FR14 Appli Empower ABA PDF

Le Jeudi 02 février 2017 – Maison de l’Amérique Latine – Paris 7ème
Présenté par Alain Barreau
THINGS YOU FORGOT

OR DIDN'T KNOW
ABOUT EMPOWER
©2016 Waters Corporation 1
Things you forgot or
didn’t know about Empower
 Empower 3 is powerful with many features available

 In this presentation we show >20 topics that
You might have forgotten,
you might not know,
… or are completely new.
 We will try to show all the slides, but

only have 1 hour… so we’ll see how far
we get!
 All the options are available in
Empower 3 FR3, our most recent
release.

Topics listed
 View Filters [4]  Add Peaks and Integration events

 View As Functionality [13] during Review [74]
 Result Audit Viewer [16]  ID’s in project view [78]
 Global Project view [25]  Copy and Paste [81]
 Custom Field to check Manual  Export to JCAMP [86]
Integration [32]  Compare Calibration Curves [88]
 JP, EP, USP – Signal to Noise [38]  Empower Analytics [90]
 Shifting peaks (relative) [43]  Current User/System licence
 Who is using what System now status [94]
(Mobile) [55]  Walk-Up Interface [96]
 Protect Systems and Nodes from  Mass Analysis Window [102]
being deleted [65]  Location Field [107]
 Protect Parent Projects from being  MS Peak Tracking [109]
acquired in [69]  ICH Impurity [114]
 Copy Settings to Sub-Projects [72]  Instrument Control [119]

View Filters

View Filter – Just in Time
 Any table in Empower can apply a filter – Just in Time

 Code for Just in Time is: =#
 Example:
 Fill information:
 Now the projects with ‘Default’ in the name are shown

View Filter – Just in Time
 A maximum of three =# options is possible
 Fill the Just in Time filter
 This gives an overview of the requested projects

View Filter – FAT Settings of Projects
 Click Edit View on the Project View, and add the following
8 columns to the view.
 Save the View Filter and Apply

 Now for each of the projects the FAT settings are shown

View Filter – See latest Result Set
 To only see the latest Result Set(s) belonging to corresponding

Sample Set(s), edit the view filter
 In the column ‘Result Set ID’ create a Group By Condition
 Enter the following Information
 The information is filled, then save and apply the filter
 Latest Result Set(s) of the Sample Set(s) are shown

View Filter – Last User Login
 To see the last user login… after a certain date.

 Go to System Audit Trail (1221 records)
 Click Edit View to start creating the Filter

 Use the View Filter Wizard

 Wizard is started
 Select the Displayed Columns:

 Click Next > until Save View Filter now:
 Enter Name and Click Finish

 Select in the 1st row ‘Sequence’ and start the Group By function
 Fill the Group By Condition, Click OK
 Now fill the rest of the filter, save the filter

 Upon applying the filter, the change date needs to be entered
 Any successful login after this date is displayed (8 records only)

View As Functionality

View As functionality
 To see the relation between all data in an Empower project, the

view as functionality is powerful
 It works from all tables… including view as Audit Records

View As functionality
 There is an extra option available

 When you want to go back to the previous view simply select
– View as previous
– View as next
 That way you can easily navigate back and forth

Result Audit Viewer

Result Audit Viewer
 To review data, the Result Audit Viewer can be used

 Open a Result Set into review
 Browse to the icons on the top right
Alter Sample Print
Preview Run Sample Result Audit

Viewer
 Click Result Audit Viewer icon and the viewer is started

 All information from the Result Set can be viewed using one
page…

Result History

Result Differences

Results can then be compared
 Result ID 1453 and 1463 can be taken into review

 Using overlay the slight difference in the integration can be
shown

Result Processing Method

Result Sample Set Method

Result Instrument Method

Result Method Set

Global Project View

Global Project View
 In the project view, select 2 (or more) projects
 Right Mouse Click, Open

 The projects are opened in a Global Project View

Global Project View
 Simply activate or deactivate additional projects by clicking the

‘available projects’ button
 The following view is shown
 Select an additional project and Click Activate

 Project is added to the Global Project view
Global Project View - Search
 The view filters also work across multiple projects
 In this example a filter for Sample Name ‘Sample 6’ is applied
 Two different projects and the same Sample Name is shown

 With the same sample name selected in the Injection, simply
select View As – Results
– Results of the corresponding Injections in two projects are displayed

Global Project View - Compare
 With the same sample name selected in the previous slide we

can simply overlay those results
 Select the two results, right mouse click ‘Compare’
 Two results will be shown

– Apply the following settings to display
– Properties, Overlay, Overlay in Single Plot
– Properties, Overlay, All Chroms in Overlay

Global Project View - Compare
 Both Results (including the integration) are shown in the

overlay plot

Global Project View – Audit Trail
 Within the Global Project View it is also possible to see both the
Project and the System Audit Trail
 In the Global Projects tree, select Audit Trails

Global Project View – Audit Trail
 Within the Global Project View it is also possible to see both the
Project and the System Audit Trail
 In the Global Projects tree, select Audit Trails
 Now the Audit Trails are shown for System and Project
 We can use view filter to search specific actions
System Audit Trail
Projects Audit Trail

Custom Field to check
for Manual Integration

 To easily check for Manual Adjustment of Integration, one can

create a Custom Field that checks for these changes using the
Integration Type of the peak
See proposed formula

Remember: In case of regulated / controlled work

environment, the Custom Fields as shown in this
example, do need structural testing and validation
prior to its usage
 The proposed formula:

EQ(EQ(Int Type,"BB")+EQ(Int Type,"BV")+EQ(Int Type,"VB")
+EQ(Int Type,"VV")+EQ(Int Type,"EE")+EQ(Int Type,"VE")
+EQ(Int Type,"EV")+EQ(Int Type,"TV")+EQ(Int Type,"VT")
+EQ(Int Type,"TT")+EQ(Int Type,"BS")+EQ(Int Type,"SB")
+EQ(Int Type,"VR")+EQ(Int Type,"RV")+EQ(Int Type,"BG")
+EQ(Int Type,"GB")+EQ(Int Type,"VX")+EQ(Int Type,"XV")
+EQ(Int Type,"Group"),0)

 Result in Review

 Result in Review
 Slight adjustment would

immediate flag the peak
for change in Integration
Type, or addition of peaks

 This can be taken a step further by creating a Result Type

Custom Field using the previous Calculation as a Use As ‘Value’
See proposed formula EQ(SUM(IntVal),0)

 These Custom Fields can also be brought into Preview

JP, EP, USP – Signal to Noise

JP, EP and USP – Signal to Noise
 S/N calculations can be done without the use of a Custom Field

 It is calculated as follows
2H
S/N 
h
Where H is the height of the peak measured from the peak apex to a baseline extrapolated
Where h is the difference between the largest and smallest noise values observed over a
distance of ≥x times the width at the half-height of the peak if possible, situated equally
around the peak of interest after the injection of a blank
 Processing method, Suitability Tab
©2016 Waters Corporation * Depends on the used Pharmacopoeia 41

 Allows determination of noise within a blank injection centered

on the peak region
 Allows user to specify a noise segment based on peak width at
half height:
– USP Half Height Multiplier for Noise Region
– EP Half Height Multiplier for Noise Region
– JP Half Height Multiplier for Noise Region
 Using more blanks calculates multiple noise values for each

blank injection, then uses the average of the noise value

 Half Height Multiplier for EP s/n region = 5

 That gives the following regions for the calculation

 In the Results tab an extra column is available to see what the

Channel IDs were used for Blank in the S/N calculation
 even if more than one blank is used

Shifting peaks (Relative)

Shifting peaks (Relative)
 If you have a chromatogram with many peaks, the alignment

might be a lot of work
– Changing mobile phase
– Changing method settings
 Empower can help to overcome this

Review window: Method Set Option

Review window: Zoom settings

Processing Method Layout
As an example the last 5 peaks will be used

Processing Method Layout
Manually identify peaks

Manually assign
peak 1 to the peak at 27.2 min
Peak 2, Peak 3, Peak 4 and Peak 5 are not

effected by the manual assignment of Peak 1

Setup processing method
for critical peak (groups)
 If peak 1 is modified, you should verify peak 2 too!

Must function in combination with RT
Reference
Peak 2 is effected by the

manual assignment of Peak 1.
Peak name disappears and as
peak 2 is a must peak it flags
red if the peak is not present /
not assigned.

Relative Retention Time (RRT)
 RRT = RT of the peak / RT of the RT Reference

Manually assign peaks
Now Peak 2 and Peak 3 are

automatically assigned to
the correct peaks after the
the manual assigment of
Peak 1

Conclusion
 Avoid repetitive action: by linking the components

 Extra check in review if all peaks have been identified by the
use of the ‘must’ function in the processing method

Who is using what system now?
Mobile?

Who is using what system now?
 To check the licenses in use, View the System Monitor
 Of the two systems available, not one is currently in use
 In case no systems are shown, go to View, Options

 Select ‘Show All Objects’

Or… one can go use Empower Mobile

Login with normal Empower account

Show your Favorite Systems

Show all Systems

Track Running Injections

And also … Administrative Tasks

Check User Account

Change User Password

Protect Systems and Nodes
from being deleted

from being deleted
 If you do not want your Systems and Nodes being deleted (e.g.
by mistake) follow these steps
 Open the properties of the Node, select Access Tab
 Check the Group(s) you Allow Access to

from being deleted
 Then change the allowed access to ‘Owner Only’
 Click OK, login as other user (= NOT Administrator)

from being deleted
 The node can be seen… and the Properties cannot be changed!
Reboot of the LAC/E

is still allowed and possible
 Selecting and using the corresponding LC system is possible…

deleting the LC system is not

Protect Parent Projects
from being acquired in

 By removing group access from the Parent Projects, these

projects can still be seen, but access is restricted
 Colour of the folder is greyish/yellow
No Access (only Admin)

Used for Acquisition


 By removing group access from the Parent Projects, these

projects can still be seen, but access is restricted
 Colour of the other folders is bright-yellow



Copy settings from Parent Projects
to Sub-Projects

Copy settings from Parent Projects
to Sub-Projects
 Changes or settings in a Parent can easily be copied to its

corresponding Sub Projects
 Press ‘Copy to Sub-Projects’
– Accessible on General, Access and Processing
Copy to Sub-Projects works on the selected settings…

before Clicking OK one can change the settings for
the Parent to be different

Add Component Names
and Integration Events
during Review

Add Component Names during review
 At first view no peaks are assigned…
 Right mouse click on the peak, select Add/Edit Component Name

 Enter the component name
 Click OK

Add Integration Event during review
 Component name is added to the method

and applied to the chromatogram
 Right mouse click in the chromatogram, select Add Integration

Event
 Add the Integration Event
 Click OK

Add Integration Event during review
 The integration event is inserted

and applied to the chromatogram

ID’s in Project View

 Normal Project view with Default View Filter, would not show
the ID’s…
 One could create view filter to always show the ID’s

 But in Empower 3 there is a possibility to Persist ID columns in
Project
 That way the ID’s will always be visible for all Project Tabs

 In Sample Sets
 In Result Sets
 And also in Injections, Channels, Methods, Results, Peaks,

Fractions, Sign Offs, and Curves

Copy and Paste

Copy and Paste
 From Review / Preview / any Tables

 From Review, select the chromatogram
 Right Mouse Click, Copy
 Paste into Word Excel

Copy and Paste
 From Preview, select the chromatogram

 Right Mouse Click, Copy
Paste in Word Paste in Excel

as picture

Copy and Paste
 From Preview, select area to copy to the clipboard

 Select the Area, on release it is copied to clipboard
Paste in Word Paste in Excel

Copy and Paste
 On a Table, select the information needed

 From the menu select File, Copy Table
Paste in Excel

Export to JCAMP

Export to JCAMP
 Directly export data* to JCAMP without creation of an export

method
 Select the data*
 In the menu select Database, Export to JCAMP
 Exported data can

be opened using an
external viewer
©2016 Waters Corporation * Sample Sets, Samples, Channels 89

Comparing Calibration Curves

Comparing Calibration Curves
 Calibration Curves can easily be compared

 Select the Curves of Interest
 Right Mouse click, and select compare

 Easily the difference between the selected curves can be seen

Empower Analytics

Empower Analytics
 Empower Analytics offers business owners, system managers,

and laboratory managers insight into business processes, work
flows, and laboratory operations
 Empower Analytics consists of various dashboard reports that

present statistical data scanned from the Empower database.
The pre-defined statistical reports provide both summary and
detailed information that can assist you in deciding where and
how to improve laboratory efficiency
 In Configure the System

 From the menu select Tools
 Select Empower Analytics…

Empower Analytics
 The first step in your System Overview and Usage

Empower Analytics
 Dashboard - Insight in your manual results

Current User/System licence status

Current User/System licence status
 To check the licenses in use, View the System Monitor
 The active licenses are visible using the Waters License Wizard
 Click, Show Licenses
 All the activated licenses are listed

Walk-Up Interface

Walk-Up Interface
 This interface is designed for high-throughput laboratories where

users walk up to a computer system and run samples using
predetermined methods.
 Simplified Interface for easy access and acquisition of Samples
 Log in, and select the project and the system.

Walk-Up Interface
 Fill the interface. Method, System, Sample Names, Method Set,

Number of Samples, Start Position, Injection Volume, Run Time
give the Sequence Name
Press Run Sample(s)
Place the Samples in the System
Press OK.

Walk-Up Running
 The Samples will be injected, system status can be shown.

Walk-Up Method Set
 With the Run and Process option set, and when the Method Set
contains a Report Method, the injection is:
– Processed with given Processing Method
– Reported with given Reporting Method
– Printed, if printer is selected!
 With the properties in the Walk-Up, the interface can be set to

meet the needs of the groups using the Walk-Up interface
– The slides with the properties are given in the next page

Walk-Up Properties
 There are 6 additional properties available in Walk-Up Interface

Mass Analysis Window

Qualitative MS: Mass Analysis
 A new “Mass Analysis” window is added to Review which will

allow users to view and analyze the PDA and MS spectral and
chromatographic data from a single result
 The window is displayed by clicking on the “Mass Analysis”
button in the Window menu. Window is empty when the current
result does not contain PDA or MS data
 Start review from the injection or the PDA channel

Mass Analysis Window:
Start from review: Step 1
PDA

Setup in properties (right click)
 Access to properties: modification of the mass analysis view
 Fast review:
Access to icons/buttons: modification of the mass analysis view

New window: Step 2
PDA & MS Spectra of each Integrated Peak
PDA Chromatogram, Extracted

Wavelength
MS XIC for all Integrated Peaks
 Automatic Extraction of XIC Chromatograms from most intense m/z Peak

Location Field

Location Field
 With Empower 3 FR3 the location field has been introduced

 List of Locations can be maintained in the Default Strings
 Then it can be applied to

– Users
– Nodes
– Systems

MS Peak Tracking

MS Peak Tracking
 Available in Empower 3 FR3
 Processing method enhanced
 MS Peak Tracking option
 Tracking options
– None
– Apex
– Combined
– Number of decimal places

MS Peak Tracking
 New fields
– Assigned Mass
– Notes
 Automatically
assigns mass
– Using Base Peak (m/z)
– For peaks of the same
mass but different
retention times
 Option to manually
assign mass to
override auto
assignment
– Add notes for
manually assigned
mass

Properties: Peak Labels

Report: Component Summary Table
(for unknown peaks!)
m/z
Retention Time
Column Type

ICH Impurity
Deviating Thresholds
for Specified Impurities

Deviating Thresholds for Specified
Impurities

Summary Slide

Summary Slide

Automatically calculate total
impurities

Instrument Control

Instrument Control
 Empower 3 FR3 has a possibility of controlling 472 Instrument

Modules from 16 Vendors (and growing)

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Instrument Control

Solution Overview
Import weights from balances directly

into Empower
 Starts from inside Empower, no additional login required.

 Interacts with an Empower Sample Set Method
– Map weights to sample and component fields.
 Import weights to existing and running sample set methods
 Keeps a complete audit trail of all weights acquired for FAT projects
©2017 Waters Corporation COMPANY CONFIDENTIAL 142

Mapping weights to a sample set method

Basic Solution Architecture
Ethernet Conversion Direct Cable

(if required by balance) Connection
Client PC
SDS
Empower
Sample Weight Importer
Empower Toolkit

Advanced Solution Architecture
Empower Network
Tibbo Device to
connecting a balance
to network
http://tibbo.com/soi/tdst.html
Ethernet Conversion
(if required by balance)

Rencontrer nos experts
Salle actuelle Salon Miranda (RdC près du vestiaire)
Logiciels Instrumentations Consommables Service

Solutions Gammes Colonnes Contrats
informatiques
Applications Préparation SAV
d’échantillons
Flacons Formation
Aurélie Chambon Taraneh Kargar-Grisel Gilles Jaouen Reda Zarrou
Alain Barreau Isabelle Jarecki Myriam Harmouche Sébastien Lahalle
Damien Martin Bruno Contrastin

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Le Jeudi 02 février 2017 – Maison de l’Amérique Latine – Paris 7ème

Présenté par Alain Barreau

THINGS YOU FORGOT

 Empower 3 is powerful with many features available

 We will try to show all the slides, but

©2016 Waters Corporation 2

 View Filters [4]  Add Peaks and Integration events

©2016 Waters Corporation 3

©2016 Waters Corporation 4

 Any table in Empower can apply a filter – Just in Time

 Now the projects with ‘Default’ in the name are shown

©2016 Waters Corporation 5

 A maximum of three =# options is possible

 Fill the Just in Time filter

 This gives an overview of the requested projects

©2016 Waters Corporation 6

 Save the View Filter and Apply

©2016 Waters Corporation 7

 To only see the latest Result Set(s) belonging to corresponding

 The information is filled, then save and apply the filter

 Latest Result Set(s) of the Sample Set(s) are shown

©2016 Waters Corporation 8

 To see the last user login… after a certain date.

 Click Edit View to start creating the Filter

©2016 Waters Corporation 9

 Select the Displayed Columns:

©2016 Waters Corporation 10

 Fill the Group By Condition, Click OK

 Now fill the rest of the filter, save the filter

©2016 Waters Corporation 11

 Upon applying the filter, the change date needs to be entered

 Any successful login after this date is displayed (8 records only)

©2016 Waters Corporation 12

©2016 Waters Corporation 13

 To see the relation between all data in an Empower project, the

©2016 Waters Corporation 14

 There is an extra option available

©2016 Waters Corporation 15

©2016 Waters Corporation 16

 To review data, the Result Audit Viewer can be used

Preview Run Sample Result Audit

 Click Result Audit Viewer icon and the viewer is started

©2016 Waters Corporation 17

©2016 Waters Corporation 18

©2016 Waters Corporation 19

 Result ID 1453 and 1463 can be taken into review

©2016 Waters Corporation 20

©2016 Waters Corporation 21

©2016 Waters Corporation 22

©2016 Waters Corporation 23

©2016 Waters Corporation 24

©2016 Waters Corporation 25

 In the project view, select 2 (or more) projects

 Right Mouse Click, Open

©2016 Waters Corporation 26

 Simply activate or deactivate additional projects by clicking the

 The following view is shown

 Select an additional project and Click Activate

 The view filters also work across multiple projects

 In this example a filter for Sample Name ‘Sample 6’ is applied

 Two different projects and the same Sample Name is shown

©2016 Waters Corporation 28

 With the same sample name selected in the previous slide we