLID (2000)). Furthermore, humans also had affect by contact directly for a rapid rates,
damage and the eye disorders especially critical in high concentrations has occurred (EHC 54 (1986), ACGIH (7th, 2001)). It was
set as Category 1 based on the above fact.
4 Respiratory/skin sensitizer
(Respiratory [Respiratory sensitization] Two or more asthma or asthma-like symptoms by ammonia exposures have been reported by
Respiratory (Respiratory (Respiratory sensitization)May humans (ATSDR 2004, ACGIH (2001)). Based on the fact that a statistically significant relevance is indicated between
sensitization: sensitization)Health sensitization)Da cause allegy or ammonia gas exposure and the respiratory symptom including bronchial asthma by one report (ATSDR 2004) and that in
Category1; Skin hazard nger asthma symptoms a different report ammonia is made the asthmatic cause by the provocation test (ATSDR 2004). it was referred to as
sensitization: Not ; (Skin ; (Skin pr breathing Category 1. [Skin sensitization] Although there is no animal test data of NH3 itself, as it is in a form of gas at an ordinary
classified sensitization)- sensitization)- difficulties if inhaled; temperature and normal pressure , its examination in solution is being carried out. As skin sensitization was clearly denied
(Skin sensitization)- by the Open epicutaneous test using a guinea pigs (IUCLID 2000, it was put outside of the Category.
5 Germ cell mutagenicity

Suspected of
causing genetic
defects (state route The substance was classified as Category 2. Because there are increases in chromosome aberration and sister chromatid
Category 2 Health hazard Warning of exposure if it is exchange in the study/analysis of the blood samples taken from people who have been exposed to ammonia and people
conclusively proven who have not (ATSDR 2004), and there is a positive result from the in vivo mutagenicity test (the micronucleus test in
that no other routes mice: ATSDR (2004)).
of exposure cause
the hazard)
6 Carcinogenicity There is no finding which suggests carcinogenicity as a result of mixing ammonia in drinking water and administration to
Classification not mice for two years (EHC 54 (1986)), but there is also a description of tumors in the stomach and intestines (details
possible - - - unknown) (RTECS (2004)). Information is still more nearly need for a classification and it determined that "It cannot be
classified."
7 Toxic to reproduction There is only the description of decrease weight gain of 120-day old child in administration for pregnant and lactational
Classification not - - - period (ATSDR (2004)), but it is not obvious on the effect to reproductive potential in administration before pregnancy
possible
(premating), and so it cannot be classified since data is insufficient
8 Specific target organs/systemic Since difficulty breathing, lung edema, bronchial pneumonias, etc. are reported in humans (DFGOTvol.6 (1992), ATSDR
Cause damage to (2004), IRIS (1991), BSDB (2005)), and significant toxicity effects to the respiratory systems containing lungs, such as
Category 1 (respiratory) Health hazard Danger organs (respiratory) dyspnea, cyanosis, haemorrhage lung and pulmonary edema, interstitial pneumonias, etc. are observed also in animal
studies (EHC 54 (1986)), it was classified into Category 1 (respiratory systems). In addition, the toxic expressing levels
presumed from animal data (EHC 54 (1986)) is also equivalent to the guidance value Category 1.
9 Specific target organs/systemic In repeated inhalation study of rats, the interstitial pneumonias accompanied by a peribronchitis is seen in the range of
toxicity following repeated May cause damage
exposure to organs (lung) the guidance value of Category 2 (EHC 54 (1986)), and the same clinical features as a contractile lung functional disorder,
Category 2 (lung) Health hazard Warning through prolonged an obstructive pulmonary disease, etc. with chronic dyspnea is reported in humans who received occupational exposure
or repeated of ammonia in large quantities (IUCLID (2000)). It was classified in Category 2 (lung) based on these facts. In addition,
influence on lungs are seen in other animals, or in other examinations from which a test condition differs (EHC 54 (1986),
exposure IUCLID 2000).
10 Aspiration hazard Not applicable - - - Gas (GHS definition)
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 96-hour LC50=0.083mg NH3/L of fishes (Pink salmon) (EHC54, 1986).
aquatic life
environment (chronic) Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are
Category 1 Environment Warning aquatic life with long unknown.
lasting effects
GHS Classification
ID565 2-Chloroethanol
6 Flammable liquids Category 3 Flame Warning Flammable liquid and Flash point: 60degC
vapour
mixtures
9 Pyrophoric liquids Not classified - - - Not ignite spontaneously on coming into contact with air at normal temperatures
11 Self-heating substances and Classification not - - - Test methods applicable to liquid substances are not available
mixtures possible
flammable gases
13 Oxidizing liquids Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to
Not applicable - - - carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not - - - No data available
possible
Health Hazards
Skull and
1 Acute toxicity (oral) Category 3 crossbones Danger Toxic if swallowed SPECIES: Rat ENDPOINT: LD50 VALUE: 71mg/kg REFERENCE SOURCE: ACGIH (2001), RTECS (2004)
1 Acute toxicity (dermal) Category 2 Skull and Danger Fatal in contact with Dermal toxicity LD50 of a rabbit is 67mg/kg (IUCLID (2000)).
crossbones skin
1 Acute toxicity (inhalation: Skull and There are descriptions about LC50 = 0.3mg/L (but exposure time is unknown) (RTECS (2000)) and that death was
vapour) Category 1 Danger Fatal if inhaled
crossbones observed with 1 hour exposure to 7.5ppm (ACGIH (2001)). Soit is supposed to be Category 1.
1 Acute toxicity (inhalation: dust, Classification not - - - No data available
mist) possible
2 Skin corrosion / irritation Results as both being irritating and not irritating is obtained in animal examination (IUCLID (2000)). But PATTY (5th,
Not classified - - -
2005) states that there is no skin irritation.
3 Serious eye damage / eye Causes serious eye The result which is irritating is obtained in the animal studies (IUCLID (2000)). Although PATTY (5th, 2005) is setting to
irritation Category 2A Exclamation mark Warning irritation extremly irritating. But there is no evidence as irreversible, it is set as Category 2A.
sensitization: (Respiratory (Respiratory (Respiratory
Classification not sensitization)-; (Skin sensitization)-; sensitization)- There is proof that there is no skin sensitization by animal studies etc. (PATTY (5th, 2005), IUCLID (2000).). About
possible; Skin sensitization)- (Skin ; (Skin respiratory sensitization, there is no data and it cannot be classified..
sensitization: Not sensitization)- sensitization)-
classified
Suspected of
causing genetic
defects (state route There are negative results from the in vivo (multi-generation) reciprocal translocation test in mice, mouse chromosome
of exposure if it is aberration test and dominant lethal test ((PATTY (5th, 2001)) and from the DNA damage test in rats (IUCLID (2000)), but
Category 2 Health hazard Warning conclusively proven there are positive results from in vivo chromosome aberration tests in rat bone-marrow (inhalation). There are also
that no other routes positive results from the in vitro (CHO) chromosome aberration test, the sister chromatid exchange test and the Ames
test (PATTY (5th, 2001)). So the substance was classified as Category 2.
of exposure cause
the hazard)
6 Carcinogenicity ACGIH is classified into A4 and there is also data in which carcinogenicity is not indicated in an animal examination. But
Category 1 - - - there is the proof it is carcinogenic to humans in epidemiological data (PATTY (5th, 2005)). So it is set as Category 1.
Category 2 Health hazard Warning damaging fertility or There is effect to embryo in animal experiment even if it is limited result (DFGOT vol. 5 (1993)), it is doubted about
the undorn child reproductive toxicity to human
8 Specific target organs/systemic

toxicity following single exposure Cause damage to
organs (central
nervous system,
Category 1 (central blood system,
Since the effects to the central nervous system, cardiovascular systems, renal, lung, and liver in human are observed
nervous system, blood kidneys, liver,
system, kidneys, liver, Health hazard Danger respiratory); May (DFGOT vol.5 (1993)), it is classified into Category 1. Since there is the description which irritates the airway seriously
respiratory); Category 3 cause respiratory (ICSC (J) (2003)), together with the effect on lung, and the target organ is the respiratory systems. Moreover, since the
(narcotic) irritation or may anaesthetic by inhalations is indicated (DFGOT vol.5 (1993)), it is also classified into Category 3 (anaesthetic).
cause drowsiness
and dizziness
(narcotic)

toxicity following repeated Causes damage to
exposure organs (blood
system) through
prolonged or
Category 1 (blood Danger repeated exposure; Though effects on blood systems, liver, kidney were seen (RTECS (2004)), viewed from a guidance value, it is classified in
system); Category 2 Health hazard ; Warning May cause damage Category 1 for blood system, and Category 2 for liver and kidney .
(liver, kidneys) to organs (liver,
kidneys) through
prolonged or
repeated exposure
10 Aspiration hazard Classification not - - - No data available

possible
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 72-hour ErC50=5.6mg/L of algae (Scenedesmus) (IUCLID, 2000).
environment (acute)
11 Hazardous to the aquatic Toxic to aquatic life Classified into Category 2, since acute toxicity was Category 2, and rapid degradability is unknown, though supposed less
environment (chronic) Category 2 Environment - with long lasting
effects bio-accumulative (log Kow=0.03(PHYSPROP Database, 2005)).
GHS Classification
ID566 Zinc chloride
CAS 7646-85-7 Date Classified: Jul. 24, 2006 (Environmental Hazards: Mar. 31, 2006)
7 Flammable solids Not classified - - - Non-combustible substance (Hommel, 1991)
mixtures
10 Pyrophoric solids Not classified - - - Non-combustible substance (Hommel, 1991)
11 Self-heating substances and Not classified - - - Non-combustible solid (Hommel, 1991)
mixtures
in contact with water, emit Not classified - - - Stable to water (Weiss, 2nd, 1985)
flammable gases
14 Oxidizing solids Not classified - - - UNRTDG No. 2331, Class: 8; PGIII
16 Corrosive to metals Classification not - - - Melting point: 732degC (ICSC, 2002). Test methods applicable to solid substances are not available.
possible
Health Hazards
Category 4 Exclamation mark Warning Harmful if swallowed ENDPOINT: LD50
VALUE: 1100 mg/kg
REFERENCE SOURCE: EU-RAR (2004)
1 Acute toxicity (dermal) Category 2 Skull and Danger Fatal in contact with It was set as Category 2 based on guinea pig LD50 = 173mg/kg (IUCLID (2000)).
crossbones skin
1 Acute toxicity (inhalation: Classification not
vapour) possible - - - No data available
1 Acute toxicity (inhalation: dust, Skull and LC50 value decided for the animal is not acquired. But the humans deaths after exposure is reported though an exposure
mist) Category 1-5 Danger Fatal if inhaled
crossbones level was unknown (ACGIH (2001), PATTY (5th, 2001)). Therefore, it was set to category 1-5.
2 Skin corrosion / irritation Causes severe skin The dermal surface inflammatory change and ulcers are observed in rabbit skin irritation test (EU-RAR (2004)). Also
Category 1A-1C Corrosion Danger burns and eye formations of pustule and vesicles on skin in human patch test were reported (DFGOTvol.19 (2002)). Therefore it was
damage classified as Category 1A-1C.
3 Serious eye damage / eye An eye has in an accident two reports of the humans who received concentrated zinc chlorides exposure (EU-RAR
irritation Category 1 Corrosion Danger Causes serious eye (2004)). It resulted in cornea cicatrization permanent subsequently to edema, and was set as Category 1 based on
damage description (EU-RAR (2004)) that recovery took 6 - 28 weeks.
Classification not sensitization)-; (Skin sensitization)-; sensitization)- [Respiratory sensitization] The occupational asthmas by soldering flux has been reported by humans (DFGOTvol.19
possible; Skin sensitization)- (Skin ; (Skin (2002)) but causes are unknown. since they are also exposed to ammonium chlorides. Therefore, it cannot be classified.
sensitization: [Skin sensitization] No data
possible
Suspected of
causing genetic
defects (state route
of exposure if it is The substance was classified as Category 2. Based on the positive results from the chromosome aberration tests using
Category 2 Health hazard Warning conclusively proven rats and mice (the in vivo mutagenicity test in somatic cells) (EU-RAR (2004), EHC 221(2001)).
that no other routes
of exposure cause
the hazard)
6 Carcinogenicity Presently there is no institution which has defined the classification Category about the carcinogenicity of the zinc
chloride. Each existing long-term animal examination (DFGOT vol.19 (2002)) has defect on protocol as a carcinogenicity
Classification not - - - tests, and the data which can be utilized about the carcinogenicity of zinc itself is also restricted. EU and U.S. also stated
possible
that carcinogenic evaluation has insufficient information (IRIS (2006), EU-RAR (2004)). From the above thing, since data
was insufficient, it determined "It cannot be classified."
Category 2 Health hazard Warning damaging fertility or Based in the reduction of the number of littermates in the dose causing general toxicity of maternal animals
(DFGOTvol.19 (2002)), it is classified into the Category 2
the undorn child
8 Specific target organs/systemic The artery occlusions in the lungs and fibrosis, cyanosis, ARDS syndrome, etc. are reported in humans after inhalation
Cause damage to exposure (ACGIH (7th 2001), PATTY (5th, 2001), and the symptoms includes the irritation to nose, the throat, and the
Category 1 (respiratory, Health hazard Danger organs (respiratory, respiratory tracts in addition to nausea, cough, etc. (EU-RAR (2004), ACGIH (7th, 2001)). Furthermore, there is the report
liver, pancreas) liver, pancreas) of liver damages and pancreatic achylias by oral ingestion (EHC 221 (2001)). It was classified into Category 1 (respiratory
system, liver, pancreas) based on these information.
toxicity following repeated organs (lung, liver) In addition to the lung lymphocytic infiltration and the fatty degeneration of the liver, with higher concentrations, high
exposure Category 1 (lung, liver) Health hazard Danger through prolonged death rates is seen with a mouse by inhalation exposure (DFGOT vol.19 (2002)). It was classified in Category 1 (lungs,
or repeated liver) by comparing toxic effect concentrations seen in murine lung and liver with the guidance value.
exposure
possible
environment (acute) Category 1 Environment Warning aquatic life It was classified into Category 1 from 48-hour EC50=0.1mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2002).
environment (chronic) Category 1 Environment Warning aquatic life with long Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water is
lasting effects unknown., though less bioaccumulative (BCF=178 (existing chemical safety inspections data)).
GHS Classification
ID567 Hydrochloric acid
2 Flammable gases Not classified - - - Non-combustible gas (Hommel, 1991)
4 Oxidizing gases Not classified - - - UNRTDG No.1050, Class: 2.3, Subsidiary risks Class: 8
Liquefied gas Gas cylinder Warning pressure; may UNRTDG No. 1050, Class: 2.3. "Critical temp: 51 degC" (Hommel, 1991)
explode if heated
mixtures
mixtures
flammable gases
possible - - - Test methods applicable to gas substances are not available
Health Hazards
1 Acute toxicity (oral) Skull and It was set as Category 3 based on the toxic value of the higher one.(Rat LD50=238 to 277 mg/kg and 700 mg/kg (SIDS
Category 3 crossbones Danger Toxic if swallowed (2002)), and higher one is former.)
1 Acute toxicity (dermal) Not classified - - - Based on rabbit LD50 >5010mg/kg (SIDS (2002)), it was set as the outside of Category.
1 Acute toxicity (inhalation: gas) Skull and It was considered as Category 3, based on 1411ppm obtained from the statistical calculations after conversion from rat
Category 3 crossbones Danger Toxic if inhaled LC50 = 4.2, 4.7 and 283mg/L/60min (SIDS (2002)). In addition, since it became lower than the lowest value of calculated
data, lowest value 4.2mg/L (4-hour product portfolio managements equivalents 1411ppm) of data is adopted.
1 Acute toxicity (inhalation: Classification not - - - No data available
vapour) possible
1 Acute toxicity (inhalation: dust, Skull and Rat LC50 = 1.68mg/L / 1h is the aerosol data (SIDS (2002)). It was set as category 2 based on 4-hour value 0.42mg/L of
mist) Category 2 Danger Fatal if inhaled
crossbones this value.
2 Skin corrosion / irritation There are reports of cases that corrosivity was observed in rabbit skin irritation test with 1 - 4 hour exposure depending
Causes severe skin on concentration (SIDS (2002)), that stimulation and ulcer accompanied by skin discoloration having occurred on mice
Category 1A-1C Corrosion Danger burns and eye and rats with 5-30 minute exposure (SIDS (2002)), and that it also caused mild to serious stimulativeness, sore and burn
damage (SIDS (2002)). Because of what mentioned above, this product was considered to have corrosivity, and it was classified
as Category 1A-1C.
3 Serious eye damage / eye About damage and the stimulativeness of an eye, it is based on exposure to hydrochloric acid as waters of this product
irritation
Causes serious eye altogether. A serious stimulus, damage, and corrosiveness is indicated for eye in a result of two or more animal (including
Category 1 Corrosion Danger
damage a rabbit) examinations (SIDS (2002)), and fear of permanent damage or loss of eyesight is indicated to be also in humans
(SIDS (2002)).
4 Respiratory/skin sensitizer [Respiratory sensitization] Since it was listed as one of the chemical substances causing the sensitivity of occupational
(Respiratory allergy, created by the specially set-up committee of the Japanese occupational and environmental allergology meeting,
Respiratory (Respiratory (Respiratory sensitization)May it was referred to as Category 1. Still, there is a report that the postexposure bronchial spasms was caused by humans
sensitization: sensitization)Health sensitization)Da cause allegy or
Category1; Skin hazard nger asthma symptoms to the cleaning agents which included hydrogen chlorides and that asthmatic symptoms were still caused by slight
sensitization: Not ; (Skin ; (Skin pr breathing stimulus one year later (ACGIH (2003)). [Skin sensitization] Adding to the negative result (SIDS (2002)) in Maximization
classified sensitization)- sensitization)- difficulties if inhaled; Test of a guinea pigs, and Ear Swelling Test of a mouse, there is a report (SIDS (2002)) that nobody indicated positive
(Skin sensitization)- reactions in the test applied to 15 humans on 10-14th days after [ induction of sensitization ] , and it put outside of the
Category.
5 Germ cell mutagenicity No data from in vivo tests are found, except for positive results in sex-linked recessive lethal tests using drosophila.
Classification not - - - Although there are positive results from some in vitro mutagenicity tests, these results are considered as insufficient to
possible
be the basis for mutagenesis in human germ cells. So it was decided that the substance "could not be classified".
6 Carcinogenicity Based on the classification of Group 3 (1992) by IARC, and A4 (2003) by ACGIH, it was set as the outside of Category. In
addition, in carcinogenicity tests of rats or mice, there is no evidence which suggests carcinogenicity (SIDS (2002)), and
Not classified - - - many human epidemiological studies are also negative in the relation between cancer occurrence and hydrogen chloride
exposure (IARC 54 (1992), PATTY (5th, 2001)).
7 Toxic to reproduction All data are the results of the test in the administration to pregnancy rat or mouse, and there is no bad effect to the
Classification not development of neonatal animals. However, it was unknown about the effect to reproductive function and reproductive
possible - - - potential in the administration before pregnancy (premating) to parent animals, "it cannot be clasified" since data is
insufficient.
8 Specific target organs/systemic The symptoms, such as dyspnea, laryngitis, bronchitis, bronchus contraction, and pneumonia, is presented by inhalation
exposure in humans, and the upper airway edema, respiratory tract inflammations, necrosis, and a lung blister are
Cause damage to reported. (DFGOTvol.6 (1994), PATTY (5th, 2001), IARC 54 (1992), ACGIH (2003)). Moreover, in the animal studies, the
Category 1 (respiratory) Health hazard Danger organs (respiratory) toxic effects with morphological injury to lungs and bronchial tubes, such as bronchitis with mucosal necrosis, pulmonary
edema, bleeding, thrombus, etc. in the guidance value in Category 1 (ACGIH (2003), SIDS (2002)). It was classified into
Category 1 (respiratory systems) based on the above the results in human and animal.
toxicity following repeated organs (tooth, There are two or more reports that humans who receive repeated exposure complain injury to teeth by erosions ( SIDS
exposure Category 1 (tooth, respiratory organs) and (2002), EHC 21 (1982), DFGOTvol.6 (1994), and PATTY (5th, 2001)), and increased frequency of a chronic bronchitis
Health hazard Danger
respiratory organs) through prolonged is also reported. (DFGOTvol.6 (1994)). It was classified as Category 1 (a tooth, respiratory systems) based on these
or repeated information.
exposure
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 48-hour EC50=0.492mg/L of Crustacea (Daphnia magna), and others (SIDS, 2005).
aquatic life
11 Hazardous to the aquatic Toxicity factor is considered to be strong acid as aqueous solution, but toxic effect is eased by the buffer action in the
environment (chronic) Not classified - - - environmental water.
GHS Classification
ID568 Thionyl dichloride
CAS 7719-09-7 Date Classified: Feb. 20, 2007 (Environmental Hazards: Mar. 31, 2006)
6 Flammable liquids Not classified - - - Non-combustible (ICSC(J), 2002; Hommel, 1991).
8 Self-reactive substances and Not classified - - - Not classified based on UNRTDG Class: 8, though containing unsaturated S=O bonds as chemical groups associated with
mixtures self-reactive properties present
9 Pyrophoric liquids Not classified - - - Non-combustible (ICSC (J), 2002; Hommel, 1991)
11 Self-heating substances and Not classified - - - Non-combustible (ICSC(J), 2002; Hommel, 1991)
mixtures
12 Substances and mixtures, which Metal or half-metal (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) is not included.
in contact with water, emit Not applicable - - - It is known that this product decomposes very violently when contacted by water, and generates sulfur dioxide, sulfur
flammable gases
dichloride, chlorines and chloride (all being nonflammable gases) with accompanied by fever (Hommmel (1991)).
13 Oxidizing liquids Not classified - - - Not classified because of UNRTDG Class: 8 though inorganic compounds containing oxygen and halogen.
16 Corrosive to metals Classification not - - - Classification not possible due to lack of data. UNRTDG Class: 8.
possible
Health Hazards
1 Acute toxicity (oral) Skull and Category 3 based on SPECIES: Rat (female and male); ENDPOINT: LD50; VALUE (lower value): 270mg/kg; REFERENCE
Category 3 Danger Toxic if swallowed
crossbones SOURCE: IUCLID (2000)
1 Acute toxicity (dermal) Classification not - - - No data available
possible
1 Acute toxicity (inhalation: Since the saturated vapor pressure concentration of this product is 12300ppm, it is thought that all inhalation tests were
vapour) Category 2 Skull and Danger Fatal if inhaled done with vapor. It was classified as Category 2 based on rat LC 50 with 1 hour exposure test = 500ppm (equivalent of
crossbones LC50 = 249ppm in 4-hour exposure) (ACGIH (7th, 2001)).
mist) possible - - - No data available
2 Skin corrosion / irritation Causes severe skin Corrosivity and severe irritation on animals are described (IUCLID (2000)). It was classified as Category 1A-1C based on
Category 1A-1C Corrosion Danger burns and eye the fact that severe skin irritations is indicated also on humans (ACGIH (2001), HSDB (2005)) and that it is classified as
damage EU-R35.
3 Serious eye damage / eye This product is a skin corrosive substance. It was set as Category 1 based on what is indicated that caustics and severe
irritation Category 1 Corrosion Danger Causes serious eye irritation are indicated by the animal (IUCLID (2000)), and there is severe irritation also in humans (HSDB (2005), PATTY
damage (5th, 2001)).
sensitization:
possible
5 Germ cell mutagenicity It was decided that the substance could not be classified by the technical guidelines. Because there are no results from
Classification not
possible - - - in vivo mutagenicity tests, and only the data from the in vitro mutagenicity test (the bacterial reverse mutation test only)
(IUCLID (2000)) are reported.
possible
8 Specific target organs/systemic Based on the description that difficulty breathings and lung edemas are observed in humans (ACGIH (7th, 2001)), and
Category 1 (respiratory) Health hazard Danger organs (respiratory) that the strong respiratory tract irritation is reported (ACGIH (7th, 2001), HSDB (2005)), it was classified into Category 1
(respiratory system)
9 Specific target organs/systemic Classification not
toxicity following repeated - - - No data available
exposure possible
possible
11 Hazardous to the aquatic Classification not
environment (acute) - - - Insufficient data available.
possible
environment (chronic) possible - - - Classification not possible due to lack of data
GHS Classification
ID569 Phosphoryl trichloride
CAS 10025-87-3 Date Classified: May 24, 2006 (Environmental Hazards: Mar. 31, 2006)
6 Flammable liquids Not classified - - - Non-combustible (Weiss, 2nd, 1985).
mixtures
9 Pyrophoric liquids Not classified - - - Non-combustible (Weiss (2nd, 1985)
11 Self-heating substances and Not classified - - - Non-combustible (Weiss, 2nd, 1985)
mixtures
in contact with water, emit Not applicable - - - Although it reacts intensely to the water (dangerous DB (the 2nd edition, 1993)), the occurring gas is hydrogen chlorides
flammable gases
(inert gas).
13 Oxidizing liquids Not classified - - - Not classified because of UNRTDG Class: 8 though inorganic compounds containing oxygen and chlorine.
possible - - - Classification not possible due to lack of data metal corrosion. UNRTDG Class: 8.
Health Hazards
VALUE: 380 mg/kg
REFERENCE SOURCE: RTECS (2005), IUCLID (2000)
1 Acute toxicity (inhalation: Category 1 Skull and Danger Fatal if inhaled Since the saturated vapor pressure concentration of this product is 5248ppm, it is thought that the inhalation test was
vapour) crossbones by with vapor. It was classified as Category 1 based on rat LC50 = 48ppm (ACGIH (7th, 2001)).
2 Skin corrosion / irritation Causes severe skin Based on the descriptions that it indicates corrosivity and severe irritation on animals (IUCLID (2000)) and also on
Category 1A-1C Corrosion Danger burns and eye humans (ACGIH (7th, 2001) and HSDB (2000), Institut national de recherche, and CDROMCD 613 (May 2000.3p.)), it was
damage classified as Category 1A-1C.
3 Serious eye damage / eye This product is a skin corrosive substance. With a rabbit, there is a statement of strong eye stimulativeness and a strong
irritation
Category 1 Corrosion Danger Causes serious eye necrosis, and loss of eyesight (IUCLID (2000), GESTIS (2005)), and with humans, there is a statement of strong eye
damage stimulativeness, corrosiveness, and loss of eyesight is (ACGIH (7th, 2001), ICSC (J), (2002), HSDB (2005)). So it was set
as Category 1.
sensitization:
possible
5 Germ cell mutagenicity Classification not - - - No data available
possible
possible
8 Specific target organs/systemic The effects to the central nervous systems on dizziness, headaches, loss of appetite, weakness, nausea, vomiting, etc.
Category 1 (central Cause damage to are described in humans (ICSC (J) (2002), HSDB (2005)), and since the denaturation of the nerve cell was observed in
nervous system, Health hazard Danger organs (central the repeat-dose studies in the rat, it was classified into Category 1 (central nervous system). Due to the descriptions
respiratory) nervous system, that chest pain, cough, breathing difficulties, bronchitis, bronchopneumonia and pulmonary edema are observed in humans
respiratory) (ACGIH (2001)), and that breathing difficulties is described in guinea pigs (RTECS (2005)). So it was classified into
Category 1 (respiratory systems).
9 Specific target organs/systemic Since symptoms, such as giddiness, headache, loss of appetite, sluggishness, nausea, and vomiting, etc., in humans was
exposure
Causes damage to indicated (ACGIH and (7th 2001), (HSDV(2005)), and there was the statement (IUCLID (2000)) that the degeneration of
organs (central the brain-cell was seen in the rat with the dose of guidance value range of category 1, it was classified in Category 1
Category 1 (central nervous system, (central nervous systems). It was classified into Category 1 (respiratory systems) based on the description of the
nervous system, Health hazard Danger respiratory organs, influence on the respiratory systems, such as bronchitis, bronchopneumonia, and accumulation of fluid in the lungs, in
respiratory organs, kidneys) through humans (ACGIH (7th, 2001)), and the desciption of the respiratory distress in a ratwith the dosage of the guidance value
kidneys)
prolonged or range of Category 1 (IUCLID (2000)). It was classified in Category 1 (kidney) based on a description of the fatty
repeated exposure degenerations of kidney with the dosage of the guidance value range of Category 1 with a rat, and a description of a
glomerulonephritis in humans.
possible
environment (acute) - - - No data available
possible
environment (chronic) possible - - - No data available.
GHS Classification
ID570 Chlorine
2 Flammable gases Not classified - - - Non-combustible (ICSC(J), 2000; etc.)
May cause or
4 Oxidizing gases Category 1 Flame over circle Danger intensify fire; Categoly 1 and oxidizing gas (ISO 10156-2)
oxidizer
Low pressure liquefied
gas Gas cylinder Warning pressure; may Low pressure liquefied gas because of the critical temp: 143.8 to 144degC.
explode if heated
mixtures
mixtures
flammable gases
possible
Health Hazards
1 Acute toxicity (oral) Classification not - - - No data available
possible
- - - No data available
possible
Skull and
1 Acute toxicity (inhalation: gas) Category 2 crossbones Danger Falat if inhaled It was considered as Category 2 based on each 4-hour equivalent of two data of a rat being LC50 = 146ppm (EHC 21
(1982), ACGIH (2005)).
vapour)
mist)
2 Skin corrosion / irritation It was classified as Category 1A-1C based on the descriptions that there is a case where it produced slight burn to the
human face with exposure to chlorine gas (EHC 21 (1982)) and that corrosivity may be seen on skin (HSDB (2005)). In
Causes severe skin
Category 1A-1C Corrosion Danger burns and eye addition, there are descriptions that "frostbite and corrosivity. Skin burns and pain." as primary disaster/acute
damage manifestation when liquid chlorine touches the skin (ICSC (J), (2000)) and that liquid chlorine causes chilblain and a burn
(HSDB (2005)), contacting liquefied chlorine needs special care. This product is classified as Xi; R36/R37/R38 in EU (EU
Annex I (2005)).
3 Serious eye damage / eye Although mild by level at a There is statement that irritation was acknowledged in the ophthalmic by the monkey (PATTY
irritation
Causes serious eye (5th, 2001)), and that from mild to severe irritation on human depend on concentration, but that all are recovered for a
Category 1 Corrosion Danger short times (EHC 21 (1982)), and there is a statement that irritation may acknowledge in the ophthalmic of human, and a
damage
critical or permanent obstacle may be done (HSDB (2005)). The case of being the highest-risk was taken among these
information, and it was set as Category 1. In addition, this product is classified into Xi; R36/R37/R38 by EU.
sensitization:
possible; Skin sensitization)-; (Skin sensitization)-; sensitization)- Respiratory sensitization: Since data is insufficient, it cannot be classified. Skin sensitization: No data
possible
5 Germ cell mutagenicity There are no data from multi-generation epidemiological and mutagenicity tests in humans, and there is a report of a
Not classified - - - negative result in an in vivo micronucleus test in mammals (mice). So the substance was regarded as outside the
categories.
6 Carcinogenicity Not classified - - - It was set as the outside of Category based on being classified into the group 3 according to IARC (ACGIH-TLV (2005)),
and classified into A4 according to ACGIH (ACGIH (2005)).
7 Toxic to reproduction Based on the description of no effect to the reproductive potential of parents and the development and growth of
Not classified - - - neonatal in the test of rat and mouse (EHC 21 (1982), IRIS (2002), IUCLID (2000)), and no effect to every stage from
pregnancy to lactation in chlorine plant employees (EHC 21 (1982)), it was considered as on the outside of Categry.
toxicity following single exposure In mouse, rabbit, and dog, in the equivalent dose to the amount of exposure of guidance value of Category 1, respiratory
disorders, such as pulmonary edema, haemorrhage lung, decrease of lung function, bronchitis, and tract epithelium
necrosis, are observed. The similar disorders are observed also in rat with no descritption of dosage (EHC 21 (1982)).
Moreover, in mouse, cat, rabbit and guinea pig, there are also the descriptions of the inflammation of respiratory tract
Category 1 (respiratory, Cause damage to membrane, choking, breathing-rate reduction, and upper respiratory tract irritation (EHC 21 (1982), ACGIH (2005), PATTY
Health hazard Danger organs (respiratory, (5th, 2001)). Also in humans, disorder or irritation to respiratory system, such as pneumonia, pulmonary edema, bronchitis,
nervous system) nervous system) tracheal ulcer, decrease of lung function, asthma and asthmatic symptoms (RADS), irritation to throat or nose, cough, and
breathing difficulties are described (EHC 21 (1982), ACGIH (2005), PATTY (5th, 2001)). It was classified into Category 1
(respiratory systems) based on these information. It was classified into Category 1 (nerve systems) based on the
description that it causes vomiting, headache, sense of uneasiness, syncope, fatigue, etc. and also causes
photosensitivity enhancement and direct effect to the cerebral cortex in humans (EHC 21 (1982), PATTY (5th, 2001)).

exposure There are a publication that a disorder is done to lungs with the dosage of guidance value range of the Category 1 in an
Causes damage to inhalation experiment of a rat and a mouse, and a publication (EHC 21 (1982), PATTY (5th, 2001), IUCLID (2000)) that the
organs (respiratory airway epithelium inflammation and histologic changes were seen. A potential of causing a bronchus disease and
organs, kidneys, pulmonary hemorrhage in humans is pointed out (EHC 21 (1982)), and the views on a cough, the pain of a throat, coughing
Olfactory organ) up of blood,chest pains, etc. are indicated (ACGIH (2005)). Moreover, there is also statements that there are fears of lung
Category 1 (respiratory through prolonged permanent failure and a chronic bronchitis (HSDFS (1998), SITTIG (4th, 2002)). It was classified in Category 1
organs, kidneys, Danger or repeated (respiratory systems) based on these information. It was classified in Category 1 (kidney) based on the statement
Olfactory organ); Health hazard ; Warning exposure; May (PATTY (5th, 2001)) that biochemical changes which indicates the effects on kidney function was seen with the dosage
Category 2 (tooth) cause damage to of guidance value range of Category 1 in the rat inhalation experiments. It was classified in Category 1 (olfactus organ)
organs (tooth) and Category 2 (tooth), based on descriptions in EHC 21 (1982) and PATTY (5th, 2001) that dysosmia was caused in
through prolonged humans, and descriptions in HSDFS (1998) and SITTIG (4th, 2002) that a disorder is done to a tooth. In addition, although
or repeated there was a publication (IRIS (2002)) that the dosage of guidance value range of Category 2 indicated 10%-20% of
exposure underweight in oral administration to mice and rats as compared with the control, it was considered the secondary
effects under influence on a respiratory-organs system or the kidney.
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 96-hour LC50=14microg/L of fishes (Rainbow trout) (IUCLID, 2000).
aquatic life
Category 1 Environment Warning aquatic life with long
lasting effects unknown.
GHS Classification
ID571 Phosphorus (yellow)
CAS 12185-10-3 Date Classified: Mar. 23, 2006
7 Flammable solids Not classified - - - UNRTDG No. 1381, Class: 4.2, Subsidiary risks Class: Class: 6.1, PG I
8 Self-reactive substances and Not classified - - - Classified in UNRTDG No. 1381, Class: 4.2, Subsidiary risks Class: 6.1, PGI
mixtures
10 Pyrophoric solids Catches fire
Category 1 Flame Danger spontaneously if UNRTDG No. 1381, Class: 4.2, Subsidiary risks Class: 6.1, PGI
exposed to air
11 Self-heating substances and Not applicable - - - Pyrophoric solids
mixtures
in contact with water, emit Not classified - - - UNRTDG No. 1381, Class: 4.2, Subsidiary risks Class: Class: 6.1, PGI
flammable gases
14 Oxidizing solids Not applicable - - - Containing no oxygen , chlorine and fluorine.
16 Corrosive to metals Not classified - - - UNRTDG No. 1381, Class: 4.2, Subsidiary risks Class: Class: 6.1, PGI
Health Hazards
1 Acute toxicity (oral) Rat LD50 = 3.76 mg/kg (male), 3.03 mg/kg (female) (ATSDR (1997)). Estimated lethal dose for humans in oral is 1-2
Category 1 Skull and Danger Fatal if swallowed mg/kg (PATTY (5th, 2001), ACGIH (2001), ATSDR (1997), HSDB (2005), IUCLID (2004)). Even if based on any data, it is
crossbones set as Category 1.
1 Acute toxicity (dermal) Category 1 Skull and Danger Fatal in contact with Rat LD50 = approx. 29mg/kg and 100mg/kg. The former higher toxicity was adopted and it was set as Category 1.
crossbones skin
possible
2 Skin corrosion / irritation There are descriptions that it causes burn when contacting human skin (ACGIH (2001), ATSDR (1997), ICSC (2004)), and
Causes severe skin
that it originates not only in thermals but in corrosive effects (ATSDR (1997)). Moreover, also in the animal studies, it is
Category 1A-1C Corrosion Danger burns and eye evaluated as "corrosive" or "necrosis" (IUCLID (2004), ATSDR (1997)). Based on what mentioned above, it was classified
damage as Category 1A-1C.
irritation Causes serious eye A serious injury accompanied by a eyelids convulsion, photophobia and lacrimation by touching the human eye, or corneal
Category 1 Corrosion Danger cloudings is caused (PATTY (5th, 2001), HSDB (2005)). Or redness, a pain, eyesight loss, and a serious burn are indicated
damage
(ICSC (2004)). So it was set as Category 1.
sensitization:
Classification not
possible; Skin - - - No data available
sensitization:
Classification not
possible
5 Germ cell mutagenicity Classification not
possible - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not - - - Classification not possible due to lack of data
possible
7 Toxic to reproduction
It is described that in the rat study (generation study) with administration covering two reproductive cycles from 80 days
before mating, mortality of mother animals was observed with high doses, most of them (13/16) occured during delivery
period, and that administration of yellow phosphorus may be the possible cause (IRIS (1991)).
Suspected of Since although concentration of the death to an delivery period is considered to be an adverse effects to reproduction,
Category 2 Health hazard Warning damaging fertility or influence of maternal toxicities cannot be denied, either, it was classified into Category 2.
the undorn child In addition, inhibition of growth and survival of a child was observed in lactation period with the administration starting
three weeks before mating and the effect on lactation is suggested as a cause of this (ATSDR (1997)).

toxicity following single exposure organs (liver,
kidneys, digestive
Category 1 (liver, system, blood It was classified into Category 1(liver, kidney, digestive systems, hematopoietic systems, central nervous systems), since
kidneys, digestive system, central there are reports or descriptions that it affects to wide range of organs, such as the liver, kidney, gastrointestinal system,
system, blood system, nervous system); haematopoietic system, central nerves by acute exposure of this product to human (ACGIH (2001), PATTY (5th, 2001),
central nervous Health hazard Danger May cause IRIS (1991), HSDB (2005)). Moreover, it was classified into Category 3 (respiratory irritant) due to the respiratory irritant
system); Category 3 respiratory irritation by short time exposures is also observed (ATSDR (1997)). In addition, the reason of the death in the examination of
(respiratory tract or may cause mouse is that mucosal swellings or mucus secretions occurred by irritation, the airway was closed and died by
irritation) drowsiness and suffocation (ATSDR (1997)).
dizziness
(respiratory tract
irritation)
9 Specific target organs/systemic Causes damage to According to human case reports or epidemiological study, a necrosis of a jaw part and bony destruction, so-called
Category 1 (bone, organs (bone, blood) "phossy jaw" is reported (IRIS (1991), PATTY (5th, 2001), ATSDR (1997)) , and the denaturation of the mouth and
exposure
blood) Health hazard Danger through prolonged anemia are also reported (PATTY (5th, 2001), ATSDR (1997)).) Moreover, effects on bone is observed also the animal
or repeated studies (IRIS (1991).). The effects above were considered to be serious toxicity, it was classified in Category 1 (a bone,
exposure hematologic).
- - - Insufficient data available.
possible
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 96-hour LC50=2microg/L of fishes (Bluegill) (AQUIRE, 2003).
aquatic life
lasting effects
GHS Classification
ID572 chlordane , pur
1 Explosives Classification not - - - No data available
possible
7 Flammable solids Classification not
8 Self-reactive substances and Classification not - - - No data available
mixtures possible
10 Pyrophoric solids Judging from the description that "it does not burn itself due to its noncombustibility" (NAERG (J), (2001)), even if it
Not classified - - - contacts air at room temperature, it does not ignite spontaneously.
11 Self-heating substances and Not classified - - - It is based on the description "it is nonflammable and does not burn itself" (NAERG (J) (2001)).
mixtures
flammable gases
14 Oxidizing solids Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon
Not applicable - - - (but not to other elements).
16 Corrosive to metals Classification not - - - Test methods applicable to solid substances are not available. Melting point: >55degC
possible
Health Hazards
1 Acute toxicity (oral)
Category 4 Exclamation mark Warning Harmful if swallowed 11 rat LD50 values corresponded (EHC 34 (1984), IARC vol.79 (2001), ACGIH (2001), JMPR 180 (1970)), and it was set as
Category 4 based on 314 mg/kg from statistical calculations.
1 Acute toxicity (dermal) Skull and Toxic in contact In the rat and rabbit data, lower rat LD50 value was adopted (EHC 34 (1984)). It was set as Category 3 based on LD50 =
Category 3 Danger
crossbones with skin 205 mg/kg (the lower one among two LD50).
1 Acute toxicity (inhalation: Classification not - - - Since LC50 value on rodent is unknown, it cannot be classified only based on the data on cats (RTECS (2005)).
vapour) possible
2 Skin corrosion / irritation It is reported that when human skin was irritated by exposed (HSDB (2005), HSFS (2005)), a feeling of warmth, itching,
and rash often appear (ATSDR (1994), HSFS (2005)). Animal data which follows standard skin irritation test is not found.
Category 2 Exclamation mark Warning Causes skin But in single or repeated exposure tests, description that "a severe irritation is caused" is seen about skin symptoms
irritation (EHC 34 (1984)). Based on what mentioned above, this product is thought to have irritativeness and it was classified as
Category 2.
3 Serious eye damage / eye It was set as Category 2A-2B based on the description that stimulates eyes or mucosa according to an accident to
irritation Category 2A-2B Exclamation mark Warning Causes serious eye humans (HSDB (2005), HSFS (2005)), that atomizing of the mixture which includes this product always starts
irritation conjunctivitis (ATSDR (1994)).
sensitization:
possible
Suspected of
causing genetic
defects (state route Although several dominant lethal tests in mice (in vivo multi-generation mutagenicity tests) were negative (EHC 34(1984),
Category 2 Health hazard Warning of exposure if it is IARC 79(2001)), there are positive results from the in vivo micronucleus test and chromosome aberration test (the in vivo
conclusively proven mutagenicity test in somatic cells) (ATSDR (1994), IARC 79(2001)). Some in vivo genotoxicity tests (DNA damage tests,
that no other routes sister chromatid exchange tests) are also positive (IARC 79(2001)). So the substance was classified as Category 2.
of exposure cause
the hazard)
6 Carcinogenicity
Suspected of
causing cancer
(state route of
Category 2 Health hazard Warning exposure if it is It was set as Category 2 based on being classified into 2B by IARC (2001), and into 2B by Japan Society for
conclusively proven Occupational Health (2002), and being classified into A3 according to ACGIH (1996), respectively.
of exposure cause
the hazard)
7 Toxic to reproduction With exposure in perinatal or lactational periods, the increase of the child mortality rate during lactation period is
observed (ATSDR (1994), EHC 34 (1984), IRIS (1997)) ,and neurobehavioral effects are observed in some cases (IARC 79
(2001), ATSDR (1994)).
Suspected of Development of general toxicity of the examination substance is also described at such dose (EHC 34 (1984), IRIS
Category 2 Health hazard Warning damaging fertility or (1997)).
the undorn child Therefore, it was classified into Category 2.
In addition, although the increase in mortality rate of child during lactation period is observed, there is also a report that
indicates the possibility that it is the influence via lactation (ATSDR (1994), IRIS (1997)).
8 Specific target organs/systemic There are many reports of neurological symptoms, such as spasm, vomiting, ataxia, and distraction after being exposed to
Category 1 (nervous Cause damage to humans (IARC 79 (2001), EHC 34 (1984), PIMs (2000)). Moreover, the elevation of liver enzymes is reported (IARC 79
system, liver) Health hazard Danger organs (nervous (2001)). On the other hand, it is described that the significant increase in the lipid peroxidation of the liver was observed
system, liver) in the rat (IARC 79 (2001)). Based on these findings in human and animal it was classified into Category 1 (nervous
systems, liver).
toxicity following repeated In two or more examinations using a rat, a mouse, and a dog, a rise of liver enzymes, an increase in liver weight, and the
Causes damage to
exposure
organs (liver, hepatocytes enlargement accompanied by histologic changes, such as uniformity, margination of cytoplasm, and a
Category 1 (liver, nervous system, necrosis, are seen with a low doses (IARC 79 (2001), EHC 34 (1984), JMPR 080 (1967), and IRIS (1997)), moreover, a
nervous system, Health hazard Danger brainblood vessels, spasm, a trembling, the influence on autonomic nerves and a sense organ, etc. are seen (IARC 79 (2001), EHC 34 (1984)).
brainblood vessels, blood) through Moreover, in investigation of the humans who received prolonged exposure by aerosols, neurophysiological effect is
blood) prolonged or ascertained (IRIS (1997), JMPR 080 (1967)), and there is also a report (IRIS (1997)) of a cerebrovascular disease, anemia
repeated exposure and a decrease of platelets by occupational exposure or epidemiological study. It was classified in Category
1(liver,nervous systems, cerebrovascular, blood) based on the above result.

- - - Insufficient data available.
possible
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 96-hour LC50=0.4microg/L of Crustacea (Pink shrimp), and others (EHC34, 1984).
aquatic life
11 Hazardous to the aquatic Very toxic to Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical
Category 1 Environment Warning aquatic life with long substances safety inspections data)), and bioaccumulative (BCF=27900 (existing chemical substances safety inspections
lasting effects data)).
GHS Classification
ID573 Hydrogen peroxide
1 Explosives Not classified based on UNRTDG Class: 5.1, Subsidiary risks Class: 8. However, the substance could be classified as
explosives since it contains -O-O- bonds as chemical groups associated with explosive properties present.
6 Flammable liquids Not classified - - - Non-combustible (ICSC(J), 2000; Hommel, 1991).
8 Self-reactive substances and Not classified based on UNRTDG Class: 5.1, Subsidiary risks Class: 8, though containing -O-O- bonds as chemical groups
mixtures Not classified - - - associated with explosive properties present
9 Pyrophoric liquids Not classified - - - Non-combustible (ICSC (J), 2000; Hommel, 1991)
11 Self-heating substances and Not classified - - - Non-combustible (ICSC(J), 2000; Hommel, 1991)
mixtures
in contact with water, emit The physical-properties value (boiling point, melting point, viscosity, others) of the solution of the various concentration
Not applicable - - - of this substance is judged to be a stable in the water based on being adopted as much of the literature as universal
flammable gases
values.
13 Oxidizing liquids May cause fire or Category 1 based on GHS Classification manual. UNRTDG No. 2015, Class: 5.1, Subsidiary risks Class: 8, PG
Category 1 Flame over circle Danger explosion; strong I(HYDROGEN PEROXIDE,STABILIZED or HYDROGEN PEROXIDE,AQUEOUS SOLUTION,STABILIZED with more than
oxidizer 60% hydrogen peroxide)
16 Corrosive to metals Classification not Although it is considered as UNRTDG class 5.1 (subsidiary risks 8), this subfollowing classification is considered based on
- - -
possible skin corrosivenesses. Since there is no data about corrosion behavior, it cannot be classified.
Health Hazards
1 Acute toxicity (oral) Category 4 Exclamation mark Warning Harmful if swallowed It was set as Category 4 based on LD50 = 311mg/kg obtained from the calculation using four rat data (EU-RAR (2003)).
1 Acute toxicity (dermal) Category 5 - Warning May be harmful in It was set as Category 5 based on rat LD50= 4060mg/kg (EU-RAR (2003)).
contact with skin
1 Acute toxicity (inhalation: Skull and The saturated vapor pressure concentration of this product is 1980ppm. And it was classified as Category 3 based on rat
vapour) Category 3 Danger Toxic if inhaled
crossbones LC50 = 1438ppm of obtained by the test considered to have been performed with steam (EU-RAR (2003)).
mist) possible
2 Skin corrosion / irritation The conclusion with necrosis which penetrates to all layers of the skin or corrosivity is indicated in 3 minute, 1 hour, or 4
Causes severe skin hour application on rabbits (EU-RAR (2003), ECETOC Special Report 10 (1996)), and in EU, it is classified as C; R35,
Category 1A-1C Corrosion Danger burns and eye therefore, this product is thought to have corrosivity on skin. However, since information is insufficient to subcategorize,
damage it was classified as Category 1A-1C.
3 Serious eye damage / eye Causes serious eye This product is a skin corrosive substance. There is a publication that severe irritation for an animal and it is corrosive
irritation Category 1 Corrosion Danger
damage (ECETOC JACC (1993), EU-RAR (2003)). It was set as Category 1 based on the above information.
sensitization: Respiratory sensitization: No data
Classification not (Respiratory (Respiratory (Respiratory Skin sensitization: With the guinea pigs, there are negative results (EU-RAR (2003), ECETOC JACC (1993)) by two
possible; Skin sensitization)-; (Skin sensitization)-; sensitization)- examinations, and it is indicated in humans that a large group of persons was negative in the patch test (EU-RAR (2003)).
sensitization: sensitization)- (Skin ; (Skin However, there is also a statement (EU-RAR (2003)) that two examples were positive among 158 examples in the human
Classification not sensitization)- sensitization)- patch test, and since data is insufficient, it cannot be classified.
possible
5 Germ cell mutagenicity The substance was regarded as outside the categories. Because there are no results from multi-generation
Not classified - - - epidemiological and mutagenicity tests in humans and in vivo mutagenicity tests in germ cells, and there is a report of a
negative result from a micronucleus test in mice (EU-RAR (2003), ECETOC Special Report 10 (1996)), and there are no
positive results from in vivo genotoxicity tests in germ cells.
6 Carcinogenicity It was classified into 3 according to IARC, and classified into A3 according to ACGIH. IARC which has newer
Not classified - - - classification year was adopted and it was set as the outside of Category by the technical guideline.
7 Toxic to reproduction There is the description that the effect to human sperm is observed in the in vitro experiment (ECETOC JACC (1993)),
Suspected of and there is no description about the general toxicity to parent animals in the animal test, but based on the description
Category 2 Health hazard Warning damaging fertility or that there is the effect to sperm motility, the effedct to estrousl cycle of female, the effect to the decrease of the
the undorn child number of delivery maternal animal, and the weight decrease of offspring, (ECETOC JACC (1993)), it is classified into the
Category 2.
8 Specific target organs/systemic The irritations to the nose, the throat, and the tracheal are reported in human (ACGIH (2001)) and animal (EU-RAR
Cause damage to (2003)). In animals, there are the descriptions that it causes the congestion, pneumonedema, emphysema of lung and
Category 1 (respiratory organs (respiratory tracheal and necrosis of tract epithelium within the guidance level of Category 1 (EU-RAR (2003), ECETOC Special
organs, central nervous Health hazard Danger organs, central Report 10 (1996)). It was classified into Category 1 (respiratory tracts) based on these results. Based on the descriptions
system) nervous system) of headache, giddiness, tremor, spasm, coma, and cerebral infarction in humans (ACGIH (2001), EU-RAR (2003)), it was
classified into Category 1(central nervous systems).
toxicity following repeated organs (lung)
exposure through prolonged Since a fibrous tissues appears here and there in pneumoconiosiss with the dosage of guidance value range of Category
or repeated 1 in the inhalation testof steam in a dog (EU-RAR (2003)) , and there was the statement that mixture of atelectatic lung
Category 1 (lung); Danger exposure; May area and emphysema area is seen and it has irritation in lung also in humans (ECETOC JACC (1993)) , it was classified
Category 2 (blood) Health hazard ; Warning cause damage to in Category 1 (lung). It was classified in Category 2 (blood) on the basis that effect was seen on the white blood cell
organs (blood) counts and the hematocrit values by oral administration in rats with the dosage of the guidance value range of Category
through prolonged 2 and hemolytic was seen (EU-RAR (2003)).
or repeated
exposure
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 48-hour EC50=2.4mg/L of Crustacea (Water flea) (EU-RAR, 2003).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Rapidly degrading in water.
GHS Classification
ID574 Formic acid
6 Flammable liquids The flash point varies with literature and is stated as 59 degC (o.c.) - 69 degC (measurements unknown). Among those,
Category 3 Flame Warning Flammable liquid and the lowest value of 59 degC (Open Cup) (Merck (13th, 2001)) was adopted, and it was classified as Category 3 (the
vapour acceptance criteria of GHS: flash point is 23 degC or more and, 60 degC or less).
mixtures
9 Pyrophoric liquids Not classified - - - The ignition points is 520 degC - 601.1degC (ICSC (J), (1997), NFPA (13th, 2002), dangerous decibel (the 2nd edition,
1993))
11 Self-heating substances and Not classified - - - Not classified because of UNRTDG Class: 8, Subsidiary risks Class: 3
mixtures
flammable gases
13 Oxidizing liquids Not applicable - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but
not to other elements).
16 Corrosive to metals Classification not It is UNRTDG class 8 subsidiary risks 3. Although indicated as corossive to metals (HSDB (2005)) also in literature, since
possible - - - there is no data, it cannot be classified.
Health Hazards
1 Acute toxicity (oral) It was set as Category 4 based on LD50= 1085mg/kg obtained from the calculation using five data of oral rat LD50
Category 4 Exclamation mark Warning Harmful if swallowed values(DFGOT vol.19 (2003), PATTY (5th, 2001), NTP TR19 (1992)).
possible
1 Acute toxicity (inhalation: Exclamation mark Since the saturated vapor pressure concentration of this product is 45544ppm, it is thought that each inhalation test was
vapour) Category 4 Warning Harmful if inhaled
done with vapor. It was classified as Category 4 based on rat LC50 = 3929ppm (7.4 mg/L) (DFGOT vol.19 (2003)).
mist) possible
2 Skin corrosion / irritation Causes severe skin It has corrosive damage on human skin(PATTY and (5th, 2001), NTP TR19 (1992), ICSC (J) (1997)), and severe irritation
Category 1A-1C Corrosion Danger burns and eye and corrosivity are also observed for animals (DFGOT vol.19 (2003), PATTY (5th, 2001), IUCLID (2000)). These
damage statements and C:R35 of the EU classification were judged collectively, and it was classified as Category 1A-1C.
irritation Causes serious eye This is a skin corrosive substances (ICSC (J), (1997)), irreversible damages is done to an eye on humans (PATTY (5th,
Category 1 Corrosion Danger damage 2001), NTP TR19 (1992)), and a burn, severe stimulus, or corrosiveness to an animal eye (PATTY and (5th, 2001), DFGOT
vol.19 (2003), NTP TR19 (1992), RTECS (2004), and IUCLID (2000)). So it was set asCategory 1 based on things.
sensitization:
possible
5 Germ cell mutagenicity It was decided that the substance could not be classified by the technical guidelines. Because there are no data from in
Classification not - - - vivo tests and the in vitro mutagenicity tests do not show strong positive results in several parameters (DFGOT vol. 19
possible (2003), PATTY (5th, 2001), NTP TR19 (1992), IUCLID (2000)).
6 Carcinogenicity Classification not - - - Classification not possible due to lack of data
possible
7 Toxic to reproduction Suspected of Although there was no descriptions on general toxicity of parent animals, based on the report that shows the newborn's
Category 2 Health hazard Warning damaging fertility or survival rate decrease (NTP TR19 (1992)), it is classified into the Category 2.
the undorn child
toxicity following single exposure It was classified into Category 1(blood) based on the descriptions of effects to blood, such as hemolysis and a
Cause damage to coagulopathy, in humans (DFGOT vol.19 (2003), PATTY(5th, 2001) vol.5). It was classified into Category 1 (liver, kidney)
Category 1 (blood organs (blood based on the descriptions of liver dysfunction being indicated in humans (DFGOT vol.19 (2003)) and renal dysfunction
system, liver, kidneys, Health hazard Danger system, liver, (DFGOT vol.19 (2003), PATTY (5th, 2001) vol.5). Due to the descriptions that it affects to respiratory systems, such as
respiratory organs) kidneys, respiratory pneumonia, breathing difficulty, and bronchitis in human (DFGOT vol.19 (2003), PATTY(5th, 2001) vol.5 and NTP TR19
organs) (1992)), and decreased respiratory functional is described also in guinea pigs, with the dosage range of guidance value of
Category 1 (DFGOT vol.19 (2003)). So it was classified into Category 1.

toxicity following repeated organs (kidneys)
exposure Category 1 (kidneys) Health hazard Danger through prolonged In humans, there was the statement that proteinuria and hematuria are seen (NTP TR19 (1992)), and since nephropathy
or repeated was suggested, it was classified in Category 1 (kidney).
exposure
possible
11 Hazardous to the aquatic Harmful to aquatic
environment (acute) Category 3 - - life It was classified into Category 3 from 48-hour EC50=34.2mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic Since rapidly degrading (BOD: 110% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=-
environment (chronic) Not classified - - -
0.54 (PHYSPROP Database, 2005)).
GHS Classification
ID575 chloroacetaldehyde
6 Flammable liquids Category 4 - Warning Combustible liquid Category 4 because of its flash point: 88degC
mixtures
9 Pyrophoric liquids Since flash measurements is performed under temperatures higher than normal temperatures (88 degC) (ICSC (1997)), it
Not classified - - - is judged as not igniting spontaneously.
11 Self-heating substances and Not classified - - - Not classified because of UNRTDG Class: 6.1
mixtures
flammable gases
13 Oxidizing liquids Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to
Not applicable - - - carbon (but not to other elements).
possible
Health Hazards
Category 2 Skull and Danger Fatal if swallowed ENDPOINT: LD50
crossbones VALUE: 23.0 mg/kg
REFERENCE SOURCE: ACGIH (2001), PATTY (5th, 2001)
Category 2 crossbones Danger skin It was set as Category 2 based on rabbit LD50= 67.0mg/kg (ACGIH (2001), PATTY (5th, 2001)).
1 Acute toxicity (inhalation: The saturated vapor pressure concentration of this product is 131, 680ppm, and it is presumed that inhalation toxicity
vapour) Skull and
Category 2 crossbones Danger Fatal if inhaled study was done in the state of steam. It was classified as Category 2 based on the lower of two rat LC50 values (103,
122ppm), LC50 = 103ppm (DFGOT vol.12 (1998)). It is Category 2 though almost Category 1.
mist) possible
2 Skin corrosion / irritation Causes severe skin It was classified as Category 1A-1C based on the statement that severe damage (ACGIH (2001)) and severe corrosivity
Category 1A-1C Corrosion Danger burns and eye (DFGOT vol.12 (1998)) were seen on rabbit skin .
damage
irritation Causes serious eye This product has skin corrosivity. Based on the statement of the serious damage with rabbit eye (ACGIH (2001)) and
Category 1 Corrosion Danger damage ocular tissue damage with human (ACGIH (2001)), and caustic being indicated to an eyeby vapor on this substance (ICSC
(J), (1997)). Based on the above statement, it was set to CAtegory 1.
sensitization:
possible; Skin sensitization)-; (Skin sensitization)-; sensitization)- Respiratory sensitization: No data. ; Skin sensitization: It cannot be classified because of lack of information.
possible
5 Germ cell mutagenicity There are no human multi-generation epidemiological data, multi-generation mutagenicity tests, in vivo mutagenicity tests
Classification not in germ cells, in vivo mutagenicity tests in somatic cells, nor data from in vivo genotoxicity tests in germ cells. Although
possible - - - there are no positive results from in vivo genotoxicity tests in somatic cells, there are positive results from the in vitro
mutagenicity test (for more than 2 parameters, the strength unknown)) (DFGOT vol.12 (1998)). After receiving experts'
opinions it was decided that the substance could not be classified.
6 Carcinogenicity
Suspected of
causing cancer
(state route of
Category 2 Health hazard Warning exposure if it is It was set as Category 2 based on the category 3 of existing EU.
conclusively proven
of exposure cause
the hazard)
7 Toxic to reproduction Classification not

8 Specific target organs/systemic May cause damage
toxicity following single exposure Category 2 (respiratory) Health hazard Warning to organs Due to the description that in humans, vapors of this product may show respiratory tracts caustics and cause lung
(respiratory) edemas (ICSC (J) (1997)), it was classified into Category 2 (respiratory systems).

toxicity following repeated - - - Insufficient data available
exposure possible
environment (acute) possible - - - Insufficient data available.
environment (chronic) - - - Classification not possible due to lack of data
possible
GHS Classification
ID576 Chloroprene
1 Explosives Not classified - - - UNRTDG Class: 3, Subsidiary risks Class: 6.1
6 Flammable liquids Category 2 Flame Danger Highly flammable Category 2 because of its flash point: -20degC and initial boiling point: 59 to 59.4degC. Category 1 based on UNRTDG
liquid and vapour Class: 3, PG I.
8 Self-reactive substances and Not classified based on UNRTDG Class: 3, Subsidiary risks Class: 6.1, though containing unsaturated C=C bonds as
mixtures Not classified - - - chemical groups associated with self-reactive properties present
9 Pyrophoric liquids Not classified - - - Flash point: 440degC (Hommel, 1991)
11 Self-heating substances and Not classified - - - Not classified because of UNRTDG Class: 3, Subsidiary risks Class: 6.1
mixtures
flammable gases
13 Oxidizing liquids Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other
Not applicable - - - elements).
possible
Health Hazards
1 Acute toxicity (oral) Skull and It was set as Category 3 based on LD50= 251mg/kg obtained from the calculation using LD50 value of 2 examinations
crossbones with rats (SIDS (2003)).
1 Acute toxicity (dermal) Skull and Toxic in contact
Category 3 crossbones Danger with skin It was set as Category 2 based on rat LD50= 200mg/kg (SIDS (2003)).
1 Acute toxicity (inhalation: The saturated vapor pressure concentration of this product is 264356ppm, and it is thought that all inhalation tests were
vapour) Category 3 Skull and Danger Toxic if inhaled done with vapor. It was classified as Category 3 based on LC50 = 8.2mg/L (2280ppm) calculated from rat LC50 values of
crossbones 2 examinations which performed 4 hour exposure (SIDS (2003), IARC 19 (1979)).
2 Skin corrosion / irritation Mild to moderate erythema and edemas for rabbits and the thickening of the skin with repeated administration to the
Causes skin
Category 2 Exclamation mark Warning mouse are reported (SIDS (2003)). And dermatitis and alopecia were seen on humans (IARC 19 (1979)). It was classified
irritation as Category 2 because there is no finding of corrosivity.
3 Serious eye damage / eye Although conjunctivitis was produced with the rabbit, a duration of the problem has a statement that it was for ten days
irritation Category 2A-2B Exclamation mark Warning Causes serious eye (SIDS (2003)). Moreover, irritation and pains were produced in the eye by vapor exposure in the rat (PATTY (5th, 2001))
irritation But .the stimulative grade is unknown. So it was set as Category 2A-2B based on these data.
sensitization:
possible
May cause genetic
defects (state route
of exposure if it is
Category 1B Health hazard Danger conclusively proven The substance was classified as Category 1B. Because there are no multi-generation epidemiological data for humans
that no other routes and there are positive results from the in vivo dominant lethal tests in rodents (SIDS (2003), ACGIH (2001)).
of exposure cause
the hazard)
6 Carcinogenicity
May cause cancer
(state route of
exposure if it is It was classified into 2B according to IARC (IARC 71 (1999)), and into 2B according to an industrial hygene academic
Category 1B Health hazard Danger conclusively proven society (JETOC specially data No.190 (2004)), and was classified into 2 according to EU (EU-Annex I (2006)). Newest EU
that no other routes was employed and it was set as Category 1B.
of exposure cause
the hazard)
7 Toxic to reproduction There is the report that there is no disorder of reproductive potential of parent, embryotoxicity, and teratogenicity
(ACGIH (2001), PATTY (5th, 2001), IARC 19 (1999)). But in many other reports, there is the description of inhibition of
spermatogenesis of male rat (ACGIH (2001)), of the examples of mating impossibility and sterility of male rat and male
Category 1A Health hazard Danger May damage fertility mouse (ACGIH (2001)), and embryotoxicity as embryonic lethallity etc. and malformation as hydrocephalus and
or the undorn child meningoencephalocele etc. (ACGIH (2001), SIDS (2003), IARC 19 (1999)). There is the description that it occure
dysorders of spermatogenesis and it is observed sperm morphological defect on humans, and there is a lot of natural
abortion among the wives of chloroprene laborers (IARC 19 (1979)). It is classified into the Category 1A from these
information.
toxicity following single exposure Due to the descriptions that it shows the central nervous systems depressions in dosage range of guidance value in
Category 1 in rat, mouse, and rabbit (IARC 19 (1979)), and that it shows central nervous system depressant action also in
Cause damage to human (IARC 19 (1979)), it was classified into Category 1 (central nervous systems). Due to the descriptions that it
Category 1 (central organs (central causes liver damage in dosage range of the guidance value of Category 1 in rat (ACGIH (2001)), and that it cases damage
nervous system, Health hazard Danger nervous system, to liver, lungs, and the kidney in human (IARC 19 (1979)), it was classified into Category 1(liver, lungs, kidney). Due to the
respiratory, liver, respiratory, liver, descriptions that it affects the airway in dosage range of the guidance value of Cagegory 1 in rat (PATTY (5th, 2001)),
kidneys) and that it develops dyspnea by stimulates mucosa (IARC 19 (1979)), it was classified into Category 3 (airway
kidneys) stimulativeness). In addition, since there is no description of specific conditions about central nervous systems or the
degree of inhibition and no description of related-anesthetic actions, it was classified into Category 1 (central nervous
system). Category 1 (lung) and Category 3 (respiratory irritant) were classified into Category 1 (respiratory systems).

exposure Causes damage to
organs (nervous It was classfied in Category 1(nervous systems,cardiovascular systems) based on the statement that pathological
system, changes was seen in the cardiovascular system and the nervous system in humans (IARC 19 (1979)) and the
cardiovascular statementthat there were complaints of neurological symptoms such as headache, giddiness, and insomnia, and a rapid
Category 1 (nervous system, tooth, nerve pulse, and chest pain (IARC 19 (1979)) . Since there was the statement of a dental corrosion, gingivitis, a periodontal
system, cardiovascular of tooth, immune membrane flame, and a decreased immunoreaction in humans (IARC 19 (1979)) , it was classified in Category 1 (a tooth,
system, tooth, nerve of system, lung, liver, periodontal tissue, immunity system). Since there are the statement that plasma cholinesterase reduction in activity was
tooth, immune system, stomach) through seen in humans (IARC 19 (1979)) , and the statement that the necrobiosis in liver was seen in the amount of exposure of
Health hazard Danger prolonged or the guidance value range of Category 1in the rat and a hamster and the organization obstacle of lungs in the rat (PATTY
lung, liver, repeated (5th, 2001)), it was classified in Category 1 (lungs,liver). It was classified in Category 1 (stomach) and Category 2 (blood,
stomach);Category 2 exposure;May cause olfactus organ) based on the statement that the abnormalities in blood coagulation, the denaturation and fault formation
(blood, Olfactory organ, damage to organs of a sense-of-smell epithelium, and fault formation of the front gastric epithelium were seen in a rat in the amount of
respiratory organs) (blood, Olfactory exposure of the guidance value range of Category 2(PATTY (5th, 2001)) , and the statement that gastrointestinal
organ, respiratory disorders was seen in humans (IARC 19 (1979)). Based on the statement of the inflammation of a nasal cavity in the
organs) through amount of exposure of the guidance value range of Category 2 in a rat (PATTY (5th, 2001)), it was classified in Category
prolonged or 2 (respiratory tracts).
repeated exposure

11 Hazardous to the aquatic Not classified - - - It carried out the outside of Category from 96-hour LC50=245mg/L of fishes (Bluegill) (SIDS, 2003).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since not water-insoluble (aqueous solubility = 874.9 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.
GHS Classification
ID577 germanium tetrahydride
2 Flammable gases Category 1 - Danger Extremely flammable Category 1 because "the flammable range with air is 95.2-97.2%" (Hazardous Materials DB, 2nd, 1993) and the lower
gas flammable limit is 0.8-2.8 vol%. (It is ignitable when in a mixture of 13% or less by volume in air.)
4 Oxidizing gases Not classified - - - UNRTDG Class: 2.3, Subsidiary risks Class: 2.1
High pressure liquefied
gas Gas cylinder Warning pressure; may Critical temp: 34.85degC (Hommel, 1991)
explode if heated
mixtures
mixtures
flammable gases
possible
Health Hazards
possible
possible
Skull and
1 Acute toxicity (inhalation: gas) Category 1 crossbones Danger Falat if inhaled It was considered as Category 1 based on guinea pigs LC50 value = 260mg/m3 (equivalent: 83ppm) (RTECS (2004)) in the
4-hour inhalation experiments.
vapour)
mist)
2 Skin corrosion / irritation Category 2 Exclamation mark Warning Causes skin Since there was a description of redness and pains as danger information on human health (ICSC (J), (1995)), it was
irritation classified as Category 2.
3 Serious eye damage / eye Causes serious eye Since there is a statement that the eye had redness and paint (ICSC (J), (1995)) as danger information on human health ,
irritation Category 2A-2B Exclamation mark Warning
irritation it was set as Category 2A-2B.
sensitization:
sensitization)- sensitization)-
Classification not
possible
6 Carcinogenicity Classification not - - - No data available
possible
organs (liver,
kidneys); May cause
Category 1 (liver, damage to organs The denaturation of liver and kidney tissue and the effects on central nervous system are observed in the dosage range
kidneys); Category 2 (blood system); May of the guidance value of Category 1 in animal studies (ACGIH (2001), RTECS (2004)). There is the description that an it
(blood system); Health hazard Danger cause respiratory irritates to airway as effect of short-term exposure to human and affectes to blood (ICSC (J) (1995)). Moreover, there
Category 3 (narcotic ; Exclamation mark ; Warning irritation or may are the descriptions that in human, it may cause the symptoms, such as headache, giddiness, syncope, and vomiting, and
effects, respiratory cause drowsiness it causes the kidney disorders by the cythemolytic gas, and there is the description that the targets of toxic effects are
central nervous systems, kidney and blood (SITTIG (4th, 2002)). From these results, they were classified into Category 1
tract irritation) and dizziness (liver, kidney), Cateogry 2 (blood), and Category 3 (anesthetic actions, respiratory irritant).
(narcotic effects,
respiratory tract
irritation)
9 Specific target organs/systemic Classification not It cannot be classified because of lack of information. In addition, there is the statement in SITTIG (4th, 2002) that
toxicity following repeated - - -
exposure possible prolonged exposure may cause kidney disorders and a haemolytic activity in humans.
environment (acute) possible - - - No data available
environment (chronic) - - - No data available.
possible
GHS Classification
ID578 Phosphorus pentachloride
7 Flammable solids Not classified - - - Non-combustible (ISCS (1997))
mixtures
10 Pyrophoric solids Not classified - - - Not classified because of "Non-combustible" (ICSC, 1997)
11 Self-heating substances and Not classified - - - Not classified because of a non-combustible substance.(ICSC (1997))
mixtures
in contact with water, emit Not classified - - - Although it reacts violently with water, what are generated is phosphates and hydrogen chlorides, and is all nonflammable.
flammable gases
14 Oxidizing solids Not classified - - - Not classified in UNTDG Class: 5.1
16 Corrosive to metals Classification not - - - Test methods applicable to solid substances are not available.
possible
Health Hazards
VALUE: 600 mg/kg
REFERENCE SOURCE: IUCLID (2000)
possible
1 Acute toxicity (inhalation: dust, There was a statement of rat LC50: 0.205mg/L (RTECS (2004)). But it was presupposed that test time is unstated.
mist)
Classification not - - - Therefore, it cannot be classified since data is insufficient.
possible However, when there are necessities, such as a display, handling similar to category 2 is recommended from a viewpoint
of safety.
Category 1B Corrosion Danger burns and eye Based on the descriptions that it is corrosive in rabbit test (IUCLID (2000)) and that it is corrosive to skin (ICSC (1997)),
damage and the fact its UN Transportation Classification is class 8-II, it was classified as Category 1B.

irritation Category 1 Corrosion Danger It was categoried into Category 1 from skin corrosivity / irritation being categoried into Category 1B.
damage
sensitization:
possible
5 Germ cell mutagenicity Classification not - - - Classification not possible due to lack of data
possible
possible - - - Classification not possible due to lack of data and reports
7 Toxic to reproduction Classification not - - - Classification not possible due to lack of data
possible
8 Specific target organs/systemic Cause damage to Due to the description that it irritates the airway and causes bronchitis (ACGIH (2001)) and lung edema (ICSC (1997)) by
Category 1 Danger organs (respiratory); inhalation of fume, it was classified into Category 1 (respiratory system). Although there is the description that oral
(respiratory); Category Health hazard ; Warning May cause damage intake, coldness of skin by skin contact, change of pules, and the cardiovascular system collapse with shallow breathing
2 (circulatory system) to organs are the major cuases for immediate death (HSDB (2005)). And it is in priorty 2, therefore, it was classified into Category
(circulatory system) 2(circulatory organ).
toxicity following repeated to organs (bone)
exposure Category 2 (bone) Health hazard Warning through prolonged Although there is the statement that the disability of bone is caused by inhaling over a long times (HSDB (2005)) , since
or repeated it was priority 2, it was classified in Category 2 (bone).
exposure
possible
possible
GHS Classification
ID579 Ethyl acetate
CAS 141-78-6 Date Classified: Aug. 18, 2006 (Environmental Hazards: Feb. 10, 2006)
6 Flammable liquids Category 2 Flame Danger Highly flammable Flash point: <23degC, Initial Boiling point: >35degC
liquid and vapour
8 Self-reactive substances and Not classified - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
mixtures
9 Pyrophoric liquids Not classified - - - It is accepted that, even if it contacts air in room temperatures, it does not igniting spontaneously from the experience in
manufacture and treatment.
flammable gases
13 Oxidizing liquids Not applicable - - - Organic compounds containing oxygen chemically bonded only to carbon (but not to other elements).
16 Corrosive to metals Classification not - - - There is no data. Acetate which is one of the hydrolysis products corrodes aluminum.
possible
Health Hazards
1 Acute toxicity (oral) Based on that all of oral rat LD50 values are more than 5000 mg/kg (ACGIH (2001), DFGOT (vol.12 1991), and Patty (5th.
(2001)), it was set as the outside of Category.
1 Acute toxicity (dermal) Not classified - - - It was set as outside of Category based on the rabbit was not died at 18000mg/kg (DFGOT (vol.12.1991)).
1 Acute toxicity (inhalation: Maximum vapor concentration is 350g/m3 (20degC). (GESTIS(2005))
vapour)
As the highest result, LC50: 57.6g/m3 (ACGIH (1991)) is below saturated concentration, it is interpreted as not being
Not classified - - - mist. Since even the lowest LC50 value: 14620ppm (DFGOT (vol.12.1999)) is 2.5 times more than the limit of Category 4:
2000ppm, it was classified as out of Category.
possible
2 Skin corrosion / irritation Not classified - - - As it caused "no irritation" in tests on humans (DFGOT (vol.12, 1999)) and rabbits (IUCLID (2000)), it was classified as
"out of Category". Observed effect was "defatting" with long-term repeated skin exposure only.
3 Serious eye damage / eye Causes eye The irritation was seen in the eye of the rabbit. But it recovered within seven days (ECETOC (TR48 (2), 1998)). So it was
irritation Category 2B - Warning
irritation set as "Category 2B".
Classification not sensitization)-; (Skin sensitization)-; sensitization)- Literature was not able to be obtained about respiratory sensitization. It was put "outside of the Category" based on the
possible; Skin sensitization)- (Skin ; (Skin skin sensitization test results of the humans and rabbits. (IUCLID (2000), DFGOT (vol.12, 1991))
classified
5 Germ cell mutagenicity The substance was regarded as "outside the categories" based on negative results from in vivo micronucleus tests.
Not classified - - - (DFGOT (vol.12, 1991), IUCLID (2000))
possible
organs (respiratory);
May cause
Category 1 respiratory irritation The upper respiratory tract irritation in human at 400ppm exposure is reported (ACGIH (2001), DFGOT (vol.12, 1999)).
(respiratory); Category Health hazard Danger or may cause Anesthesia and lung injury are reported by explosion of near lethal level (DFGOT (vol.12, 1999)). "A respiratory-organs
3 (narcotic effects) drowsiness and system : Category 1", and "Anesthesia : Category 3" were applied.
dizziness (narcotic
effects)
9 Specific target organs/systemic Classification not The case in human work exposure is combined exposure, and cannot be judged only now. Animal experiments inhalation
exposure possible exposure concentrations exceeds the guidance value maximum (250 ppm or 1 mg/L) of Category 2.
10 Aspiration hazard Classification not No data available on chemical pneumonia, though it could be classified based on the criteria 2b with the dynamic viscosity
possible - - - at 25degC and 40degC.
11 Hazardous to the aquatic Not classified - - - It carried out the outside of Category from 48-hour EC50=164mg/L of Crustacea (Water flea) (IUCLID, 2000).
environment (acute)
11 Hazardous to the aquatic Not classified - - - Since not water-insoluble (aqueous solubility =80000 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.
GHS Classification
ID580 Phosphorous trichloride
6 Flammable liquids Not classified - - - Non-combustible (Hommel, 1991).
mixtures
9 Pyrophoric liquids Not classified - - - Non-combustible (Hommel (1991))
11 Self-heating substances and Not classified - - - Non-combustible (Hommel, 1991)
mixtures
12 Substances and mixtures, which In contact with
in contact with water, emit
flammable gases water releases It is based on the statement that it is reacts violently with water, generates inflammable Phosphine with fever, and has
Category 1 Flame Danger flammable gases the possibility of fire and explosion (NFPA (13th, 2002)), and accompanied by generating of a diphosphan with ignitability
which may ignite (Bretheric (J) (5th, 1998)).
spontaneously
13 Oxidizing liquids Classification not - - - Classification not possible due to lack of data on oxidation nature, though compounds containing chlorine.
possible
15 Organic peroxides Not applicable - - - Inorganic compound
Health Hazards
1 Acute toxicity (oral) Skull and From oral, rat: 18mg/kg (RTECS (2004)), it was set as Category 2. There were two reports and both were priority 2, the
Category 2 crossbones Danger Fatal if swallowed higher one of toxicity was adopted.
possible
Skull and
1 Acute toxicity (inhalation: Category 2 Danger Fatal if inhaled It was classified as Category 2 based on rat LC50: 104ppm/4h (ACGIH (2001)).
vapour) crossbones
2 Skin corrosion / irritation Causes severe skin Since severe corrosiveness with 60 second exposure on rabbits (IUCLID (2000)), severe irritation on human (ACGIH
Category 1A Corrosion Danger burns and eye (2001)) and severe irritation or corrosive on humans (HSDB (2005)) are reported, and also since the UN classification is
damage subsidiary risks class 8, it was classified as Category 1A.
3 Serious eye damage / eye Causes serious eye There is a statement that corrosive to the human eye (ICSC (J), (1997)). Since skin caustic / irritant was categoried into
irritation Category 1 Corrosion Danger damage Category 1A, it was set as Category 1.
Classification not sensitization)-; (Skin sensitization)-; sensitization)-
possible; Skin sensitization)- (Skin ; (Skin No data available
sensitization:
possible
5 Germ cell mutagenicity The substance was regarded as outside the categories. Because of the reports indicating negative results in the
Not classified - - - chromosome aberration tests and micronucleus tests using both mouse bone-marrow cells and human peripheral blood
lymphocytes (IUCLID (2000)). The substance was also negative in the in vitro Ames test (IUCLID (2000)).
possible - - - Classification not possible due to lack of data and reports
7 Toxic to reproduction Classification not - - - Although there is a statement which was normal in mouse and rat sperm and did not have changes of fetal bone of rat
possible (IUCLID (2000)), since data is insufficient, it cannot classify.
8 Specific target organs/systemic In the human inhalation exposure, the irritation to throat and pharyngeal mucous membrane, bronchitis, breathing
difficulty, nausea, reduction in lung capacity (ACGIH (2001)), pulmonary edemas (ICSC (J) (1997)), burning eye or throat,
Category 1 (respiratory) Health hazard Danger Cause damage to chest pressure sensation, photophobia, heartache, wheezing, itchiness, blear eye feeling, and lung function abnormalities
organs (respiratory)
(IUCLID (2000)) were reported. So it classified into Category 1 (respiratory system). About the irritations of the skin and
eye, they are described in the section of skin corrosivity/skin irritation, and eye irritation.
exposure organs (respiratory
organs) through
prolonged or Because of the statement (ACGIH (2001)) which causes a disorder in the respiratory systems, such as bronchitis,
Category 1 (respiratory Danger repeated exposure; emphysema, and decreased lung function in repeated inhalation exposure of humans, it was classified in Category 1
organs); Category 2 Health hazard ; Warning May cause damage (respiratory systems).Moreover, although the osteomyelitis of the jawbone called "Phossy jaw (phosphorus necrosis)"
(bone) to organs (bone) was reported (HSDB (2005)) , since it was priority2, it was classified in 2 (bone tissue).
through prolonged
or repeated
exposure
possible
possible
GHS Classification
ID581 Borane, trifluoro-
2 Flammable gases Not classified - - - Non-combustible (ICSC, 1993; Hommel, 1991).
4 Oxidizing gases Not classified - - - UNRTDG Class: 2.3, Subsidiary risks Class: 8
Compressed gas Gas cylinder Warning pressure; may Compressed gas because of "the critical temp: -12.25degC to -12.25degC" (Hommel, 1991: HSDB, 2005), "the critical
explode if heated pressure: 4.98MPa" (HSDB, 2005), and the state in a usual circulation.

mixtures
mixtures
flammable gases
16 Corrosive to metals Classification not Although it is UNRTDG class 2.3 subsidiary risks 8, these 8 is corrosive in exposure to human bodies such as inhalation.
possible - - - Since test methods is not established (gas), corrosion behavior cannot be classified.
Health Hazards
1 Acute toxicity (oral) Classification not
possible
1 Acute toxicity (inhalation: gas) Skull and Danger
Category 2 crossbones Falat if inhaled It was considered as Category 2 based on rat LC50 = 436ppm (ACGIH (2001)).
vapour)
mist)
2 Skin corrosion / irritation Causes severe skin It is reported to have corrosiveness on human skin and caused severe burns (ICSC (J), (1993), HSDB (2005)), therefore,
Category 1A-1C Corrosion Danger burns and eye it was classified as Category 1A-1C.
damage
3 Serious eye damage / eye Causes serious eye It was set as Category 1 based on the statement that caustic was seen in the human skin, and human eye caustic was
damage indicated and there was severe irritation (ICSC (J), (1993), HSDB (2005)).
Classification not sensitization)-; (Skin sensitization)-; sensitization)- Respiratory sensitization: No data
possible; Skin sensitization)- (Skin ; (Skin Skin sensitization: No data
sensitization: sensitization)- sensitization)-
Classification not
possible
possible
toxicity following single exposure May cause damage
to organs
Based on the descriptions that respiratory irritant, corrosion of the respiratory tract, and the obstacle of pulmonaries
(respiratory, (the congestion of pulmonaries, pulmonary edemas, pneumonia) in humans (ICSC (J) (1993), HSDB (2005), RTECS
Category 2 (respiratory, Health hazard cardiovascular (2005)), it was classified into Category 2 (respiratory systems). It was classified into Category 2 (cardiovascular system)
cardiovascular system); ; Exclamation mark Warning system); May cause based on that the cardiovascular systems disorders (a cardiomyopathy, a circulatory shock) are described in human
Category 3 (narcotic respiratory irritation (HSDB (2005)). Based on the destription that the effect to nervous system in human (hyporeflexia, drowsiness, syncope,
effects) or may cause blood-pressure decreased, hyperpnea and respiration depressed) (ICSC (J) (1993), HSDB (2005)), it was classified into
drowsiness and Category 3 (anesthetic action).
dizziness (narcotic
effects)

exposure organs (kidneys,
respiratory organs)
Category 1 (kidneys, through prolonged Nephrotoxicity, pneumonia, and stimulative of respiratory organs in a rat with the amount of administration of Category 1
respiratory organs); Danger or repeated guidance value range (50 ppm / 6h/(day)) are indicated (ACGIH (2001)). Nephrotoxicity, nasal mucosas/gums bleeding,
Category 2 (bone, Health hazard ; Warning exposure; May decreased lung function, osteosclerosis, bone fragility, enamel dissolution and fluoride deposit are indicated in humans
tooth) cause damage to (ICSC (J), (1993), IUCLID (2000), HSDB (2005)) . It was classified in Category 1 (kidney, respiratory system) and Category
organs (bone, tooth) 2 (bones,tooth) based on these statements.
through prolonged
or repeated
exposure
environment (acute) Category 3 - - life It was classified into Category 3 from 48-hour EC50=21.3mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic Harmful to aquatic Classified into Category 3, since acute toxicity was Category 3, and behavior in water and bioaccumulative potential are
environment (chronic) Category 3 - - life with long lasting
effects unknown.
GHS Classification
ID582 Lead, tetraethyl-
CAS 78-00-2 Date Classified: Mar. 23, 2006 (Environmental Hazards: Feb. 10, 2006)
6 Flammable liquids Although the flash point at 93 - 94 degC (Hommmel, Sax) is at the maximum, or outside of Category 4, there is other
information, including 71 degC, 80 degC, etc., in another document (IUCLID (2000)). These may have been influenced by
Category 4 - Warning Combustible liquid
impurity dichloroethane (flash point: 13 degC). Also taking these commercial items into consideration, it was classified as
as "Category 4".
8 Self-reactive substances and Not applicable - - - There are no chemical groups associated with self-reactive properties present in the molecule.
mixtures
9 Pyrophoric liquids Not classified - - - Not classified in UNRTDG Class: 4.2
12 Substances and mixtures, which It is not made a class 4.2 by UNRTDG. Aqueous solubility measurements is carried out. It is clear not to carry out an
in contact with water, emit Not classified - - -
flammable gases intense reaction, even if it contacts water.
13 Oxidizing liquids Not applicable - - - Organic compounds containing no oxygen, fluorine and chlorine.
possible
Health Hazards
Skull and
crossbones
Danger Fatal if swallowed Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE(ave.): 13.1mg/kg;
1 Acute toxicity (dermal) Category 3 Skull and Danger Toxic in contact It was set as Category 3 based on the rabbit dermal LD50 = 990mg/kg (DFGOT vol.15 (2001)).
crossbones with skin
1 Acute toxicity (inhalation: Since saturated vapor at room temperature is about 500ppm, it was evaluated as gas. Rat LC50 converted for 4 hour is
vapour) Skull and
Category 1 crossbones Danger Fatal if inhaled 32.13ppm and falls into Category 1. (When the same experiment was assumed to be steam and converted for 4 hours the
value is 0.425mg/L and it is also Category 1.)
1 Acute toxicity (inhalation: dust, Classification not - - - Classification not possible due to lack of data
mist) possible
Category 2 Exclamation mark Warning Causes skin It was classified as "Category 2" based on IUCLID, etc.
2 Skin corrosion / irritation irritation
irritation Category 2A-2B Exclamation mark Warning It was classified into "Category 2" based on IUCLID etc. There is no experimental data which distinguishes 2A and 2B.
irritation
possible; Skin No data available
possible
5 Germ cell mutagenicity The substance was regarded as "outside the categories" because it was negative in rat dominant lethal tests and there
are no other in vivo data. It was also negative in the bacterial return modification test.
6 Carcinogenicity Not classified - - - Since it was judged as class 3 in IARC, and A4 in ACGIH, it was set as "Outside of Category."
7 Toxic to reproduction Although the ferotoxity of rat/mouse is observed only in the administration range occuring maternal toxicity (ACGIH
Suspected of
Category 2 Health hazard Warning damaging fertility or (2001), but the material have extremely-high toxicity and it cannot be judged as the toxicity effect to mother is the only
the undorn child cause of the effect to embryo. R61 and R62 are attached by the category of EU. and it is classified into the "Category 2"
by the above.
organs (central
nervous system);
Category 1 (central May cause
nervous system); respiratory irritation Since the central nervous system effects are reported in laborers and the animals experiments, it was classified into
Category 3 (respiratory Health hazard Danger or may cause "Category 1." Moreover, "Category 3" was added since the irritations of the nose and the throat are suggested (HSFS
tract irritation) drowsiness and (2002)).
dizziness
(respiratory tract
irritation)
toxicity following repeated organs (inhalation,
exposure Category 1 (inhalation, nervous system) Since nervous system damage was seen in the gasoline inhalation addict, and the expert described that a major factor
Health hazard Danger
nervous system) through prolonged was a tetraethyl lead (Patty (5th.2001)), it was classified in "Category 1".
or repeated
exposure
10 Aspiration hazard Classification not - - - Insufficient data available.
possible
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 96-hour LC50=0.02mg/L of fishes (Bluegill) (EHC85, 1989).
aquatic life
environment (chronic) Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and
Category 1 Environment Warning aquatic life with long
bioaccumulative potential are unknown.
lasting effects
GHS Classification
ID583 calcium cyanide
7 Flammable solids Not classified - - - Non-combustible (ICSC, 1998; NFPA, 13th, 2002; ,Weiss, 2nd, 1985)
mixtures
10 Pyrophoric solids Not classified - - - Non-combustible (ICSC, 1998; NFPA, 13th, 2002; Weiss, 2nd, 1985)
11 Self-heating substances and Not classified - - - Non-combustible (ICSC (1998), NFPA (13th, 2002), Weiss (2nd, 1985))
mixtures
12 Substances and mixtures, which Although it is known that this product reacts violently with water and generates flammable toxicity hydrogen cyanide gas
in contact with water, emit
flammable gases Classification not - - - (ICSC (1998)), there is no detailed data, and it cannot be classified. Although it becomes the outside of category based
possible on the UNRTDG class 6.1, it is preassumed that it should be included in water reacting burning materials with considering
the hazardous nature of this product.
14 Oxidizing solids Not applicable - - - Inorganic compounds containing no oxygen and halogen.
16 Corrosive to metals Classification not - - - Test methods applicable to solid substances are not available.
possible
Health Hazards
possible
possible
vapour) possible
2 Skin corrosion / irritation Category 3 - Warning Causes mild skin It was classified as Category 3 based on the statement that redness and stimulation on human skin were observed (ICSC
irritation (J), (1998)).
3 Serious eye damage / eye Causes serious eye It was set as Category 2A-2B based on the statement that humans had redness and pain (ICSC (J), (1998)).
irritation Category 2A-2B Exclamation mark Warning
irritation
sensitization:
sensitization)- sensitization)-
Classification not
possible
5 Germ cell mutagenicity Classification not - - - No data available
possible
possible
to organs (central
nervous system);
Category 2 (central May cause
nervous system); Health hazard respiratory irritation Since the chest pressures, confusion, spasms, coughing, dizziness, headaches, closeness, feeling of sickness, breath
Category 3 (respiratory ; Exclamation mark Warning or may cause shortness, seizure, loss of consciousness, vomiting, weakness, and irritation of respiratory tract etc. were described
tract irritation) drowsiness and (ICSC (J) (1998)), it was classified into Category 2 (central nervous system) and Category 3 (respiratory irritation).
dizziness
(respiratory tract
irritation)
toxicity following repeated - - - Classification not possible due to lack of data
exposure possible
possible
possible
GHS Classification
ID584 Parathion
possible
6 Flammable liquids Not classified - - - Flash point: 120degC (ICSC, 2004)
8 Self-reactive substances and Classification not
mixtures possible - - - No data available
9 Pyrophoric liquids Not classified - - - "may burn but does not ignite readily." (HSDB, 2005)
mixtures possible
in contact with water, emit Classification not
flammable gases
13 Oxidizing liquids Classification not
possible
Health Hazards
Skull and
crossbones
Danger Fatal if swallowed The data of rat LD50 is based on 5.56mg/kg (statistically calculated values) (IARC30 (1983), JMPR901 (1995)).
1 Acute toxicity (dermal) It is based on rat LD50 = 6.8mg/kg (IARC30 (1983)) which is lower among rat and rabbit. A rat statistically calculated
Category 1 Skull and Danger Fatal in contact with value was 5.71mg/kg. But it was less than lowest value of the data, LD50 value used for decision is the lowest value of
crossbones skin data: 6.8mg/kg.
vapour) possible
1 Acute toxicity (inhalation: dust, Category 1 Skull and Danger Fatal if inhaled It is based on rat LC50 0.032mg/L (4hours) (a statistically calculated values, ACGIH (2003) others).
mist) crossbones
2 Skin corrosion / irritation Causes mild skin
Category 3 - Warning irritation It is based on the test result on rabbits (a mild irritant) (JMPR (1995)).
3 Serious eye damage / eye Causes eye
irritation Category 2B - Warning It is based on a studies of rabbits (Slightly irritating) (IUCLID (2000)).
irritation
Classification not sensitization)-; (Skin sensitization)-; sensitization)- Respiratory sensitization: No data . Skin sensitization: It is based on the knowledge of negativity as a result
possible; Skin sensitization)- (Skin ; (Skin of the examination by the Magnusson Kligman method using the guinea pigs (JMPR (1995)).
classified
5 Germ cell mutagenicity It is based on the negative results in the multi-generation mutagenicity test (mouse dominant lethal test) (IARC 30
(1983)) and in the in vivo mutagenicity test (the in vivo mouse micronucleus test) (JMPR901 (1995)).
6 Carcinogenicity Not classified - - - It is based on the ACGIH classifications of A4, IARC classification of 3, and the EPA classification of C.
In the rat two generation test, it is based on there was the disorder to the reproduction and the growth capacity in
Category 2 Health hazard Warning damaging fertility or nascent under the condition that maternal toxicity is not obvious (ACGIH (2003) and IARC30 (1983) etc).
the undorn child
8 Specific target organs/systemic Based on the descriptions that the acute symptoms with the decreasing of cholinesterase activities (cholinergic nervous
Cause damage to symptom; respiration failure, severe nystagmus, weakness of muscles of leg and the decreased tendon reflexes etc. were
Category 1 (nervous Health hazard Danger organs (nervous observed (ACGIH (2003)), and that the decreasing of cholinesterase activities, tremor, and movement dysfunction
system)
system) syndrome were observed in the equivalent dosage of Category 1 in rat (ACGIH (2003)). So it was classified into Category
1 (nervous system).
exposure organs (nervous It was classified in Category 1 (nervous systems, optic organs) on the basis that the cholinesterase activity reduction in
Category 1 (nervous Health hazard Danger system) through the plasma and red corpuscles was seen in rat with Category 1 guidance value and tremors, hair loss,g ait abnormality,
system) prolonged or etc. were seen as a symptom and degeneration and atrophy of the retina were seen (JMPR901 (1995)).
repeated exposure
10 Aspiration hazard Classification not - - - No data available on an animal experimentation or etc, though Dynamic viscosity(calculated value): <=14mm2/s
possible
environment (acute) Category 1 Environment Warning aquatic life It was classified into Category 1 from 48-hour LC50=0.001mg/L of Crustacea (Daphnia magna) (ECETOC TR91, 2003).
environment (chronic) Category 1 Environment Warning aquatic life with long Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though
lasting effects supposed less bioaccumulative (log Kow=3.83(PHYSPROP Database, 2005)).
GHS Classification
ID585 dioxathion
6 Flammable liquids Not classified - - - Non-combustible (ICSC, 1998; Sax, 11th, 2004; HSDB, 2005).
8 Self-reactive substances and Classification not - - - Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-
mixtures possible reactive properties present.
9 Pyrophoric liquids Not classified - - - Non-combustible (ICSC, 1998; Sax (11th, 2004); HSDB , 2005)
11 Self-heating substances and Not classified - - - Non-combustible (ICSC (1998), Sax (11th, 2004), HSDB (2005))
mixtures
12 Substances and mixtures, which Since measurement of water solubility, a water-octanol distribution coefficient, etc. is performed (ICSC (1998) etc.), it is
flammable gases judged that it is stable in the water.
13 Oxidizing liquids Classification not - - - Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to
possible phosphorus.
Health Hazards
1 Acute toxicity (oral) Skull and It was set as Category 2 based on LD50= 29mg/kg obtained from the calculation using six data of rat LD50 values
Category 2 crossbones Danger Fatal if swallowed (ACGIH (2002), JMPR 125 (1968)).
1 Acute toxicity (dermal) Category 2 Skull and Danger Fatal in contact with LD50= 67.6mg/kg calculated from four data (ACGIH (2002), PATTY (5th, 2001)) of rat LD50 value. And LD50= 85mg/kg
crossbones skin of two data (equivalence) of rabbit LD50 value. It was set as Category 2 based on LD50= 67.6mg/kg of the lower value.
vapour) - - - No data available
possible
Since the saturated vapor pressures concentrations pressure of this product is 0.000115mg/L (6*10^(-7)ppm), it is
1 Acute toxicity (inhalation: dust, Category 2 Skull and Danger Fatal if inhaled thought that the inhalation study was done in mist. It was set as category 2 based on rat LC50 = 0.3495mg/L (ACGIH
mist) crossbones (2002)).
2 Skin corrosion / irritation Classification not
possible
3 Serious eye damage / eye Mild and transient conjunctivitis is produced in a rabbit. But there was no effect in a corneal (ACGIH (2002), PATTY (5th,
irritation Category 2B - Warning Causes eye 2001), HSDB (2005)). And that there were the haze eye and stimulativeness in humans (ICSC (J) (1998), HSFS (1998)).
irritation So it was set as Category 2B.
Classification not
possible
5 Germ cell mutagenicity Classification not - - - It was decided that the substance could not be classified by the technical guidelines. Because there are no results from
possible in vivo tests and there are no records of strong positive results in vitro tests in several parameters.
6 Carcinogenicity Not classified - - - Not classified because of
7 Toxic to reproduction Since there is the description that there is no malformation in the parent animals, next generation and the third
generation in the rat three generation test (ACGIH (2002), PATTY (5th, 2001)), and there is the description that there is
Not classified - - - no abnormal findings of parent animals of rat, and no bad effect to the reproductive behavior fertility and to the number
of a lactating- litter neonatal, and the size and the anatomic structure of neonatal is normal (JMPR 125 (1968)), it was
considered as on the outside of Categry.
8 Specific target organs/systemic Cause damage to Due to the description that miosis, muscle spasticity, salivation, sweating, nausea, dizziness, closeness, convulsion,
toxicity following single exposure Category 1 (nervous Health hazard Danger organs (nervous incoordination, loss of consciousness, etc. were observed in human (ACGIH (2002), PATTY (5th, 2001), ICSC (J) (1998),
system)
system) HSFS (1998)), it was classified into Category 1 (nerve system).
toxicity following repeated It was classified in Category 1 (nervous systems) based on the statements that inhibition of cholinesterasethe in plasma
exposure organs (nervous
Category 1 (nervous Health hazard Danger system) through and a red corpuscle,hyperexcitability, tremor in rats and dogs with the dosage of guidance value range of Category 1
system) prolonged or (ACGIH (2002), PATTY (5th, 2001)), and the statements of the cholinesterase inhibition in plasma by repeated exposure
repeated exposure also in humans (ACGIH (2002), PATTY (5th, 2001), JMPR 125 (1968), HSDB (2005)).

possible
environment (acute) Category 1 Environment Warning aquatic life It was classified into Category 1 from 48-hour EC50=0.35microg/L of Crustacea (Daphnia magna) (HSDB, 2004).
GHS Classification
ID586 Ethane, 1,2-dibromo-
mixtures
9 Pyrophoric liquids Not classified - - - Non-combustible (Hommel, 1991)
mixtures
flammable gases
16 Corrosive to metals Not classified - - - UNRTDG Class: 6.1, PGI
Health Hazards
1 Acute toxicity (oral) Skull and Rat LD50 values of 146 mg/kg (male), 117 mg/kg (female), and 140 mg/kg (male and female) (EHC 177 (1996))
Category 3 crossbones Danger Toxic if swallowed corresponded to classification target, and it was set as Category 3 based on the lowest value of 117 mg/kg.
1 Acute toxicity (dermal) Category 3 Skull and Danger Toxic in contact It was set as Category 3 based on rabbit LD50= 450mg/kg (EHC 177 (1996)).
crossbones with skin
1 Acute toxicity (inhalation: Rat LC50 value 2.304mg/L and 4.620mg/L (4-hour equivalent of 2.31mg/L) (EHC 177 (1996)) corresponded as subjects
vapour)
Skull and of classification. Both were equivalent to about 300ppm, and it was classified as Category 2 with the application of the
Category 2 crossbones Danger Fatal if inhaled gaseous classification Category.
[saturated vapor pressure concentration: 10^(6) *1.5 / 101(kPa) = 14851ppm]
Although significant irritation accompanied by erythema and edema which progress to necrosis and eschar was observed
with repetitive application on shaved rabbit abdominal, it is described that it recovered completely within seven days after
Causes skin the end of exposure (EHC 177 (1996)). On humans, from the results of single exposure test on skin, it is judged to have
Category 2 Exclamation mark Warning irritation serious stimulativeness (IUCLID (2000)), and other reports indicate severe irritation (EHC 177 (1996), PATTY (5th, 2001),
ATSDR (1992)). From these information, this product may result in corrosion. So it was judged to have severe irritation, it
was classified as Category 2.
3 Serious eye damage / eye There is irritation on the conjunctiva and necrotic slight for corneal surfaces by rabbits eye drops, it did not bequeath
irritation
Causes serious eye injury 12 days afterward, and had recovered completely (EHC 177 (1996)). Moreover, it is indicated that there is ocular
Category 2 Exclamation mark Warning irritation severe irritation in humans (EHC 177 (1996)). Since it was judged that it had the moderates irritation from these
information to an eye, it was set as Category 2.
sensitization:
Classification not (Respiratory (Respiratory (Respiratory [respiratory sensitization] No data
possible; Skin sensitization)-; (Skin sensitization)-; sensitization)- [Skin sensitization] Although there is a report (BUA 66 (1991)) which suggests sensitizing by humans, it cannot be said
sensitization: sensitization)- (Skin ; (Skin that the accuracy as a proof is sufficient, and since data is insufficient, it cannot be classified..
possible
Suspected of
causing genetic There are positive results from the DNA damage test using rat testicular cells (in vivo genotoxicity test in germ cells) and
defects (state route from several DNA damage tests and DNA binding tests using somatic cells such as hepatocytes from rats or mice (in
Category 2 Health hazard Warning of exposure if it is vivo genotoxicity test in somatic cells) (IARC 71(1999), EHC 177(1996)). Furthermore, there are positive results in several
conclusively proven parameters for the in vitro mutagenicity tests (IARC 71(1999), EHC 177(1996)). The substance was classified as Category
of exposure cause 2 based on the above results.
the hazard)
6 Carcinogenicity
May cause cancer
(state route of
exposure if it is
Category 1B Health hazard Danger conclusively proven It was set as Category 1B based on being classified into 2A (2002) according to industrial hygene society, and being
classified into 2A (1999) according to IARC, respectively.
of exposure cause
the hazard)
7 Toxic to reproduction There is the report about the failure of pregnancy in the mating between the male rat exposed with ten-week inhalation
Suspected of
Category 2 Health hazard Warning damaging fertility or and the female rat no processing, and the decrease of mating formation in the mating between the female rat exposed
the undorn child with three-week inhalation and the male rat no processing (EHC 177(1996)). Since general toxicity (reduced weight gain,
dead) occurs spontaneously in the dose causing these effects, it is classified into the Category 2.
toxicity following single exposure organs (liver, Due to the descriptions that the liver fatty metamorphosis, centrilobular necrosis, and proximal convoluted tubules of
kidneys, central kidneys were observed by suicide attempt or mistaking (EHC 177(1996), PATTY (5th, 2001), IARC 71(1999), ACGIH
Category 1 (liver, nervous system); (2001), BUA 66 (1991)), and that centrilobular fatty change degenerations and necrosis in hepatic and renal tubule edema
kidneys, central Health hazard Danger May cause in liver were observed also in rat (EHC 177 (1996)). So it was classified into Category 1 (liver, kidney). Moreover, due to
nervous system); ; Exclamation mark ; Warning respiratory irritation the descriptons that there are some reports which mistaking for the anesthetic in humans caused poisoning (ACGIH
Category 3 (respiratory or may cause (2001), BUA 66 (1991)), furthermore, that it affects to central nervous systems and causes an awareness decreases is
tract irritation) drowsiness and caused (ICSC (1993)), it was classified into Category 1 (central nervous system). In addition, it also classified into
dizziness Category 3 (respiratory irritant) according to the description which also has irritaiton in airways (EHC 177 (1996), ICSC
(respiratory tract (1993)).
irritation)
toxicity following repeated It was classified in Category 2 (respiratory tracts) based on statements that not only stimulative to the pharynx and a
exposure bronchus (PATTY (5th, 2001)), but also lungs damage and bronchitis were affected in humans by occupational exposure
May cause damage
to organs (ICSC (1993)), and statements that a necrosis and atrophy of olfactory epithelium in nasal cavity, dysplasia, hyperplasia,
(respiratory organs, and gigantocellularis of a squamous epithelium cell in a respiratory tract were seen in inhalation exposure of rats or
Category 2 (respiratory Health hazard Warning liver, kidneys) mouse with the concentration (0.577 mg/L) equivalent to the guidance value Category 2 (EHC 177 (1996)) . Moreover, a
organs, liver, kidneys) through prolonged potential that humans will also affect liver and the kidney as effect of long-term or repeated exposure is suggested (ICSC
or repeated (1993)), and inhalation exposure of a guinea pigs with the concentration (0.385 mg/L (50 ppm) (80 days) (the equivalent
exposure on the 90 days: 0.342 mg/L)) as equivalent to the guidance value Category 2, mild centrilobular fatty degeneration in liver,
interstitial congestion and edema in the kidney were observed (EHC 177 (1996)). On this bases, it was classified in
Category 2 (liver, kidney).

possible - - - Insufficient data available.
environment (acute) Category 3 - - life It was classified into Category 3 from 96-hour LC50=32.1mg/L of fishes (Oryzias latipes) (ECETOC TR91, 2003).
11 Hazardous to the aquatic Based on NOEC=5.81 mg/L during 28 days for the fish (Oryzias latipes) (ECETOC TR91, 2003), though acute toxicity was
Category 3.
GHS Classification
ID587 Dibromochloropropane
6 Flammable liquids Category 4 - Warning Combustible liquid Category 4 because of its flash point: >60degC and <90degC
mixtures
9 Pyrophoric liquids Not classified - - - UNRTDG : it is classified into a class 6.1 (Toxic substances) and PG 2 or 3.
flammable gases
13 Oxidizing liquids Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other
Not applicable - - -
elements).
16 Corrosive to metals Not classified - - - UNRTDG Class: 6.1 (Toxic substances), PG II or III
Health Hazards
Skull and
crossbones
Danger Toxic if swallowed Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 185 mg/kg; REFERENCE SOURCE: ATSDR (1992)
1 Acute toxicity (dermal) Category 4 Exclamation mark Warning Harmful in contact It was set as Category 4 based on rabbits dermal LD50 = 1400mg/kg (ATSDR (1992)).
with skin
Skull and
1 Acute toxicity (inhalation: Category 2 Danger Fatal if inhaled It was classified as Category 2 based on rat inhalation LC50 = 154ppm (ATSDR (1992)).
vapour) crossbones
2 Skin corrosion / irritation Not classified - - - When it was applied to the normal skin in rabbit test, there was no irritation, and since even when it was applied to the
brushing skin, only very slight erythema was observed. Therefore, it was classified as out of Category.
3 Serious eye damage / eye Causes eye Mild irritation was acknowledged in the conjunctiva and the iris of the rabbit. But it recovered completely in one to two
irritation Category 2B - Warning irritation days (ATSDR (1992)). So it was set as Category 2B.
Classification not
possible
May cause genetic
defects (state route The substance was classified as Category 1B. Based on the positive results from the in vivo multi-generation
of exposure if it is
Category 1B Health hazard Danger conclusively proven mutagenicity test using germ cells (the rat dominant lethal test (IARC 71(1999)), the in vivo mutagenicity test using germ
that no other routes cells (the chromosome aberration test using rat spermatogenic cells (IARC 71(1999)), and the in vivo mutagenicity tests
of exposure cause in somatic cells (the mouse spot test, micronucleus test using mouse or rat bone-marrow cells (IARC 71(1999)).
the hazard)
6 Carcinogenicity
Suspected of
causing cancer
(state route of
Category 2 Health hazard Warning exposure if it is Since the IARC classification is 2B, the Japanese industrial hygene academic Society classification is 2B, and the NTP
conclusively proven classification is R, it was to category 2.
of exposure cause
the hazard)
7 Toxic to reproduction In humans, azoospermia and oligospermia are observed and the possibility of infertility is suggested (IARC 71 (1999), IRIS
(2003)).
Moreover, it is reported in a reference that although this is reproductive toxicity product to male and also it effects to
infertility, it does not have an adverse effects on reproduction of male offspring (Chemically Induced Birth Defects-3rd
Category 1A Health hazard Danger May damage fertility edition), indirect correlation is observed between exposure and a sperm count (Catalog of Teratogenic Agents, 11th
or the undorn child edition).
Furthermore, it clearly describes "The spermatogenesis is inhibited in humans, and infertility is occured" (IARC 71
(1999)).
Therefore, it was classified into Category 1A.
8 Specific target organs/systemic May cause

toxicity following single exposure respiratory irritation
or may cause
Category 3 (respiratory Exclamation mark Warning drowsiness and In the rat inhalation study, since the respiratory irritation was reported (ATSDR (1992)), it was classified into Category 3
tract irritation) dizziness (respiratory irritant).
(respiratory tract
irritation)
organs (respiratory
exposure In the test of repetitive inhalation exposure to rats or mise, the influence on the respiratory systemssuch as a necrosis
Category 1 (respiratory organs, kidneys, of a nasal cavity and a trachea, pulmonary emphysema, and pneumonia (IARC 71 (1999), ATSDR (1992)), the nephrosis
organs, kidneys, liver, liver, central in kidney and nephropathia (ATSDR (1992)), the necrosis in liver (ATSDR (1992)) , meningoencephalitis and brain necrosis
central nervous system, Health hazard Danger nervous system, (ATSDR (1992)), anemia, and atrophy of the spleen (ATSDR (1992)) are accepted in the equivalent concentration for the
blood system) blood system) guidance value range of Category 1. It was referred to as Category 1 (respiratory system, kidney, liver, central nervous
through prolonged systems, and blood systems) based on these results.
or repeated
exposure
possible
11 Hazardous to the aquatic Harmful to aquatic It was classified into Category 3 from 48-hour EC50=19mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of
environment (acute) Category 3 - - life chemicals, 1999).
environment (chronic) Category 3 - - life with long lasting Classified into Category 3, since acute toxicity was Category 3 and supposed not rapidly degrading (BIOWIN), though less
effects bio-accumulative (BCF=19 (existing chemical safety inspections data)).
GHS Classification
ID588 diborane(6)
2 Flammable gases Category 1 - Danger Extremely flammable Category 1 because "the flammable range is 0.8-88 %" (ICSC, 1990; Hommel, 1991) and it is ignitable when in a mixture
gas of 13% or less by volume in air. UNRTDG No.1911, Class: 2.3(2.1)
4 Oxidizing gases Classification not
5 Gases under pressure Contains gas under Compressed gas because of "the steam pressure: 3999kPa at 17degC" (HSDB, 2006) and ">280kPa at 20degC" (GHS
High pressure liquefied Gas cylinder Warning pressure; may definition). High pressure liquefied gas because of the critidal temp: 16.7degC"(HSDB, 2006: ICSC(J), 1990) which is
gas explode if heated between -50degC and 65degC.
mixtures
mixtures
flammable gases
possible - - - Test methods applicable to gas substances are not available
Health Hazards
possible
1 Acute toxicity (inhalation: gas) Skull and Danger It was considered as Category 1 based on the lower rat inhalation LC50 value (4hrs) = 40ppm (from the two-point data of
Category 1 crossbones Falat if inhaled 40ppm (ACGIH (2001)) and 50ppm (PATTY (5th, 2001)).
vapour)
mist)
2 Skin corrosion / irritation Causes severe skin Based on the descriptions that it has skin stimulativeness on humans (HSDB (2006)) and skin corrosiveness especially
Category 1A-1C Corrosion Danger burns and eye (ICSC (1990)), it was classified as Category 1A-1C. Moreover, there is also a description of critical frostbite (ICSC
damage (1990)).
3 Serious eye damage / eye Causes serious eye There is a statement of the stimulus to the eye in humans (HSDB (2006), HSFS (1999)), especially the eye corrosive
damage (ICSC (1990)) and serious burn (ICSC (1990)). A it was set as Category 1.
sensitization:
possible
5 Germ cell mutagenicity Classification not - - - Insufficient data available
possible
7 Toxic to reproduction Classification not - - - Insufficient data available
possible
8 Specific target organs/systemic In the effect to human, due to the descriptions that the irritation to respiratory organs, lung oedema, pneumonia, and the
Category 1 (respiratory) Health hazard Danger Cause damage to effec to bronchus are observed (ICSC and (1990), HSDB (2006) and PATTY (5th, 2001)), and that the inflammation of
organs (respiratory) lung and lung oedema are desribed in the range of equivalent guidance dose of Category 1in the study using mouse
(DFGOT Vol.4 (2000)). So it was classified into Category 1 (respiratory system).
toxicity following repeated It was classified to as Category 1 (the respiratory system, nervous system) based on the indication of the pulmonary
exposure Category 1 (respiratory organs (respiratory edema by respiratory irritations with the given dose of guidance value within the limits of Category 1 in the test using a
organs, nervous Health hazard Danger organs, nervous guinea pigs (ACGIH (2001)), and the indication of poisoning of a nervous system in human impact (ACGIH (2001)) . In
system) system) through addition, the headache, giddiness, pneumonia, pulmonary edema, and irritation in lungs are indicated as the human impact
prolonged or (HSDB (2006)).
repeated exposure
possible
GHS Classification
ID589 Dimethylamine
2 Flammable gases Category 1 - Danger Extremely flammable Ignitable when in a mixture of 13% or less by volume in air. UNRTDG Class: 2.1
gas
4 Oxidizing gases Not classified - - - Not classified in UNRTDG Subsidiary risks Class: 5.1
Liquefied gas Gas cylinder Warning pressure; may Critical temp: >-50degC (Partially liquid at temperatures above -50degC)
explode if heated
mixtures
mixtures
flammable gases
16 Corrosive to metals Classification not - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.
possible
Health Hazards
1 Acute toxicity (oral) Category 4(aqueous Exclamation mark Warning Harmful if swallowed As a result of the examination using water solutions, based on rat LD50 value: 698mg/kg (ACGIH (7th, 2001), DFGOT
solution) vol.7 (1996)), it was set as Category 4. (water solutions)
possible
1 Acute toxicity (inhalation: gas) Category 4 Exclamation mark Warning Harmful if inhaled It was considered as Category 4 based on rat LC50 (4 hours) value: 4700 ml/m3 (DFGOT vol.7 (1996)).
vapour)
mist)
2 Skin corrosion / irritation There are descriptions that in 3 or 6% aqueous solutions skin application test on rabbits, erythema and edema, and
following ulcer was observed of the skin (DFGOT vol.7, 1996, ACGIH, 7th, 2001) and that the test inwhich the tip of mice
Category 1A-1C(3 - 6% Causes severe skin tail was dipped in 6% aqueous solutions for 2 hours, congestion with a clear boundary and following tissue necrosis was
solution) Corrosion Danger burns and eye observed (DFGOT vol.7, 1996, ACGIH, 7th, 2001). It was judged to have corrosivity and was classified as Category 1A-1C
damage
(3-6% aqueous solutions). Since the details of development and course of the corrosive reaction were unknown, it was
not subcategorized.
3 Serious eye damage / eye To eye of rabbit, conjunctivitis, conjunctival edemas, keratitis and corneal opacity are caused 1% aqueous solution, and
irritation
Category 1(1 - 5% Causes serious eye conjunctival hemorrhage, corneal edemas, turbidity and neovascularization are caused 5% aqueous solution, and it will
solution) Corrosion Danger damage continue 28 days. Furthermore, in higher concentrations, skin corrosiveness that a corneal becomes the translucent of
blue and white in several seconds (DFGOTvol.7 (1996), ACGIH 7th, (2001)). So it was set as Category 1 (1-5% water).
4 Respiratory/skin sensitizer Respiratory (Respiratory (Respiratory (Respiratory
sensitization: sensitization)- sensitization)-; sensitization)-; (Skin Respirator tract: No data
Classification not ; (Skin (Skin sensitization)May Skin : In Maximization test (closed epicutaneous test) using a guinea pigs, it is positive (the rate of positivity: 100%)
sensitization)Exclam (DFGOTvol.7 (1996)) and, as a description states that this substance has skin sensitization (ACGIH 7th, 2001), it was
possible; Skin sensitization)W cause allergic skin
sensitization: Category1 ation mark arning reaction referred to as Category 1.
5 Germ cell mutagenicity Although there are no data from the tests in germ cells, the report of the negative result of the in vivo chromosome
Not classified - - - aberration test using bone-marrow cells taken from rats that have been subjected to exposure to this substance for 3
months through inhalation (DFGOTvol.7 (1996)). So the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - Since it was classified into A4 according to ACGIH (7th, 2001), it carried out the outside of Category.
8 Specific target organs/systemic Due to the descriptions that the tissue injury is observed in respiratory mucosa by the exposure concentrations at
Cause damage to 600ppm or more by single inhalation exposure test in rats (PATTY (5th, 2001)), that the RD50 value in short time
Category 1 (central organs (central inhalation exposure in rat and mouse (50% breathing rates inhibitory concentration) is calculated (DFGOTvol.7 (1996)),
nervous system, Health hazard Danger nervous system, that it has respiratory irritantation, and that the central nervous system effects (incoordination and depressomotor) were
respiratory organs) respiratory organs) observed in the dosage of the guidance value of Category 1in the oral administration examination in rat, mouse, rabbit,
and guinea pig (ACGIH (7th, 2001)). So it was classified into Category 1(central nervous system, respiratory system).
organs (respiratory In the inhalation exposure test in rats and mice for two years, it was classified to as Category 1 (respiratory systems)
exposure Category 1 (respiratory Health hazard from the description that inflammation, denaturation, and hyperplastic injury at the rhinal mucosas were acknowledged in
Danger organs) through
organs) prolonged or the exposure group of 50 ppm or more of the guidance value range maximum of Category 1(ACGIH (7th, 2001), DFGOT
repeated exposure vol.7 (1996), PATTY (5th, 2001)).
11 Hazardous to the aquatic Category 2 - - Toxic to aquatic life It was classified into Category 2 from 96-hour EC50=6200microg/L of algae (Selenastrum) (AQUIRE, 2003).
environment (acute)
11 Hazardous to the aquatic Since rapidly degrading (BOD: 88% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=-0.38
(PHYSPROP Database, 2005)).
GHS Classification
ID590 Demeton-methyl
6 Flammable liquids Classification not - - - Classification not possible due to lack of data, though it is flammable (ICSC, 2001)
possible
8 Self-reactive substances and Classification not Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-
mixtures possible - - - reactive properties present.
9 Pyrophoric liquids Classification not - - - No data available
possible
in contact with water, emit Not classified - - - Since aqueous solubility measurements is performed, it judges to be stable in the water (ICSC (2001) etc.).
flammable gases
13 Oxidizing liquids Classification not - - - Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to
possible phosphorus.
Health Hazards
1 Acute toxicity (oral) O-object: It was set as Category 2 based on rat LD50= 30mg/kg obtained from the calculation using eight data (ACGIH
O-:Category 2; Skull and Danger Fatal if swallowed (2001), JMPR 264 (1973), JMPR 790 (1989)).
S-:Category 2 crossbones S-object: It was set as Category 2 based on rat LD50= 47g/kg obtained from the calculation using six data (ACGIH
(2001), PATTY (5th, 2001), JMPR 264 (1973)).
1 Acute toxicity (dermal) O-object: It was set as Category 2 based on LD50 = 100mg/kg calculated from four data (JMPR 264 (1973), JMPR 790
O-:Category 2; Skull and Fatal in contact with (1989)) of rat LD50 value.
S-:Category 1 crossbones Danger skin S-object: It was set as Category 1 based on LD50 = 45g/kg calculated from four data (PATTY (5th, 2001), JMPR 264
(1973)) of rat LD50 value.
1 Acute toxicity (inhalation: dust, The saturated vapor pressures concentrations pressure of this product is 0.396ppm (0.00373mg/L), and it is thought that
mist)
the inhalation study was done in mist.
O-:Category 2; Skull and It was set as Category 2 based on LC50 = 0.427mg/L calculated from three data (JMPR 790 (1989)) of O-body: rat LC50
S-:Category 2 crossbones Danger Fatal if inhaled value.
It was set as Category 2 based on LC50=0.21mg/L calculated from four data (PATTY (5th, 2001)) of S-body: rat LC50
value.
2 Skin corrosion / irritation O-body: Based on the description that although erythema was seen on rabbits, it recovered 72 hours afterward to
indicate mild skin irritation (JMPR 790 (1989)), it was classified as Category 3.
O-:Category 3; - Warning Causes mild skin S-body: Based on descriptions that although slight erythema and edema were observed on rabbits, it disappeared three
S-:Category 3 irritation days afterward (PATTY (5th, 2001) vol.7) and that it has mild irritation on humans (HSDB (2005)), it was classified as
Category 3.
3 Serious eye damage / eye O-body: In the rabbit, although corneal cloudings, conjunctival redness, and gum of eyelid were seen, it recovered 21 days
irritation
afterward altogether, and it is thought that it is a stimulant of primaries to eye (JMPR 790 (1989)). Based on above
O-:Category 2A-2B; Exclamation mark Warning Causes serious eye statement it was set as Category 2A-2B.
S-:Category 2B irritation S-body : although tearing and miosis were seen with the rabbit and the slight corneal cloudings, discontinuous redness,
and a conjunctiva dropsy were seen, and it disappeared seven days afterward (PATTY(5th, 2001) vol.7, JMPR 264 (1973)),
and it had mild irritation in humans (HSDB (2005)). So it was set as Category 2B.
(Respiratory Respiratory sensitization: No data
sensitization: sensitization)- (Respiratory (Respiratory Skin sensitization: O-object: Based on the statement (JMPR 790 (1989)) that it showed skin sensitivity by the
Classification not ; (Skin sensitization)-; sensitization)-; (Skin maximization test, the Klecak test, and the patch test with guinea pigs,.it was referred to as Category 1.
possible; Skin sensitization)Exclam (Skin sensitization)May S-object : Baded on the statement (PATTY(5th, 2001) vol.7, JMPR 790 (1989)) that although the maximization test
sensitization:O-: ation mark sensitization)W cause allergic skin indicated skin sensitization in guinea pigs, the skin patch tests did not show the sensitization, it was referred to as
Category1, S-: arning reaction Category 1.
Category1
Suspected of O-body : The substance was regarded as outside the categories. Because there are no positive results in human multi-
causing genetic generation epidemiological tests, multi-generation mutagenicity tests and in vivo mutagenicity tests using germ cells and
defects (state route somatic cells, and there are records of negative results from the in vivo dominant lethal tests in mice (PATTY (5th, 2001)
O-:Not classified; of exposure if it is vol. 7, JMPR 697 (1984)).
S-:Category 2 Health hazard Warning conclusively proven S-body: The substance was classified as Category 2. Because there are no positive test results from human multi-
that no other routes generation epidemiological tests, multi-generation mutagenicity tests and in vivo mutagenicity tests in germ cells, and
of exposure cause there is a record of a negative test result from the in vivo chromosome aberration test using Syrian hamster bone-
the hazard) marrow cells (PATTY (5th, 2001) vol. 7).
6 Carcinogenicity O-:Classification not

possibleS-:Classificatio - - - O-: Classification not possible due to lack of data
S-: Classification not possible due to lack of data
n not possible
O-object : since there is the description that there were the significant reduction of the gravidity and of the litter count
in rat, the reduction of oogenesis in third generation of 3/10 female, and there is the vacuolating of the epididymis
Suspected of epithelium of parent occurs in dose dependence at the dose no descriptioin about general toxicity to parent (JMPR
O-: Category 2, S-: Health hazard Warning damaging fertility or 790(1988)), and there is the description that there is the reduction of conception rate and survival rate of neonatal in the
Category 2 the undorn child dose causing reduced weight gain in parent (JMPR 264 (1973)), it is classified into the Category 2.
S-object : since there is the description that there is suppress of survival rate, nursing rate, weight gaining in rat, and
there is the reduction of the average of weight of embryo in rabbit, with the dose no description about general toxicity to
parent (PATTY(5th, 2001) vol.7, JMPR 697 (1984)), it is classified into the Category 2.

Mixture : In humans, spasm, giddiness, stuffiness, nausea, constricted pupil, muscular spasticity, salivation, sweating, loss
of consciousness, stomach cramps, diarrhea, vomiting etc. are observed, and the serum cholinesterase activity is
decreased (ACGIH (2001), PATTY(5th, 2001) vol.7, ICSC (J) (2001), HSDB (2005)). So it was classified into Category
Mixture: Cause 1(nerve systems).
Mixture: Category 1 damage to organs O-Body : In humans, miosis, muscle spasticity, salivation, sweating, nausea, dizziness, closeness, feeling of weariness,
(nervous system); O-: (nervous system); stomach cramp, vomiting, diarrhea, cramp, loss of consciousness, dysphoria, cough, and muscle fasciculation etc., are
Category 1 (nervous Health hazard Danger O-: Cause damage observed, and the serum cholinesterase activity is decreased (ACGIH (2001), PATTY (5th, 2001) vol. 7, ICSC (J) (2001),
to organs (nervous
system); S-: Category 1 system); S-: Cause HSDB (2005)). So it was classified into Category 1.
(nervous system) damage to organs S-Body : In humans, based on the description that miosis, muscle spasticity, salivation, sweating, nausea, vomited,
stomach cramps, diarrhea, dizziness, closeness, feeling of weariness, loss of consciousness, gastrointestinal disorder,
(nervous system)
fatigue, headach, sweating, lacrimation, tremor, ataxia, hiccup, muscular fasciculation, etc. are observed, and the serum
cholinesterase activity is decreased (PATTY (5th, 2001) vol. 7, ICSC (J) (2001)). So it was classified into Category 1
(nerve systems).
toxicity following repeated O-:Causes damage
exposure to organs (nervous O-object : It was classified to as Category 1 (nervous systems) since the toxic symptoms of cholinergics are looked, and
system) through inhibition of cholinesterase activity in brains, plasma and serum are indicated by the dosage of guidance value within the
prolonged or limits of Category 1in rats (JMPR 264 (1973), JMPR 790 (1989)), and cholinesterase inhibition is indicated in humans
O-:Category 1 (nervous repeated exposure; (JMPR 264 (1973)).
system); S-:Category 1 Health hazard Danger S-:Causes damage S-object : It was referred to as Category 1 (nervous systems) since the toxic symptoms of the cholinergics (mild tremor
(nervous system) to organs (nervous and bundle twich) are seen, and inhibition of cholinesterase activity in brains, plasma and serum is indicated in rats and
system) through dogs, by the dosage of guidance value within the limits of Category 1(PATTY(5th, 2001) vol.7, JMPR 264 (1973), JMPR
prolonged or 790 (1989)).
repeated exposure
10 Aspiration hazard O-: Classification not

possible; S-:
- - - No data available (o-, S-)
Classification not
possible
environment (acute) Category 1 Environment Warning aquatic life It was classified into Category 1 from 96-hour LC50=190microg/L of Crustacea (Amphipod) (AQUIRE, 2003).
GHS Classification
ID591 Parathion, methyl-
possible
7 Flammable solids Not classified - - - Not classified because of "Non-combustible" (ICSC (1997)
10 Pyrophoric solids Not classified - - - There are statements like "it burns but ignites easily." (NAEGR (J) (2001)) or like "Not flammable at normal
temperature" (HSDB (2005)), and even if it contacts air at room temperature, it does not ignite spontaneously.
11 Self-heating substances and Classification not Since the melting points are 37 - 38 degC (Merck (13th, 2001)), and 140 degC or less, the test for which it was suitable
mixtures possible - - - has not been established.
in contact with water, emit Classification not - - - No data available
flammable gases possible
14 Oxidizing solids Classification not - - - No data available
possible
Health Hazards
1 Acute toxicity (oral) Since the sexual differences which exceed the differences between examinations in rat LD50 value (EHC 145 (1993),
Skull and
Category 2 crossbones Danger Fatal if swallowed ATSDR (2001), JMPR 902 (1995)) of 15 examples which were made to classification target is not observed, It was set as
Category 2 based on 11.2 mg/kg obtained by statistical calculation to male and female.
1 Acute toxicity (dermal) The statistical work including male and female was done and 66.4mg/kg was obtained. (In the LD50 value using eight rats
Skull and Fatal in contact with (EHC 145 (1993), ATSDR (2001), JMPR 902 (1995)), the sexual differences which exceed the examinations difference
Category 2 crossbones Danger skin was not observed.) On the other hand, there was rabbit LD50 = 300mg/kg. It was set as Category 2 since lower
calculated rat value 66.4mg/kg was adopted.
possible
1 Acute toxicity (inhalation: dust, The sexual differences which exceeds the difference during an examination on 11 rat LC50 value (EHC 145 (1993),
mist) Category 2 Skull and Danger Fatal if inhaled ATSDR (2001), JMPR 902 (1995)) is not acknowledged. It was set as Category 2 based on 0.0611mg/L calculated by
crossbones statistical work including males and females.
2 Skin corrosion / irritation Causes mild skin In rabbit skin application test, descriptions "although very slight to moderate erythema was observed, all recovered within
Category 3 - Warning irritation 48 hours" and "mild irritation" are found. Therefore it was classified as Category 3.
3 Serious eye damage / eye Causes eye Based on the description (JMPR 902 (1995)) of "mild redness was acknowledged, but it recovered in 48 hours"for rabbit
irritation Category 2B - Warning
irritation eye drop, it was set as Category 2B.
sensitization: (Respiratory (Respiratory (Respiratory [Respiratory sensitization] It cannot be classified.
Classification not sensitization)-; (Skin sensitization)-; sensitization)- [Skin sensitization] Based on the fact that sensitizing was not observed in the guinea pig skin sensitization test of
possible; Skin sensitization)- (Skin ; (Skin Magnusson-Kligman(JMPR 902 (1995)) , and that sensitizing was not also found from the result of having examined the
sensitization: Not sensitization)- sensitization)- possibility of allergy in 200 humans (EHC 145 (1993)), it was put outside of the Category.
classified
Suspected of
causing genetic
defects (state route The substance was classified as Category 2. Based on the positive results from the in vivo micronucleus test in rats and
of exposure if it is mice and the in vivo chromosome aberration test in rats (both are in vivo mutagenicity tests in somatic cells) (ATSDR
Category 2 Health hazard Warning conclusively proven (2001), EHC 145(1993)). The results of the epidemiological studies indicating the abnormal increases of chromosome
that no other routes aberrations in exposed human peripheral blood lymphocytes (ATSDR (2001, EHC 145(1993)) also support this
of exposure cause classification.
the hazard)
6 Carcinogenicity Not classified - - - Since it is classified into 3 according to IARC (1987) and was classified into A4 according to ACGIH (1996), respectively,
it carried out the outside of Category.
In the three-generation reproduction study of rats, decreased number of litter size and reduction of litters viability were
observed (EHC 145 (1993)) and with exposures in pregnancy, lincreased embryo absorption and embryo loss in post-
Suspected of implantation are also observed (JMPR 902 (1995), JMPR 902 (1995), ATSDR (2001)).
Category 2 Health hazard Warning damaging fertility or Although there is also a report which is not mentioned about the general toxicity in the parental animals at such effective
the undorn child dosage, there are reports about the facts of inhibition of weight gain in mother animal, and development of cholinergic
symptom(JMPR 902 (1995), ATSDR (2001)).
Therefore, it was classified into Category 2.
8 Specific target organs/systemic Both humans and animals caused a significant reduction in cholinesterase activity by exposure to methyl parathion (EHC
Cause damage to 145 (1993), PATTY (5th, 2001), ATSDR (2001)), and showed the neural symptoms of cholinergic property as a result
Category 1 (nervous Health hazard Danger organs (nervous (PATTY (5th, 2001), ATSDR (2001)), and have resulted in death (ATSDR (2001)). With reference to the guidance value
system)
system) from the dose which marked a significant reduction in cholinesterase activities in the single exposure test to the rat, it
was set as Category 1 (nervous systems).
toxicity following repeated Inhibition of the cholinesterase activities is looked by exposure regardless of an animal species or an administration route
exposure Causes damage to (EHC 145 (1993), JMPR 902 (1995), ATSDR (2001)). When the influence is strong, within the dose which is equivalent to
Category 1 (nervous organs (nervous the guidance value Category 1, it has affected neurologic symptoms such as a tremor and hyperactivity (JMPR 902
Health hazard Danger system) through (1995), ATSDR (2001), EHC 145 (1993)), or peripheral neuropathy (sciatic nerve) is observed histopathologically (EHC 145
system) prolonged or (1993), JMPR 902 (1995)). Moreover, inhibition of the cholinesterase activities is mainly reported not a little in humans by
repeated exposure occupational exposure (EHC 145 (1993), ACGIH (2001)). It was classified to as Category 1 (nerve systems) based on the
above facts.

possible
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 48-hour LC50=0.14microg/Lof Crustacea (Daphnia magna) (EHC 145 and 1993) .
aquatic life
environment (chronic) Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though
Category 1 Environment Warning aquatic life with long supposed less bioaccumulative (log Kow=2.86(PHYSPROP Database, 2005)).
lasting effects
GHS Classification
ID592 paraquat-dimethylsulfate
7 Flammable solids Not classified - - - Non-combustible
mixtures
10 Pyrophoric solids Not classified - - - Non-combustible
11 Self-heating substances and Not classified - - - Not combustible.
mixtures
flammable gases
14 Oxidizing solids Not classified - - - It does not contains fluorine and chlorine. Although it contains oxygen as sulfate ester, this nonion is not considered as
an oxidizer.
possible - - - Test methods applicable to solid substances are not available.
Health Hazards
1 Acute toxicity (oral) Skull and Statistics calculation of the data (ACGIH (2001), EHC 39 (1984)) of four examinations was done, and 230.3mg/kg was
Category 3 crossbones Danger Toxic if swallowed obtained. It is set as Category 3.
1 Acute toxicity (dermal) Skull and Toxic in contact Statistics calculation of three data (ACGIH (2001), EHC 39 (1984)) was done, and 214.5mg/kg was obtained. It is set to
Category 3 crossbones Danger with skin Category 3.
1 Acute toxicity (inhalation: Classification not There is no acute inhalation test data for steam, and it cannot be classified. Vapor pressure is very low and a fatal dose
vapour) - - -
possible of steam will not be generated at normal temperature.
1 Acute toxicity (inhalation: dust, Category 1 Skull and Danger Fatal if inhaled It was set as Category 1 since all three data (ACGIH (2001), EHC 39 (1984)) were 0.05mg/L or less except the time when
mist) crossbones dust sizes is large.
2 Skin corrosion / irritation Causes skin Since there was information that it stimulated human skin (ACGIH (2001)) and animal skin (EHC 39 (1984)), it was
Category 2 Exclamation mark Warning
irritation classified as "Category 2." In repeated exposure, skin necrosis is also seen on rats and mice. (EHC 39(1984))
3 Serious eye damage / eye Causes eye The stimulus of the eye was reported with humans (ACGIH (2001)) and rabbits (EHC 39 (1984)). But the rabbit had
irritation Category 2B - Warning irritation recovered in 4 days, it was set to "Category 2B."
sensitization: (Respiratory (Respiratory (Respiratory About respiratory sensitization, there is no information and it cannot be classified. About skin sensitization: It was put
Classification not sensitization)-; (Skin sensitization)-; sensitization)- "outside of the Category" because there is a report that sensitization was not observed with guinea pigs (EHC 39
possible; Skin sensitization)- (Skin ; (Skin (1984)).
classified
5 Germ cell mutagenicity Not classified - - - The substance was regarded as "outside the categories". Because there are negative results from dominant lethal tests
in mice and in vivo bone-marrow tests (EHC 39 (1984)). No positive results have been found in in vitro tests either.
6 Carcinogenicity Since paraquat has been classified into C by EPA, it becomes the outside of Category. However, about methyl sulfates of
Classification not
possible - - - counterion, each evaluation agencies has categorized dimethyl sulfates analogue into carcinogenic. The evaluation about
Paraquat = 2 methyl hydrogen sulfate has not been performed.
7 Toxic to reproduction Since there is no bad effect in oral administration experiment in three generation of rat (EHC 39 (1984)), it is considered
Not classified - - - as "out of the Category."
8 Specific target organs/systemic Cause damage to Kidney, liver, and lungs were common with each recovery case of the human accident exposure (EHC 39 (1984)). Since
toxicity following single exposure Category 1 (kidneys, Health hazard Danger organs (kidneys, the respiratory disorders are mentioned in examples of accidents (ACGIH (2001)), lungs were unified with this and put to
liver, respiratory) liver, respiratory) "Category 1 (kidney, liver, respiratory system)."
toxicity following repeated organs (lung,
exposure It was classified to as Category 1 (lungs, kidney, liver), because of the harmful effects in lungs, kidney, and liver by serum
Category 1 (lung, Health hazard Danger kidneys, liver) chemistry (ChE, GPT) and by pathological examination (EHC 39 (1984)) in the repeated oral administration experiment for
kidneys, liver) through prolonged rats within the guidance value of Category 1.
or repeated
exposure
possible
possible
GHS Classification
ID593 Ethane, bromo-
6 Flammable liquids Category 2 Flame Danger Highly flammable Category 2 because of its flash point: <23degC and initial Boiling point: >35degC
liquid and vapour
mixtures
9 Pyrophoric liquids Not classified - - - There is data which says the ignition points is 511degC and it is thought that it does not ignite in room temperatures.
mixtures possible
flammable gases
16 Corrosive to metals Classification not There is no examination data of metal corrosiveness and it cannot be classified. There is information that it reacts as
possible - - - promptly as with aluminum powders (IARC 52 (1991)), and there is fear of metal corrosion.
Health Hazards
1 Acute toxicity (oral) Category 4 Exclamation mark Warning Harmful if swallowed Category 4 based on SPECIES: Rat; ENDPOINT: LD50;:1350mg/kg; REFERENCE SOURCE: CICADS 42 (2002)
1 Acute toxicity (dermal) There is no quantitive experimental data and it cannot be classified. In addition, there is a report that this substance
Classification not
possible - - - contact to the rabbit skin for 6 hours and toxic effects was not seen (CICADS 42 (2002)). But ACGIH attaches Notation
of Skin. so the bad influence by skin exposure in long-term/repetition is considered.
1 Acute toxicity (inhalation: There is rat inhalation data that is converted to 8273ppm for 4 hours. Other two data are close to 13500ppm, which is a
vapour) May be harmful if
Category 5 - Warning inhaled little more than 2.5 times the maximum of Category 4: 5000ppm (CICADS 42 (2002), IARC 52 (1991)), it was classified as
Category 5.
1 Acute toxicity (inhalation: dust, Classification not - - - Classification not possible due to lack of data
mist) possible
2 Skin corrosion / irritation Causes mild skin There is a test result of irritant and non-irritant on rabbits (CICADS 42 (2002)). And it was classified as Category 3
Category 3 - Warning irritation based on the statement of "skin irritant" on humans (Patty (5th.2001)).
3 Serious eye damage / eye Causes serious eye Although the quantitive experiment report was not obtained, it was set as "Category 2A-2B" by the statement of eye
irritation Category 2A-2B Exclamation mark Warning irritation irritant about humans (ICSC (2001), CICADS 42 (2002), ACGIH (2001), Patty (5th.2001)).
Classification not sensitization)-; (Skin sensitization)-; sensitization)- About respiratory and skin sensitization: It cannot be classified because examination data and epidemiology information
possible; Skin sensitization)- (Skin ; (Skin cannot be obtained.
Classification not
possible
5 Germ cell mutagenicity The only in vivo test results which have been found were from experiments with drosophila (CICADS 42 (2002)). In in
Classification not - - - vitro tests, there is one strong positive result from the Ames test (0.185 revertants/nmol (review of original text by Dr.
possible Sofuni)) but the chromosome aberration test is negative (IARC 52 (1991)). So it cannot be considered that there are
several positive results. It was decided that the substance could not be classified according to the experts comments.
6 Carcinogenicity
Suspected of
causing cancer
(state route of
exposure if it is A carcinogenic examination using rats and mice was performed by NTP (TR-363 (1989)), ACGIH is estimating it as A3
Category 2 Health hazard Warning conclusively proven based on this result. EU has classified into Car.Cat.3. It was set as "2" from these. Since IARC does not have several
that no other routes studies reports, it is concluded that it classified into 3.
of exposure cause
the hazard)
7 Toxic to reproduction Since, testicular atrophy in the male rat is reported (NTP-TR-363 (1989)) and this is considered to be the influence on
Suspected of the reproduction potential of male (CICADS 42 (2002)), it was classified into "Category 2".
Category 2 Health hazard Warning damaging fertility or There is an epidemiologic report of adverse effect to the female workers in pregnancy (ACGIH (2001)).
the undorn child However, since it was a mixed exposure with other solvents, it removed from the evidence of evaluation

organs (nervous
system, respiratory);
Category 1 (nervous May cause The influence from anesthetic on the peripheral and central nerves is reported in a human case (ACGIH (2001)).
system, respiratory); Moreover, since the respiratory-organs stimulus and the lung stimulus were also described (Patty (5th.2001)). So it was
Category 3 (narcotic Health hazard Danger respiratory irritation set as "Category 1 (nerve system, the respiratory system) and Category 3 (anesthetic)".
effects) or may cause Anesthesia is identified in the animal inhalation experiments, too.
drowsiness and
dizziness (narcotic
effects)

toxicity following repeated to organs (central Since HSDB (2005) has the description which suggests a chronic effects on the central nervous systems in humans, and
exposure Category 2 (central nervous system) an ACGIH-TVL advice value has the statement of "CNS impair", it was classified to as Category 2 (central nervous
nervous system) Health hazard Warning through prolonged systems). Although "hepatic dysfunction" was mentioned in the TLV advice value, it was withheld to use for classification
or repeated since the inhalation exposure test for rats, which is used as an evidence, was carried out overdose the guidance value of
exposure 2, 583 ppm * 4 hours /a day.
possible
possible
environment (chronic) possible - - - No data available.
GHS Classification
ID594 Hydrobromic acid
2 Flammable gases Not classified - - - Non-combustible (Hommel, 1991; ICSC(J), 2001)
4 Oxidizing gases Not classified - - - UNRTDG Class: 2.3
Liquefied gas Gas cylinder Warning pressure; may Liquefied gas because of the critical temp: >65degC and the steam pressure: >3 atm at 20degC.
explode if heated
mixtures
mixtures
flammable gases
possible - - - Test methods are not available.
Health Hazards
possible
1 Acute toxicity (inhalation: gas) Skull and Danger
Category 3 crossbones Toxic if inhaled It was considered as Category 3 based on rat inhalation LC50 = 1430ppm (4hr) (ACGIH (2004)).
vapour)
mist)
2 Skin corrosion / irritation Causes severe skin It was classified as Category 1A-1C based on the report of necrosis on human skin (DFGOT vol.13 (1999)) and a
Category 1A-1C Corrosion Danger burns and eye statement about corrosivity (ICSC (J) (2001)).
damage
3 Serious eye damage / eye Causes serious eye It was set as Category 1 based on the report (DFGOT vol.13 (1999)) of the serious eye membrane stimulus by humans
damage (DFGOT vol.13 (1999)), and a statement called corrosiveness (ICSC (J), (2001)).
Classification not
possible
possible
8 Specific target organs/systemic By the inhalation test of the rat within the guidance value of Category 1, necrosis of turbinates and fibrinonecrotic
Category 1 (respiratory Cause damage to tracheitis are reported (ACGIH (2004)). Since serious stimuli of the nose and upper airway, bronchopneumonia and acute
organs) Health hazard Danger organs (respiratory pulmonary edemas, etc. were also reported in humans (DFGOT vol.13 (1999)). So it was set as Category 1(respiratory
organs) tracts).
toxicity following repeated organs (respiratory It was classified to as Category 1 (the respiratory system, tooth) based on the report of tooth decalcification, change of
exposure Category 1 (respiratory organs, tooth)
organs, tooth) Health hazard Danger through prolonged gums (DFGOT vol.13 (1999)), and a cough, breathlessness, and a progressive obliterative bronchuolitis (PATTY (5th,
or repeated 2001)) in humans.
exposure
possible
possible
GHS Classification
ID595 Oxalic acid
1 Explosives There are no chemical groups associated with explosive properties present in the molecules. (A violent reaction of the
Not applicable - - - substance with strong oxidizing agents causes a danger of an explosion or a fire. A reaction of the substance with a
certain kind of silver compounds produces explosive Silver Oxalate. (ICSC(J), 996))
7 Flammable solids Classification not
possible - - - Classification not possible due to lack of data, though "Flammble" (ICSC(J), 1996)
mixtures - - - No data available
possible
10 Pyrophoric solids Classification not - - - No data available
possible
flammable gases
14 Oxidizing solids Not applicable - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon
and hydrogen (but not to other elements).
16 Corrosive to metals Classification not Since it is a solid with the melting points of 189.5 degC (HSDB (2005)), test methods suitable for this substance have not
possible - - - been established.
Health Hazards
1 Acute toxicity (oral) Although three rat LD50 values are reported (475mg/kg, 375 mg/kg, 7.5 g/kg: PATTY (5th, 2001)), two higher toxicicity
Category 4 Exclamation mark Warning Harmful if swallowed
values were adopted and they were set as Category 4.
1 Acute toxicity (dermal) Based on the report that 20000 mg/kg of the rabbit was considered as not lethal (PATTY (5th, 2001)), it was set as the
Not classified - - - outside of Category.
vapour) possible
2 Skin corrosion / irritation Causes severe skin It was classified as Category 1 based on the statements that burn was produced on a local skin regions with airborne
Category 1 Corrosion Danger burns and eye dust on humans (ACGIH (2001)) that corrosivity is indicated to the skin (ICSC (J), (1996)).
damage
3 Serious eye damage / eye The eye was also set to Category 1 based on skin corrosiveness Category 1. This is supported by a statement (ACGIH
irritation Category 1 Corrosion Danger Causes serious eye (2001)) that a quite critical burn is produced in an ophthalmic in humans, and statement (ICSC (J), (1996)) that caustic is
damage indicated to an ophthalmic.
sensitization:
possible
5 Germ cell mutagenicity Classification not - - - It was decided that the substance could not be classified because there are no data from in vivo tests, and there are no
possible positive results from in vitro mutagenicity tests either (PATTY (2001), NTP DB (2006)).
7 Toxic to reproduction Suspected of Since under the conditions the effect on parent animals is unknown, the reduction of the number of littermates was
Category 2 Health hazard Warning damaging fertility or
the undorn child reported (PATTY (5th, 2001)), it is classified into the Category 2.

toxicity following single exposure Category 2 (respiratory Health hazard Warning to organs Since respiratory tract corrosive and pulmonary oedemas by inhalation were pointed out in humans (ICSC (J) (1996)), it
organs) (respiratory organs) was set as Category 2 (respiratory systems).

toxicity following repeated organs (kidneys)
exposure Category 1 (kidneys) Health hazard Danger through prolonged Since the increase of urinary stones in humans was reported (ACGIH (2001), PATTY (5th, 2001)), it was classified to as
or repeated Category 1 (kidney).
exposure
11 Hazardous to the aquatic Harmful to aquatic It was classified into Category 3 from 48-hour EC50=15mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of
environment (acute) Category 3 - - life chemicals, 1998).
11 Hazardous to the aquatic Since rapidly degrading (the decomposition of TOC: 100% (Existing Chemicals Safety Check Data)), and supposed less
bio-accumulative (log Kow=-2.22 (PHYSPROP Database, 2005)).
GHS Classification
ID596 Bromine
6 Flammable liquids Not classified - - - Not combustible.
mixtures
9 Pyrophoric liquids Not classified - - - Not combustible
11 Self-heating substances and Not classified - - - Not combustible.
mixtures
flammable gases
13 Oxidizing liquids Although oxygen, fluoride, and chlorine are not included, they are indicated to Enhances combustion of other substances
on the ICSC cards. It is an oxidizing liquid. However, in UNRTDG, subsidiary risks nature 5.1 is not attached to the UN
Classification not - - - number 1744. Although it was thought that oxidizing powers did not exceed 65% nitrate which is a minimum standard
possible substance of PG III, there was no released data. So it presupposed "It cannot classify." Although a possibility of be in
outer category is large, references to risk of combustion aids should be attached to MSDS.
16 Corrosive to metals Corrosion Warning May be corrosive to It is not necessary to do the examination defined in the United Nations, and is judged as "Category 1". Because reacting
Category 1
metals violently with aluminum is known (Bretherick (J) (1998)).
Health Hazards
1 Acute toxicity (oral) Skull and There are the value of 1700 mg/kg (RTECS (2004)) and 2600 mg/kg (IUCLID (2000)) in oral LD50 of rats. The lower one
crossbones was adopted and it was set as Category 3.
possible - - - There is no transdermal absorptions lethal toxicity data, and it cannot be classified.
1 Acute toxicity (inhalation: Category 1 Skull and Danger Fatal if inhaled There was no suitable data for rats. So two mice data (ACGIH (2001)) were converted for 4 hours, and LC50: 120ppm and
vapour) crossbones 61.5ppm were obtained. And it was classified as Category 1 based on he lower one. T+; R26 is used in the EU risk phrase.
mist) possible - - - Classification not possible due to lack of data
2 Skin corrosion / irritation The experimental result on rats is a stimulation (IUCLID (2000)). But there is a statement of skin corrosion on humans
(Patty (5th.2001), HSDB (2005), HSFS (1998)), and the risks phrases of R35 was applied in EU. So it was classified as
Category 1 - - -
Category 1. There is no test data with sub-category A-C. But it is designated to be class 8 PG Division I by UNRTDG.
So it is considered to be Category 1A.
3 Serious eye damage / eye The animal experiment in ACGIH (2001) is exposure to a vapor, and is not what medicated the eye with the liquid. It is
irritation Category 1 Corrosion Danger Causes serious eye indicated as the eye stimulus in another part. HSFS (1998) also has severe eye description of stimulus. Since Category of
damage a skin stimulus is 1, an eye is also set to "Category 1" by provision of GHS.
sensitization:
possible
5 Germ cell mutagenicity Classification not - - - The substance cannot be classified because there are no test reports about the mutagenicity.
possible
6 Carcinogenicity Since there was no test reports and there was also no evaluation result, and it presupposed "It cannot classify." Mr.
Classification not - - - Shirasu's experimental result recorded and selected by IUCLID (2000) is an evaluation of a fumatory agent and a methyl
possible
bromide, and is not a thing about an elements d bromine.
possible - - - Classification not possible due to lack of data on toxic to rproduction and epidemiology.
8 Specific target organs/systemic By the animal experiments with an exposure amount (300ppm) which is less than the guidance value (2500ppm) of
Cause damage to Category 1, dysfunction of the central nerve system, damages to lungs and bronchus, and bleeding in gastrointestinal
Category 1 (respiratory, organs (respiratory, mucosa are observed (ACGIH (2001)). Symptoms in connection with the respiratory organ-system and central nerve
central nervous Health hazard Danger central nervous system are also indicated by humans (Patty (5th.2001)). So it was set as "Category 1(a central nervous system,
system) system) respiratory-organ system)". The respiratory tract irritation was included in the respiratory systems. The effect on the
digestive system is not adopted as organ toxicity because it is caused by the corrosiveness of this substance.
toxicity following repeated Causes damage to
exposure organs (respiratory
Category 1 (respiratory organs, nervous Since it is reported of the effects on the respiratory, nervous and endcrine systems in the animal experiments of
organs, nervous system, Health hazard Danger system, endocrine exposures which is below the guidance value (10mg of oral/kg/d, 50 ppm of inhalation (steam) / 6 h/d) of Category
endocrine system) system) through 1(ACGIH (2001), Patty (5th.2001)) , it was classified to as Category 1 regarding these as target organs.
prolonged or
repeated exposure
10 Aspiration hazard Classification not There is the statements of chemical pneumonia by steam inhalation (IUCLID (2000)), but there was no report of the
- - -
possible influence by aspiration and we could not classify it.
environment (acute) Category 1 Environment Warning It was classified into Category 1 from 48-hour LC50=1000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
aquatic life
lasting effects
GHS Classification
ID597 Nitric acid
1 Explosives Not classified - - - Not an explosive product, though containing chemical groups associated with explosive properties present.
8 Self-reactive substances and Although it excludes the grouping relevant to autoreactive in a molecule and includes atomic team which relates to
mixtures Not applicable - - - explosibility, it is classified into the oxidizing liquid. So it is excepted from the definition of autoreactive from the
statement of the GHS documents 2.8.1.
9 Pyrophoric liquids Not classified - - - Non-combustible (Hommel, 1991)
mixtures
flammable gases
13 Oxidizing liquids May intensify fire;
Category 3 Flame over circle Warning Category 3 because of UNRTDG Subsidiary risks Class: 5.1, PG III, though it is a strong oxidizing agent (NFPA, 13th, 2002)
oxidizer
16 Corrosive to metals There is no data and it cannot be classified. (a stainless steel, aluminum, and glass are durable as a container. Steels,
Classification not Monel metal, nickels and coppers are corroded. There is a description as (Hommmel (1991)) and it is presumed as
possible - - -
Category 1.)
Health Hazards
1 Acute toxicity (oral) Classification not Although there is a lethal (IUCLID (2000)) statement of 430 mg/kg in humans, there is no other data and it cannot be
possible - - - classified.
possible
1 Acute toxicity (inhalation: dust, Category 2 Skull and Danger Fatal if inhaled Nitric acid did not exist as steam and gas, and it considered that all the data of LC50 was mist. Since all of five data were
mist) crossbones within the range of 0.05 - 0.5mg/L, it was set as Category 2.
Category 1A Corrosion Danger burns and eye There is a description of corrosivity on humans (ICSC (1994)) and (HSDB (2005)), and its UN classification is class 8I, it
damage was classified as Category 1A.

irritation Causes serious eye There is a statement that if exposed to the human eye, severe burns will take place, and muddiness of a cornea and
Category 1 Corrosion Danger damage visual impairment result in vision loss (ACGIH (2001)). And it was set as Category 1 since skin corrosivity / irritation was
categoried into Category 1A.
sensitization:
(Respiratory (Respiratory (Respiratory
Classification not
possible
5 Germ cell mutagenicity Classification not Although there is a report of negative results from the in vitro Ames test (DFGOTvol.3 (1991)), the substance cannot be
possible - - - classified because there are no reports about in vivo tests.
There is a result in the inhalation exposure test report of two cases using rats that shows no carcinogenicity
6 Carcinogenicity Classification not - - - (DFGOTvol.3 (1991), (IUCLID (2000)). But there is no report of evaluation organizations, such as IARC, therefore it
possible cannot be classified.
7 Toxic to reproduction Although there is the description that teratogenicity and ferotoxity does not occur and there is only a slight ossification
Classification not - - - inhibition of cranial bone in embryo in the drinking water administration test to pregnancy rat (IUCLID (2000)), but it is
possible
considered as insufficient data for classification, and it is considered as it cannot be classified.
8 Specific target organs/systemic According to the statements that when humans inhale the steam generated from nitrate, irritation of the upper airway,
Cause damage to coughing, breathing difficulty, pain of the breast or pulmonary are caused depending on the exposure concentration and
Category 1 (respiratory) Health hazard Danger organs (respiratory) exposure time (ACGIH (2001), DFGOTvol.3 (1991), ICSC(J), (1994), and HSDB (2005)). So it was classified into Category
1. (respiratory systems).
toxicity following repeated organs (tooth,
exposure According to the statement of the chronic bronchitis by occupation exposure of the steam generated from mist or nitric
Category 1 (tooth, Health hazard Danger respiratory organs) acid (ACGIH (2001)) and erosion of tooth (ACGIH (2001), (DFGOTvol.3 (1994)), it was classified to as Category 1 (tooth,
respiratory organs) through prolonged respiratory system).
or repeated
exposure
10 Aspiration hazard May be fatal if
Category 1 Health hazard Danger swallowed and It was classified into Category 1 based on the statement that of chemical lobar pneumonia by aspiration (ACGIH (2001)).
enters airways
possible
GHS Classification
ID598 Potassium hydroxide
7 Flammable solids Not classified - - - Non-combustible substance (Hommel, 1991)
mixtures
10 Pyrophoric solids Not classified - - - Non-combustible (Hommel (1997)
mixtures
in contact with water, emit Not classified - - - Although generation of heat will be carried out if it dissolves in water, combustible gases does not occur.
flammable gases
14 Oxidizing solids Classification not - - - Classification not possible, though containing oxygen (but not halogen).
possible
Health Hazards
Skull and
crossbones
Danger Toxic if swallowed Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 284mg/kg; REFERENCE SOURCE: Priority 1
possible
vapour) possible
Category 1B Corrosion Danger burns and eye Since there are descriptions that it was corrosive in rabbit test (SIDS (2001)) and that it has corrosivity on humans
damage (SIDS (2001)), and its UN classification is class 8II. Therefore it was classified as Category 1B.
3 Serious eye damage / eye Causes serious eye Since there are statements of irreversible damage with humans (SIDS (2001)), and of corrosive in rabbit test (SIDS
irritation Category 1 Corrosion Danger damage (2001)), and since skin caustic / stimulative GHS classifications are in Category 1B, it was categoried into Category 1.
sensitization: (Respiratory (Respiratory (Respiratory [Sensitaization of respiratory organs]:It cannot be classified.
Classification not sensitization)-; (Skin sensitization)-; sensitization)- Skin sensitization : There is a negative statement (SIDS (2001)) by guinea pigs test and, since the intravital existence of
possible; Skin sensitization)- (Skin ; (Skin both potassium ions and hydroxide ion deny the cause of skin sensitization(SIDS(2001))., it was put outside of the
sensitization: Not sensitization)- sensitization)- division, although there is no report on humans.
classified
5 Germ cell mutagenicity With regard to in vitro tests of potassium hydroxide, there are negative data from the Ames test (SIDS (2001)), but there
are no in vivo test data. But sodium hydroxide is negative in in vivo mutagenicity tests in somatic cells (micronucleus
Not classified - - - tests) and it is also negative in in vivo mutagenicity tests in germ cells (detection of aneuploidy in oocytes), though under
restricted conditions (SIDS (2001)). So by analogy we presumed that data from potassium hydroxide could be the same
and we judge that it will be appropriate to regard potassium hydroxide as outside the categories
6 Carcinogenicity Classification not - - - There is no reliable data and there is also no report of evaluation organizations, such as International Agency for Res. on
possible Cancer. So it cannot classify.
possible - - - Classification not possible due to lack of data on potassium hydroxide.
8 Specific target organs/systemic It was classified into Category 1(respiratory systems) according to the statement that inhalation exposure to the
toxicity following single exposure Category 1 (respiratory) Health hazard Danger Cause damage to particles or the mist will cause such damages as burns to the nose and bronchial tube and result even in lung edemas
organs (respiratory) (SIDS (2001), ACGIH (2001) and PATTY (5th, 2001)).
9 Specific target organs/systemic Classification not The example for repeated dose in toxicity research of potassium hydroxide is not found. It cannot be classified without a
exposure possible report on humans.
10 Aspiration hazard May be fatal if
Category 1 Health hazard Danger swallowed and It was classified into Category 1 based on the statement of die of pneumonia by aspiration (ACGIH (2001)).
enters airways
possible
GHS Classification
ID599 Sodium hydroxide
CAS 1310-73-2 Date Classified: Mar. 15, 2007 (Environmental Hazards: Mar. 31, 2006)
7 Flammable solids Not classified - - - Non-combustible (ICSC, 2000;Hommel, 1991; Weiss, 2nd, 1985)
mixtures
10 Pyrophoric solids Not classified - - - Non-combustible (ICSC, 2000; Hommel, 1991; Weiss, 2nd, 1985)
11 Self-heating substances and Not classified - - - Not combustible (ICSC (2000))
mixtures
12 Substances and mixtures, which Water solubility, underwater pH measured value, etc. are performed, and it is stable to water (ICSC (2000), Merck (13th,
flammable gases 2001), etc.).
14 Oxidizing solids Not classified - - - Not classified because of UNRTDG Class: 8 though inorganic compounds containing oxygen.
16 Corrosive to metals Classification not - - - Test methods applicable to solid substances are not available. UNRTDGClass: 8. Corrosive to Aluminum.(ICSC, 2000)
possible
Health Hazards
1 Acute toxicity (oral) Classification not It cannot classify according to the guideline, since there is only data of rabbit LD50 value of 325mg/kg but no data of
- - -
possible rodent(SIDS, 2002).
possible
vapour) possible
Causes severe skin Based on the descriptions that at 0.5% or more of concentration, it is irritating to human skin (SIDS, 2002), and causes
Category 1A-1C Corrosion Danger burns and eye severe corrosion (DFGOT vol.12, 1999) and that at 8% or more of concentration, it caused corrosion on pig skin (SIDS,
damage 2002) and severe necrosis on rabbit skin with 5% and 4 hour application (ACGIH, 7th, 2001-ATTY, 5th, 2001), it was
classified as Category 1A-1C. In addition, sub-categorizing is difficult.
3 Serious eye damage / eye It was set as Category 1 from description (ACGIH, 7th, 2001;DFGOT vol.12, 1999-ATTY, 5th, 2001) that severe and
irritation Category 1 Corrosion Danger Causes serious eye serious hazard were caused to human's eye, and from description (SIDS, 2002) that corrosive was caused at 1.2% or more
damage to a rabbit eye.
sensitization: (Respiratory (Respiratory (Respiratory Respiratory sensitization: No data
possible; Skin Skin sensitization: It was put outside of the Category based on the description (SIDS, 2002;IUCLID) of no skin
sensitization)- (Skin ; (Skin sensitisation by the sensitivity test on the human skin.
classified
5 Germ cell mutagenicity The substance was regarded as outside the categories. Based on the negative results from the in vivo micronucleus test
Not classified - - - in mouse bone-marrow (SIDS, 2002) and the Ames tests, which are in vitro mutagenicity tests) (SIDS, 2002; DFGOT
vol.12, 1999).
6 Carcinogenicity Classification not There was a report that carcinogenic is not acknowledged in the administration in drinking drink in water for 12 weeks
possible - - - once per week (DFGOT vol.12, 1999). But it presupposed that data is insufficient and it cannot taxonomic.
7 Toxic to reproduction Classification not - - - Since there is the description that there is no useful data in Reproductive and developmental toxicity (SIDS,
possible 2002;DFGOT vol.12, 1999), it is considered as not to be classified because of insufficient data.
8 Specific target organs/systemic Cause damage to It was set as Category 1(respiratory systems) based on the descriptions that the human respirator and airway are
toxicity following single exposure Category 1 (respiratory) Health hazard Danger organs (respiratory) stimulated and lung edemas is caused (SIDS, 2002; ACGIH, 7th, 2001; DFGOT vol.12, 1999; ATTY, 5th, 2001).
9 Specific target organs/systemic Classification not Although there was description (ACGIH, 7th, 2001;DFGOT vol.12, 1999-ATTY, 5th, 2001) that it injures lungs in the
exposure possible repeated inhalation exposure of rats, it was presupposed not to be classified because of data deficiency.
possible
11 Hazardous to the aquatic Harmful to aquatic It was classified into Category 3 from 48-hour LC50=40.4mg/L of Crustacea (Ceriodaphnia) (SIDS, 2004).
environment (acute) Category 3 - -
life
11 Hazardous to the aquatic Toxicity factor is considered to be strong base as aqueous solution, but toxic effect is eased by the buffer action in the
environmental water.
GHS Classification
ID600 Lead distearate
7 Flammable solids Not classified - - - Non-combustible (Weiss (2nd, 1985))
mixtures
10 Pyrophoric solids Not classified - - - Non-combustible (Weiss, 2nd, 1985)
11 Self-heating substances and Not classified - - - Non-combustible (Weiss, 2nd, 1985)
mixtures
in contact with water, emit Not classified - - - Since aqueous solubility is measured, it is stable in the water. (Merck (13th, 2001), SRC (2006))
flammable gases
14 Oxidizing solids Not applicable - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon
(but not to other elements).
Health Hazards
1 Acute toxicity (oral) Classification not Although there are two data (IUCLID (2000)) of rat LD50> 15000mg/kg and LD50> 2000mg/kg, it cannot classify with
possible - - - only these data.
possible
mist) possible
2 Skin corrosion / irritation Classification not
possible
3 Serious eye damage / eye Classification not
irritation - - - No data available
possible
possible; Skin No data available
possible
possible
6 Carcinogenicity
May cause cancer
(state route of
exposure if it is It was classified into R by NTP(NTP (2005)), into Group 2A by IARC (IARC 87 (2004)), into A3 by ACGIH(ACGIH-TLV
Category 1B Health hazard Danger conclusively proven (2004)), and into 2B by Japan Society for Occupational Health(JETOC specially data No.190 (2004)). So it was set as
that no other routes Category 1B.
of exposure cause
the hazard)
7 Toxic to reproduction There is no reproductive toxicity data as lead stearates. However, since lead is known as the development neural
May damage fertility toxicity material and reproductive toxicity in human (ACGIH-TLV (2004), ATSDR (draft 2005)), it is classified into the
Category 1A Health hazard Danger or the undorn child Category 1A.
Refer to [ID 168, a lead, CAS NO:439-92-1], [ID 48, oxidization lead (II), CAS NO:1317-36-8], and [lead acetates (II), CAS
NO:301-04-2] about health toxicity.
8 Specific target organs/systemic There is no information about a single exposure to lead stearate. However, as toxicity of the inorganic lead compounds,
toxicity following single exposure besides the inhibition of hemoglobin synthesis induced to humans by delta-aminolevulinic acid and heme synthase
Cause damage to inhibition, anemia caused by the shortening of red cell life span, interstitial disorders, the reduction of urinary output, the
Category 1 (blood
system, kidneys, Health hazard Danger organs (blood proximal tubule damages which cause the Fanconi syndromes represented by alubuminuria, bloody urine, urine pillars,
nervous system) system, kidneys, glucosuria and amino acid urine, etc. are observed. As they act on the peripheral nerves, especially weakness of the line
nervous system) of the limbs, pain, and convulsion are identified, and as their influences on the central nerve systems such as ataxie,
headach, abnormal sebsation, depression, and coma are identified with high concentration exposures. These influences
are acute ones
Causes damage to There is no repetitive exposure information about lead stearate. However, the hemoglobin composition prevention which
exposure
organs (blood originated in delta-aminolevulinic acid and heme synthetases inhibition, the anemia by shortening of red cell life span, an
Category 1 (blood system, kidneys, interstitial disorders, oliguria, and the proximal tubule damages which assumes the Fanconi syndromes represented by
system, kidneys, Health hazard Danger nervous system) albuminuria, bloody urine, a urinary cast, diabetes, amino acid urine to human as toxicity of the inorganic lead compounds
nervous system) through prolonged are seen. It acts on the peripheral nerves, especially the weakness, pain, and convulsion of the muscles of extremities are
acknowledged, and in high concentration exposures the effects on the central nervous systems such as ataxie, headache,
or repeated dysesthesia, depression, and a coma, etc. are acknowledged. It was classified to as Category 1 (blood systems, kidney,
exposure nervous system), based on these effects which are seen equally in acute effect or chronic effect (ACGIH-TLV (2004)).

possible
possible
possible

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ID Name CAS No.

ID501 2-(Dimethylamino)ethyl methacrylate 2867-47-2

ID524 alpha-cyano-3-phenoxybenzyl 2,2-dichloro- 63935-38-6

ID529 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol- 79983-71-4

1 Acute toxicity (inhalation: dust, Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: No data available

6 Carcinogenicity Classification not possible No data available

10 Pyrophoric solids Not applicable Classified as "liquid" according to GHS definition

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

6 Carcinogenicity Classification not possible No data available

2 Flammable gases Not applicable Classified as "solid" according to GHS definition

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

15 Organic peroxides Not applicable Organic compounds containing no "-O-O-" structure

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

8 Specific target organs/systemic Classification not possible Insufficient data available

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

10 Aspiration hazard Classification not possible No data available

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

15 Organic peroxides Not applicable Organic compounds containing no "-O-O-" structure

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

9 Specific target organs/systemic Insufficient data available

10 Pyrophoric solids Not applicable Classified as "liquid" according to GHS definition

1 Acute toxicity (inhalation: dust, Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

7 Toxic to reproduction Classification not possible No data available

10 Aspiration hazard Classification not possible No data available

15 Organic peroxides Not applicable Organic compounds containing no "-O-O-" structure

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

5 Germ cell mutagenicity Classification not possible No data available

12 Substances and mixtures, which

15 Organic peroxides Not applicable Organic compounds containing no "-O-O-" structure

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

8 Specific target organs/systemic Insufficient data available

9 Specific target organs/systemic Insufficient data available

8 Self-reactive substances and

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

7 Toxic to reproduction Classification not possible No data available

10 Aspiration hazard Classification not possible No data available

10 Pyrophoric solids Not applicable Classified as "liquid" according to GHS definition

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

10 Aspiration hazard Classification not possible No data available

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

6 Carcinogenicity Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

5 Germ cell mutagenicity Classification not possible No data available

1 Acute toxicity (inhalation: Classification not possible No data available

10 Aspiration hazard Classification not possible No data available

1 Acute toxicity (inhalation: Classification not possible No data available

4 Respiratory/skin sensitizer Respiratory sensitizer: Respiratory sensitizer: No data available

5 Germ cell mutagenicity Classification not possible No data available

6 Carcinogenicity Classification not possible No data available