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Hydrogel Microvalve Device Modeling and Simulation

Ibrahim M. W. A. (1), Saunders J. R. (2), and Moussa Walied A. (3)


(1)
& (3) Multiphysics and MEMS simulation laboratory, (1) (2) &(3) Mechanical
Engineering Department, University of Alberta, Edm, AB, Canada. T6G 2G8
(1)
mwa1@ualberta.ca & (3) walied.moussa @ualberta.ca

Abstract

The modeling and simulation of volume of diameter and depth 250 µm


fabricated 3-D hybrid hydrogel and 200 µm, respectively. The
microvalve using a commercial FE diaphragm is fabricated out four separate
package is presented in this paper. A layers of PDMS material, bonded using
PDMS diaphragm is deflected to surface tension driven self-alignment
197.5µm. A stimulated hydrogel volume method [7].
swelled to 465% of its original volume.
Results of the finite element analysis are
reported and a comparison to the
fabricated model results is made.

1- Introduction

Hydrogel material has the unique


characteristic of responding to external
stimulus by changing in volume. These
external stimuli can include light, pH, Fig.1. Schematic of 3-D hydrogel
electric field, or temperature [1-4]. Thus, microvalve [8].
hydrogels can be used in microfluidic
devices as actuators and sensors, The thickness (t) and diameter (2r) of the
performing both functions diaphragm are 50 µm and 700 µm
simultaneously. It can be easily respectively. The height of the
fabricated in-situ in the microchannel microchannel (h) is 200 µm.
using the standard lithography process
[5,6]. 2- Model
In this paper, a finite element analysis
is carried out on a fabricated 3-D hybrid The model was built and finite
hydrogel microvalve as shown is Figure element analysis was done using a
1. The hydrogel material components are commercial FE analysis package. The
acrylic acid (AA) and 2-hydrooxyethyl model has the same dimensions and
methacrylate (HEMA) in a 1:4 mol ratio. material properties of the fabricated
The external stimulus used to stimulate microvalve. The simulation and the
the hydrogel is a pH 11 buffer solution. results of the FE analysis are reported
The hydrogel is fabricated in cylindrical hereafter.

Proceedings of the 2005 International Conference on MEMS, NANO and Smart Systems (ICMENS’05)
0-7695-2398-6/05 $20.00 © 2005 IEEE
3- Results 5- References

The hydrogel volume is constrained [1] A. Suzuki and T. Tanaka, “Phase


from the top by a Pyrex sheet causing transition in polymer gels induced by visible
the hydrogel to swell only in the radial light,” Nature, vol. 346, pp. 345-347, 1990.
and vertical downward direction. The
[2] David T. Eddington, David J. Beebe,
hydrogel swelled to a 465% of its
“Flow control with hydrogels” Advanced
original volume. The hydrogel swelling Drug Delivery Reviews, Vol 56, pp 199-210,
caused the PDMS diaphragm to deflect 2004.
to a 197.5 µm. Figure 2 displays the
simulation results of the swelled [3] Michael J. Bassetti, Jeffrey S. Moore,
hydrogel microvalve and the deflected David J. Beebe, “Development of
diaphragm. electrically triggered hydrogels for
microfluidic applications”
Microtechnologies in Medicine & Biology
2nd Annual International conference, pp410-
413, 2002.

[4] Tae Gwan Park, Allan S. Hoffman,


“Synthesis and characterization of pH-
and/or temperature sensitive hydrogels”
Journal of Applied Polymer Science, Vol.
46, Issue 4, pp 659-671, March 2003.

[5] B.H. Jo, L.M.V. Lerberghe, K.M.


Motsegood, and D.J. Beebe, “Three-
dimensional micro-channel fabrication in
polymethylsiloxane (PDMS) elastomer,” J.
Fig.2 Schematic of the swelled hydrogel Microeletromechanical ystems, Vol. 9, pp.
and deformed diaphragm. 76-81, 2000.

4- Conclusions. [6] J. Hoffman, M. Plotner, D. Kuckling,


W-J. Fischer, “Photopatterning of thermally
sensitive hydrogels useful for
1- FE analysis of hydrogel microvalve microactuators,” Sensors and actuators, vol.
device was performed. 77, pp 139-144, 1999.
2- The hydrogel volume swelled to a 465
% with 2% increase in volume compared [7] B. H. Jo, L. M. V. Lerberghe, K. M.
to the fabricated microvalve. Motsegood, and D. J. Beebe, “Three-
3- The fabricated hydrogel microvalve dimensional micro-channel fabrication in
caused a diaphragm deflection of 185 polydimethylsiloxane (PDMS) elastomer,”
µm only. This could be attributed to J. Microelectromech Syst., vol. 9. pp. 76-81,
ideal environmental conditions the 2000.
microvalve is being simulated under
[8] Robin H. Liu, Qing Yu, and David J.
which may not be the case during the
Beebe, “Fabrication and Characterization of
fabrication and actuation processes. Hydrogel-Based Microvalves,” J.
Microelectromech Syst., vol. 11., 2002

Proceedings of the 2005 International Conference on MEMS, NANO and Smart Systems (ICMENS’05)
0-7695-2398-6/05 $20.00 © 2005 IEEE

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