This is Critical appraisal for article Seah and Agrawal, (2020).

Can
the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A
Review of Coronaviruses and Ocular Implications in Humans and
Animals

1. What is the research question?

Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes?

2. What is the study type (design)?

Review of previous studies

3. Selection issues.

As the literature on human ocular CoV infection is still sparse, there is

value in studying ocular manifestations of CoVs in various animals. It
was also suggested that the SARSCoV-2 virus may recognize ACE2 from
a diversity of animal species including cats and non-human primates.30
Hence, understanding the ocular manifestations of animal CoV infections
may provide insights into the spectrum of ocular diseases that CoVs can
cause. This will be covered in the subsequent segments of this review
article.

4. What are the outcome factors and how are they measured?

ocular infection

mechanisms of transmissions

transmission through ocular tissue,

relationship between human CoVs and the eye

5. What are the study factors and how are they measured?
 relationship between human CoVs and the eye, measured through animal
studies

6. What important potential confounders are considered?

he examples in animals also highlight that CoVs are a heterogeneous

group of viruses that can cause ocular implications through a wide variety
of mechanisms. Some of these mechanisms are extremely different from
those adopted by human CoVs. Nevertheless, there are lessons to be
learned by understanding these infections.

7. What is the statistical method used in the study?

Not applicable.

8. Statistical results.

Prevalence of infection through included studies was described

9. What conclusions did the authors reach about the research

question?

However, the examples in animals also highlight that CoVs are a

heterogeneous group of viruses that can cause ocular implications
through a wide variety of mechanisms. Some of these mechanisms are
extremely different from those adopted by human CoVs.

ophthalmologists and other health-care workers should continue to err on

the side of caution and continue to prevent the possible transmission of
CoVs through ocular tissue.

10. Are ethical issues considered?

This is review of previous studies, no risk of human applicable.