TUGAS REGIMEN DOSIS PEMBERIAN INFUS

Soal
1. A drug belonging to the Cephalosporin antibiotics has a volume of distribution of 10 L
and an elimination rate constant (k) value of 0,2 /hr. A steady state plasma concentration
of 10 µg/mL is desired. What is the infusion rate required to maintain this concentration?

Jawaban :
Diketahui : Css = 10 µg/L → 10 / 1000 = 0,01 mg/ml
k = 0,2 /jam
Vd = 10 L → 10000 ml
Ditanya : R (laju infus) ……?
Dijawab : R = Css x k x Vd
R = 0,01 x 0,2 x 10.000
R = 20 mg/jam

2. A patient was administrated an IV infusion a certain antibiotics at an infusion rate of 15

mg/hr. blood samples were taken from this patient at 8 and at 24 hr and the plasma
concentration for this drug were found to be 5.5 and 6.5 mg/L, respectively. Calculate
approximately the elimination haff-life of this drug.

Jawaban :
K = (-2,303/T) log (Css-Cp/Css)
= 0,234 /jam
T1/2 = o,694/ 0,234 = 2,96 jam

3. A septicemia patient was administrated by constant IV infusion an antibiotics that has an

elimination half life (tx) of 6 hr. the rate of infusion was 2 mg/hr. at the end of second
day of treatment, the serum drug concentration was 10 mg/L. Calculate the total body
celareance Cl for this drug.

Jawaban :
Dikatehui : t1/2 = 6 jam
R = 2 mg/jam
Css = 10 mg/jam
Ditanya : Cl….?
R
Dijawab : Css =
Cl
R 2mg / jam
Cl = = = 0,2 L/jam = 200 ml/jam
Css 10 mg/ L