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3D Printing Medical/Healthcare Global

Market

2016
[PROCESS (Photopolymerization {Stereolithography,
Digital light processing, 2 photon polymerization};
Deposition {Fused deposition modelling, Extrusion
bioprinting}; Fusion {Selective laser sintering, Direct metal
laser sintering, Selective laser melting, Electron Beam
Melting, Laser-assisted bioprinting}; Jetting
{Multijet/Polyjet, Binder jetting, Inkjet-based bioprinting});
CATEGORY (Product, Services, Material {Metals, Polymers,
Ceramics, Others}); APPLICATION (Implants & Prosthetics,
Tissue engineering, Surgical instruments, Surgical guides,
Pharmaceutical applications); END USERS (Hospitals,
Biotech & Pharma companies, Academic institutes,
Others); REGION (North America, Europe, Asia-Pacific and
Rest of the World)]

– Forecast to 2022

IQ4I Research &


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LIST OF COMPANIES MENTIONED IN THE REPORT

Company Name Headquarters


3D Bioprinting Solutions Russia
3D Systems United States
Adaptive 3D India
Additively AG Switzerland
Advanced Prototype United States
AK Medical China
Aprecia Pharmaceuticals United States
Arcam AB Sweden
Aspect Biosystems Canada
Atomic filament United States
BioBots United States
BotFeeder Canada
Camplex Australia
Cellink Sweden
Confirmis United States
Cyfuse Biomedical Japan
Dimension polymers United States
Eastman 3D solutions United States
Embody Orthopedic Limited United Kingdom
EnvisionTEC United States
EOS Germany
ExOne United States
Fit Production Germany
FormLabs United States
Imaginarium Spain
Indeigogo United States
LayerWise United States
Materialise Belgium
MedShape United States
Mimedis AG Switzerland
Mobelife Belgium
Morgan Advanced Ceramics Germany
Morgan Electro Ceramics Germany
Morgan Technical Ceramics United Kingdom
Nanoscribe GmbH Germany
Natureworks United States
NovaBeans India

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Company Name Headquarters


Optomec United States
Organovo United States
Oxford Performance Materials United States
Pandoram Technologies India
Phonax Switzerland
Poietis France
Printelize Poland
Rapid 3D Canada
Renishaw United States
Revotek China
Rokit United States
RoosterBio United States
Sculpteo France
Shapeways United States
Sirona Germany
SkinPrint United States
SLM solutions Germany
Sonova Switzerland
Stratasys United States
TETRA Germany
TeViDo Biodevices United States
Texas instruments United States
Think3D India
Tissue Regeneration System United States
VETCT United Kingdom
WhiteClouds United States
Worrel Design United States

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1 EXECUTIVE SUMMARY

3D printing/additive manufacturing is a technology that fabricates 3D products in layer


fashion by adding different type of materials. This technology was introduced in late 1980’s
and has made our lives better in numerous ways and is industrially revolutionizing day-by-
day by manufacturing prototypes, customized body parts & organs and medical devices etc
in healthcare sector. Even though, traditional product manufacturing process is still in the
market, the emergence of novel 3D printing technology is rapidly increasing due to high
demand for personalized products. It is one of the promising technologies facilitating
advancement in utilizing speedy CAD designing process for engineering the product. Earlier,
most of the printers were compatible with single material type, but today the trend has
changed to multi-material printers, which are chiefly used for prototyping. Currently, 3D
printing services in healthcare sector is used mainly for preparation of anatomical models,
medical equipments, prosthetic parts and tailor-made sensors etc for hospitals with
comprehensive quality.

At present, bioprinting is still in its formative years where demand for tissue engineering and
transplanting organs has raised in the market to meet the unmet need. Recently in March
2016, life of nine-month old baby with congenital heart defect was saved from Chinese
doctors by performing open heart surgery utilizing Materialise’s Mimics software to convert
MRI scan to 3D printable heart model. These kind of advanced technologies has not only
shown path for tissue engineering segment but also has taken a great step towards
development of regenerative medicine and cell culture where scientists have developed 3D
printed embryonic stem cell blocks for tissue regeneration and medical testing purpose
which is a breakthrough event in the industry. In February 2016, Cell Applications and
Cyfuse Biomedical introduced scaffold-free Kenzan method where array of needles are used
for development of manipulatable vascular tissues for heart, liver, skin, pancreas, lung &
trachea and cartilage which is setting-up a trend in the industry.

Eventually, rise in 3D printing technology has rolled its focus on pharmaceutical industry
where personalized medicine with appropriate dosage, size, color and delivery mode is
adopted for improved patient-care. For instance, in August 2015 Aprecia pharmaceuticals
developed Spritam, an anti-epileptic drug for epileptic seizures. Since, populace are gearing
up to adapt novel technologies for betterment of healthy lives, factors such as high demand

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for customized implants, high investment in R&D and usage of CAD/CAM technology are
driving the market, whereas high cost of printers and limited type of material availability are
the factors hindering the market growth. Reimbursement is still a challenge, as the
technology is expensive.

As estimated by IQ4I Research, the global 3D printing healthcare market is expected to


reach $2,841.2 million by 2022. The 3D printing healthcare market by category is classified
into products, services and materials where services market holds the major share followed
by materials. Material segment is divided into metals, polymers, ceramics and others, where
polymer accounts for the largest share in the market.

The 3D printing healthcare by process is divided into Photopolymerization, Deposition,


Fusion, Jetting. Among these fusion segment holds the largest share in 2015 and jetting is
the fastest growing segment with highest CAGR. Further application is classified into implant
and prosthetics (dental, orthopedic, hearing aid, others), tissue engineering, surgical guides,
surgical instruments, pharma applications, where implant & prosthetics segment is
accounting with a largest share and pharma applications with a fastest growing CAGR.

End-users is segmented into hospitals, biotech & pharmaceutical companies, academic


institutions and others (CROs) and geographically, North America dominates with the largest
market share due to high expenditure and increased healthcare awareness, whereas Europe
holds the second largest share followed by Asia Pacific and Rest of the world.

Patents are explored for both process and technologies from the year 2011-2016 since
continuous research and innovations are on-going from different companies for advanced
product offerings. Filing of patents exhibited significant impact on the growth of company’s
product portfolio to maintain dominant position in the industry. Some of the major companies
included in 3D printing healthcare market are 3D systems, Arcam AB, EnvisionTEC, EOS,
ExOne, Materialise N.V., Optomec, Organovo, Reinshaw, Nano3D biosciences, SLM
solutions and Stratasys. At present, extensive choice of viable 3D printers for various
industrial applications are available where 3D Systems and Stratasys plays a major role with
high market capitalization.

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FIGURE 1

3D PRINTING HEALTHCARE GLOBAL MARKET REVENUE, BY REGION,


(2014-2022) ($MN)

North America Europe


1,400.0 800.0
1,200.0 700.0
Market size ($MN)

Market size ($MN)


1,000.0 600.0
500.0
800.0
400.0
600.0
300.0
400.0 188.3
220.1 200.0
200.0 100.0
- -
2014 2015 2016 2022 2014 2015 2016 2022
5.5%
North America
Europe
Asia-Pacific
ROW
Asia-Pacific ROW
700.0 200.0
600.0
Market size ($MN)
Market size ($MN)

150.0
500.0
400.0
100.0
300.0
200.0 50.0 31.6
100.0
- -
2014 2015 2016 2022 2014 2015 2016 2022

Source: National Additive Manufacturing Innovation Institute (NAMII), European Additive Manufacturing Group
(EAMG), Korea 3D Printing Association (K3DPA), World Health Organizations (WHO), Industry Expert Interviews
and IQ4I analysis

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2 3D PRINTING HEALTHCARE GLOBAL MARKET, BY


CATEGORY

TABLE 1

3D PRINTING HEALTHCARE GLOBAL MARKET REVENUE,


BY CATEGORY, (2014-2022) ($MN)

CAGR (%)
Category 2014 2015 2016 2022
(2015-2022)
Products 157.3 XX XX XX XX
Services XX XX XX XX XX

Materials XX XX XX XX XX

Total XX XX XX 2,841.2 XX

Services commanded the largest revenue of $XX million of the global 3D printing healthcare
market in 2015. The market is expected to grow at a CAGR of XX% from 2015 to 2022 to
reach $XX million by 2022. Products are expected to grow at a strong CAGR of XX% from
2015 to 2022.

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FIGURE 2

3D PRINTING HEALTHCARE MATERIALS GLOBAL MARKET REVENUE,


BY TYPE, (2015 V’S 2022) ($MN)

2015 2022

8.0
39.6

Others Ceramic

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3 GLOBAL 3D PRINTING HEALTHCARE MARKET, BY


PROCESS

FIGURE 3

3D PRINTING HEALTHCARE GLOBAL MARKET, BY PROCESS,


(2015) ($MN)

44.1

16.5

Fusion Jetting
Deposition Photopolymerisation
Stereolithography Digital Light Processing (DLP)
Two-Photon Polymerization (2PP)

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FIGURE 4

3D PRINTING HEALTHCARE JETTING GLOBAL MARKET REVENUE,


BY TECHNOLOGY, (2015 V’S 2022) ($MN)

700.0

600.0

500.0
Market size ($MN)

400.0
2015
300.0 2022

200.0
129.0
100.0

-
Multijet/Polyjet Binder Jetting Ink Jet based bio-printing

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4 3D PRINTING HEALTHCARE GLOBAL MARKET, BY


APPLICATION

FIGURE 5

3D PRINTING HEALTHCARE GLOBAL MARKET REVENUE,


BY APPLICATION, (2015-2022) ($MN)

3,000.0

2,500.0
Market size ($MN)

2,000.0

1,500.0

1,000.0

500.0

-
2014 2015 2016 2017 2018 2019 2020 2021 2022
Implants & Prosthetics Tissue engineering Surgical instruments
Surgical guides Pharma applications

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5 3D PRINTING HEALTHCARE GLOBAL MARKET, BY


END-USER

FIGURE 6

3D PRINTING HEALTHCARE GLOBAL MARKET REVENUE, BY END-USER,


(2015 V’S 2022) ($MN)

2,500.0

2,000.0
Market size ($MN)

1,500.0

1,000.0
379.0
500.0
12.5
-
Hospitals Academic Biotech & Pharma Others (CROs)
institutes
2015 2022

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6 MARKET ANALYSIS

6.1 DRIVERS

6.1.1.1 High demand for customization

Customization is a raising trend in developing products with advanced technology especially


in healthcare market. Modern customers demand for highly configured products for elevated
sustainability which drives the market growth. This customization has pushed the traditional
methods of manufacturing products which has shown a strong competitive edge between the
existing and new companies. As customer satisfaction is mainly focused, the unmet need in
the market has been identified and hence there is high demand for manufacturers to develop
and deliver personalized products. Since, customization shortens surgical procedures; it
allows the doctors to visualize intricate structural models by improving product fit and altering
end product build size. In healthcare, customization is mainly focused on segments such as
manufacturing medical devices, implants, organs, tissue engineering, surgical guides and
instruments etc. For instance, 3D Systems are developing custom coverings for artificial
limbs and prosthesis using 3D printing technology. These technologies have transformed
even hearing aid sector where 99% of products developed are customized. At present, even
pharmaceutical industry is showing a dramatical change in developing medicines with
customized dosage which is positively impacting in treating various therapeutic applications.

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6.2 MARKET SHARE ANALYSIS BY MAJOR PLAYERS

FIGURE 7

GLOBAL 3D PRINTING HEALTHCARE MARKET SHARE ANALYSIS,


BY KEY PLAYER, 2015, (%)

30.1% 30.3%

Stratasys
Others

The total market size of 3D printing healthcare is $XX million where, Stratasys accounted for
the share of 30.3%. Stratasys is a leading global provider of 3D printing and additive
manufacturing solutions. 3D printing solutions is impacting and creating opportunities in
various applications which strengthened the product portfolio. Development of personalized
products, increased product functionality and efficient low volume production has improved
the adoption of 3D products in market. Expansion of services gives a break for investors to
capitalize in this segment.

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7 INTRODUCTION

7.1 RESEARCH METHODOLOGY

The research on 3D printing healthcare market involved both widespread secondary and
primary research. The secondary research was carried out on company websites, annual
reports, SEC filings, associations, articles, press releases and journals to identify and collect
both the qualitative and quantitative data. The primary sources were experts from supply
side such as president, managing director, supervisory director, consultant, business
development manager and chief technical officers. From demand side, reference laboratory
heads, hospitals, and purchase managers. All the primary sources were interviewed to
acquire and verify critical qualitative and quantitative information and also to assess the
future forecast of all the segments in 3D printing healthcare market. Along with these,
additional information was extracted about the key players in this industry with their market
revenues, products and developments. The factors responsible for growth and restriction of
the 3D printing healthcare along with the future opportunities were also determined through
secondary research and verified through primary sources.

The following illustrative figure shows the market research methodology applied in making
this report on the global 3D printing healthcare market.

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FIGURE 8

3D PRINTING HEALTHCARE GLOBAL MARKET: RESEARCH


APPROACH

• Technical information of 3D printing healthcare & their components


• Strategic insights, financial revenues and competitive intelligence of key

Secondary players
Research • Category, process, application and end-users of 3D printing healthcare
• Market trends and growth scenario of sub markets and parent market

• Market size, CAGR and market trends validation


• Market size of sub segments and market shares of major players
• Biomaterials with regulatory approvals and technological
Primary
Research advancements in 3D printing market
• Validation of factors influencing market and regional market shares

• Bottom-up and Top-down approach


• Data triangulation
Market • Qualitative & Quantitative analysis
Breakdown
• 3D Printing healthcare market segmentation

7.1.1 MARKET SIZE ESTIMATI ON


The size of the global 3D printing healthcare market and its various segments and sub-
segments were estimated and validated through secondary and primary research. All the 3D
printing healthcare market percentage share, splits, and breakdowns were determined using
secondary sources and verified through primary sources to get the final quantitative and
qualitative data. This data is consolidated and added with detailed inputs and analysis from
IQ4I and presented in this report.

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FIGURE 9

3D PRINTING HEALTHCARE GLOBAL MARKET: TOP-DOWN AND


BOTTOM-UP APPROACH

Global 3D Printing Market

Global 3D Printing Healthcare


Market
Overall
Market Size
Market Share of 3D Printing Healthcare Segments and CAGR

Market Share of Category/Process/


Applications
Market Share of the Players in
the Overall 3D Printing
Regional Market Shares Healthcare Market

Sub segments
Top Players Market Revenue in 3D Printing
Market Size
Healthcare Market: 3D Systems (U.S.), Arcam
and
AB (Sweden), Envision TEC (U.S.), EOS
CAGR
(Germany), Materialise (Belgium), Optomec
(U.S.), Organovo (U.S.), Reinshaw (U.K.), Nano
3D Biosciences (U.S.), Stratasys (U.S.)

The top-down approach was used to derive the global 3D printing market size as well as the
3D printing healthcare market size by category, technology, applications, material, end-user
and regions. Different percentage splits were applied for different segments of 3D printing
healthcare market. Different percentage splits were applied across the geographies. The
bottom-up approach was followed for market share analysis of the key players and there by
deriving the final 3D printing healthcare global market value.

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FIGURE 10

3D PRINTING HEALTCHARE GLOBAL MARKET: FORECASTING MODEL

Historical Data Technology Approved


and trends of Adoption Pattern Regulations
Advancement Biomaterials
3D Printing
Healthcare Global Supply Chain Geographical
Market Share Patent analysis
Market Trend Usage
Market Drivers Market Restraints Market Threats
• Increasing demand for • High cost of printers • Stringent regulatory
implants in healthcare •Limited type of materia process for 3D printed
industry availability product approval
• High investment in R&D • Patent infringment
for new entrants

Market Opportunities Agreements & Joint New Product Launch


Factors Influencing • Acquisition, collaborations In Jan 2016, 3D Systems
ventures contributed for
Market Growth and agreements for 31.4% launched ProX DMP 320
development implementation direct metal printing for
of technology New product launch critical industrial applications.
• Expansion of existing product contributed for 7.4%

Investments
Axial 3D in December 2015 secured 300,000 Euros from Ulster University in
collaboration with Techstart NI for creating awareness globally through market
.
expansion of medical 3D printing technology.
Market Size & Forecast by
Historical Market Data Global 3D Printing
Market Trend and Process & End Users
Healthcare Market Size,
Growth Forecasting Segmental share and
Impact Analysis of Market Market Size & Forecast by
CAGR from 2015-2022
Trends Applications & Category

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7.1.2 MARKET BREAKDOWN AND DATA


TRIANGULATION

FIGURE 11

3D PRINTING HEALTHCARE GLOBAL MARKET: MARKET BREAKDOWN &


DATA TRIANGULATION

Market Share of the 3D


Printing Healthcare in
Global 3D Printing Market

Top -down

•Financial/Annual reports Demand side:


•Investor Presentations Hospitals, Academic
•SEC filings 3D Printing Research
Secondary Primary
•Scientific Journals Healthcare Supply side :
Research Research
•Organizations/ Global Market From small and major
Associations & Groups (~XX MN) companies
(2015)

Bottom -up

Major Player Analysis:


Stratasys (U.S.),
Materialise (U.K),
Arcam (U.S.) , 3D
Systems (Sweden)

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FIGURE 12

3D PRINTING HEALTHCARE GLOBAL MARKET: MARKET SEGMENTATION

Global 3D Printing Healthcare Market

Category Process Application End-user Region

North
Products PP Deposition Fusion Jetting Implant Hospitals
America
Stereolitho Multijet/ Surgical Pharma &
Services FDM DMLS Europe
graphy Polyjet Guides Biotech
Extrusion Binder Tissue Academic Asia-
Materials DLP SLS
Bioprinting Jetting Engineering Institutes Pacific
Ink Jet Surgical
2 PP EBM Others Row
Bioprinting Instruments
Pharmaceu
SLM
tical
Laser
Bioprinting

7.1.3 ASSUMPTIONS

Parameter Assumptions

The global 3D printing healthcare market revenue is


estimated to be ~15% of the global 3D printing market.
Market Revenue
The value is cross validated through top-down and
bottom-up approach as well.

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Parameter Assumptions

The CAGR for the forecasted period (2015-2022) is


assumed to be normalized and the effect of inflation,
Market growth
recession, economic downturn, regulatory or policy
changes, or other factors are not considered.

The % splits for each product type was considered based


on its revenue contribution in overall market. Similarly, %
splits was arrived for technology, material, application &
End-users based on the contribution of 3D printing
Product/Technology/Application healthcare products in respective technology, materials,
/Material/End-users market application & end-user areas. In case of pharma
application market, drug Spritam is expected to be
launched on 2nd half of 2016 in U.S. Whereas, in EU and
other countries the drug is expected to be launched on 1st
quarter of 2019.

The market shares are analyzed based on the absolute


Segmental & Sub segmental data & primary in-puts. In case of the data non-availability
market shares for the sub markets the parent market trends has been
assumed for the forecasted period.

Market share analysis of key players is performed in two


ways that is based on the primary research rankings
Market Share (Market penetration of players) and the other method is
based on the estimated 3D printing healthcare product
revenues of key players.

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