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  • Dik: Dosis: 500 MG BB 70 KG AUC: 125 MG / Dit: CL Total... ? Peny: VD

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    Syamsir mursali
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    The document discusses pharmacokinetic calculations for a patient named Dik. It provides Dik's dose, area under the curve (AUC), and half-life to calculate his clearance and volume of distribution. It determines Dik's total clearance is 0.51 liters/hour based on his elimination rate constant and calculated volume of distribution.

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    The document discusses pharmacokinetic calculations for a patient named Dik. It provides Dik's dose, area under the curve (AUC), and half-life to calculate his clearance and volume of distribution. It determines Dik's total clearance is 0.51 liters/hour based on his elimination rate constant and calculated volume of distribution.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    27 views1 page

    Dik: Dosis: 500 MG BB 70 KG AUC: 125 MG / Dit: CL Total... ? Peny: VD

    Uploaded by

    Syamsir mursali
    The document discusses pharmacokinetic calculations for a patient named Dik. It provides Dik's dose, area under the curve (AUC), and half-life to calculate his clearance and volume of distribution. It determines Dik's total clearance is 0.51 liters/hour based on his elimination rate constant and calculated volume of distribution.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    1.

    2. Dik : Dosis : 500 mg BB 70 kg


    AUC : 125 mg jam/liter
    Dit: Cl total...?
    Peny:
    Cl
    vd =
    k

    0,693
     Untuk nilai k = = 1,44
    t 1/2
    Dosis
     Cl =
    AUC
    = 500 mg/ 125 mg jam/liter
    = 4 liter/jam
     Vd = Cl/k
    = 4/1,44
    = 2,77

     Cl total = k/Vd
    = 1,44/2,77
    = 0,51 liter /jam

    Jadi clearence total = 0,51

    3.

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