Anti-inflammatory and protective investigations on the effects of

Theranekron® ”an alcoholic extract of the Tarantula cubensis”

on wound healing of peritoneal in the rat: an in vivo comparative
study
Farajollah Adib-Hashemi, Farshad Farahmand, Shamim Fattah Hesari, Bijan Rezakhaniha, Ehsan
Fallah, Amir Farshid Fayyaz, and Masoomeh Dadpay

Author information Article notes Copyright and License information Disclaimer

This article has been retracted. See Diagn Pathol. 2016 November 2; 11: 118.
This article has been cited by other articles in PMC.

Abstract
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Background
Peritoneal wounds usually occur following trauma, ablation of malignancy of the genitalia,
low pelvic tumors, or following thermal or electrical injuries. These wounds remain a
significant problem and can commonly present as wound infection, abscess, dehiscence,
delayed healing, or persistent peritoneal sinuses. These wounds result in significant
morbidity requiring prolonged hospital stay, hospital readmission, home-nursing wound
care needs; all involving significant medical costs [1].
Healing of the wound is a dynamic and complex process and the clinical evaluation of its
early and late phase may include biochemical [2,3], immunological [4], histopathological
[5] and mechanical [6,7] studies. In healing, after cessation of bleeding (hemostasis) and
clot formation, the process can be divided into three overlapping phases: inflammation,
proliferation and scar maturation. In general, injury is accomplished by fibroplasia,
angiogenesis and migration of fibroblasts, endothelial cells and epithelial cells lead to
wound contraction [8]. The healing process starts with the formation of granulation tissue
and ends with scar formation. The degree of wound healing is determined by inflammation
[9], a vital and protective response offered by the injured cells at wound site that actually
starts the process of tissue repair [10].
Treatment methods that allow wounds to heal faster and minimize cosmetic defects and the
production of exuberant granulation tissue are the most appropriate [11-13]. In parallel,
Theranekron® (Richter Pharma, Wels, Austria) is an alcoholic extract of the venom of
Tarantula cubensis, which remains active in pharmaceutical compounds for a considerable
time. Many systemic effects were described for Theranekron such as antiphlogistic,
demarcative, necrotizing action [14], but there are few reports of Theranekron effects on
wound healing in farm animals [14-16].
On the other hand, TC (Figure 1A). has been used in homeopathy to treat mixed mammary
tumors, pododermatitis abscesses with burning pains, gangrene, septicemia and toxemia by
forming a demarcation line around the lesions [17-19]. In addition, TC reduced
inflammation and tarsal bursitis volume, stimulated epithelialization in the full thickness
cutaneous wounds [15,20], improved the uterine involution, and treated the genital
microbial diseases [21], oral ulcers [20], and cutaneous papillomatosis of various species of
animals. The aim of this study was to evaluate of the effects of theranekron on the
peritoneal wound healing based by histopathological features.

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Figure 1
Operations/Surgical Procedures. A: Tarantula cubensis (Cuban Spider) and Theranekron is a
homeopathic remedy prepared from the spider Tarantula . B: Laparotomy and exposure of the
peritoneal cavity and two buttons created of the abdominal wall. C: Note that the peritoneal and
partially of the muscle was closed by purse string suture. D: The abdomen was closed in two layers
by silk sutures (with separate vicryl 3/0 stitches for the musculoperitoneum and avicryl 3/0 running
suture for the skin).
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Methods

Animals welfare
All experimental protocols were approved by the local animal care committee in
accordance with Faculty of Garmsar Veterinary Medicine office regulations. The animals
were kept two by two in individual propylene cages under standard laboratory conditions
by the dimensions of 30 × 50 × 25 cm3. Rats were maintained on a 12 hour light/dark cycle
at 22 ± 1°C and 50 ± 10% humidity. The animals were kept in standard room conditions and
fed with standard rat diet and water ad libitum.

Pharmaceutical ingredients
Theranekron® alcoholic extract (1:100) of Tarentula cubensis in alcoholic solution
1 mg/ml, purchased from Richter-Pharma AG, Wels, Austria, and or can be expressed that
each ml of pharmaceutical ingredient Theranekron contains: 1.0 mg alcoholic extract
(1:100) from Tarantula cubensis in alcoholic solution, and the final dilution was D6 and
potentisation was performed according to method 4b of the European Homeopathic
Pharmacopoeia [15,18,20,21].

Experimental design and dose preparation procedure

In current study, 24 male Wister-albino rats, weighing 210–230 g, with averagely 4 weeks
old were selected. The rats were divided into two groups and randomly allotted into one of
two experimental groups each group contained 12 animals.
Control animals in group I received normal saline (a single dose 0.3 ml with intervals
5 days for 29 days, SC), and experimental animals in group II received Tarrantula cubensis
extract (Theranekron, 1:100/D2, 0.3 ml, Richter Pharma, Austria) following surgery. On
days 9,14, 19, 24 and 29 after injury, the same volume of TC extract with dose 0.3 ml was
injected subcutaneously at the site of injury in the injured experimental group at the same
time with intervals 5 days for 29 days. Clinical signs of rats of both groups were recorded
during day 9, 14, 19, 24 and 29 of treatment.

Surgical procedure
Anesthesia was achieved with subcutaneous administration of 75 mg/kg ketamine HCl and
10 mg/kg xylazine HCl. Laparotomy was performed through a 3-cm midline incision. The
abdomen was shaved, prepared and disinfected with1% iodine alcohol and then, abdominal
cavity was entered via a 3 cm vertical midline incision. Then with peritoneal cavity
exposure two buttons were made of the abdominal wall and with this method (Figure 1B
and C), the remaining tissue between buttons is caused necrosis by anemia or congestion.
The abdomen was closed in two layers by silk sutures (with separate vicryl 3/0 stitches for
the musculoperitoneum and avicryl 3/0 running suture for the skin) (Figure 1D). A mixture
of iodine and oxytetracycline was sprayed to the laparotomy site as an antibiotic agent and
especially due to its bitter taste, it inhibited rats to chew the sutures and prevent
evisceration.to warp up, the wound tissue was removed from control and experimental rats
by sacrificing the animals on the 9, 14, 19, 24, and 29 days and or another definition, with
interval 5 days,the animal groups were euthanized 9,14, 19, 24, and 29 days after wounding
respectively by intravenous injections of pentobarbital (50 mg/kg).

Histopathological examination
The wounded tissues with 2X2 cm piece of parietal peritoneum, underlying muscle and
peripheral unwounded skin were harvested, pinned on a plastic plate (to keep the tissue flat)
and fixed in 10% buffered formalin. After fixation, each sample was cut into 3 pieces. All
pieces were embedded together into a paraffin block, and 5 μm-thick histological sections
were obtained and after wound creation and the abdominal wall were harvested and
underwent histologic evaluation. Two pathologists examined all representative fascia
sections in each rat histologically under a light microscope in blinded fashion.

The scoring system used for histological examination

All specimens were evaluated individually by two histologists who were blinded to the
drug type and the time from wounding. The main histologic outcome measures included the
amount of inflammatory infiltrates for extent and severity, fibroplasia, collagen deposition,
neovascularization (angiogenesis), re-epithelialization or complete repair. The Abramov’s
histologic scoring system was used for this study [22]. Abramov’s system assessed each
parameter independently and assigned a score of 0–3. inflammatory infiltrates or extent,
collagen deposition and complete repair were graded as: 0 (none), 1(scant), 2 (moderate), 3
(abundant).and also, severity of inflammation was scored as follows: 0 – no inflammation;
1– presence of giant cells, occasional lymphocytes and plasma cells; 2 – presence of giant
cells, plasma cells, eosinophils and neutrophils; and 3 – presence of many inflammatory
cells and microabscesses. The amount of fibrosis was scored as: 0 = no fibrosis; 1 = 
minimal, loose; 2 = moderate; and 3 = florid dense. The fibroblast maturation or fibroplasia
of granulation tissue was graded as: 0 (immature), 1 (mild maturation), 2 (moderate
maturation), 3 (fully matured). Neovascularization was graded as: 0 (none), 1(up to two
vessels per high-power field [HPF]), 2 (3–4 vessels per HPF), 3 (more than 4 vessels per
HPF).

Statistical analysis
For statistical analysis, Mann-Whitney U, Wilcoxon W, Z and the asymptotic significance
(2-tailed) were performed to analyze the significant differences between groups and a
statistically significant difference was considered at the level of P < 0.05.
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Results
Clinical observations
The affected rats manifested clinical sings of appetite loss, fever, weakness, apathy and /or
tiredness, while no clinical signs were observed in the control groups, and also, at all stages
of the experimental, after laparotomy , the formation of intraperitoneal adhesion in the
location of button was a constant finding in both groups (Figure 2). Furthermore, wound
areas decreased rapidly in size between days 24 and 29 in both the test and control groups

Figure 2
Note that adhesion sites in the location of buttons.

Histopathological findings
In regards to the histological outcomes from in vivo experiments, in the treated groups; on
the 9rd day after the operation, there was a wound extending deep to muscle layer where
the cells were edematous. The wound region was covered with low number of the
inflammatory cells and the tissue was only lightly infiltrated with polymorphonuclear
leukocytes, thus the inflammatory phase was almost finished together with moderate
number of fibroblast and collagen matrix.
In control group, the increased amounts of mononuclear inflammatory cells such as
macrophage, lymphocytes and its accumulation together with the presence higher of
fibroblasts and low blood vessels were detected (Figure 3) (Table 1). Finally, in day9, the
results of the histologic analysis showed that 95% of the severity and extent of
inflammation and fibroplasia in the wound were significantly higher statistically in the
experimental group compared with the control group (P < 0.05), also in other healing
factors, no histologic difference were noted between the test and control groups (P > 0.05)
(Figure 4) (Table 2).
Open in a separate window
Figure 3
Day14: ConrolG: the high amounts of fibroblasts and the low of collagen together with the
presence of the inflammatory cells accumulation,Day14:Experimental G: the formation of
numerous blood vessels with the presence of mononuclear cells together with the moderate
amounts of fibroblast and collagen matrix, Day19:ConrolG: The numerous number of the
blood vessels (angiogenesis)and fibroblast compeer with the less amount of inflammatory
cells, Day19:Experimental G: collagen deposition and fibroblast without blood vessels and
reduced inflammatory cells infiltration, Day24:ConrolG: parenchymal fibroblast matrix
patch induces angiogenesis and increases fibroblasts, Day24:Experimental G: increased
collagen deposition together with drastic reduction of inflammatory cells, Day29:ConrolG:
collagen deposition and fibroblasts are seen , Day24:Experimental G: Reconstruction of full-
thickness defects with thick collagen matrix without angiogenesis and inflammation cells.

Table 1
Evaluation of histological scoring system described by Abramov’s in the control and
experimental groups on the peritoneal wound healing in the rats

histological Day 14 Day 19 Day 24 Day 29

scores

contr experiment contr experiment contr experiment contr experiment

ol al group ol al group ol al group ol al group
group group group group

_ _ _ _
The extent of +++ + ++ +
inflammation

_ _
The severity +++ + + + + +
of
inflammation

_ _
Angiogenesis +++ +++ +++ ++ +++ ++

Fibroplasia + ++ + ++ ++ ++ + +++
 histological Day 14 Day 19 Day 24 Day 29
scores

contr experiment contr experiment contr experiment contr experiment

ol al group ol al group ol al group ol al group
group group group group

Complete re- + + + ++ ++ ++ + +++

epithelializati
on or
complete
wound
healing

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The number of the histopathological scores: 0:_; 1:+; 2:++; 3:+++.

Figure 4
Histopathological scores in all days of the experimental. CG: Control Group, EG: Experimental
Group. Series1: The extent of inflammation, Series2: The severity of inflammation, Series3:
Angiogenesis, Series4: Fibroplasia, Series5: Complete wound healing.

Table 2
Analysis of histological scores by test statistics

Histol Day 14 Day 19 Day 24 Day 29

ogical
scores

M Wil Z As M Wil Z As M Wil Z As M Wil Z Asy

W coxo tes ym W coxo tes ym W coxo tes ym W coxo tes mp
U n t p. U n t p. U n t p. U n t .
W. Sig. W. Sig. W. Sig. W. Sig.
(2- (2- (2- (2-
tail tail tail tail
ed) ed) ed) ed)

The 0.0 10.0 −2. 0.0 0.0 10.0 −2. O. 0.0 10.0 −2. 0.0 6.0 27.0 −2. 0.0
extent 00 00 49 13 00 00 49 O1 00 00 64 08 00 00 34 19
of 4 4 3 6 5
inflam
matio
n

The 0.0 10.0 −2. 0.0 0.0 10.0 −2. 0.0 8.0 18.0 0.0 1.0 6.0 27.0 −2. 0.0
severit 00 00 64 08 00 00 64 08 00 00 00 00 00 00 34 19
y of 6 6 5
inflam
matio
Histol Day 14 Day 19 Day 24 Day 29
ogical
scores

M Wil Z As M Wil Z As M Wil Z As M Wil Z Asy

W coxo tes ym W coxo tes ym W coxo tes ym W coxo tes mp
U n t p. U n t p. U n t p. U n t .
W. Sig. W. Sig. W. Sig. W. Sig.
(2- (2- (2- (2-
tail tail tail tail
ed) ed) ed) ed)

Angio 4.0 14.0 −1. 0.1 0.0 10.0 −2. 0.0 0.0 10.0 −2. 0.0 0.0 21.0 −3. 0.0
genesi 00 00 52 27 00 00 64 08 00 00 49 13 00 00 14 02
s 8 6 4 6

Fibrop 0.0 10.0 −2. 0.0 0.0 10.0 −2. 0.0 4.0 14.0 −1. 0.1 0.0 21.0 −3. 0.0
lasia 00 00 49 13 00 00 64 08 00 00 52 27 00 00 14 02
4 6 8 6

compl 8.0 18.0 0.0 1.0 0.0 10.0 −2. 0.0 4.0 14.0 −1. 0.1 0.0 21.0 −3. 0.0
ete 00 00 00 000 00 00 64 08 00 00 52 27 00 00 31 01
woun 6 8 7
d
healin
 Histol Day 14 Day 19 Day 24 Day 29
ogical
scores

M Wil Z As M Wil Z As M Wil Z As M Wil Z Asy

W coxo tes ym W coxo tes ym W coxo tes ym W coxo tes mp
U n t p. U n t p. U n t p. U n t .
W. Sig. W. Sig. W. Sig. W. Sig.
(2- (2- (2- (2-
tail tail tail tail
ed) ed) ed) ed)

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MWU: Mann–Whitney U, Asymp. Sig. (2-tailed): Asymptotic Significance (2-tailed).

On the day 14 of treatment group, there’s absence of wound regeneration with minimal
neovascularization and cellular infiltrates and also, dilated blood vessels with stasis were
seen underneath and in the granulation tissue. Moreover, thick coarse collagen fibers
accumulated in the wound region under the granulation tissue with cellularity increases
mainly due to fibroblasts proliferation and new matrix deposition.
In control group, the low amounts of inflammatory cells together with the presence higher
of fibroblasts and angiogenesis were found (Figure 3) (Table 1). Finally, in day14, in all
wound healing factors, no significant differences were observed histologically in 95% of
both groups (P > 0.05) (Figure 4) (Table 2).
On the days 19 and 24 of treatment group, inflammatory cells are few and are mainly
mononuclear cells (lymphocytes, plasma cells and macrophages) and these cells remain at
the border of the scar. At this time point a small number of myofibroblasts and luminized
vessels were present in the granulation tissues of wounds. And compared to the first two
groups, healing was better. The surface was completely covered with epithelium. Compared
to other groups, less scar tissue formation was noted with thick and almost normally
arranged collagen fibers with the number of mild to moderate fibroblasts.
In control group, the presence of high numbers of fibroblasts, collagen and angiogenesis
were observed (Figure 3) (Table 1). Finally, in days 19and 24, significant differences were
observed histologically in 95% of both groups on the extent of inflammation and
angiogenesis (P < 0.05), also in other healing factors, no histologic difference were noted
between the test and control groups (P > 0.05) (Figure 4) (Table 2).
In the experimental group, on the 29th day, histopathology revealed that decreased
inflammatory cell infiltration, the fibroblasts became increasingly mature and collagen
deposited. Furthermore, the results of the histologic analysis showed that the collagen
deposition in the wound was significantly higher compared with the other groups and also,
the inhibition of angiogenesis was observed.
In control group, the low number of fibroblasts together with collagen matrix and
angiogenesis were observed (Figure 3) (Table 1). Finally, in day 29, significant differences
were observed histologically in 95% to 99% of both groups (P < 0.05) (Figure 4) (Table 2).
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Discussion
In the present study, the wound healing process of rat peritoneal was histopathogically
described during the first twenty-nine days. Other studies evaluated histologically only
certain time intervals, i.e. the seventh day by Menetrey et al. [23], the fourth and seventh
day by Rasik et al. [24], the second, fourth, seventh and fourteenth day by Whelan et al.
[25] and the first, third, fifth, seventh and tenth day by Connolly et al. [26] and they
observed an influence of various factors on the wound healing. Our study correlates with
other studies researching histopathologically the wound healing process (per primam
intentionem) of the rat skin [27-33]. The most significant pathological changes occur
during the first fourteenth days of wound healing [34] and this contributes to the
importance of our study. And in the present study, the tissue samples taken from the
wounds were examined histopathologically for inflammatory cell infiltration, fibroblast
activity, granulation, vascularization and re-epithelialization or complete regeneration.
These assessments were performed on 14 th, 19 th, 24 th and on the 29 th day after
wounding.
Wound healing is complex and involves multiple molecular processes, including
inflammation, angiogenesis, granulation tissue formation, re-epithelialization, and wound
contraction [35] .In the tissue repair process, inflammatory cells promote the migration and
proliferation of endothelial cells, leading to neovascularization of connective tissue cells
which synthesize extracellular matrices including collagen, and of keratinocytes resulting to
re-epithelialization of the wounded tissue [5,10,15,32]. Inflammation, collagen maturation,
and scar formation are some of the many phases of wound healing, which run concurrently
but independent of each other
In our study, the complete regeneration of the peritoneal wound was finished on the first
twenty-nine day after the surgery, which is comparable to humans [35,36]. In a study,
Sardari et al., [15] reported that Theranekron can significantly stimulate epithelialization in
full thickness wounds in cows during the first 14 days of healing and this is partially in
agreement with our results, because in the present study complete epithelialization was
observed in the 29th day. Our results showed that fourteenth days post-surgery allow
evaluating the low amounts of the inflammatory reaction and the beginning of re-
epithelialization. Twenty-nine days are suitable for the assessment of the proliferative phase
and re- epithelialization as well. Finally, twenty-nine days after surgery is possible to
evaluate wound maturation and scar formation.
Some reports have described Theranekron as having beneficial effects on the healing of
cow hoof injuries [14]. In parallel ,in the present study, significant differences was
observed in peritoneal wound healing in the test and control groups (P < 0.05).
Furthermore,in a study with therankron, oryan et el., [37]. showed the anti-inflammatory
effects of Tarantula cubensis (theranekron) on the tendon lesions and the number of the
inflammatory cells and the amounts of tissue swelling in the injured treated tendon was
significantly lower than the injured control tendons.This is in agreement with our study,
was observed that the anti-inflammatory effects of theranekron on the peritoneal wound
healing in rat and also, detected that the amounts of the inflammatory cells the experimental
groups were significantly lower than the injured control groups (P < 0.05).
To our knowledge, the present study is the first to reveal that subcutaneous administration
of theranekron accelerates peritoneal wound healing using rat wound model. It was
demonstrated by a significant increase in the rate of wound closure and enhanced
epithelialization. A significant increase (P < 0.05) in collagen levels were also observed,
which was further supported by histopathological studies and gain in granuloma
angiogenesis. Collagen and angiogenesis are required for normal wound healing. Therefore,
stimulating their synthesis when wound repair is defective would be beneficial for
promoting wound healing. And also, collagen is produced by fibroblasts and helps the
wound gain tensile strength during repair [38]. Several studies reported an increase in
wound tensile strength, which depends on factors in addition to collagen deposition, namely
matrix deposition and cell migration [39]. In the beginning a wound will only have little
breaking strength because the clot will alone be holding the edges together [40,41].
Thereafter tensile strength increases rapidly as collagen deposition increases and cross-
linkages are formed between the collagen fibres. Our results also showed theranekron
treatment caused a significant increase in wound collagen content measured as H&E
staining.
Angiogenesis is a complex, multistage process, in which a variety of cells are involved in
the construction of new blood vessels [42-44]. In the present study, as healing progressed,
these vessels decreased in number, but were noted to be larger calibre mature blood vessels
at day 14 in theranekron treated group compared with control group, which were consistent
with this previous study [45].
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Conclusions
This study demonstrated that histopathological evaluation of the wound site provided
evidence of a more desirable histological organization of the tissue in response to
theranekron treatment. Treatment of rats with theranekron resulted in an enhancement of
wound healing, as evidenced by increased wound re-epithelialization closure, fibroblasts
and the formation of new blood vessels. The results of our study show the efficacy of
theranekron treatment on wound healing in animals. On the basis of these results, we
believe that theranekron is a therapeutically beneficial method to treat wounds in clinical
practice.
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Acknowledgements
The authors thank Dr. Javad Javanbakht for his help to this manuscript.
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Footnotes
Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

FDH and FF: designed the study, analyzed the data and drafted the manuscript. SHFH and BR:
carried out the experiments and performed the data analysis. EF and AFF: critical revision of the
manuscript for intellectual content together with study supervision MD: histopathological analysis
together with analysis and interpretation of data and drafting of the manuscript. All authors read and
approved the final manuscript.

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Contributor Information
Farajollah Adib-Hashemi, Email: moc.liamg@imehsahaf.
Farshad Farahmand, Email: moc.oohay@dnamharaff.
Shamim Fattah Hesari, Email: moc.oohay@hfmimahs.
Bijan Rezakhaniha, Email: moc.liamg@hkrnajib.
Ehsan Fallah, Email: moc.oohay@fnashe.
Amir Farshid Fayyaz, Email: moc.oohay@ffrima.
Masoomeh Dadpay, Email: moc.oohay@yapdadm.
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 Journal of Wound CareVol. 26, No. 2Research

The effects of Tarantula cubensis venom on

open wound healing in rats
N.Y. Gul Satar
, 
I.T. Cangul
, 
A. Topal
, 
H. Kurt
, 
V. Ipek
, 
G.I. Onel
Published Online:9 Feb 2017https://doi.org/10.12968/jowc.2017.26.2.66

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Abstract
Objective:
The aim of this study was to evaluate the clinical and histopathological effects of two
different dosages of alcohol extract of Tarantula cubensis (Theranekron) on open wounds.

Method:
A total of 24 Sprague-Dawley rats were randomly divided into Tarantula cubensis extract
(TCE1, n=8) 1/10 diluted, TCE (TCE2, n=8), and (3) vehicle-control (0.2 ml of 96 %
ethanol, n=8) groups. Experimental full-thickness 1 x 1cm wounds were created on dorsum
skin. TCE or vehicle were given systemically by subcutaneous injections on postoperative
days 1 and 4. Wound planimetry and procurement of biopsies was performed on days 4, 8,
12 and 16.

Results:
The mean non-epithelialised wound area in the vehicle-control group was significantly
larger than in the TCE1 group on days 4, 8, 12 and 16, and in the TCE2 group on days 8, 12
and 16 (p<0.05). The mean percentage of wound contraction was significantly higher in the
TCE1 and TCE2 groups than in the vehicle control group on days 8, 12 and 16 (p<0.05).
Histopathologically, wound healing was characterised by a significant decrease in the
neutrophil counts and a significant increase in neovascularisation; neither were effected by
TCE.

Conclusion:
Our results suggest that alcohol extract of Tarantula cubensis accelerates epithelialisation
and, thus, has beneficial effects on open wound healing in rats

https://www.magonlinelibrary.com/doi/abs/10.12968/jowc.2017.26.2.66

Homeopathy 2015; 104(03): 205-210

DOI: 10.1016/j.homp.2015.02.005
Original Paper
Copyright © The Faculty of Homeopathy 2015
Effects of Tarantula cubensis D6 on aflatoxin-induced injury in biochemical
parameters in rats

Mürsel Karabacak
, 
Gökhan Eraslan
, 
Murat Kanbur
, 
Zeynep Soyer Sarıca
› Author Affiliations
Further Information
 Abstract
 Full Text
 References

  Buy Article Permissions and Reprints

Introduction: Aflatoxins are toxic fungal metabolites that have adverse effects on humans and animals. Tarantula
cubensis D6 is used as a homeopathic medicine for different purposes. The present study investigates the effects
of Tarantula cubensis D6 on the oxidant-antioxidant balance and some biochemical parameters against exposure to
aflatoxin.

Methods: Thirty-two Sprague-Dawley female rats were used and evenly divided into four groups. Group 1 served as
control. Groups 2, 3, and 4 received 200 μl/kg.bw/day Tarantula cubensis D6 (applied subcutaneously), 400 μg/kg.bw/day
total aflatoxin (approximately 80% AF B1, 10% AF B2, 6 %AF G1, and 4%AF G2), and 200 μl/kg.bw/day Tarantula
cubensis D6 plus 400 μg/kg.bw/day total aflatoxin, respectively, for 28 days. At the end of 28 days, blood samples and
some organs (liver, kidney, brain, and spleen) were taken from all the animals. Oxidative stress markers (MDA, SOD,
CAT, GSH-Px) and some biochemical parameters (glucose, triglyceride, cholesterol, BUN, creatinine, AST, ALT and
ALP, total protein, albumin) were evaluated in blood samples and tissues.

Results: Aflatoxin caused negative changes in all oxidative stress parameters and some biochemical parameters (glucose,
triglyceride, cholesterol, creatinine, AST, ALT, ALP, total protein, albumin). Administration of Tarantula cubensis D6
partly alleviated aflatoxin-induced negative changes.

Conclusions: Our results indicated that Tarantula cubensis D6 partially neutralized the deleterious effects of aflatoxin.

Keywords

Aflatoxin - Tarantula cubensis D6 - Oxidative stress - Biochemical parameters - Rat

https://www.thieme-connect.com/products/ejournals/abstract/10.1016/j.homp.2015.02.005

Books & Journals » Kents New remedies, Clinical Cases, Lesser Writings, Aphorisms and
Precepts [Clinical Part] by Kent J. T. » Cases of Tarentula Cubensis
Cases of Tarentula
Cubensis
by James Tyler Kent

Cases of cancer cured with Tarentula Cubensis presented by J.T.Kent in his book on New
remedies and Clinical cases….

BUBO IN THE LEFT GROIN. Case I. A young man came to me

with a bubo in the left groin. He had been disappointed in that he
had not obtained relief from the treatment used. His bones ached,
his tongue was loaded, and his breath smelled badly. The
tumefaction was hard and painful, bluish and mottled, with great
burning and sharp cutting pain. It was discovered some distance
around and the heat was intense. He took Tarentula cubensis 12x,
and one powder dry on the tongue three mornings in succession.
He returned on the third day after taking his last powder saying
that he was poisoned. He complained of a wild feeling in his brain
and a drawing sensation in the scalp and muscles of the face. He
was in a great state of mental anxiety and said he felt as if he was
going to lose his reason. Mental restlessness was marked in his
countenance. He could not keep quiet even after I assured him
that he was in no danger. His primary symptoms had nearly gone
and the bubo had lost its bad colour. The next day he was much
improved in a general way and the bubo had nearly disappeared. I
saw him again in three days and the improvement was going on
rapidly. The chancre healed rapidly and in one month he told me
he had never been so well.

CANCER CURES

(In private discussion.)

In cancer patients, when painful conditions arise, for instance,

diarrhoea or urinary disturbances, caution in prescribing is
necessary, that a remedy be not administered covering only the
acute condition. Any prescription based on the more superficial,
acute disorder, not covering the deeper, chronic, carcinomatous
nature, will result in amelioration of the acute disorder only.
Meanwhile suffering from the deeper affection will increase, and
the progress of the deeper, malignant disorder will be more rapid.

Any prescrIption, to be of benefit to the patient, must have the

nature of the chronic, as much as the nature of the acute
manifestation.

The aim of the physician, first, last, and always, must be to find the
remedy which most closely corresponds to the patient, and
prescribe for the patient, Whatever manifestation that patient may
suffer, when the prescription is selected.

In cancer patients, incurability depends upon the fact that few

symptoms except those of the cancerous tissue change are
obtainable. The sharp pains, the ulceration, and the anaemia are
symptoms of the ultimate disorder. Finding symptoms that
preceded this period is necessary for gaining any curative results.

Ultimates do not indicate the remedy for the patient.

CANCER OF LIVER.
Dr. Lippe’s daughter had cancer of the liver. Her distress was
intense. As her father watched her, he noted that she rolled
constantly from side to side. This reminded him of the description
of Tarentula just published, which he had read a few days
previously, emphasizing this feature. He administered Tarentula
and obtained for the sufferer euthanasia that appeared impossible
before

https://homeopathybooks.in/kents-new-remedies-clinical-part/cases-of-tarentula-cubensis/

TARENTULA CUBENSIS
by E.B.Nash

Therapeutic use of homeopathic remedy Tarentula Cubensis described by E.B. Nash in his
book Leaders in Homeopathic Therapeutics, published in 1898….

Or the hairy spider. It is one of the most efficacious remedies for

boils, abscesses, felons, or swellings of any kind, where the
tissues put on a BLUISH COLOR, and there are INTENSE
BURNING PAINS. We used to think we had two great remedies in
ARSENICUM and ANTHRACINUM, for these swellings; but
TARANTULA CUBENSIS is simply wonderful. I have seen felons
which had kept patients awake night after night walking the floor in
agony from the terrible pains so relieved in a very short time that
they could sleep in perfect comfort until the swellings
spontaneously discharged, and progressed to a rapid cure. This
remedy should receive a thorough proving. It is a gem.

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Related Posts:
1. Cases of Tarentula Cubensis Cases of cancer cured with Tarentula
Cubensis presented by J.T.Kent in his book on New remedies and Clinical
cases.......
2. Tarentula Cubensis Tarentula Cubensis signs and symptoms of the
homeopathy medicine from the Dictionary of Practical Materia Medica by J.H.
Clarke. Find out for which conditions and symptoms Tarentula Cubensis is
used......
3. References 1- Samuel Hahnemann, Organon of Medicine, 2000 compiled
by Dr.Jalali......
4. TARENTULA CUBENSIS Homeopathy medicine Tarentula Cubensis
from William Boericke's Pocket manual of homoeopathic materia medica,
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E.B.Nash
https://homeopathybooks.in/leaders-in-homeopathic-therapeutics-by-e-b-nash/tarentula-
cubensis-5/

Books & Journals » Dictionary of Practical Materia Medica by J.H. Clarke » Tarentula

Cubensis

Tarentula Cubensis
by John Henry Clarke
Tarentula Cubensis signs and symptoms of the homeopathy medicine from the Dictionary
of Practical Materia Medica by J.H. Clarke. Find out for which conditions and symptoms
Tarentula Cubensis is used…

      Mygale Cubensis. Aranea peluda. Cuban

Tarentula. *N.O. Araneideae. Tincture of whole
spider.
Clinical
*Carbuncle. Chorea. Intermittents.

Characteristics
“The *Mygale Cubensis, which may be called the *Cuban
Tarentula, also found in South Carolina and Texas, is a larger
spider, of a dark brown colour, less poisonous, and covered with
more hairs than the *Tarentula Hispanica” (Hering). The chief uses
to which *Trn. *c. has been put are: (1) Carbuncle, even to
sloughing, with great prostration and diarrhoea. (2) Intermittent
fever, with evening exacerbation. A keynote symptom is “atrocious
pains.” A case of chorea in a girl of twelve is reported (*H. M.,
March, 1901) cured with *Trn. *c. 6. The movements were
confined to the left side, and occurred chiefly at night, when *Trn.
*c. was prescribed.

Relations
*Compare: In intermittents, Aran-d. Carbuncle, Anthrac., Lachesis,
Silicea SYMPTOMS.

Mind
Anxiety. Delirium.

Head
Headache.

Stool
Diarrhoea.

Urinary Organs
Retention of urine.

Generalities
Toxaemia.

Skin
The bite is painless, the person is not sensible of it till next day,
when an inflamed pimple is found surrounded by a scarlet areola,
from the pimple to some other part of the body a red erysipelatous
line is seen, marking the line followed by the spider over the skin
after biting. This pimple swells, the inflamed areola spreads, chills
and fever set in with copious sweat and retention of urine, the
pimple becomes a hard, large, exceedingly painful abscess,
ending by mortification of the integuments over it, and having
several small openings, discharging a thick, sanious matter
containing pieces of mortified cellular tissue, fasciae, and tendons,
the openings by growing run into one another, forming a large
cavity, at this period the fever takes the intermittent type with
evening exacerbations. In two cases, in delicate children, the bite
proved fatal, but the majority recover in from three to six weeks.

Fever
Chills followed by intense burning fever supervene on second or
third day, with great thirst, anxiety, restlessness, headache,
delirium, copious perspiration and retention of urine. Later the
fever takes the intermittent type, with evening paroxysms,
accompanied by diarrhoea and great prostration

Books & Journals » Homeopathic Drug Pictures by M.L. Tyler » TARENTULA

CUBENSIS

TARENTULA CUBENSIS
by Margaret Lucy Tyler

TARENTULA CUBENSIS symptoms of the homeopathy remedy from Homeopathic Drug

Pictures by M.L. Tyler. What are the symptoms of TARENTULA CUBENSIS? Keynote
indications and personality traits of TARENTULA CUBENSIS…

Introduction
      Tarentula cubensis is a remedy that has stared and
beckoned for many years: because it was one of the 144
precious “cm” s, “grafts from his pocket case”, sent to us by DR.
NASH, after his visit to this country. If so high in the estimation
of such a prescriber as to have a place in his pocket case, and to
be one of his “144”, surely it was worth trying for the septic
conditions for which he advocates it in his Leaders (?) as
follows:
“Tarentula cubensis, or the hairy spider. It is one of the most
efficacious remedies for boils, abscesses, felons, or swellings of
any kind where the tissues put on a bluish colour, and there are
intense burning pains.

“We used to think that we had two great remedies in Arsenicum

and Anthracinum; but Tarentula cubensis is simply wonderful. I
have seen felons which had kept patients awake night after night
walking the floor in agony from the terrible pains so relieved in a
very short time that they could sleep in perfect comfort until the
swellings spontaneously discharged and progressed to a rapid
cure. This remedy should receive a thorough proving. It is a gem.”

One may say, that many experiences with this remedy have more
than confirmed its worth.

KENT, New Remedies, gives a case showing the powerful action

of Tarentula cubensis in Carbuncle on the back of neck.

A lady, age about 30, suffered greatly from a carbuncle on the

back of her neck. She had applied many domestic remedies and
obtained no relief. The tumefaction seemed destined to suppurate.
It was mottled bluish and the pain was intense, knife cutting and
burning. She was sick at the stomach to vomiting, and at night she
was delirious. Her eyes were staring and there was some 0 fever;
the tongue was foul and the breath fetid. There was great tension
in the scalp and muscles of the face. She begged for morphine to
“stop that burning and cutting.” Tarentula cubensis 12x, one dose,
produced quiet immediately and the angry looking tumefaction
failed to complete its work: it did not suppurate. The discoloration
was gone in two days, and the hardness soon disappeared also.
She regained her normal state very rapidly, and she said to me a
short time ago that she had never had her old headache since that
swelling left her, showing how deeply the medicines affected her
whole system.
If a part is mottled (Lachesis), bluish, growing dark, with those
symptoms, Tarentula cubensis must be the most appropriate
remedy.

In regard to Tarentula cubensis, Dr. Oscar Hansen, of

Copenhagen in his Textbook of Rare Homoeopathic Remedies,
writes: “Therapeutics. Gangrene. Carbuncle, even sloughing, with
great prostration and diarrhoea, intermittent fever of evening
exacerbation. Acts magically in the most terrible burning, stinging
pains here. A purplish hue with the above pains is characteristic.
(Compare Lachesis, Anthracinum, Silica.) Recommended in the
last stage of tuberculosis pulmonum. Diphtheria, malignant type,
deposit dark-coloured, fetid breath, septic fever. Typhoid fever,
fetid dark stool, great prostration.”

Our Materia Medica textbooks have so little to say about the

Tarentula-either the Spanish or Cuban, that it may be helpful to
quote a discussion in America, on a paper entitled “Tarentula in
Meningitis” by Dr. Neiswander (Ohio) which appeared some time
ago in the Homoeopathic Recorder. Here we learn a great deal
about Tarentula cubensis, for knowledge of which we are greedy,
since it is such a very potent remedy, especially in septic
conditions, and since so little is to be learnt about it in our
textbooks.

By the way, Dr. Neiswander’s Tarentula in Meningitis” was the

Hispania. But what Dr. Roberts has to say regarding the origin of
the cubensis, is of the greatest interest. He tells us that we have
here not only the Cuban Tarentula, but a rotten Cuban Tarentula;
which gives us, he suggests, not only the temperament and
mental symptoms of Tarentula, but the septic element of the
decomposed spider. Sounds nasty? but it works. And it comes into
line, to some extent, with Pyrogen, ‘gotten” as they say “across the
ditch”, from rotten meat. These have powers of combating similar
conditions of sepsis, and are drugs of the greatest importance and
value. We will reproduce from the discussion on the two drugs.
DR. MACFARLAN: I don’t know anything about Tarentula
hispania, but I know that Tarentula cubensis is a wonderful
remedy. I made that proving about ten years ago. I also made a
good cure with it in a terrible case of cough, something like
whooping cough that seemed to tear the patient to bits. Tarentula
does tear them to bits, and I gave it with a marvellous response
from the start.

Tarentula cubensis produces great drowsiness, I think it is more

useful in whooping cough than Ipecac. or Castanea vesca or any
other remedy I know; it is marvellous.

DR.BENTHACK: I have never before heard of its use in

meningitis, but Tarentula cubensis is my standby in any abscess
where there is severe pain. I formerly thought I had a wonderful
remedy for such conditions in Arsenicum and Anthracinum, but I
have found Tarentula cubensis in the 30th potency does much
better.

DR. ROBERTS: Tarentula is one of the most interesting of the

spider poisons. I think we get a better concept of it we study its
habits. Tarentula hispania, as you know, is found in the western
part of this country, I have been told that before the rainy season
they migrate in herds, travelling in leaps and bounds. It makes its
nest in the ground, a burrow lined with web, and turning a sharp
angle after going down a few inches. Here the spiders sits to
watch for its prey.

It does its work by violence, one sharp pounce on the neck of its
victim, serving the ganglia. It strikes and retreats, never holding
on. It is a perfect coward when away from home. It is in these
things you get the characteristics, for you find this sudden violence
all through the remedy-the sudden impulse to do harm.

One Tarentula patient whom I knew seemed to be quiet and

peaceable; the nurse left the room and instantly the patient
jumped from bed before the nurse left the room and instantly the
patient jumped from bed, swept everything from the shelf and was
back in bed before the nurse could get back. That is Tarentula:
violence of onslaught, fear to face real opposition or when they are
away from home-just as the spider does in its natural setting.

In regard to Tarentula cubensis, while it is not mentioned in this

paper, it is much like Tarentula hispania; it is the same spider or
closely related, only coming from Cuba. Dr. T.F.Allen told me the
history of this remedy. The Tarentula cubensis was being shipped
to this country in a container with alcohol to preserve it. The
container broke on the way up, the alcohol ran out and the
specimen decomposed. However, a potency was made, and it is
the pyogenic effect of the decomposition that is the greatest
differentiation between Tarentula hispania and the Tarentula
cubensis, for all our higher potencies were made from that stock. It
is worth consideration, because there you get the mentality of
Tarentula hispania and the septic conditions of Tarentula
cubensis.

DR. FARRINGTON: It would be interesting to re-prove a fresh

specimen of Tarentula cubensis. That is one deficiency you might
say, in our materia medica and its provings, that we have evidently
not got the real symptoms of Tarentula cubensis. Perhaps it would
result in a reproduction of what we get from Tarentula hispania.

DR. FARRINGTON: Probably the accident gave us a new remedy

which we would not have had before, much as an accident gave
us Causticum, because that is a compound subject, Hahnemann’s
tincture acris kali, which cannot be found in any pharmacopoeia
except the Homoeopathic.

A number of years ago I reported a case to this society, of a young

fellow of eighteen who was supposed to have had dementia
praecox cured with Tarentula, and his symptoms and his general
behaviour were just as Dr. Roberts has described. He would fly
into a rage over something and throw whatever was in his hand,
whatever he could reach. He nearly killed his mother with a big
pitcher. She objected to something he had done or said and he
threw it at her and just missed her, and smashed an enormous
mirror to smithereens.

Another interesting symptom of Tarentula is the heart. A number

of you know those heart symptoms, sudden and violent, and in
some of our materia medicas the condition Tarentula produces
and cures is called St. Vitus’ Dance of the heart.

Several years ago I was called in the middle of the night to South
Bend, Indiana, and found a man of forty-five years of age, pales
as death, frightened. His heart was beating rapidly and he thought
he was going to die; in fact, the physician who examined him told
him that he had a serious heart trouble and did not have long to
live.

I examined his heart very carefully and found no lesions

whatsoever, but every now and then he would start to jump, and
then it would go like that, up and down, and then settle down; and
he had a previous history of diarrhoea and digestive symptoms,
referable especially to the colon, and I have to add, though I
asked him a few questions, I could get very few symptoms
besides the objective ones. I think what I said to him did him
almost as much good as the medicine. I told him he was suffering
from auto-intoxication and had no heart disease at all, and I gave
him a dose of Tarentula. Two weeks later he was up to see me,
apparently a well man.

DR. GREEN. I have had a chance to watch Tarentula fairly closely

and I want to add to what Dr. Roberts said about the sudden sly,
destructive tendency, a tendency to change one’s disposition
altogether from a sweet, wholesome, rational person, to someone
who is so terribly self-centered and selfish, and who wants nothing
but to have everyone standing around waiting on him, and even to
interfere with the nurse going on or off duty, because of some
imaginary ailment like feigning a swoon, or some thing to oblige
that person to stay near.
DR. BENTHACK said that before he knew Tarentula was used in
ulcers, he used to depend on Arsenic for burning ulcers. “That
reminds me to say that I have learned that Tarentula and
Arsenicum are complementary remedies in such chronic cases.”

Veneno de tarántula alberga

componentes útiles para la creación
de fármacos
EFEMéxico15 nov. 2017

Fotografía del 26 de marzo de 2017, que muestra un ejemplar de tarántula de rodillas rojas (Brachypelma
smithi), en el tarantulario "Aracneé", situado en Coyuca de Benitez, Guerrero (México). El veneno de la
tarántula contiene toxinas que, utilizadas en la creación de fármacos, pueden evitar arritmias cardiacas,
reducir las molestias intramusculares o mejorar la permeabilidad capilar, explicó hoy la biotecnóloga Herlinda
Clement. EFE

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 Menéame
El veneno de la tarántula contiene toxinas que, utilizadas en la creación de
fármacos, pueden evitar arritmias cardiacas, reducir las molestias intramusculares
o mejorar la permeabilidad capilar, explicó hoy la biotecnóloga Herlinda Clement.

La enzima hialuronidasa presente en el veneno de la tarántula (Lycosa tarántula)

tiene "importancia médica" pues "incrementa la velocidad de absorción en
medicamentos, disminuye el malestar de dolencias intramusculares y mejora la
permeabilidad capilar", entre otros usos.

Al participar en el Coloquio de Divulgación sobre Riqueza Natural y Sociedad

celebrado en la Universidad Nacional Autónoma de México (UNAM), la experta
aclaró que, contrario de lo que se piensa, el veneno de este arácnido "no es tóxico
para los humanos", ya que solo provoca una leve urticaria.

"Su veneno no es tóxico para nosotros los humanos, pero sí tienen compuestos
muy importantes que pueden servir como herramientas o la elaboración de
fármacos", aseguró.

En declaraciones a Efe, la investigadora enumeró otros posibles usos de los

venenos de la tarántula, como la parálisis que provocan sus toxinas en la larva del
gusano cogollero, un insecto que suele dañar cosechas de maíz.

"Sería una buena alternativa, en lugar de usar pesticidas que dañan a los
humanos, usar este compuesto que es más natural", dijo la experta del Instituto de
Biotecnología de la UNAM.

Además, el veneno de esta araña posee actividad antibacteriana que elimina

algunas bacterias dañinas para el ser humano.
Clement aclaró que "por el momento" no existen fármacos que se sirvan de estas
propiedades.

Para llevar a cabo esta empresa, se necesita el apoyo de compañías que "estén
interesadas en producir fármacos a nivel industrial con la toxina o el péptido de
este tipo de arácnidos".

Durante su conferencia, relató los experimentos que se llevan a cabo en el

aracnario del laboratorio que dirige el doctor Gerardo Costa en el que ella trabaja.

"Para extraer este veneno, lo que hacemos es tener una esponja, agua, ligas, un
cubito y un aparato para dar descargas eléctricas", explicó.

Hacen morder a la araña una cánula y posteriormente se le aplican "ligeros toques

eléctricos" en la base de sus colmillos, para así obtener el veneno, cosechado en
minúsculos cubos y almacenado de -20 a -70 grados centígrados para su estudio.

El veneno es depositado en un gel que separa sus componentes, a fin de obtener

extractos concretos.

Con respecto a los arácnidos, cuyo veneno sí es dañino para el ser humano, como
la araña violinista (Loxosceles laeta) o la viuda negra (Latrodectus mactans), la
especialista indicó que "existen diferentes grados de parálisis dependiendo de la
persona".

"Un adulto con un sistema inmunológico dañado puede experimentar un

envenenamiento mucho más severo", o si la araña acaba de comer, también
afectará a la cantidad de veneno y, por ende, sus efectos.
https://www.efe.com/efe/america/mexico/veneno-de-tarantula-alberga-componentes-utiles-
para-la-creacion-farmacos/50000545-3439672

El veneno de tarántula puede evitar la muerte

de condrocitos
Volver a Músculos y huesos

Ester Crespo. Madrid | dmredaccion@diariomedico.com

Lunes, 08 de Diciembre de 2014 - 01:00
Una sustancia del veneno de esta araña previene la muerte de las
células del cartílago en una lesión mecánica y una metodología de
técnicas proteómicas identifica biomarcadores de diagnóstico en la
patología.
Una sustancia que se encuentra en el veneno de la tarántula, GsMTx4, previene la muerte
de las células del cartílago en una lesión mecánica, según un trabajo de la Universidad de
Duke, en Carolina del Norte (Estados Unidos), publicado en Proceedings of the National
Academy of Sciences. Diario Médico expone los resultados del estudio en esta
sección, Objetivo: artrosis, que con la colaboración de Bioibérica Farma persigue centrar la
atención sobre los avances terapéuticos en esta enfermedad reumatológica.
Para llegar a esta conclusión, los investigadores identificaron los canales Piezo 1 y Piezo 2,
presentes en el cartílago de los mamíferos, que intervienen en la muerte celular cuando el
cartílago sufre una lesión causada por una tensión mecánica. Tras identificarlos, se
preguntaron "qué se podría emplear para bloquearlos. Aprovechamos el hecho de que el
canal Piezo 1 es sensible a GsMTx4 -toxina de la Grammostola spatulata, un tipo de araña-,
hallazgo que descubrió hace varios años Frederick Sachs, de la Universidad de Búfalo, en
Nueva York", apunta Wolfgang Liedtke, profesor asociado de Neurología, Anestesiología y
Neurobiología de la Universidad de Duke, en Carolina del Norte (Estados Unidos), y autor
del estudio.
Potencia de la sustancia
Los investigadores han demostrado que GsMTx4 inhibe Piezo 1/Piezo 2, algo que no se
conocía antes. Para Liedtke, los aspectos más sorprendentes del estudio fueron observar la
actividad conjunta de Piezo 1 y Piezo 2, que estos canales podían ser inhibidos por dosis
más bajas de GsMTx4 y la potencia de esta sustancia para prevenir la muerte celular de
condrocitos en un modelo de lesión mecánica. Este nuevo descubrimiento, según Farshid
Guilak, profesor de Cirugía Ortopédica en Duke y otro de los autores, podría conducir a
posibles avances farmacológicos para proteger las articulaciones y prevenir el dolor
asociado con las lesiones de cartílago.
"El andamio proteico de la célula juega un papel enorme en cómo los canales Piezo 1 y
Piezo 2 funcionan. La dinámica del citoesqueleto es importante para la inserción de los
canales Piezo en la membrana. Una vez en la membrana, los canales parecen perder su
sensibilidad de manera que dosis más bajas de GsMTx4 son suficientes para inhibir el
canal. Esta estrategia podría ser usada para intentar tratar las lesiones de la articulación con
GsMtx4", explica Liedtke.
Los siguientes pasos en la investigación, según el científico estadounidense, serán
establecer si GsMTx4 también actúa después de que la lesión mecánica ha sido causada,
observar si esta sustancia tóxica trabaja contra la lesión articular postraumática en modelos
de animales con esta condición y demostrar cómo funcionan Piezo 1 y Piezo 2 en
condiciones de inflamación y de degeneración.
En relación con este hallazgo, los investigadores descubrieron hace unos meses que la
estimulación mecánica moderada de las células del cartílago -similar a la experimentada
durante el ejercicio leve- promueve la salud mediante la activación del canal de iones
TRPV4. Además, pudieron observar que los ratones que no cuentan con canales TRPV4
tienen más posibilidades de desarrollar artrosis.

Theranekron D6
Natural therapy
Theranekron is a homeopathic remedy prepared from the spider Tarantula cubensis. The whole spider is
processed and diluted in 60% alcohol and potentiated following the rules of the “Pharmacopeia germanica”.
Indications for Theranekron are based on the “drug pictures” referred to in homeopathic literature.

Necrotising - demarcation - stimulation of healing

Theranekron stimulates the demarcation of necrotic tissue in inflammatory and purulent processes.
Epithelialisation and a faster healing process are induced. Its antiinflammatory properties inhibit the continuing
of already present inflammation. Resorption of body fluids is also stimulated by Theranekron which leads to
reduction of swelling and oedema.

Practical use in buiatrics

Theranekron is used in different diseases of the hoof, the udder and the birth canal. These include panaritium,
laminitis, foot rot, arthritis, abscesses, injuries and many more. Blunt trauma to the udder, eczema and udder
oedema associated with mastitis are successfully treated with Theranekron. Injuries of the birth canal often
occur in cattle, as well as retention of the fetal membranes. The use of Theranekron stimulates the healing
process and eases the release of the placenta.

Practical use in dogs

Theranekron supports the conventional therapy of purulent and necrotic processes. Repeated application of
Theranekron leads to demarcation and shrinking of swelling to make surgical extirpation easier. With
abscesses and inflammation of the skin and its appendages the antiinflammatory, resorption stimulating and
demarcating effect are very useful.

https://www.richter-pharma.at/product-theranekron-d6_301.htm